{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:58:05Z","timestamp":1723139885646},"reference-count":47,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Oncol"],"DOI":"10.3892\/ijo.2018.4490","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:26:15Z","timestamp":1531992375000},"source":"Crossref","is-referenced-by-count":3,"title":["Integrative analysis of dysregulated microRNAs and mRNAs in multiple recurrent synchronized renal tumors from patients with von Hippel-Lindau disease"],"prefix":"10.3892","author":[{"given":"Charles-Henry","family":"Gattolliat","sequence":"first","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Couv\ufffd","sequence":"additional","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Meurice","sequence":"additional","affiliation":[{"name":"Bioinformatic Platform, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\ufffddric","family":"Or\ufffdar","sequence":"additional","affiliation":[{"name":"Genomic Platform, Gustave Roussy, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Droin","sequence":"additional","affiliation":[{"name":"Genomic Platform, Gustave Roussy, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Chiquet","sequence":"additional","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Ferlicot","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1186, Gustave Roussy, Paris-Sud University, Paris-Saclay University, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Verkarre","sequence":"additional","affiliation":[{"name":"PREDIR INCa, Department of Urology, AP-HP, Bic\ufffdtre Hospital, 94270 Le Kremlin-Bic\ufffdtre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viorel","family":"Vasiliu","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Necker Hospital, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Molini\ufffd","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Cytology, Saint Joseph Hospital, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"M\ufffdjean","sequence":"additional","affiliation":[{"name":"PREDIR INCa, Department of Urology, AP-HP, Bic\ufffdtre Hospital, 94270 Le Kremlin-Bic\ufffdtre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dessen","sequence":"additional","affiliation":[{"name":"Bioinformatic Platform, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Giraud","sequence":"additional","affiliation":[{"name":"PREDIR INCa, Department of Urology, AP-HP, Bic\ufffdtre Hospital, 94270 Le Kremlin-Bic\ufffdtre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Bressac-De-Paillerets","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1186, Gustave Roussy, Paris-Sud University, Paris-Saclay University, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Gardie","sequence":"additional","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Tean Teh","sequence":"additional","affiliation":[{"name":"National Cancer Centre, Duke Graduate Medical School, Cancer Science Institute of Singapore, Institute of Molecular and Cellular Biology, Singapore 138673, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\ufffdphane","family":"Richard","sequence":"additional","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Gad","sequence":"additional","affiliation":[{"name":"Oncogenetics Laboratory, EPHE, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"key20200713185118_b1-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.semcancer.2012.05.005","article-title":"Von Hippel-Lindau: How a rare disease illuminates cancer biology","volume":"23","author":"Richard","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"key20200713185118_b2-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/00000478-198210000-00007","article-title":"Prognostic significance of morphologic parameters in renal cell carcinoma","volume":"6","author":"Fuhrman","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"key20200713185118_b3-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/ng.2699","article-title":"Integrated molecular analysis of clear-cell renal cell carcinoma","volume":"45","author":"Sato","year":"2013","journal-title":"Nat Genet"},{"key":"key20200713185118_b4-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12885-018-4176-1","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma","volume":"18","author":"Wu","year":"2018","journal-title":"BMC Cancer"},{"key":"key20200713185118_b5-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"e0176659","DOI":"10.1371\/journal.pone.0176659","article-title":"Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis","volume":"12","author":"Thiesen","year":"2017","journal-title":"PLoS One"},{"key":"key20200713185118_b6-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/ng.2891","article-title":"Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing","volume":"46","author":"Gerlinger","year":"2014","journal-title":"Nat Genet"},{"key":"key20200713185118_b7-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","author":"Cancer Genome","year":"2013","journal-title":"Nature"},{"key":"key20200713185118_b8-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.1158\/0008-5472.CAN-09-0146","article-title":"Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney","volume":"69","author":"Beroukhim","year":"2009","journal-title":"Cancer