{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:57:21Z","timestamp":1789959441550,"version":"4.0.1"},"reference-count":41,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2024.2784","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T11:45:00Z","timestamp":1726487100000},"source":"Crossref","is-referenced-by-count":4,"title":["Clinical relevance of urinary 8\u2011hydroxydeoxyguanosine levels in patients undergoing prostate biopsy"],"prefix":"10.3892","volume":"21","author":[{"given":"Yi-Chia","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Urology, Ditmanson Medical Foundation Chia\u2011Yi Christian Hospital, Chiayi 600566, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Nei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Urology, An Nan Hospital, China Medical University, Tainan 709204, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Tzu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Shin","family":"Tzai","sequence":"additional","affiliation":[{"name":"Department of Urology, An Nan Hospital, China Medical University, Tainan 709204, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Chin","family":"Jou","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, St Martin De Porres Hospital, Chiayi 600044, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Shyan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"key20240930104733_b1-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"key20240930104733_b2-MCO-21-5-02784"},{"key":"key20240930104733_b3-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jfma.2015.10.011","article-title":"Incidence and survival of adult cancer patients in Taiwan, 2002\u20132012","volume":"115","author":"Chiang","year":"2016","journal-title":"J Formos Med Assoc"},{"key":"key20240930104733_b4-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1442-2042.2011.02738.x","article-title":"Use of Chinese medicine among prostate cancer patients in Taiwan: A retrospective longitudinal cohort study","volume":"18","author":"Lin","year":"2011","journal-title":"Int J Urol"},{"key":"key20240930104733_b5-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s00432-014-1638-y","article-title":"Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice: Results from Japanese observational cohort","volume":"140","author":"Inamoto","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20240930104733_b6-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1017\/S104161021400218X","article-title":"The association between prostate cancer and mood disorders: A nationwide population-based study in Taiwan","volume":"27","author":"Chen","year":"2015","journal-title":"Int Psychogeriatr"},{"key":"key20240930104733_b7-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/cgt.2013.77","article-title":"Prostate cancer: From the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments","volume":"21","author":"Balistreri","year":"2014","journal-title":"Cancer Gene Ther"},{"issue":"e2015189","key":"key20240930104733_b8-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.15189","article-title":"Type of androgen deprivation therapy and risk of dementia among patients with prostate cancer in Taiwan","volume":"3","author":"Huang","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"126","key":"key20240930104733_b9-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10030126","article-title":"Oxidative stress and antioxidant status in high-risk prostate cancer subjects","volume":"10","author":"Shukla","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"key20240930104733_b10-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.1007\/s11356-021-15922-y","article-title":"Analysis of oxidative stress indicators in Polish patients with prostate cancer","volume":"29","author":"Drozdz-Afelt","year":"2022","journal-title":"Environ Sci Pollut Res Int"},{"key":"key20240930104733_b11-MCO-21-5-02784","author":"Al-Taie"},{"key":"key20240930104733_b12-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"119","DOI":"10.7888\/juoeh.35.119","article-title":"8-hydroxyguanine in urine and serum as an oxidative stress marker: Effects of diabetes and aging","volume":"35","author":"Li","year":"2013","journal-title":"J Uoeh"},{"key":"key20240930104733_b13-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cccn.2003.09.010","article-title":"Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics","volume":"339","author":"Wu","year":"2004","journal-title":"Clin Chim Acta"},{"key":"key20240930104733_b14-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/pcn.12319","article-title":"Analysis of oxidative stress expressed by urinary level of biopyrrins and 8-hydroxydeoxyguanosine in patients with chronic schizophrenia","volume":"69","author":"Miyaoka","year":"2015","journal-title":"Psychiatry Clin Neurosci"},{"key":"key20240930104733_b15-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.lungcan.2008.04.014","article-title":"Significance of the urinary 8-OHdG level as an oxidative stress marker in lung cancer patients","volume":"63","author":"Yano","year":"2009","journal-title":"Lung Cancer"},{"key":"key20240930104733_b16-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3892\/mco.2018.1665","article-title":"Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia","volume":"9","author":"Ohtake","year":"2018","journal-title":"Mol Clin Oncol"},{"key":"key20240930104733_b17-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.envint.2019.02.006","article-title":"Sex hormones and oxidative stress mediated phthalate-induced effects in prostatic enlargement","volume":"126","author":"Chang","year":"2019","journal-title":"Environ Int"},{"key":"key20240930104733_b18-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"236","DOI":"10.6004\/jnccn.2023.0014","article-title":"NCCN Guidelines\u00ae Insights: Prostate cancer early detection, version 1.2023","volume":"21","author":"Moses","year":"2023","journal-title":"J Natl Compr Canc Netw"},{"key":"key20240930104733_b19-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer","volume":"280","author":"D'Amico","year":"1998","journal-title":"JAMA"},{"issue":"c332","key":"key20240930104733_b20-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72352","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"key20240930104733_b21-MCO-21-5-02784"},{"key":"key20240930104733_b22-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/pcan.2013.13","article-title":"Oxidative