{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:31:25Z","timestamp":1779114685067,"version":"3.51.4"},"reference-count":25,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.3892\/mco.2015.512","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T13:27:39Z","timestamp":1424093259000},"page":"555-558","source":"Crossref","is-referenced-by-count":28,"title":["Oxaliplatin-based chemotherapy induces extravasated platelet aggregation in the liver"],"prefix":"10.3892","volume":"3","author":[{"given":"HIDEHIRO","family":"TAJIMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TETSUO","family":"OHTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOHARU","family":"MIYASHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHINICHI","family":"NAKANUMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIKI","family":"MATOBA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKASHI","family":"MIYATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEISHO","family":"SAKAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOICHI","family":"OKAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISAMU","family":"MAKINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUN","family":"KINOSHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIRONORI","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEISHI","family":"NAKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATSUNOBU","family":"OYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASAFUMI","family":"INOKUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HISATOSHI","family":"NAKAGAWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROYUKI","family":"TAKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROHISA","family":"KITAGAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SACHIO","family":"FUSHIDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROKO","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,2,16]]},"reference":[{"key":"key20180107145000_b1-mco-0-0-512","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/annonc\/mdh095","article-title":"Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer","volume":"15","author":"Rubbia-Brandt","year":"2004","journal-title":"Ann Oncol"},{"key":"key20180107145000_b2-mco-0-0-512","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.surg.2009.01.004","article-title":"Prevalence and clinical relevance of pathological hepatic changes occurring after neoadjuvant chemotherapy for colorectal liver metastases","volume":"147","author":"Hubert","year":"2010","journal-title":"Surgery"},{"key":"key20180107145000_b3-mco-0-0-512","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","article-title":"Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases","volume":"24","author":"Vauthey","year":"2006","journal-title":"J Clin Oncol"},{"key":"key20180107145000_b4-mco-0-0-512","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1245\/s10434-010-1317-4","article-title":"Sinusoidal obstruction syndrome impairs long-term outcome of colorectal liver metastases treated with resection after neoadjuvant chemotherapy","volume":"18","author":"Tamandl","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"key20180107145000_b5-mco-0-0-512","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1245\/s10434-012-2438-8","article-title":"Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis","volume":"19","author":"Robinson","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"key20180107145000_b6-mco-0-0-512","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00428-007-0497-1","article-title":"The pathological response to neoadjuvant chemotherapy with FOLFOX-4 for colorectal liver metastases: a comparative study","volume":"451","author":"Aloysius","year":"2007","journal-title":"Virchows Arch"},{"key":"key20180107145000_b7-mco-0-0-512","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/SLA.0b013e31815774de","article-title":"Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy","volume":"247","author":"Nakano","year":"2008","journal-title":"Ann Surg"},{"key":"key20180107145000_b8-mco-0-0-512","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/annonc\/mds074","article-title":"Oxaliplatin-related thrombocytopenia","volume":"23","author":"Jardim","year":"2012","journal-title":"Ann Oncol"},{"key":"key20180107145000_b9-mco-0-0-512","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10147-010-0176-0","article-title":"Splenomegaly in FOLFOX-naive stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy","volume":"16","author":"Miura","year":"2011","journal-title":"Int J Oncol"},{"key":"key20180107145000_b10-mco-0-0-512","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1245\/s10434-010-1494-1","article-title":"Evaluation of chemotherapy-associated liver injury in patients with colorectal cancer liver metastases using indocyanine green clearance testing","volume":"18","author":"Krieger","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"key20180107145000_b11-mco-0-0-512","first-page":"203","article-title":"The aspartate aminotransferase to platelet ratio before chemotherapy predicts adverse events for FOLFOX and XELOX regimens including bevacizumab as the first-line therapy for stage IV, recurrent and metastatic colorectal cancer","volume":"4","author":"Sato","year":"2013","journal-title":"J Gastrointest Oncol"},{"key":"key20180107145000_b12-mco-0-0-512","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1245\/s10434-011-2112-6","article-title":"Liver injury due to chemotherapy-induced sinusoidal obstruction syndrome is associated with sinusoidal capillarization","volume":"19","author":"Narita","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"key20180107145000_b13-mco-0-0-512","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/hepr.12107","article-title":"Evaluation and management of hepatic injury induced by oxaliplatin-based chemotherapy in patients with hepatic resection for colorectal liver metastasis","volume":"44","author":"Morine","year":"2014","journal-title":"Hepatol Res"},{"key":"key20180107145000_b14-mco-0-0-512","doi-asserted-by":"crossref","first-page":"G469","DOI":"10.1152\/ajpgi.00407.2012","article-title":"Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment","volume":"304","author":"Lalor","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20180107145000_b15-mco-0-0-512","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcu.1870070208","article-title":"Correlation between sectional area of the spleen by ultrasonic tomography and actual volume of the removed spleen","volume":"7","author":"Koga","year":"1979","journal-title":"J Clin Ultrasound"},{"key":"key20180107145000_b16-mco-0-0-512","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/lt.22351","article-title":"Transjugular intrahepatic portosystemic shunt for the treatment of sinusoidal obstruction syndrome in a liver transplant recipient and review of the literature","volume":"18","author":"Campos-Varela","year":"2012","journal-title":"Liver Transpl"},{"key":"key20180107145000_b17-mco-0-0-512","first-page":"343","article-title":"Platelet immunology. ELISA for detection of platelet antibodies, platelet-specific antigens and platelet glycoproteins","volume":"39","author":"Taaning","year":"1992","journal-title":"Dan Med Bull"},{"key":"key20180107145000_b18-mco-0-0-512","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1182\/blood-2011-02-334524","article-title":"Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis","volume":"118","author":"Battinelli","year":"2011","journal-title":"Blood"},{"key":"key20180107145000_b19-mco-0-0-512","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.prostaglandins.2006.03.004","article-title":"Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver","volume":"80","author":"Cui","year":"2006","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"key20180107145000_b20-mco-0-0-512","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bpj.2012.06.050","article-title":"Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-\u03b21","volume":"103","author":"Venkatraman","year":"2012","journal-title":"Biophys J"},{"key":"key20180107145000_b21-mco-0-0-512","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jcp.24143","article-title":"HGF regulates the activation of TGF-\u03b21 in rat hepatocytes and hepatic stellate cells","volume":"228","author":"Narmada","year":"2013","journal-title":"J Cell Physiol"},{"key":"key20180107145000_b22-mco-0-0-512","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0008-6363(02)00326-7","article-title":"Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1\/VEGF-receptor-1","volume":"55","author":"Parenti","year":"2002","journal-title":"Cardiovasc Res"},{"key":"key20180107145000_b23-mco-0-0-512","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/cncr.23099","article-title":"Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases","volume":"110","author":"Ribero","year":"2007","journal-title":"Cancer"},{"key":"key20180107145000_b24-mco-0-0-512","first-page":"430","article-title":"Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis","volume":"56","author":"Rubbia-Brandt","year":"2010","journal-title":"Hepatology"},{"key":"key20180107145000_b25-mco-0-0-512","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jso.23142","article-title":"Effect of bevacizumab added preoperatively to oxaliplatin on liver injury and complications after resection of colorectal liver metastases","volume":"106","author":"van der Pool","year":"2012","journal-title":"J Surg Oncol"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mco.2015.512\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T14:50:28Z","timestamp":1515336628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mco.2015.512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,16]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,2,16]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.3892\/mco.2015.512"],"URL":"https:\/\/doi.org\/10.3892\/mco.2015.512","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"value":"2049-9450","type":"print"},{"value":"2049-9469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,16]]}}}