{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:49:56Z","timestamp":1778669396271,"version":"3.51.4"},"reference-count":85,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Oncol"],"DOI":"10.3892\/ijo.2019.4846","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T09:10:56Z","timestamp":1563786656000},"source":"Crossref","is-referenced-by-count":2,"title":["In vitro attenuation of classic metastatic melanoma\u2011related features by highly diluted natural complexes: Molecular and functional analyses"],"prefix":"10.3892","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-1481","authenticated-orcid":false,"given":"Jenifer","family":"Gon\ufffdalves","sequence":"first","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Potrich","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ferreira Dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Costa Gagosian","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Rodrigues Rossi","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Jacomasso","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Mendes","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Federal University of S\ufffdo Paulo, S\ufffdo Paulo \u2011 SP 04023\u2011062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Bonciani Nader","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Federal University of S\ufffdo Paulo, S\ufffdo Paulo \u2011 SP 04023\u2011062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Brochado Winnischofer","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edvaldo","family":"Trindade","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Camargo De Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammatory and Neoplastic Cells\/Laboratory of Sulfated Polysaccharides Investigation, Cell Biology Department, Section of Biological Sciences, Federal University of Paran\ufffd, CEP 81530\u2011980 Curitiba\u2011PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"key20200713190002_b1-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"key20200713190002_b2-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br J Dermatol"},{"key":"key20200713190002_b3-ijo-55-03-0721","first-page":"591","article-title":"Vital signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030","volume":"64","author":"Guy","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key20200713190002_b4-ijo-55-03-0721","unstructured":"American Cancer SocietySurvival Rates for Melanoma Skin Cancer, by StageAmerican Cancer SocietyAtlanta, GA2017https:\/\/www.cancer.org\/cancer\/melanoma-skin-cancer\/detection-diagnosis-staging\/survival-rates-for-melanoma-skin-cancer-by-stage.html. Accessed February 1, 2019"},{"key":"key20200713190002_b5-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"516","DOI":"10.2340\/00015555-2035","article-title":"Metastatic melanoma - A review of current and future treatment options","volume":"95","author":"Maverakis","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"key20200713190002_b6-ijo-55-03-0721","unstructured":"American Cancer Society Skin CancerAmerican Cancer Society, Inc.Atlanta, GA2016http:\/\/www.cancer.org\/cancer\/cancercauses\/sunanduvexposure\/skin-cancer-facts Accessed May 10 , 2018"},{"key":"key20200713190002_b7-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"607","DOI":"10.21873\/anticanres.11354","article-title":"Selumetinib inhibits melanoma metastasis to mouse liver via suppression of EMT-targeted genes","volume":"37","author":"Ryu","year":"2017","journal-title":"Anticancer Res"},{"key":"key20200713190002_b8-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1097\/CMR.0000000000000291","article-title":"In-vitro and in-vivo inhibition of melanoma growth and metastasis by the drug combination of celecoxib and dacarbazine","volume":"26","author":"Sadhu","year":"2016","journal-title":"Melanoma Res"},{"key":"key20200713190002_b9-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev.pathol.3.121806.151541","article-title":"Molecular pathogenesis of cutaneous melanocytic neoplasms","volume":"4","author":"Ibrahim","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"key20200713190002_b10-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: Optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"key20200713190002_b11-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.canlet.2017.03.037","article-title":"Research progress in advanced melanoma","volume":"397","author":"Luo","year":"2017","journal-title":"Cancer Lett"},{"key":"key20200713190002_b12-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1016\/j.ejca.2011.06.052","article-title":"New drugs in melanoma: It's a whole new world","volume":"47","author":"Eggermont","year":"2011","journal-title":"Eur J