{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:34:32Z","timestamp":1757612072108,"version":"3.44.0"},"reference-count":50,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2025.2887","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T11:58:06Z","timestamp":1754654286000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Neuropilin\u20111 expression in primary and metastatic prostate cancer: Expression patterns and clinicopathological correlations"],"prefix":"10.3892","volume":"23","author":[{"given":"Kamil","family":"Kowalczyk","sequence":"first","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Kaczorowski","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Piotrowska","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50\u2011368 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kie\u0142b","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Dudek","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine\u2011National Research Institute, 4th Military Clinical Hospital in Wroclaw, 50\u2011981 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Gurwin","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Karwacki","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine in Opole, University of Opole, 45\u2011052 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Krajewski","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Szyde\u0142ko","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Ha\u0142o\u0144","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Dzi\u0119giel","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50\u2011368 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Ma\u0142kiewicz","sequence":"additional","affiliation":[{"name":"University Centre of Excellence in Urology, Department of Minimally Invasive and Robotic Urology, Wroclaw Medical University, 50\u2011556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"key20250904101553_b1-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"key20250904101553_b2-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1158\/1055-9965.EPI-20-1005","article-title":"Rising prostate cancer incidence in Sub-saharan africa: A trend analysis of data from the african cancer registry network","volume":"30","author":"Seraphin","year":"2021","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20250904101553_b3-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent global patterns in prostate cancer incidence and mortality rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur Urol"},{"key":"key20250904101553_b4-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.eururo.2022.11.023","article-title":"Disparities and trends in genitourinary cancer incidence and mortality in the USA","volume":"84","author":"Schafer","year":"2023","journal-title":"Eur Urol"},{"key":"key20250904101553_b5-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of prostate cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J Oncol"},{"key":"key20250904101553_b6-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1158\/1078-0432.CCR-08-0563","article-title":"Neuropilins in tumor biology","volume":"15","author":"Bagri","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key20250904101553_b7-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00262-013-1500-0","article-title":"Neuropilin 1: Function and therapeutic potential in cancer","volume":"63","author":"Chaudhary","year":"2014","journal-title":"Cancer Immunol Immunother"},{"key":"key20250904101553_b8-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/path.2182","article-title":"Neuropilins in physiological and pathological angiogenesis","volume":"212","author":"Staton","year":"2007","journal-title":"J Pathol"},{"key":"key20250904101553_b9-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2004.12.047","article-title":"The neuropilins and their role in tumorigenesis and tumor progression","volume":"231","author":"Guttmann-Raviv","year":"2006","journal-title":"Cancer Lett"},{"key":"key20250904101553_b10-MCO-23-4-02887","first-page":"5736","article-title":"Vascular endothelial growth factor is an autocrine survival factor for Neuropilin-expressing breast carcinoma cells","volume":"61","author":"Bachelder","year":"2001","journal-title":"Cancer Res"},{"key":"key20250904101553_b11-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1016\/S0002-9440(10)63772-8","article-title":"Neuropilin-1 in human colon cancer: Expression, regulation, and role in induction of angiogenesis","volume":"164","author":"Parikh","year":"2004","journal-title":"Am J Pathol"},{"key":"key20250904101553_b12-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1158\/1078-0432.CCR-07-0001","article-title":"Targeting neuropilin 1 as an antitumor strategy in lung cancer","volume":"13","author":"Hong","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"685980","key":"key20250904101553_b13-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.685980","article-title":"Role of NRP1 in bladder cancer pathogenesis and progression","volume":"11","author":"Dong","year":"2021","journal-title":"Front Oncol"},{"key":"key20250904101553_b14-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/cncr.10177","article-title":"Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma","volume":"94","author":"Fakhari","year":"2002","journal-title":"Cancer"},{"issue":"1552","key":"key20250904101553_b15-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061552","article-title":"Novel histopathological biomarkers in prostate cancer: Implications and perspectives","volume":"11","author":"Kie\u0142b","year":"2023","journal-title":"Biomedicines"},{"key":"key20250904101553_b16-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"26690","DOI":"10.1074\/jbc.M003955200","article-title":"The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1","volume":"275","author":"Fuh","year":"2000","journal-title":"J Biol Chem"},{"issue":"112","key":"key20250904101553_b17-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-05798-2","article-title":"NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting","volume":"7","author":"Sharma","year":"2024","journal-title":"Commun Biol"},{"key":"key20250904101553_b18-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/380435a0","article-title":"Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature"},{"key":"key20250904101553_b19-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"issue":"9","key":"key20250904101553_b20-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-9","article-title":"Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells","volume":"9","author":"Zhang","year":"2010","journal-title":"Mol Cancer"},{"issue":"159","key":"key20250904101553_b21-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05696-1","article-title":"NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis"},{"key":"key20250904101553_b22-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"5801","DOI":"10.1158\/0008-5472.CAN-12-0995","article-title":"Neuropilin-1-dependent regulation of EGF-receptor signaling","volume":"72","author":"Rizzolio","year":"2012","journal-title":"Cancer Res"},{"key":"key20250904101553_b23-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"18069","DOI":"10.1074\/jbc.M201681200","article-title":"Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165","volume":"277","author":"Gu","year":"2002","journal-title":"J Biol Chem"},{"key":"key20250904101553_b24-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ydbio.2012.06.026","article-title":"NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system","volume":"369","author":"Maden","year":"2012","journal-title":"Dev