{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:20:58Z","timestamp":1779200458607,"version":"3.51.4"},"reference-count":101,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2025.2868","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:31:35Z","timestamp":1750667495000},"page":"1-13","source":"Crossref","is-referenced-by-count":1,"title":["Mesenchymal stem cell therapy for breast cancer\u2011related secondary lymphedema (Review)"],"prefix":"10.3892","volume":"23","author":[{"given":"Shunxin","family":"Han","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junrong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuteng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"key20250714143314_b1-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.jaad.2017.03.022","article-title":"Lymphedema: Pathophysiology and clinical manifestations","volume":"77","author":"Grada","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"key20250714143314_b2-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"612","DOI":"10.4252\/wjsc.v12.i7.612","article-title":"Adipose-derived stem cell therapy shows promising results for secondary lymphedema","volume":"12","author":"Hu","year":"2020","journal-title":"World J Stem Cells"},{"issue":"241","key":"key20250714143314_b3-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-024-02472-9","article-title":"Current diagnostic and quantitative techniques in the field of lymphedema management: A critical review","volume":"41","author":"Vargo","year":"2024","journal-title":"Med Oncol"},{"key":"key20250714143314_b4-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1200\/JCO.19.02896","article-title":"Breast cancer-related lymphedema: Risk factors, screening, management, and the impact of locoregional treatment","volume":"38","author":"McLaughlin","year":"2020","journal-title":"J Clin Oncol"},{"issue":"e065045","key":"key20250714143314_b5-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-065045","article-title":"Which physical therapy intervention is most effective in reducing secondary lymphoedema associated with breast cancer? Protocol for a systematic review and network meta-analysis","volume":"12","author":"Aguilera-Egu\u00eda","year":"2022","journal-title":"BMJ Open"},{"key":"key20250714143314_b6-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1002\/cncr.33042","article-title":"Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China","volume":"126","author":"Zhang","year":"2020","journal-title":"Cancer"},{"key":"key20250714143314_b7-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/ijc.IJC_22_19","article-title":"A descriptive study on prevalence of arm\/shoulder problems and its impact on quality of life in breast cancer survivors","volume":"58","author":"Jariwala","year":"2021","journal-title":"Indian J Cancer"},{"key":"key20250714143314_b8-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: Profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"key20250714143314_b9-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1007\/s00520-020-05521-x","article-title":"Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis","volume":"28","author":"Hasenoehrl","year":"2020","journal-title":"Support Care Cancer"},{"key":"key20250714143314_b10-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S1470-2045(13)70076-7","article-title":"Incidence of unilateral arm lymphoedema after breast cancer: A systematic review and meta-analysis","volume":"14","author":"DiSipio","year":"2013","journal-title":"Lancet Oncol"},{"key":"key20250714143314_b11-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1136\/ijgc-2019-001032","article-title":"Lower extremity lymphedema in patients with gynecologic malignancies","volume":"30","author":"Dessources","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"key20250714143314_b12-MCO-23-2-02868","author":"Bruno"},{"key":"key20250714143314_b13-MCO-23-2-02868","author":"Hassan"},{"key":"key20250714143314_b14-MCO-23-2-02868","author":"Bouhali"},{"issue":"34673","key":"key20250714143314_b15-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/srep34673","article-title":"High-resolution 3D volumetry versus conventional measuring techniques for the assessment of experimental lymphedema in the mouse hindlimb","volume":"6","author":"Frueh","year":"2016","journal-title":"Sci Rep"},{"key":"key20250714143314_b16-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/mrm.30255","article-title":"Spherical echo-planar time-resolved imaging (sEPTI) for rapid 3D quantitative T2* and susceptibility imaging","volume":"93","author":"Wang","year":"2025","journal-title":"Magn Reson Med"},{"issue":"16239","key":"key20250714143314_b17-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-01270-1","article-title":"Multiparameter MRI-based model integrating radiomics and deep learning for preoperative staging of laryngeal squamous cell carcinoma","volume":"15","author":"Xie","year":"2025","journal-title":"Sci