{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:37:57Z","timestamp":1788316677325,"version":"build-2803163510"},"reference-count":25,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2021.2466","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T10:56:40Z","timestamp":1639479400000},"source":"Crossref","is-referenced-by-count":1,"title":["Hypocellular Philadelphia chromosome\u2011positive mixed\u2011phenotype acute leukemia successfully treated with dasatinib: A case report"],"prefix":"10.3892","volume":"16","author":[{"given":"Shin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Wakayama","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kito","sequence":"additional","affiliation":[{"name":"Department of Pathology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Matsunami General Hospital, Gifu 501\u20116062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"key20220302121551_b1-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/MOH.0000000000000570","article-title":"Optimal therapeutic strategies for mixed phenotype acute leukemia","volume":"27","author":"Wolach","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"key20220302121551_b2-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1038\/leu.2010.202","article-title":"Mixed-phenotype acute leukemia: Historical overview and a new definition","volume":"24","author":"Weinberg","year":"2010","journal-title":"Leukemia"},{"key":"key20220302121551_b3-MCO-16-2-02466","author":"Swerdlow"},{"key":"key20220302121551_b4-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1182\/blood-2010-10-314682","article-title":"Mixed-phenotype acute leukemia: Clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification","volume":"117","author":"Matutes","year":"2011","journal-title":"Blood"},{"key":"key20220302121551_b5-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1309\/AJCPPVUPOTUVOIB5","article-title":"Mixed phenotype acute leukemia: A study of 61 cases using World health organization and European Group for the immunological classification of leukaemias criteria","volume":"142","author":"Weinberg","year":"2014","journal-title":"Am J Clin Pathol"},{"key":"key20220302121551_b6-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1038\/sj.leu.2404848","article-title":"Acute bilineal leukemia: A rare disease with poor outcome","volume":"21","author":"Weir","year":"2007","journal-title":"Leukemia"},{"key":"key20220302121551_b7-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s12185-011-0953-1","article-title":"Clinical characteristics and outcomes of mixed phenotype acute leukemia with Philadelphia chromosome positive and\/or bcr-abl positive in adult","volume":"94","author":"Wang","year":"2011","journal-title":"Int J Hematol"},{"key":"key20220302121551_b8-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/ejh.12343","article-title":"Philadelphia chromosome-positive mixed phenotype acute leukemia in the imatinib era","volume":"93","author":"Shimizu","year":"2014","journal-title":"Eur J Haematol"},{"issue":"4493","key":"key20220302121551_b9-MCO-16-2-02466","article-title":"Hypoplastic acute myeloid leukemia","volume":"108","author":"Park","year":"2006","journal-title":"Blood"},{"key":"key20220302121551_b10-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/1097-0142(19810915)48:6<1410::aid-cncr2820480624>3.0.co;2-4","article-title":"Hypoplastic acute leukemia","volume":"48","author":"Needleman","year":"1981","journal-title":"Cancer"},{"key":"key20220302121551_b11-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/hon.2900040406","article-title":"Hypoplastic acute leukemia: Review of 70 cases with multivariate regression analysis","volume":"4","author":"Berdeaux","year":"1986","journal-title":"Hematol Oncol"},{"key":"key20220302121551_b12-MCO-16-2-02466","first-page":"699","article-title":"Outcome of biphenotypic acute leukemia","volume":"84","author":"Killick","year":"1999","journal-title":"Haematologica"},{"key":"key20220302121551_b13-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1046\/j.1365-2141.1998.00523.x","article-title":"Adult biphenotypic acute leukaemia: An entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression","volume":"100","author":"Legrand","year":"1998","journal-title":"Br J Haematol"},{"key":"key20220302121551_b14-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00277-013-1694-4","article-title":"Acute leukemias of ambiguous lineage in adults: Molecular and clinical characterization","volume":"92","author":"Heesch","year":"2013","journal-title":"Ann Hematol"},{"key":"key20220302121551_b15-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s12185-014-1531-0","article-title":"Successful treatment of Philadelphia chromosome-positive mixed phenotype acute leukemia by appropriate alternation of second-generation tyrosine kinase inhibitors according to BCR-ABL1 mutation status","volume":"99","author":"Kawajiri","year":"2014","journal-title":"Int J Hematol"},{"key":"key20220302121551_b16-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.2169\/internalmedicine.55.5223","article-title":"Two elderly patients with philadelphia chromosome positive mixed phenotype acute leukemia who were successfully treated with dasatinib and prednisolone","volume":"55","author":"Takata","year":"2016","journal-title":"Intern Med"},{"key":"key20220302121551_b17-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3109\/10428194.2010.509453","article-title":"Dasatinib is effective against optic nerve infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"51","author":"Satake","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"key20220302121551_b18-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/WNO.0b013e318281b84d","article-title":"Transient optic perineuritis as the initial presentation of central nervous system involvement by pre-B cell lymphocytic leukemia","volume":"33","author":"Townsend","year":"2013","journal-title":"J Neuroophthalmol"},{"key":"key20220302121551_b19-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12185-020-03065-8","article-title":"The eyes have it: CNS leukemia presenting as optic neuritis","volume":"113","author":"Quann","year":"2021","journal-title":"Int J Hematol"},{"key":"key20220302121551_b20-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/nop\/npw006","article-title":"Optic neuropathy in the context of leukemia or lymphoma: Diagnostic approach to a neuro-oncologic emergency","volume":"4","author":"Myers","year":"2017","journal-title":"Neurooncol Pract"},{"key":"key20220302121551_b21-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1182\/blood-2008-02-140665","article-title":"Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia","volume":"112","author":"Porkka","year":"2008","journal-title":"Blood"},{"key":"key20220302121551_b22-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00062752-199704010-00002","article-title":"The function of BCR\/ABL and related proto-oncogenes","volume":"4","author":"Gotoh","year":"1997","journal-title":"Curr Opin Hematol"},{"key":"key20220302121551_b23-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/ejh.12056","article-title":"Abrupt evolution of Philadelphia chromosome-positive acute myeloid leukemia in myelodysplastic syndrome","volume":"90","author":"Fukunaga","year":"2013","journal-title":"Eur J Haematol"},{"key":"key20220302121551_b24-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.leukres.2003.10.027","article-title":"Philadelphia chromosome positive myelodysplastic syndrome and acute myeloid leukemia-retrospective study and review of literature","volume":"28","author":"Keung","year":"2004","journal-title":"Leuk Res"},{"key":"key20220302121551_b25-MCO-16-2-02466","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/ccr3.2204","article-title":"Hypoplastic acute myeloid leukemia in an elderly patient. A long-term partial remission with low-dose prednisone and G-CSF","volume":"7","author":"Islam","year":"2019","journal-title":"Clin Case Rep"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:19:18Z","timestamp":1646216358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2021.2466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,12,14]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2021.2466","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"value":"2049-9450","type":"print"},{"value":"2049-9469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"article-number":"33"}}