Biol"},{"key":"key20250904101553_b25-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1182\/blood-2005-10-4113","article-title":"Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A","volume":"107","author":"Narazaki","year":"2006","journal-title":"Blood"},{"key":"key20250904101553_b26-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1083\/jcb.146.1.233","article-title":"Neuropilin-1 mediates collapsin-1\/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165","volume":"146","author":"Miao","year":"1999","journal-title":"J Cell Biol"},{"key":"key20250904101553_b27-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1182\/blood-2007-08-110205","article-title":"Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor","volume":"111","author":"Acevedo","year":"2008","journal-title":"Blood"},{"key":"key20250904101553_b28-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1172\/JCI15467","article-title":"Semaphorins as signals for cell repulsion and invasion","volume":"109","author":"Goshima","year":"2002","journal-title":"J Clin Invest"},{"key":"key20250904101553_b29-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/sj.cdd.4401707","article-title":"The brain within the tumor: New roles for axon guidance molecules in cancers","volume":"12","author":"Ch\u00e9dotal","year":"2005","journal-title":"Cell Death Differ"},{"key":"key20250904101553_b30-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.mcn.2003.12.007","article-title":"Differential MAP kinases activation during semaphorin3A-induced repulsion or apoptosis of neural progenitor cells","volume":"25","author":"Bagnard","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"key20250904101553_b31-MCO-23-4-02887","first-page":"5230","article-title":"Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells","volume":"63","author":"Bachelder","year":"2003","journal-title":"Cancer Res"},{"key":"key20250904101553_b32-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1096\/fj.00-0250com","article-title":"Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression","volume":"14","author":"Miao","year":"2000","journal-title":"FASEB J"},{"key":"key20250904101553_b33-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1038\/onc.2016.482","article-title":"Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality","volume":"36","author":"Tse","year":"2017","journal-title":"Oncogene"},{"key":"key20250904101553_b34-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/sj.bjc.6605539","article-title":"Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity","volume":"102","author":"Jia","year":"2010","journal-title":"Br J Cancer"},{"key":"key20250904101553_b35-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3322\/caac.21391","article-title":"Prostate cancer-major changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Buyyounouski","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"key20250904101553_b36-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1097\/PAS.0000000000001497","article-title":"The 2019 international society of urological pathology (ISUP) consensus conference on grading of prostatic carcinoma","volume":"44","author":"van Leenders","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"key20250904101553_b37-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate Cancer-2024 update. Part I: Screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur Urol"},{"issue":"4578","key":"key20250904101553_b38-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184578","article-title":"Role of IL-17A and IL-17RA in prostate cancer with lymph nodes metastasis: Expression patterns and clinical significance","volume":"15","author":"Kie\u0142b","year":"2023","journal-title":"Cancers (Basel)"},{"key":"key20250904101553_b39-MCO-23-4-02887","first-page":"2065","article-title":"VEGFR1 and NRP1 endothelial expressions predict distant relapse after radical prostatectomy in clinically localized prostate cancer","volume":"33","author":"Talagas","year":"2013","journal-title":"Anticancer Res"},{"key":"key20250904101553_b40-MCO-23-4-02887","first-page":"1067","article-title":"Differential expression of Neuropilin-1 in malignant and benign prostatic stromal tissue","volume":"10","author":"Vanveldhuizen","year":"2003","journal-title":"Oncol Rep"},{"key":"key20250904101553_b41-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1365-2559.2009.03406.x","article-title":"Differential expression of the semaphorin 3A pathway in prostatic cancer","volume":"55","author":"Yacoub","year":"2009","journal-title":"Histopathology"},{"issue":"e73081","key":"key20250904101553_b42-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073081","article-title":"Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: An interracial comparative study","volume":"8","author":"Hu","year":"2013","journal-title":"PLoS One"},{"key":"key20250904101553_b43-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1136\/jcp.48.9.876","article-title":"A \u2018quickscore\u2019 method for immunohistochemical semiquantitation: Validation for oestrogen receptor in breast carcinomas","volume":"48","author":"Detre","year":"1995","journal-title":"J Clin Pathol"},{"issue":"221","key":"key20250904101553_b44-MCO-23-4-02887","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0221-9","article-title":"Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue-a review","volume":"9","author":"Fedchenko","year":"2014","journal-title":"Diagn Pathol"},{"key":"key20250904101553_b45-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1097\/01.ju.0000143448.04161.cc","article-title":"Prognosis of patients with lymph node positive prostate cancer following radical prostatectomy: Long-term results","volume":"172","author":"Daneshmand","year":"2004","journal-title":"J Urol"},{"key":"key20250904101553_b46-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.eururo.2008.05.023","article-title":"Good outcome for patients with few lymph node metastases after radical retropubic prostatectomy","volume":"54","author":"Schumacher","year":"2008","journal-title":"Eur Urol"},{"key":"key20250904101553_b47-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1016\/j.juro.2009.07.022","article-title":"Natural history of persistently elevated prostate specific antigen after radical prostatectomy: Results from the SEARCH database","volume":"182","author":"Moreira","year":"2009","journal-title":"J Urol"},{"key":"key20250904101553_b48-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.euo.2021.01.001","article-title":"Management of persistently elevated prostate-specific antigen after radical prostatectomy: A systematic review of the literature","volume":"4","author":"Ploussard","year":"2021","journal-title":"Eur Urol Oncol"},{"key":"key20250904101553_b49-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1111\/j.1464-410X.2009.09016.x","article-title":"Definition and preoperative predictors of persistently elevated prostate-specific antigen after radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database","volume":"105","author":"Moreira","year":"2010","journal-title":"BJU Int"},{"key":"key20250904101553_b50-MCO-23-4-02887","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.eururo.2019.01.048","article-title":"Persistent Prostate-specific antigen after radical prostatectomy and its impact on oncologic outcomes","volume":"76","author":"Preisser","year":"2019","journal-title":"Eur Urol"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:15:57Z","timestamp":1756970157000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2025.2887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,8]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2025.2887","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"type":"print","value":"2049-9450"},{"type":"electronic","value":"2049-9469"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}