Rep"},{"key":"key20250714143314_b18-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-016-3919-4","article-title":"Therapy modalities to reduce lymphoedema in female breast cancer patients: A systematic review and meta-analysis","volume":"159","author":"Rogan","year":"2016","journal-title":"Breast Cancer Res Treat"},{"issue":"15347354211044107","key":"key20250714143314_b19-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1177\/15347354211044107","article-title":"Effects of acupuncture and moxibustion on breast cancer-related lymphedema: A systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Gao","year":"2021","journal-title":"Integr Cancer Ther"},{"key":"key20250714143314_b20-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/SPC.0000000000000311","article-title":"Advances in understanding and management of lymphoedema (cancer, primary)","volume":"11","author":"Keeley","year":"2017","journal-title":"Curr Opin Support Palliat Care"},{"key":"key20250714143314_b21-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1097\/SLA.0000000000000763","article-title":"Vascularized lymph node transfer for treatment of lymphedema: A comprehensive literature review","volume":"261","author":"Raju","year":"2015","journal-title":"Ann Surg"},{"issue":"e0670","key":"key20250714143314_b22-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010670","article-title":"Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review: Erratum","volume":"97","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"key20250714143314_b23-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3109\/2000656X.2014.964726","article-title":"Stem cells show promising results for lymphoedema treatment-a literature review","volume":"49","author":"Toyserkani","year":"2015","journal-title":"J Plast Surg Hand Surg"},{"key":"key20250714143314_b24-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1515\/revneuro-2019-0002","article-title":"Mesenchymal stem cell therapy for the treatment of traumatic brain injury: Progress and prospects","volume":"30","author":"Das","year":"2019","journal-title":"Rev Neurosci"},{"issue":"22","key":"key20250714143314_b25-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: Cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen Med"},{"key":"key20250714143314_b26-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1152\/japplphysiol.01116.2012","article-title":"Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema","volume":"114","author":"Jensen","year":"2013","journal-title":"J Appl Physiol (1985)"},{"key":"key20250714143314_b27-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/SLA.0b013e31826a9064","article-title":"A novel autologous cell-based therapy to promote diabetic wound healing","volume":"256","author":"Castilla","year":"2012","journal-title":"Ann Surg"},{"key":"key20250714143314_b28-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.maturitas.2017.04.015","article-title":"Effectiveness of four inflammatory markers in predicting prognosis in 2374 women with breast cancer","volume":"101","author":"Wariss","year":"2017","journal-title":"Maturitas"},{"key":"key20250714143314_b29-MCO-23-2-02868","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1039\/D0MH01295E","article-title":"\u2018Nano-lymphatic\u2019 photocatalytic water-splitting for relieving tumor interstitial fluid pressure and achieving hydrodynamic therapy\u2020","volume":"7","author":"Cong","year":"2020","journal-title":"Mater Horiz"},{"key":"key20250714143314_b30-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1093\/eurheartj\/ehad377","article-title":"A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension","volume":"44","author":"Zhuang","year":"2023","journal-title":"Eur Heart J"},{"key":"key20250714143314_b31-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41586-025-08724-6","article-title":"Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium","volume":"641","author":"Schoofs","year":"2025","journal-title":"Nature"},{"key":"key20250714143314_b32-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/jso.25661","article-title":"Review of preclinical and clinical studies of using cell-based therapy for secondary lymphedema","volume":"121","author":"Chen","year":"2020","journal-title":"J Surg Oncol"},{"key":"key20250714143314_b33-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1096\/fj.12-222695","article-title":"Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema","volume":"27","author":"Avraham","year":"2013","journal-title":"FASEB J"},{"issue":"42","key":"key20250714143314_b34-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-023-00580-1","article-title":"Increased infiltration of CD4+ T cell in the complement deficient lymphedema model","volume":"24","author":"Nishioka","year":"2023","journal-title":"BMC Immunol"},{"issue":"1371","key":"key20250714143314_b35-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031371","article-title":"Dynamics