{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:19:34Z","timestamp":1736399974524,"version":"3.32.0"},"reference-count":46,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2024.2817","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T10:46:46Z","timestamp":1734605206000},"source":"Crossref","is-referenced-by-count":0,"title":["Cathelicidin, but not vitamin D, is associated independently with sepsis in pediatric patients with cancer and febrile neutropenia"],"prefix":"10.3892","volume":"22","author":[{"given":"Paola","family":"Garc\u00eda\u2011Garc\u00eda","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Laboratory, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Palomo\u2011Colli","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2011Oncology, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Silva\u2011Jivaja","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Laboratory, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Ju\u00e1rez\u2011Villegas","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2011Oncology, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Vidal\u2011Romero","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, FES Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"S\u00e1nchez\u2011rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Castel\u00e1n\u2011Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Laboratory, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"key20250105075259_b1-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/pbc.25288","article-title":"Why pediatric patients with cancer visit the emergency department: United States, 2006-2010","volume":"62","author":"Mueller","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"key20250105075259_b2-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1200\/JCO.2012.47.2365","article-title":"Outcomes of critically ill patients with hematologic malignancies: Prospective multicenter data from France and Belgium-a groupe de recherche respiratoire en r\u00e9animation onco-h\u00e9matologique study","volume":"31","author":"Azoulay","year":"2013","journal-title":"J Clin Oncol"},{"key":"key20250105075259_b3-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1200\/JCO.2016.66.9549","article-title":"Effects of organizational characteristics on outcomes and resource use in patients with cancer admitted to intensive care units","volume":"34","author":"Soares","year":"2016","journal-title":"J Clin Oncol"},{"key":"key20250105075259_b4-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1093\/jpids\/piac080","article-title":"Predictors of septic shock or bacteremia in children experiencing febrile neutropenia post-chemotherapy","volume":"11","author":"Avil\u00e9s-Robles","year":"2022","journal-title":"J Pediatric Infect Dis Soc"},{"key":"key20250105075259_b5-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00280-020-04155-4","article-title":"Efficacy and safety of oral magnesium supplementation in reducing febrile neutropenia episodes in children with solid tumors treated with cisplatin-based chemotherapy: Randomized clinical trial","volume":"86","author":"Castel\u00e1n-Mart\u00ednez","year":"2020","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1070","key":"key20250105075259_b6-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73075.2","article-title":"Prospective cohort study of the predictive value of inflammatory biomarkers over clinical variables in children and young people with cancer presenting with fever and neutropenia","volume":"10","author":"Phillips","year":"2021","journal-title":"F1000Res"},{"issue":"2097","key":"key20250105075259_b7-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072097","article-title":"Immunologic effects of vitamin D on human health and disease","volume":"12","author":"Charoenngam","year":"2020","journal-title":"Nutrients"},{"key":"key20250105075259_b8-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.clnu.2019.08.010","article-title":"Association between vitamin D status and sepsis in children: A meta-analysis of observational studies","volume":"39","author":"Xiao","year":"2020","journal-title":"Clin Nutr"},{"issue":"660","key":"key20250105075259_b9-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0660-4","article-title":"Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: Systematic review and meta-analysis","volume":"18","author":"de Haan","year":"2014","journal-title":"Crit Care"},{"issue":"e64348","key":"key20250105075259_b10-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064348","article-title":"Serum 1,25-dihydroxyvitamin D: An outcome prognosticator in human sepsis","volume":"8","author":"Nguyen","year":"2013","journal-title":"PLoS One"},{"key":"key20250105075259_b11-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"key20250105075259_b12-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bpj.2009.09.060","article-title":"Antimicrobial and membrane disrupting activities of a peptide derived from the human cathelicidin antimicrobial peptide LL37","volume":"98","author":"Thennarasu","year":"2010","journal-title":"Biophys J"},{"key":"key20250105075259_b13-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.1021\/bi0273563","article-title":"Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37","volume":"42","author":"Henzler