Res"},{"key":"key20200713185118_b9-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/gcc.20865","article-title":"Copy number profiling in von Hippel-Lindau disease renal cell carcinoma","volume":"50","author":"Shuib","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"key20200713185118_b10-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1186\/s13059-014-0433-z","article-title":"Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution","volume":"15","author":"Fisher","year":"2014","journal-title":"Genome Biol"},{"key":"key20200713185118_b11-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key20200713185118_b12-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/PPO.0b013e318250c001","article-title":"Causes and consequences of microRNA dysregulation","volume":"18","author":"Iorio","year":"2012","journal-title":"Cancer J"},{"key":"key20200713185118_b13-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"key20200713185118_b14-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.urology.2009.10.033","article-title":"Identification of a microRNA panel for clear-cell kidney cancer","volume":"75","author":"Juan","year":"2010","journal-title":"Urology"},{"key":"key20200713185118_b15-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1741-7015-8-64","article-title":"The VHL-dependent regulation of microRNAs in renal cancer","volume":"8","author":"Neal","year":"2010","journal-title":"BMC Med"},{"key":"key20200713185118_b16-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.eururo.2015.11.029","article-title":"Renal cell carcinoma programmed death-ligand 1, a new direct target of hypoxia-inducible factor-2 alpha, is regulated by von Hippel-Lindau gene mutation status","volume":"70","author":"Messai","year":"2016","journal-title":"Eur Urol"},{"key":"key20200713185118_b17-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: Open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"key20200713185118_b18-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key20200713185118_b19-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1038\/bjc.2013.552","article-title":"MicroRNA profile: A promising ancillary tool for accurate renal cell tumour diagnosis","volume":"109","author":"Silva-Santos","year":"2013","journal-title":"Br J Cancer"},{"key":"key20200713185118_b20-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"10521","DOI":"10.18632\/oncotarget.3294","article-title":"Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer","volume":"6","author":"Christinat","year":"2015","journal-title":"Oncotarget"},{"key":"key20200713185118_b21-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"329","DOI":"10.4161\/cbt.27314","article-title":"MicroRNA expression signatures of stage, grade, and progression in clear cell RCC","volume":"15","author":"Gowrishankar","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"key20200713185118_b22-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3109\/01902140902822312","article-title":"Differentially expressed microRNAs in small cell lung cancer","volume":"35","author":"Miko","year":"2009","journal-title":"Exp Lung Res"},{"key":"key20200713185118_b23-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.4161\/cc.9.6.11006","article-title":"MicroRNA-210: A unique and pleiotropic hypoxamir","volume":"9","author":"Chan","year":"2010","journal-title":"Cell Cycle"},{"key":"key20200713185118_b24-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/cdd.2010.119","article-title":"miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity","volume":"18","author":"Puiss\u00e9gur","year":"2011","journal-title":"Cell Death Differ"},{"key":"key20200713185118_b25-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1158\/0008-5472.CAN-14-1161","article-title":"Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis","volume":"74","author":"Couv\u00e9","year":"2014","journal-title":"Cancer Res"},{"key":"key20200713185118_b26-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/sj.cdd.4402310","article-title":"A microRNA component of the hypoxic response","volume":"15","author":"Kulshreshtha","year":"2008","journal-title":"Cell Death Differ"},{"key":"key20200713185118_b27-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.5037\/jomr.2013.4102","article-title":"MicroRNA deregulations in head and neck squamous cell carcinomas","volume":"4","author":"Chen","year":"2013","journal-title":"J Oral Maxillofac Res"},{"key":"key20200713185118_b28-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/onc.2012.636","article-title":"Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer","volume":"33","author":"Kong","year":"2014","journal-title":"Oncogene"},{"key":"key20200713185118_b29-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1128\/MCB.01276-10","article-title":"MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia","volume":"31","author":"Bruning","year":"2011","journal-title":"Mol Cell Biol"},{"key":"key20200713185118_b30-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1158\/0008-5472.CAN-13-2041","article-title":"miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation","volume":"74","author":"Hell","year":"2014","journal-title":"Cancer