Cancer"},{"key":"key20200713190002_b13-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"key20200713190002_b14-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00428-017-2113-3","article-title":"Molecular genetic and immunotherapeutic targets in metastatic melanoma","volume":"471","author":"Melis","year":"2017","journal-title":"Virchows Arch"},{"key":"key20200713190002_b15-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.cell.2017.01.034","article-title":"How much longer will we put up with $100,000 cancer drugs?","volume":"168","author":"Workman","year":"2017","journal-title":"Cell"},{"key":"key20200713190002_b16-ijo-55-03-0721","first-page":"76","volume-title":"WHO Traditional Medicine Strategy: 2014-2023","author":"World Health Organization","year":"2013"},{"key":"key20200713190002_b17-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S2095-4964(15)60156-X","article-title":"Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo","volume":"13","author":"Ghosh","year":"2015","journal-title":"J Integr Med"},{"key":"key20200713190002_b18-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S2095-4964(16)60230-3","article-title":"Psorinum 6\u00d7 triggers apoptosis signals in human lung cancer cells","volume":"14","author":"Mondal","year":"2016","journal-title":"J Integr Med"},{"key":"key20200713190002_b19-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3831\/KPI.2014.17.008","article-title":"Relative apoptosis-inducing potential of homeopa-thic Condurango 6C and 30C in H460 lung cancer cells in vitro: -Apoptosis-induction by homeopathic Condurango in H460 cells","volume":"17","author":"Sikdar","year":"2014","journal-title":"J Pharmacopuncture"},{"key":"key20200713190002_b20-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/S2095-4964(15)60201-1","article-title":"Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro","volume":"13","author":"Saha","year":"2015","journal-title":"J Integr Med"},{"key":"key20200713190002_b21-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.homp.2014.10.001","article-title":"DNA fragmentation and cell cycle arrest: A hallmark of apoptosis induced by Ruta graveolens in human colon cancer cells","volume":"104","author":"Arora","year":"2015","journal-title":"Homeopathy"},{"key":"key20200713190002_b22-ijo-55-03-0721","first-page":"2","article-title":"Modulation of TERT and Top II activities by the homeopathic nosode, Hep C 30 in demonstrating its anticancer potential against Hep G2 liver cancer cells: A commentary on one of our Published Research Anisur","volume":"4","author":"Khuda-Bukhsh","year":"2018","journal-title":"BAOJ Med Nurs"},{"key":"key20200713190002_b23-ijo-55-03-0721","first-page":"98","volume-title":"Pol\u00edtica Nacional de Pr\u00e1ticas Integrativas e Complementares no SUS","author":"da Sa\u00fade","year":"2015","edition":"2nd edition"},{"key":"key20200713190002_b24-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jinf.2005.08.017","article-title":"Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages","volume":"52","author":"de Oliveira","year":"2006","journal-title":"J Infect"},{"key":"key20200713190002_b25-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.cellbi.2006.06.011","article-title":"Activation of bone marrow cells treated with Canova in vitro","volume":"30","author":"Abud","year":"2006","journal-title":"Cell Biol Int"},{"key":"key20200713190002_b26-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.micron.2005.08.005","article-title":"Phagocytosis, endosomal\/lysosomal system and other cellularaspects of macrophage activation by Canova medication","volume":"37","author":"Lopes","year":"2006","journal-title":"Micron"},{"key":"key20200713190002_b27-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.micron.2007.02.005","article-title":"Activation of mononuclear bone marrow cells treated in vitro with a complex homeopathic medication","volume":"39","author":"Cesar","year":"2008","journal-title":"Micron"},{"key":"key20200713190002_b28-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2407-9-293","article-title":"Stimulation of lymphocyte anti-melanoma activity by co-cultured macrophages activated by complex homeopathic medication","volume":"9","author":"Guimar\u00e3es","year":"2009","journal-title":"BMC Cancer"},{"key":"key20200713190002_b29-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1472-6882-11-101","article-title":"Developments on drug discovery and on new therapeutics: Highly diluted tinctures act as biological response modifiers","volume":"11","author":"de Oliveira","year":"2011","journal-title":"BMC Complement Altern Med"},{"key":"key20200713190002_b30-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.homp.2011.05.005","article-title":"Mercurius