Wildman","year":"2003","journal-title":"Biochemistry"},{"key":"key20250105075259_b14-MCO-22-2-02817"},{"key":"key20250105075259_b15-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"328","DOI":"10.7326\/0003-4819-64-2-328","article-title":"Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia","volume":"64","author":"Bodey","year":"1966","journal-title":"Ann Intern Med"},{"key":"key20250105075259_b16-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"268","DOI":"10.5694\/j.1326-5377.2006.tb00558.x","article-title":"Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: A consensus statement; Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: A consensus statement","volume":"185","author":"Munns","year":"2006","journal-title":"Med J Aust"},{"key":"key20250105075259_b17-MCO-22-2-02817","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Medical progress vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"key20250105075259_b18-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/MPH.0000000000000515","article-title":"Risk factors for febrile neutropenia in children with solid tumors treated with cisplatin-based chemotherapy","volume":"38","author":"Castel\u00e1n-Mart\u00ednez","year":"2016","journal-title":"J Pediatr Hematol Oncol"},{"key":"key20250105075259_b19-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s12098-012-0925-3","article-title":"Evaluation of predictors of adverse outcome in febrile neutropenic episodes in pediatric oncology patients","volume":"80","author":"Bothra","year":"2013","journal-title":"Indian J Pediatr"},{"key":"key20250105075259_b20-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1097\/INF.0b013e318124aa44","article-title":"Admission clinical and laboratory factors associated with death in children with cancer during a febrile neutropenic episode","volume":"26","author":"Santolaya","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"key20250105075259_b21-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4274\/tjh.galenos.2023.2023.0185","article-title":"Etiology and factors affecting severe complications and mortality of febrile neutropenia in children with acute leukemia","volume":"40","author":"Erba\u015f","year":"2023","journal-title":"Turk J Haematol"},{"key":"key20250105075259_b22-MCO-22-2-02817","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s13312-018-1395-0","article-title":"Risk factors for microbiologically-documented infections, mortality and prolonged hospital stay in children with febrile neutropenia","volume":"55","author":"Das","year":"2018","journal-title":"Indian Pediatr"},{"key":"key20250105075259_b23-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/MPH.0b013e31820ff632","article-title":"Microbiology and mortality of pediatric febrile neutropenia in El Salvador","volume":"33","author":"Gupta","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"key20250105075259_b24-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nri.2016.29","article-title":"The immunology of host defence peptides: Beyond antimicrobial activity","volume":"16","author":"Hancock","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"key20250105075259_b25-MCO-22-2-02817","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood.V90.7.2796","article-title":"The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils","volume":"90","author":"S\u00f8rensen","year":"1997","journal-title":"Blood"},{"key":"key20250105075259_b26-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"34121","DOI":"10.1074\/jbc.M111.250431","article-title":"Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin d receptor-independent pathway","volume":"286","author":"Park","year":"2011","journal-title":"J Biol Chem"},{"key":"key20250105075259_b27-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/SHK.0b013e31816d2269","article-title":"Efficacy of LL-37 and granulocyte colony-stimulating factor in a neutropenic murine sepsis due to pseudomonas aeruginosa","volume":"30","author":"Cirioni","year":"2008","journal-title":"Shock"},{"key":"key20250105075259_b28-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1093\/cid\/cix483","article-title":"Serum LL-37 levels associated with severity of bronchiolitis and viral etiology","volume":"65","author":"Mansbach","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key20250105075259_b29-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.eimc.2018.06.011","article-title":"Vitamin D binding protein, but not vitamin D or vitamin D-related peptides, is associated with septic shock mortality","volume":"37","author":"Suberviola","year":"2019","journal-title":"Enferm Infecc Microbiol Clin (Engl Ed)"},{"key":"key20250105075259_b30-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.micinf.2013.01.001","article-title":"Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock","volume":"15","author":"Barbeiro","year":"2013","journal-title":"Microbes Infect"},{"issue":"5973","key":"key20250105075259_b31-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21175973","article-title":"Therapeutic potential of cathelicidin peptide LL-37, an antimicrobial agent, in a murine sepsis model","volume":"21","author":"Nagaoka","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20250105075259_b32-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1021\/acs.jmedchem.8b00036","article-title":"Python