{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:03:39Z","timestamp":1783703019213,"version":"3.55.0"},"reference-count":47,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Oncol"],"DOI":"10.3892\/ijo.2020.5069","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T07:18:45Z","timestamp":1590391125000},"page":"574-586","source":"Crossref","is-referenced-by-count":24,"title":["MicroRNA\u2011103a\u20113p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma"],"prefix":"10.3892","volume":"57","author":[{"given":"Min","family":"Fu","sequence":"first","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2011Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2011Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2011Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2011Hao","family":"Du","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2011Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2011Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2011Yuan","family":"Ge","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"key20200713190541_b1-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.semradonc.2012.03.009","article-title":"Biology and management of salivary gland cancers","volume":"22","author":"Adelstein","year":"2012","journal-title":"Semin Radiat Oncol"},{"key":"key20200713190541_b2-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.oraloncology.2004.12.004","article-title":"Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature","volume":"41","author":"Rapidis","year":"2005","journal-title":"Oral Oncol"},{"key":"key20200713190541_b3-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1054\/ijom.2003.0448","article-title":"Adenoid cystic carcinoma of the head and neck - a 20 years experience","volume":"33","author":"Kokemueller","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"key20200713190541_b4-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ijom.2013.04.006","article-title":"Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma","volume":"42","author":"Gao","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"key20200713190541_b5-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","article-title":"Adenoid cystic carcinoma of the head and neck - An update","volume":"51","author":"Coca-Pelaz","year":"2015","journal-title":"Oral Oncol"},{"key":"key20200713190541_b6-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key20200713190541_b7-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10495-018-01513-9","article-title":"MicroRNA-663 antagonizes apoptosis antago-nizing transcription factor to induce apoptosis in epithelial cells","volume":"24","author":"Benakanakere","year":"2019","journal-title":"Apoptosis"},{"key":"key20200713190541_b8-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1002\/hep.29920","article-title":"Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins","volume":"68","author":"Fang","year":"2018","journal-title":"Hepatology"},{"key":"key20200713190541_b9-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.canlet.2009.05.030","article-title":"MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines","volume":"286","author":"Liu","year":"2009","journal-title":"Cancer Lett"},{"key":"key20200713190541_b10-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/exd.13119","article-title":"MicroRNA-23b-3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF-\u03b2-SMAD2 signalling pathway","volume":"26","author":"Barbollat-Boutrand","year":"2017","journal-title":"Exp Dermatol"},{"key":"key20200713190541_b11-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"key20200713190541_b12-ijo-57-02-0574","first-page":"4237","article-title":"Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma","volume":"17","author":"Yan","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713190541_b13-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.biopha.2018.05.157","article-title":"Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma","volume":"105","author":"Wang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"key20200713190541_b14-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/jop.12894","article-title":"miR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma","volume":"48","author":"Brown","year":"2019","journal-title":"J Oral Pathol Med"},{"key":"key20200713190541_b15-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12943-015-0344-y","article-title":"miR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3","volume":"14","author":"Sun","year":"2015","journal-title":"Mol Cancer"},{"key":"key20200713190541_b16-ijo-57-02-0574","first-page":"1101","article-title":"Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38\/JNK\/ERK signal pathway","volume":"9","author":"Liang","year":"2017","journal-title":"Am J Transl Res"},{"key":"key20200713190541_b17-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1158\/0008-5472.CAN-12-0667","article-title":"miR-103\/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4","volume":"72","author":"Chen","year":"2012","journal-title":"Cancer Res"},{"key":"key20200713190541_b18-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijms18050910","article-title":"miR-103 Promotes Proliferation and Metastasis by Targeting KLF4 in Gastric Cancer","volume":"18","author":"Zheng","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20200713190541_b19-ijo-57-02-0574","first-page":"4083","article-title":"MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713190541_b20-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3727\/096504017X15000757094686","article-title":"miR-103 Functions as a Tumor Suppressor by Directly Targeting Programmed Cell Death 10 in NSCLC","volume":"26","author":"Yang","year":"2018","journal-title":"Oncol Res"},{"key":"key20200713190541_b21-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.4161\/cc.26146","article-title":"Tumor protein D52 represents a negative regulator of ATM protein levels","volume":"12","author":"Chen","year":"2013","journal-title":"Cell Cycle"},{"key":"key20200713190541_b22-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1006\/geno.2001.6610","article-title":"Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system","volume":"76","author":"Wilson","year":"2001","journal-title":"Genomics"},{"key":"key20200713190541_b23-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.1158\/0008-5472.CAN-03-3881","article-title":"Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer","volume":"64","author":"Rubin","year":"2004","journal-title":"Cancer