of immune cell infiltration and fibroblast-derived IL-33\/ST2 axis induction in a mouse model of post-surgical lymphedema","volume":"26","author":"Uemura","year":"2025","journal-title":"Int J Mol Sci"},{"key":"key20250714143314_b36-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jid.2015.12.001","article-title":"Excess lymphangiogenesis cooperatively induced by macrophages and CD4(+) T cells drives the pathogenesis of lymphedema","volume":"136","author":"Ogata","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"7614","key":"key20250714143314_b37-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147614","article-title":"Emerging anti-inflammatory pharmacotherapy and cell-based therapy for lymphedema","volume":"23","author":"Ogino","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20250714143314_b38-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.bbi.2025.04.004","article-title":"Fueling the fire in the lung-brain axis: The salience network connects allergen-provoked TH17 responses to psychological stress in asthma","volume":"128","author":"Higgins","year":"2025","journal-title":"Brain Behav Immun"},{"issue":"200","key":"key20250714143314_b39-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-025-04065-5","article-title":"Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies","volume":"74","author":"De Castro","year":"2025","journal-title":"Cancer Immunol Immunother"},{"key":"key20250714143314_b40-MCO-23-2-02868","article-title":"Expression of Th1 and Th2 cytokines in serum of patients with lupus nephritis","volume":"40 746","author":"Li","year":"2013","journal-title":"Mod Prev Med"},{"key":"key20250714143314_b41-MCO-23-2-02868","author":"Zhu"},{"issue":"1363811","key":"key20250714143314_b42-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1363811","article-title":"Molecular pathophysiology of secondary lymphedema","volume":"12","author":"Lee","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"6621","key":"key20250714143314_b43-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126621","article-title":"Current mechanistic understandings of lymphedema and lipedema: Tales of fluid, fat, and fibrosis","volume":"23","author":"Duhon","year":"2022","journal-title":"Int J Mol Sci"},{"key":"key20250714143314_b44-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/RLU.0000000000000688","article-title":"Lymphoscintigraphy for the assessment of autologous stem cell implantation in chronic lymphedema","volume":"40","author":"Pe\u00f1a Qui\u00e1n","year":"2015","journal-title":"Clin Nucl Med"},{"key":"key20250714143314_b45-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.bjps.2018.09.007","article-title":"Adipose-derived regenerative cells and fat grafting for treating breast cancer-related lymphedema: Lymphoscintigraphic evaluation with 1 year of follow-up","volume":"72","author":"Toyserkani","year":"2019","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1540","key":"key20250714143314_b46-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071540","article-title":"Prospective validation of indocyanine green lymphangiography staging of breast cancer-related lymphedema","volume":"13","author":"J\u00f8rgensen","year":"2021","journal-title":"Cancers (Basel)"},{"key":"key20250714143314_b47-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"key20250714143314_b48-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3727\/096368916X693040","article-title":"\u03b2-catenin accumulation is associated with increased expression of nanog protein and predicts maintenance of MSC self-renewal","volume":"26","author":"Yu","year":"2017","journal-title":"Cell Transplant"},{"key":"key20250714143314_b49-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol Biol Cell"},{"key":"key20250714143314_b50-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1365-2796.2007.01844.x","article-title":"Immunomodulation by mesenchymal stem cells and clinical experience","volume":"262","author":"Le Blanc","year":"2007","journal-title":"J Intern Med"},{"issue":"10.3791\/61848","key":"key20250714143314_b51-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3791\/61848","article-title":"A murine tail lymphedema model","author":"Hassanein","year":"2021","journal-title":"J Vis Exp"},{"key":"key20250714143314_b52-MCO-23-2-02868","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2458\/lymph.4651","article-title":"A modified mouse-tail lymphedema model","volume":"53","author":"Arruda","year":"2020","journal-title":"Lymphology"},{"key":"key20250714143314_b53-MCO-23-2-02868","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.12677\/ACM.2022.125612","article-title":"Modern medical progress of peripheral lymphedema treated by integrated traditional Chinese and western medicine","volume":"12","author":"Yu","year":"2022","journal-title":"Adv Clin Med"},{"key":"key20250714143314_b54-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/jjco\/hyn090","article-title":"Autologous