solubilis: Actions on macrophages","volume":"100","author":"de Oliveira","year":"2011","journal-title":"Homeopathy"},{"key":"key20200713190002_b31-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.homp.2017.02.004","article-title":"Differential effects of Zincum metallicum on cell models","volume":"106","author":"Gon\u00e7alves","year":"2017","journal-title":"Homeopathy"},{"key":"key20200713190002_b32-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.homp.2004.10.003","article-title":"Histopathological and immunopheno-typing studies on normal and sarcoma 180-bearing mice treated with a complex homeopathic medication","volume":"94","author":"Sato","year":"2005","journal-title":"Homeopathy"},{"key":"key20200713190002_b33-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/jcb.21713","article-title":"Gene expression profiling of macrophages following mice treatment with an immunomodulator medication","volume":"104","author":"de Oliveira","year":"2008","journal-title":"J Cell Biochem"},{"key":"key20200713190002_b34-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"212459","DOI":"10.1093\/ecam\/nep119","article-title":"Treatment with at homeopathic complex medication modulates mononuclear bone marrow cell differentiation","volume":"2011","author":"Cesar","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713190002_b35-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.homp.2015.08.007","article-title":"Inhalation therapy with M1 inhibits experimental melanoma development and metastases in mice","volume":"105","author":"Ferrari de Andrade","year":"2016","journal-title":"Homeopathy"},{"key":"key20200713190002_b36-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1471-2407-10-113","article-title":"In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model","volume":"10","author":"Guimar\u00e3es","year":"2010","journal-title":"BMC Cancer"},{"key":"key20200713190002_b37-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","article-title":"Emerging Biological Principles of Metastasis","volume":"168","author":"Lambert","year":"2017","journal-title":"Cell"},{"key":"key20200713190002_b38-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"key20200713190002_b39-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/jcp.22766","article-title":"Cellular modeling of cancer invasion: Integration of in silico and in vitro approaches","volume":"227","author":"Kam","year":"2012","journal-title":"J Cell Physiol"},{"key":"key20200713190002_b40-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: Functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"key":"key20200713190002_b41-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1242\/jcs.116392","article-title":"The tumor microenvironment at a glance","volume":"125","author":"Balkwill","year":"2012","journal-title":"J Cell Sci"},{"key":"key20200713190002_b42-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"key20200713190002_b43-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1038\/sj.onc.1206757","article-title":"Axis of evil: Molecular mechanisms of cancer metastasis","volume":"22","author":"Bogenrieder","year":"2003","journal-title":"Oncogene"},{"key":"key20200713190002_b44-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/jemt.22810","article-title":"Unexpected effect of the vehicle (grain ethanol) of homeopathic FSH on the in vitro survival and development of isolated ovine preantral follicles","volume":"80","author":"Lima","year":"2017","journal-title":"Microsc Res Tech"},{"key":"key20200713190002_b45-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S2095-4964(17)60346-7","article-title":"Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: The role of ethanol as a possible confounder and statistical bias","volume":"15","author":"Chirumbolo","year":"2017","journal-title":"J Integr Med"},{"key":"key20200713190002_b46-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/nprot.2010.43","article-title":"Detection of Mycoplasma in cell cultures","volume":"5","author":"Young","year":"2010","journal-title":"Nat Protoc"},{"key":"key20200713190002_b47-ijo-55-03-0721","first-page":"e51046","article-title":"In vitro cell migration and invasion assays","volume":"88","author":"Justus","year":"2014","journal-title":"J Vis Exp"},{"key":"key20200713190002_b48-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol Biol"},{"key":"key20200713190002_b49-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0003-2697(03)00251-3","article-title":"Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients","volume":"319","author":"Martins","year":"2003","journal-title":"Anal Biochem"},{"key":"key20200713190002_b50-ijo-55-03-0721","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"key20200713190002_b51-ijo-55-03-0721","first-page":"163","article-title":"Assessment