Res"},{"key":"key20200713190541_b24-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1005>3.0.CO;2-O","article-title":"The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma","volume":"29","author":"Balleine","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"key20200713190541_b25-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3892\/ijo.2013.2200","article-title":"Patterns of TPD52 overexpression in multiple human solid tumor types analyzed by quantitative PCR","volume":"44","author":"Tennstedt","year":"2014","journal-title":"Int J Oncol"},{"key":"key20200713190541_b26-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.3892\/ijo.2016.3690","article-title":"Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma","volume":"49","author":"Kumamoto","year":"2016","journal-title":"Int J Oncol"},{"key":"key20200713190541_b27-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"7369","DOI":"10.1007\/s13277-014-2006-x","article-title":"Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene?","volume":"35","author":"Byrne","year":"2014","journal-title":"Tumour Biol"},{"key":"key20200713190541_b28-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.18632\/oncotarget.6319","article-title":"Decreased TPD52 expression is associated with poor prognosis in primary hepato-cellular carcinoma","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713190541_b29-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3727\/096504016X14774889687280","article-title":"Tumor Protein D52 (TPD52) Inhibits Growth and Metastasis in Renal Cell Carcinoma Cells Through the PI3K\/Akt Signaling Pathway","volume":"25","author":"Zhao","year":"2017","journal-title":"Oncol Res"},{"key":"key20200713190541_b30-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.2147\/OTT.S108890","article-title":"miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52","volume":"9","author":"Chen","year":"2016","journal-title":"OncoTargets Ther"},{"key":"key20200713190541_b31-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.biopha.2018.06.033","article-title":"Over-expression of miR-15a-3p enhances the radiosensitivity of cervical cancer by targeting tumor protein D52","volume":"105","author":"Wu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"key20200713190541_b32-ijo-57-02-0574","article-title":"Establishment of a human cancer cell line from adenoid cystic carcinoma of the minor salivary gland","author":"Li","year":"1990","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"key20200713190541_b33-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/0022034511401407","article-title":"TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma","volume":"90","author":"Dong","year":"2011","journal-title":"J Dent Res"},{"key":"key20200713190541_b34-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.7150\/thno.19712","article-title":"Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma","volume":"7","author":"Yang","year":"2017","journal-title":"Theranostics"},{"key":"key20200713190541_b35-ijo-57-02-0574","first-page":"1579","article-title":"MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma","volume":"54","author":"Xu","year":"2019","journal-title":"Int J Oncol"},{"key":"key20200713190541_b36-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713190541_b37-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"key20200713190541_b38-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.canlet.2017.09.044","article-title":"miR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2\/E2F4-repressing complexes","volume":"412","author":"Zhu","year":"2018","journal-title":"Cancer Lett"},{"key":"key20200713190541_b39-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12943-018-0935-5","article-title":"Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1\/mTOR pathway","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol Cancer"},{"key":"key20200713190541_b40-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00428-018-2423-0","article-title":"MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: A cohort study","volume":"473","author":"Andreasen","year":"2018","journal-title":"Virchows Arch"},{"key":"key20200713190541_b41-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1016\/j.bbagen.2013.07.028","article-title":"MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway","volume":"1830","author":"He","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key20200713190541_b42-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/s41467-018-05065-z","article-title":"miR-103 promotes endo-thelial maladaptation by targeting lncWDR59","volume":"9","author":"Natarelli","year":"2018","journal-title":"Nat Commun"},{"key":"key20200713190541_b43-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1073\/pnas.0510928103","article-title":"MicroRNAs direct rapid dead-enylation of mRNA","volume":"103","author":"Wu","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713190541_b44-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.1111\/j.1742-4658.2008.06697.x","article-title":"Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells","volume":"275","author":"Ummanni","year":"2008","journal-title":"FEBS J"},{"key":"key20200713190541_b45-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"5259","DOI":"10.1158\/0008-5472.CAN-17-3058","article-title":"miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis-Associated Genes","volume":"78","author":"Croset","year":"2018","journal-title":"Cancer Res"},{"key":"key20200713190541_b46-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.canlet.2019.02.026","article-title":"MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy","volume":"449","author":"Xu","year":"2019","journal-title":"Cancer Lett"},{"key":"key20200713190541_b47-ijo-57-02-0574","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3892\/ijo.2015.3171","article-title":"miR-125a regulates angiogenesis of gastric cancer by targeting vascular endothelial growth factor A","volume":"47","author":"Dai","year":"2015","journal-title":"Int J Oncol"}],"container-title":["International Journal of Oncology"],"original-title":[],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:32:48Z","timestamp":1597260768000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijo.2020.5069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,5,25]]}},"URL":"https:\/\/doi.org\/10.3892\/ijo.2020.5069","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]}}}