{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:49:13Z","timestamp":1792403353978,"version":"4.4.0"},"reference-count":21,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2021.2390","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:09:42Z","timestamp":1631009382000},"source":"Crossref","is-referenced-by-count":4,"title":["Combination of immune check inhibitor and immunomodulatory arabinomannan extracted from <i>Mycobacterium\u00a0tuberculosis<\/i>: A case report"],"prefix":"10.3892","volume":"15","author":[{"given":"Kunihiko","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoichi","family":"Kaira","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Iemura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Shinomiya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako\u00a0","family":"Shiono","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyumi","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kagamu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Saitama 350\u20111298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"key20211013103201_b1-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1056\/NEJMoa0909530","article-title":"Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR","volume":"362","author":"Maemondo","year":"2010","journal-title":"N Engl J Med"},{"key":"key20211013103201_b2-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1056\/NEJMoa1713137","article-title":"Osimertinib in Untreated EGFR-mutated advanced non-small-cell lung cancer","volume":"378","author":"Soria","year":"2018","journal-title":"N Engl J Med"},{"key":"key20211013103201_b3-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","article-title":"Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer","volume":"373","author":"Borghaei","year":"2015","journal-title":"N Engl J Med"},{"key":"key20211013103201_b4-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1056\/NEJMoa1606774","article-title":"Pembrolizumab versus chemotherapy for PD-L1-positive Non-Small-Cell lung cancer","volume":"375","author":"Reck","year":"2016","journal-title":"N Engl J Med"},{"key":"key20211013103201_b5-MCO-15-5-02390","first-page":"245","article-title":"Einflu\u03b2 von Erysipel","volume":"3","author":"Busch","year":"1866","journal-title":"Berliner Klin Wschr"},{"key":"key20211013103201_b6-MCO-15-5-02390","first-page":"399","article-title":"On the treatment of malignant tumor with an extract from tubercle bacilli","volume":"76","author":"Maruyama","year":"1966","journal-title":"Jpn J Dermatol"},{"key":"key20211013103201_b7-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.suronc.2006.05.002","article-title":"Lessons from Coley's Toxin","volume":"15","author":"Tsung","year":"2006","journal-title":"Surg Oncol"},{"key":"key20211013103201_b8-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1248\/yakushi1947.101.8_713","article-title":"Studies on hot water extract of Mycobacterium tuberculosis. I. Structural analyses of polysaccharides (author's transl)","volume":"101","author":"Kobatake","year":"1981","journal-title":"Yakugaku Zasshi"},{"key":"key20211013103201_b9-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1248\/bpb.26.1336","article-title":"Antimetastatic effect of an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, Z-100, through the production of interleukin-12","volume":"26","author":"Oka","year":"2003","journal-title":"Biol Pharm Bull"},{"key":"key20211013103201_b10-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1348-0421.2002.tb02705.x","article-title":"Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: Restoration of helper T cell responses via suppression of glucocorticoid-genesis","volume":"46","author":"Oka","year":"2002","journal-title":"Microbiol Immunol"},{"key":"key20211013103201_b11-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1248\/bpb.27.82","article-title":"Z-100, an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, augments anti-tumor activities of X-ray irradiation against B16 melanoma in association with the improvement of type 1 T cell responses","volume":"27","author":"Oka","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"key20211013103201_b12-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jdermsci.2011.05.007","article-title":"Specific substance of Maruyama (SSM) suppresses immune responses in atopic dermatitis-like skin lesions in DS-Nh mice by modulating dendritic cell functions","volume":"63","author":"Mitsuishi","year":"2011","journal-title":"J Dermatol Sci"},{"key":"key20211013103201_b13-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.21873\/anticanres.14537","article-title":"Recovery of the sensitivity to Anti-PD-1 antibody by celecoxib in lung cancer","volume":"40","author":"Kobayashi","year":"2020","journal-title":"Anticancer Res"},{"key":"key20211013103201_b14-MCO-15-5-02390","author":"Murphy"},{"key":"key20211013103201_b15-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-6445-1_1","article-title":"Overview of vaccine adjuvants: Introduction, history, and current status","volume":"1494","author":"Shah","year":"2017","journal-title":"Methods Mol Biol"},{"key":"key20211013103201_b16-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat Med"},{"issue":"E3821","key":"key20211013103201_b17-MCO-15-5-02390","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153821","article-title":"Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC)","volume":"20","author":"Hsu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20211013103201_b18-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1158\/0008-5472.CAN-15-0255","article-title":"Classifying cancers based on T-cell infiltration and PD-L1","volume":"75","author":"Teng","year":"2015","journal-title":"Cancer Res"},{"key":"key20211013103201_b19-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1084\/jem.20052494","article-title":"Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy","volume":"203","author":"Reits","year":"2006","journal-title":"J Exp Med"},{"key":"key20211013103201_b20-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/s41591-018-0232-2","article-title":"Radiotherapy induces responses of lung cancer to CTLA-4 blockade","volume":"24","author":"Formenti","year":"2018","journal-title":"Nat Med"},{"key":"key20211013103201_b21-MCO-15-5-02390","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1093\/annonc\/mdu057","article-title":"Phase III placebo-controlled double-blind randomized trial of radiotherapy for stage IIB-IVA cervical cancer with or without immunomodulator Z-100: A JGOG study","volume":"25","author":"Sugiyama","year":"2014","journal-title":"Ann Oncol"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T07:46:10Z","timestamp":1634111170000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2021.2390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,7]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2021.2390","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"value":"2049-9450","type":"print"},{"value":"2049-9469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"article-number":"227"}}