bone marrow stromal cells transplantation for the treatment of secondary arm lymphedema: A prospective controlled study in patients with breast cancer related lymphedema","volume":"38","author":"Hou","year":"2008","journal-title":"Jpn J Clin Oncol"},{"key":"key20250714143314_b55-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/jjco\/hyr055","article-title":"Exogenous VEGF-C augments the efficacy of therapeutic lymphangiogenesis induced by allogenic bone marrow stromal cells in a rabbit model of limb secondary lymphedema","volume":"41","author":"Zhou","year":"2011","journal-title":"Jpn J Clin Oncol"},{"key":"key20250714143314_b56-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1089\/lrb.2017.0027","article-title":"Stem cell therapy using bone marrow-derived mononuclear cells in treatment of lower limb lymphedema: A randomized controlled clinical trial","volume":"16","author":"Ismail","year":"2018","journal-title":"Lymphat Res Biol"},{"issue":"54676","key":"key20250714143314_b57-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3791\/54676","article-title":"The arteriovenous (AV) loop in a small animal model to study angiogenesis and vascularized tissue engineering","author":"Weigand","year":"2016","journal-title":"J Vis Exp"},{"key":"key20250714143314_b58-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/term.1457","article-title":"Engineering axially vascularized bone in the sheep arteriovenous-loop model","volume":"7","author":"Boos","year":"2013","journal-title":"J Tissue Eng Regen Med"},{"key":"key20250714143314_b59-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000492417","article-title":"The arteriovenous loop: Engineering of axially vascularized tissue","volume":"59","author":"Weigand","year":"2018","journal-title":"Eur Surg Res"},{"key":"key20250714143314_b60-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1089\/ten.TEA.2020.0108","article-title":"Tissue engineering of lymphatic vasculature in the arteriovenous loop model of the rat","volume":"27","author":"Robering","year":"2021","journal-title":"Tissue Eng Part A"},{"key":"key20250714143314_b61-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/PRS.0b013e31829ace13","article-title":"Molecular analysis and differentiation capacity of adipose-derived stem cells from lymphedema tissue","volume":"132","author":"Levi","year":"2013","journal-title":"Plast Reconstr Surg"},{"issue":"14401","key":"key20250714143314_b62-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41535-1","article-title":"CD31 defines a subpopulation of human adipose-derived regenerative cells with potent angiogenic effects","volume":"13","author":"Dhumale","year":"2023","journal-title":"Sci Rep"},{"key":"key20250714143314_b63-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.mvr.2015.09.001","article-title":"Impact of platelet rich plasma and adipose stem cells on lymphangiogenesis in a murine tail lymphedema model","volume":"102","author":"Ackermann","year":"2015","journal-title":"Microvasc Res"},{"key":"key20250714143314_b64-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/PRS.0000000000003110","article-title":"Adipose-derived stem cells and vascularized lymph node transfers successfully treat mouse hindlimb secondary lymphedema by early reconnection of the lymphatic system and lymphangiogenesis","volume":"139","author":"Hayashida","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"3885","key":"key20250714143314_b65-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113885","article-title":"Adipose-derived stem cells promote intussusceptive lymphangiogenesis by restricting dermal fibrosis in irradiated tissue of mice","volume":"21","author":"Ogino","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20250714143314_b66-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/PRS.0000000000006474","article-title":"The roles of podoplanin-positive\/podoplanin-negative cells from adipose-derived stem cells in lymphatic regeneration","volume":"145","author":"Dai","year":"2020","journal-title":"Plast Reconstr Surg"},{"key":"key20250714143314_b67-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1002\/sctm.20-0394","article-title":"Adipose-derived regenerative cells and lipotransfer in alleviating breast cancer-related lymphedema: An open-label phase I trial with 4 years of follow-up","volume":"10","author":"J\u00f8rgensen","year":"2021","journal-title":"Stem Cells Transl Med"},{"issue":"316","key":"key20250714143314_b68-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02603-4","article-title":"Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics","volume":"22","author":"Yang","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"key20250714143314_b69-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08210-7","article-title":"Effectiveness of manual lymphatic drainage in intensive phase I therapy of breast cancer-related lymphedema-a retrospective