cathelicidin CATHPb1 protects against multidrug-resistant staphylococcal infections by antimicrobial-immunomodulatory duality","volume":"61","author":"Cai","year":"2018","journal-title":"J Med Chem"},{"key":"key20250105075259_b33-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/MPH.0000000000000475","article-title":"Low vitamin D levels are associated with an adverse clinical outcome in febrile neutropenia","volume":"38","author":"Gupta","year":"2016","journal-title":"J Pediatr Hematol Oncol"},{"key":"key20250105075259_b34-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/j.1440-1843.2011.01924.x","article-title":"Vitamin D, innate immunity and outcomes in community acquired pneumonia","volume":"16","author":"Leow","year":"2011","journal-title":"Respirology"},{"key":"key20250105075259_b35-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1177\/0310057X1704500106","article-title":"Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis-a pilot study","volume":"45","author":"Greulich","year":"2017","journal-title":"Anaesth Intensive Care"},{"issue":"6692827","key":"key20250105075259_b36-MCO-22-2-02817","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6692827","article-title":"The pattern of microorganisms and drug susceptibility in pediatric oncologic patients with febrile neutropenia","volume":"2021","author":"Jungrungrueng","year":"2021","journal-title":"J Pathog"},{"key":"key20250105075259_b37-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1080\/08880018.2020.1767243","article-title":"Predictors of severe adverse outcomes in febrile neutropenia of pediatric oncology patients at a single institute in Thailand","volume":"37","author":"Suttitossatam","year":"2020","journal-title":"Pediatr Hematol Oncol"},{"key":"key20250105075259_b38-MCO-22-2-02817","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4067\/S0716-10182009000200001","article-title":"Etiology of febrile neutropenia episodes among cancer patients from Hospital Clinico Universidad Catolica, Santiago-chile","volume":"26","author":"Rabagliati","year":"2009","journal-title":"Rev Chilena Infectol"},{"key":"key20250105075259_b39-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s12288-020-01377-7","article-title":"Surveillance stool culture and its association with microbiologically documented infection during febrile neutropenia in patients with acute leukemia (AL) undergoing induction chemotherapy","volume":"37","author":"Jadhav","year":"2021","journal-title":"Indian J Hematol Blood Transfus"},{"key":"key20250105075259_b40-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1007\/s00520-019-04961-4","article-title":"Association of time to antibiotics and clinical outcomes in patients with fever and neutropenia during chemotherapy for cancer: A systematic review","volume":"28","author":"Koenig","year":"2020","journal-title":"Support Care Cancer"},{"key":"key20250105075259_b41-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1200\/OP.23.00583","article-title":"Impact of time-to-antibiotic delivery in pediatric patients with cancer presenting with febrile neutropenia","volume":"20","author":"De Castro","year":"2024","journal-title":"JCO Oncol Pract"},{"key":"key20250105075259_b42-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1055\/a-2135-4210","article-title":"Time to antibiotics (TTA)-reassessment from the German working group for fever and neutropenia in children and adolescents (DGPI\/GPOH)","volume":"235","author":"Simon","year":"2023","journal-title":"Klin Padiatr"},{"key":"key20250105075259_b43-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/MPH.0000000000002494","article-title":"Drug Induced diabetes mellitus in pediatric acute lymphoblastic leukemia: Approach to diagnosis and management","volume":"44","author":"Handattu","year":"2022","journal-title":"J Pediatr Hematol Oncol"},{"key":"key20250105075259_b44-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1177\/193229680900300604","article-title":"Hyperglycemia in critical illness: A review","volume":"3","author":"Brealey","year":"2009","journal-title":"J Diabetes Sci Technol"},{"key":"key20250105075259_b45-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1097\/01.CCM.0000266536.14736.03","article-title":"Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock","volume":"35","author":"Sund\u00e9n-Cullberg","year":"2007","journal-title":"Crit Care Med"},{"key":"key20250105075259_b46-MCO-22-2-02817","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/01.mph.0000212996.94929.0b","article-title":"A proposed score for predicting severe infection complications in children with chemotherapy-induced febrile neutropenia","volume":"28","author":"Rondinelli","year":"2006","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T05:53:05Z","timestamp":1736056385000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2024.2817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,12,19]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2024.2817","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"type":"print","value":"2049-9450"},{"type":"electronic","value":"2049-9469"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"article-number":"22"}}