Res"},{"key":"key20200713185118_b31-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1158\/2159-8290.CD-13-0291","article-title":"Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2\u03b1 activity","volume":"4","author":"Mathew","year":"2014","journal-title":"Cancer Discov"},{"key":"key20200713185118_b32-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"e7094","DOI":"10.1371\/journal.pone.0007094","article-title":"The Warburg effect is genetically determined in inherited pheochromocytomas","volume":"4","author":"Favier","year":"2009","journal-title":"PLoS One"},{"key":"key20200713185118_b33-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nature10642","article-title":"Reductive carboxylation supports growth in tumour cells with defective mitochondria","volume":"481","author":"Mullen","year":"2011","journal-title":"Nature"},{"key":"key20200713185118_b34-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1053\/j.seminoncol.2016.09.001","article-title":"Genetic predisposition to kidney cancer","volume":"43","author":"Schmidt","year":"2016","journal-title":"Semin Oncol"},{"key":"key20200713185118_b35-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s002620050566","article-title":"Semiquantitative analysis of Th1 and Th2 cytokine expression in CD3+, CD4+, and CD8+ renal-cell-carcinoma-infiltrating lymphocytes","volume":"48","author":"Els\u00e4sser-Beile","year":"1999","journal-title":"Cancer Immunol Immunother"},{"issue":"11","key":"key20200713185118_b36-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00002371-199201000-00001","article-title":"Characterization of a human renal cell carcinoma specific cytotoxic CD8+ T cell line","volume":"1991","author":"Finke","year":"1992","journal-title":"J Immunother"},{"key":"key20200713185118_b37-ijo-53-04-1455","first-page":"685","article-title":"In vivo local expansion of clonal T cell subpopulations in renal cell carcinoma","volume":"55","author":"Gaudin","year":"1995","journal-title":"Cancer Res"},{"key":"key20200713185118_b38-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S0022-5347(05)68628-4","article-title":"In vivo description of dendritic cells in human renal cell carcinoma","volume":"162","author":"Schwaab","year":"1999","journal-title":"J Urol"},{"key":"key20200713185118_b39-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"6178","DOI":"10.1158\/0008-5472.CAN-04-4406","article-title":"Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor","volume":"65","author":"Zagzag","year":"2005","journal-title":"Cancer Res"},{"key":"key20200713185118_b40-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1093\/nar\/gki567","article-title":"Clustering and conservation patterns of human microRNAs","volume":"33","author":"Altuvia","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"key20200713185118_b41-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1752-0509-3-65","article-title":"Clustered microRNAs' coordination in regulating protein-protein interaction network","volume":"3","author":"Yuan","year":"2009","journal-title":"BMC Syst Biol"},{"key":"key20200713185118_b42-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1093\/hmg\/ddl001","article-title":"Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma","volume":"15","author":"Kawakami","year":"2006","journal-title":"Hum Mol Genet"},{"key":"key20200713185118_b43-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bone.2011.10.012","article-title":"Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma","volume":"50","author":"Thayanithy","year":"2012","journal-title":"Bone"},{"key":"key20200713185118_b44-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/bjc.2011.388","article-title":"Expression of miR-487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma","volume":"105","author":"Gattolliat","year":"2011","journal-title":"Br J Cancer"},{"key":"key20200713185118_b45-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1002\/cam4.264","article-title":"Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients","volume":"3","author":"Gattolliat","year":"2014","journal-title":"Cancer Med"},{"key":"key20200713185118_b46-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.canlet.2008.07.038","article-title":"MYC pathway is activated in clear cell renal cell carcinoma and essential for proliferation of clear cell renal cell carcinoma cells","volume":"273","author":"Tang","year":"2009","journal-title":"Cancer Lett"},{"key":"key20200713185118_b47-ijo-53-04-1455","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1089\/dna.2014.2629","article-title":"miR-134 functions as a tumor suppressor in cell proliferation and epithelial-to-mesenchymal Transition by targeting KRAS in renal cell carcinoma cells","volume":"34","author":"Liu","year":"2015","journal-title":"DNA Cell Biol"}],"container-title":["International Journal of Oncology"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:59:15Z","timestamp":1594666755000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijo.2018.4490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,19]]},"references-count":47,"URL":"https:\/\/doi.org\/10.3892\/ijo.2018.4490","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,19]]}}}