analysis","volume":"32","author":"Kasseroller","year":"2023","journal-title":"Support Care Cancer"},{"key":"key20250714143314_b70-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1097\/PRS.0000000000010388","article-title":"Extracellular vesicles from adipose-derived stem cells relieve extremity lymphedema in mouse models","volume":"152","author":"Tashiro","year":"2023","journal-title":"Plast Reconstr Surg"},{"key":"key20250714143314_b71-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.1021\/acsnano.3c06462","article-title":"Anticancer therapy targeting cancer-derived extracellular vesicles","volume":"18","author":"Cheng","year":"2024","journal-title":"ACS Nano"},{"issue":"440","key":"key20250714143314_b72-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02512-5","article-title":"Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: An in vitro study","volume":"12","author":"Yuan","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"426","key":"key20250714143314_b73-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01685-0","article-title":"SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer","volume":"8","author":"Diao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"key20250714143314_b74-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/cac2.12470","article-title":"An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis","volume":"43","author":"Li","year":"2023","journal-title":"Cancer Commun (Lond)"},{"issue":"43","key":"key20250714143314_b75-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0752-z","article-title":"Enhancement of cardiac lymphangiogenesis by transplantation of CD34+VEGFR-3+ endothelial progenitor cells and sustained release of VEGF-C","volume":"114","author":"Zhang","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"key20250714143314_b76-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jss.2013.11.1116","article-title":"Cell transplantation therapy for a rat model of secondary lymphedema","volume":"189","author":"Kawai","year":"2014","journal-title":"J Surg Res"},{"key":"key20250714143314_b77-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1089\/cell.2016.0038","article-title":"Overexpression of Prox1 induces the differentiation of human adipose-derived stem cells into lymphatic endothelial-like cells in vitro","volume":"19","author":"Deng","year":"2017","journal-title":"Cell Reprogram"},{"key":"key20250714143314_b78-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/aps.2017.140","article-title":"Regulatory T cells as a new therapeutic target for atherosclerosis","volume":"39","author":"Ou","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"key20250714143314_b79-MCO-23-2-02868","author":"Chen"},{"key":"key20250714143314_b80-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1530\/REP-20-0320","article-title":"Mesenchymal stem cells induce expansion of regulatory T cells in abortion-prone mice","volume":"161","author":"Salek Farrokhi","year":"2021","journal-title":"Reproduction"},{"issue":"e89081","key":"key20250714143314_b81-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89081","article-title":"Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function","volume":"1","author":"Gousopoulos","year":"2016","journal-title":"JCI Insight"},{"issue":"819","key":"key20250714143314_b82-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060819","article-title":"Autocrine TGF-\u03b21 maintains the stability of Foxp3+ regulatory T cells via IL-12R\u03b22 downregulation","volume":"10","author":"Choi","year":"2020","journal-title":"Biomolecules"},{"issue":"5877","key":"key20250714143314_b83-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15245877","article-title":"Promises and pitfalls of next-generation treg adoptive immunotherapy","volume":"15","author":"Christofi","year":"2023","journal-title":"Cancers (Basel)"},{"key":"key20250714143314_b84-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s10571-016-0429-1","article-title":"Adoptive regulatory T-cell therapy attenuates perihematomal inflammation in a mouse model of experimental intracerebral hemorrhage","volume":"37","author":"Mao","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"key20250714143314_b85-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jvsv.2019.10.019","article-title":"Effects of mobilized peripheral blood stem cells on treatment of primary lower extremity lymphedema","volume":"8","author":"Ehyaeeghodraty","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"103693","key":"key20250714143314_b86-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2025.103693","article-title":"Generation of human induced pluripotent stem cell line from peripheral blood of patient with lymphedema-distichiasis syndrome","volume":"85","author":"Bia\u0142obrzeska","year":"2025","journal-title":"Stem Cell Res"},{"key":"key20250714143314_b87-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1002\/cncr.34489","article-title":"Burden of