stress in prostate cancer: Changing research concepts towards a novel paradigm for prevention and therapeutics","volume":"16","author":"Paschos","year":"2013","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"6665","key":"key20240930104733_b23-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126665","article-title":"Involvement of reactive oxygen species in prostate cancer and its disparity in african descendants","volume":"25","author":"Liou","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1393078","key":"key20240930104733_b24-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1393078","article-title":"Shedding light on the shadows: Oxidative stress and its pivotal role in prostate cancer progression","volume":"14","author":"Biesiadecki","year":"2024","journal-title":"Front Oncol"},{"key":"key20240930104733_b25-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopha.2011.06.003","article-title":"Oxidative stress and antioxidant status in prostate cancer patients: Relation to Gleason score, treatment and bone metastasis","volume":"65","author":"Battisti","year":"2011","journal-title":"Biomed Pharmacother"},{"issue":"tfae056","key":"key20240930104733_b26-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae056","article-title":"Tempol effect on oxidative and mitochondrial markers in preclinical models for prostate cancer","volume":"13","author":"Rossetto","year":"2024","journal-title":"Toxicol Res (Camb)"},{"key":"key20240930104733_b27-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.clinbiochem.2005.11.018","article-title":"Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia","volume":"39","author":"Aydin","year":"2006","journal-title":"Clin Biochem"},{"key":"key20240930104733_b28-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.prnil.2016.05.002","article-title":"Oxidative stress in prostate cancer patients: A systematic review of case control studies","volume":"4","author":"Oh","year":"2016","journal-title":"Prostate Int"},{"key":"key20240930104733_b29-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1097\/01.ju.0000116617.32728.ca","article-title":"Oxidative DNA damage in patients with prostate cancer and its response to treatment","volume":"171","author":"Miyake","year":"2004","journal-title":"J Urol"},{"key":"key20240930104733_b30-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.toxlet.2023.07.013","article-title":"Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway","volume":"384","author":"Han","year":"2023","journal-title":"Toxicol Lett"},{"issue":"132182","key":"key20240930104733_b31-MCO-21-5-02784","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132182","article-title":"Phthalates (PAEs) and reproductive toxicity: Hypothalamic-pituitary-gonadal (HPG) axis aspects","volume":"459","author":"Zhang","year":"2023","journal-title":"J Hazard Mater"},{"key":"key20240930104733_b32-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1158\/0008-5472.CAN-07-5259","article-title":"Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype","volume":"68","author":"Kumar","year":"2008","journal-title":"Cancer Res"},{"key":"key20240930104733_b33-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.etap.2018.08.007","article-title":"Phthalates promote prostate cancer cell proliferation through activation of ERK5 and p38","volume":"63","author":"Zhu","year":"2018","journal-title":"Environ Toxicol Pharmacol"},{"key":"key20240930104733_b34-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.tiv.2015.12.012","article-title":"Mono-2-ethyhexyl phthalate advancing the progression of prostate cancer through activating the hedgehog pathway in LNCaP cells","volume":"32","author":"Yong","year":"2016","journal-title":"Toxicol In Vitro"},{"key":"key20240930104733_b35-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1023\/a:1026546803917","article-title":"Effects of supplemental alpha-tocopherol and beta-carotene on urinary tract cancer: Incidence and mortality in a controlled trial (Finland)","volume":"11","author":"Virtamo","year":"2000","journal-title":"Cancer Causes Control"},{"key":"key20240930104733_b36-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1001\/jama.293.11.1338","article-title":"Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial","volume":"293","author":"Lonn","year":"2005","journal-title":"JAMA"},{"key":"key20240930104733_b37-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/jnci\/djj050","article-title":"Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk","volume":"98","author":"Kirsh","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"key20240930104733_b38-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1093\/jnci\/90.6.440","article-title":"Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: Incidence and mortality in a controlled trial","volume":"90","author":"Heinonen","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"key20240930104733_b39-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.jchromb.2010.06.015","article-title":"Determination of human serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) by HPLC-ECD combined with solid phase extraction (SPE)","volume":"878","author":"Koide","year":"2010","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"95","key":"key20240930104733_b40-MCO-21-5-02784","article-title":"Detection of 8-OHdG as a diagnostic biomarker","volume":"3","author":"Korkmaz","year":"2018","journal-title":"J Lab Precis Med"},{"key":"key20240930104733_b41-MCO-21-5-02784","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/s0022-5347(17)39797-5","article-title":"In situ hybridization of prostate-specific antigen mRNA in human prostate","volume":"144","author":"Qiu","year":"1990","journal-title":"J Urol"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:49:42Z","timestamp":1727682582000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2024.2784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,9,16]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2024.2784","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"value":"2049-9450","type":"print"},{"value":"2049-9469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"article-number":"86"}}