of gelatinases (MMP-2 and MMP-9 by gelatin zymography","volume":"57","author":"Toth","year":"2001","journal-title":"Methods Mol Med"},{"key":"key20200713190002_b52-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/BF00510085","article-title":"Colorimetric growth assay for epidermal cell cultures by their crystal violet binding capacity","volume":"281","author":"Bonnekoh","year":"1989","journal-title":"Arch Dermatol Res"},{"key":"key20200713190002_b53-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"key20200713190002_b54-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"key20200713190002_b55-ijo-55-03-0721","unstructured":"TerhoPFlowing SoftwareTurku Centre for Biotechnology2013http:\/\/flowingsoftware.btk.fi\/index.php?page=1"},{"key":"key20200713190002_b56-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10555-005-1572-1","article-title":"Integrin signaling in malignant melanoma","volume":"24","author":"Kuphal","year":"2005","journal-title":"Cancer Metastasis Rev"},{"key":"key20200713190002_b57-ijo-55-03-0721","first-page":"3819","article-title":"N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells","volume":"61","author":"Li","year":"2001","journal-title":"Cancer Res"},{"key":"key20200713190002_b58-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0959-8049(96)00512-6","article-title":"High CD44 surface expression on primary tumours of malignant melanoma correlates with increased metastatic risk and reduced survival","volume":"33","author":"Dietrich","year":"1997","journal-title":"Eur J Cancer"},{"key":"key20200713190002_b59-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"e1127313","DOI":"10.1080\/23723556.2015.1127313","article-title":"Reactive oxygen species and tumor dissemination: Allies no longer","volume":"3","author":"Herraiz","year":"2016","journal-title":"Mol Cell Oncol"},{"key":"key20200713190002_b60-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.yexcr.2010.11.017","article-title":"Hyaluronan in human malignancies","volume":"317","author":"Sironen","year":"2011","journal-title":"Exp Cell Res"},{"key":"key20200713190002_b61-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713190002_b62-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH632>3.0.CO;2-#","article-title":"Expression and activation of matrix metallo-proteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression","volume":"191","author":"Hofmann","year":"2000","journal-title":"J Pathol"},{"key":"key20200713190002_b63-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/path.1080","article-title":"Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography","volume":"197","author":"Kurschat","year":"2002","journal-title":"J Pathol"},{"key":"key20200713190002_b64-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1600-0625.2007.00638.x","article-title":"Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4","volume":"17","author":"Voelcker","year":"2008","journal-title":"Exp Dermatol"},{"key":"key20200713190002_b65-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1002\/jcb.20602","article-title":"Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies","volume":"96","author":"Sanderson","year":"2005","journal-title":"J Cell Biochem"},{"key":"key20200713190002_b66-ijo-55-03-0721","doi-asserted-by":"crossref","first-page":"9661","DOI":"10.1016\/S0021-9258(18)92871-1","article-title":"Suramin. A potent inhibitor of melanoma heparanase and invasion","volume":"266","author":"Nakajima","year":"1991","journal-title":"J Biol Chem"},{"key":"key20200713190002_b67-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1600-0749.1994.tb00025.x","article-title":"Interactions of melanocytes and melanoma cells with the microenvironment","volume":"7","author":"Herlyn","year":"1994","journal-title":"Pigment Cell Res"},{"key":"key20200713190002_b68-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/jid.2011.325","article-title":"Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: Impact on melanoma cell proliferation","volume":"132","author":"Willenberg","year":"2012","journal-title":"J Invest Dermatol"},{"key":"key20200713190002_b69-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1073\/pnas.90.2.393","article-title":"Platelet-derived growth factor (PDGF) in oncogenesis: Development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB","volume":"90","author":"Forsberg","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713190002_b70-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1172\/JCI200318549","article-title":"Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors","volume":"112","author":"Abramsson","year":"2003","journal-title":"J