lymphedema in long-term breast cancer survivors by race and age","volume":"128","author":"Ren","year":"2022","journal-title":"Cancer"},{"issue":"351","key":"key20250714143314_b88-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07532-0","article-title":"UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia","volume":"16","author":"Huang","year":"2025","journal-title":"Cell Death Dis"},{"issue":"106731","key":"key20250714143314_b89-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2025.106731","article-title":"Combined inhibition of importin-\u03b2 and PBR enhances osteogenic differentiation of BMSCs by reducing nuclear accumulation of glucocorticoid receptor and promoting its mitochondrial translocation","volume":"250","author":"Deng","year":"2025","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key20250714143314_b90-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1530\/EOR-2024-0142","article-title":"Therapeutic efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with spinal cord injury: A meta-analysis","volume":"10","author":"Liu","year":"2025","journal-title":"EFORT Open Rev"},{"key":"key20250714143314_b91-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"558","DOI":"10.21037\/gs.2020.02.09","article-title":"Transcriptome analysis and functional identification of adipose-derived mesenchymal stem cells in secondary lymphedema","volume":"9","author":"Xiang","year":"2020","journal-title":"Gland Surg"},{"key":"key20250714143314_b92-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7150\/ijms.21666","article-title":"Ethical and safety issues of stem cell-based therapy","volume":"15","author":"Volarevic","year":"2018","journal-title":"Int J Med Sci"},{"key":"key20250714143314_b93-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1161\/01.CIR.0000134696.08436.65","article-title":"Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction","volume":"109","author":"Yoon","year":"2004","journal-title":"Circulation"},{"issue":"195","key":"key20250714143314_b94-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01208-w","article-title":"Mesenchymal stem\/stromal cells in cancer therapy","volume":"14","author":"Lan","year":"2021","journal-title":"J Hematol Oncol"},{"issue":"2298","key":"key20250714143314_b95-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1038\/srep02298","article-title":"Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice","volume":"3","author":"Ljujic","year":"2013","journal-title":"Sci Rep"},{"issue":"182","key":"key20250714143314_b96-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.14928","article-title":"Exploring thymic stromal lymphopoietin in the breast cancer microenvironment: A preliminary study","volume":"29","author":"Marcella","year":"2025","journal-title":"Oncol Lett"},{"issue":"180","key":"key20250714143314_b97-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02848-6","article-title":"Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: A single-center, double-blinded, randomized, placebo-controlled phase II trial","volume":"13","author":"Zang","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"93","key":"key20250714143314_b98-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0352-x","article-title":"Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem\/stromal cells: Present and future","volume":"7","author":"Astori","year":"2016","journal-title":"Stem Cell Res Ther"},{"issue":"81","key":"key20250714143314_b99-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-025-04517-1","article-title":"Scalable production of anti-inflammatory exosomes from three-dimensional cultures of canine adipose-derived mesenchymal stem cells: Production, stability, bioactivity, and safety assessment","volume":"21","author":"Thongsit","year":"2025","journal-title":"BMC Vet Res"},{"issue":"e101143","key":"key20250714143314_b100-MCO-23-2-02868","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2023-101143","article-title":"Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer's disease: A phase I\/II clinical trial","volume":"36","author":"Xie","year":"2023","journal-title":"Gen Psychiatr"},{"key":"key20250714143314_b101-MCO-23-2-02868","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1007\/s12015-022-10398-w","article-title":"Nebulization therapy with umbilical cord mesenchymal stem cell-derived exosomes for COVID-19 pneumonia","volume":"18","author":"Chu","year":"2022","journal-title":"Stem Cell Rev Rep"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:33:24Z","timestamp":1752492804000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2025.2868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":101,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,23]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2025.2868","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"value":"2049-9450","type":"print"},{"value":"2049-9469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]}}}