Clin Invest"},{"key":"key20200713190002_b71-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/cdd.2008.150","article-title":"Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009","volume":"16","author":"Kroemer","year":"2009","journal-title":"Cell Death Differ"},{"key":"key20200713190002_b72-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"15864","DOI":"10.1021\/la303477s","article-title":"Why extreme dilutions reach non-zero asymptotes: A nanoparticulate hypothesis based on froth flotation","volume":"28","author":"Chikramane","year":"2012","journal-title":"Langmuir"},{"key":"key20200713190002_b73-ijo-55-03-0721","doi-asserted-by":"crossref","first-page":"299","DOI":"10.51910\/ijhdr.v10i37.525","article-title":"Homeopathy emerging as nano-medicine","volume":"10","author":"Upadhyay","year":"2011","journal-title":"Int J High Dilution Res"},{"key":"key20200713190002_b74-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1191\/0269216302pm539oa","article-title":"The homeopathic approach to symptom control in the cancer patient: A prospective observational study","volume":"16","author":"Thompson","year":"2002","journal-title":"Palliat Med"},{"key":"key20200713190002_b75-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.otohns.2009.06.081","article-title":"Extracts from the Cochrane Library: Homeopathic medicines for adverse effects of cancer treatments","volume":"141","author":"Burton","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key20200713190002_b76-ijo-55-03-0721","first-page":"54","article-title":"A series of case reports: Clinical evaluation of a complex homeopathic injection therapy in the management of pain in patients after breast cancer treatment","volume":"16","author":"Orellana Alvarellos","year":"2010","journal-title":"Altern Ther Health Med"},{"key":"key20200713190002_b77-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/1097-0142(20010801)92:3<684::AID-CNCR1371>3.0.CO;2-#","article-title":"A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation","volume":"92","author":"Oberbaum","year":"2001","journal-title":"Cancer"},{"key":"key20200713190002_b78-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jams.2013.04.004","article-title":"The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro","volume":"6","author":"Samadder","year":"2013","journal-title":"J Acupunct Meridian Stud"},{"key":"key20200713190002_b79-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1177\/1534735411400310","article-title":"Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: Implications on mechanism of action","volume":"11","author":"Preethi","year":"2012","journal-title":"Integr Cancer Ther"},{"key":"key20200713190002_b80-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.homp.2013.06.001","article-title":"Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells","volume":"102","author":"Arora","year":"2013","journal-title":"Homeopathy"},{"key":"key20200713190002_b81-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"879585","DOI":"10.1093\/ecam\/nep042","article-title":"Bioactivity of the murex homeopathic remedy and of extracts from an australian muricid mollusc against human cancer cells","volume":"2011","author":"Benkendorff","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713190002_b82-ijo-55-03-0721","first-page":"395","article-title":"Cytotoxic effects of ultra-diluted remedies on breast cancer cells","volume":"36","author":"Frenkel","year":"2010","journal-title":"Int J Oncol"},{"key":"key20200713190002_b83-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1177\/1534735406295350","article-title":"Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models","volume":"5","author":"MacLaughlin","year":"2006","journal-title":"Integr Cancer Ther"},{"key":"key20200713190002_b84-ijo-55-03-0721","first-page":"162","article-title":"Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo","volume":"12","author":"Saha","year":"2013","journal-title":"Int J Hight Dilution Res"},{"key":"key20200713190002_b85-ijo-55-03-0721","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1177\/1534735406294224","article-title":"Homeopathic medicines do not alter growth and gene expression in prostate and breast cancer cells in vitro","volume":"5","author":"Thangapazham","year":"2006","journal-title":"Integr Cancer Ther"}],"container-title":["International Journal of Oncology"],"original-title":[],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T09:40:52Z","timestamp":1664012452000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijo.2019.4846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":85,"URL":"https:\/\/doi.org\/10.3892\/ijo.2019.4846","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]}}}