{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:32:22Z","timestamp":1760488342970,"version":"build-2065373602"},"reference-count":55,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Clin Oncol"],"DOI":"10.3892\/mco.2025.2890","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:08:39Z","timestamp":1755594519000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Silvestrol inhibits nasopharyngeal carcinoma cells and synergizes with CX\u20115461: Insights from a proteomics study"],"prefix":"10.3892","volume":"23","author":[{"given":"Maelinda","family":"Daker","sequence":"first","affiliation":[{"name":"Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor 40170, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munirah","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor 40170, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Khoo","sequence":"additional","affiliation":[{"name":"Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor 40170, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor 40170, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siok-Fong","family":"Chin","sequence":"additional","affiliation":[{"name":"UKM Medical Molecular Biology Institute, National University of Malaysia, Cheras, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siaw","family":"Hwang","sequence":"additional","affiliation":[{"name":"School of Engineering and Science, Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus, Kuching, Sarawak 93350, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Neilsen","sequence":"additional","affiliation":[{"name":"College of Clinical Sciences, School of Health, Medical and Applied Science, Central Queensland University, North Rockhampton, Queensland 4702, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"key20251014162131_b1-MCO-23-5-02890"},{"key":"key20251014162131_b2-MCO-23-5-02890"},{"key":"key20251014162131_b3-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.semcancer.2012.01.006","article-title":"Unlocking the Rosetta Stone enigma for nasopharyngeal carcinoma: Genetics, viral infection, and epidemiological factors","volume":"22","author":"Lung","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"key20251014162131_b4-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"key20251014162131_b5-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1002\/ijc.32656","article-title":"Systematic comparison of plasma EBV DNA, anti-EBV antibodies and miRNA levels for early detection and prognosis of nasopharyngeal carcinoma","volume":"146","author":"Tan","year":"2020","journal-title":"Int J Cancer"},{"issue":"514","key":"key20251014162131_b6-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12775","article-title":"Nasopharyngeal carcinoma among the Bidayuh of Sarawak, Malaysia: History and risk factors","volume":"22","author":"Linton","year":"2021","journal-title":"Oncol Lett"},{"key":"key20251014162131_b7-MCO-23-5-02890"},{"key":"key20251014162131_b8-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1200\/JCO.2015.60.9347","article-title":"Management of nasopharyngeal carcinoma: Current practice and future perspective","volume":"33","author":"Lee","year":"2015","journal-title":"J Clin Oncol"},{"key":"key20251014162131_b9-MCO-23-5-02890"},{"author":"Pannell","key":"key20251014162131_b10-MCO-23-5-02890"},{"key":"key20251014162131_b11-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-93506-5_1","article-title":"The search for anticancer agents from tropical plants","volume":"107","author":"Henkin","year":"2018","journal-title":"Prog Chem Org Nat Prod"},{"issue":"e5428","key":"key20251014162131_b12-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005428","article-title":"Altering chemosensitivity by modulating translation elongation","volume":"4","author":"Robert","year":"2009","journal-title":"PLoS One"},{"key":"key20251014162131_b13-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.18632\/oncotarget.2098","article-title":"The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease","volume":"6","author":"Patton","year":"2015","journal-title":"Oncotarget"},{"key":"key20251014162131_b14-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1182\/blood-2008-09-175430","article-title":"The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo","volume":"113","author":"Lucas","year":"2009","journal-title":"Blood"},{"issue":"e76136","key":"key20251014162131_b15-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076136","article-title":"Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer","volume":"8","author":"Kogure","year":"2013","journal-title":"PLoS One"},{"key":"key20251014162131_b16-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.leukres.2009.07.043","article-title":"Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells","volume":"34","author":"Cencic","year":"2010","journal-title":"Leuk Res"},{"issue":"e5223","key":"key20251014162131_b17-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005223","article-title":"Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol","volume":"4","author":"Cencic","year":"2009","journal-title":"PLoS One"},{"key":"key20251014162131_b18-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1172\/JCI34753","article-title":"Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model","volume":"118","author":"Bordeleau","year":"2008","journal-title":"J Clin Invest"},{"key":"key20251014162131_b19-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1158\/1078-0432.CCR-12-0839","article-title":"Dual targeting of the cyclin\/Rb\/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol","volume":"18","author":"Alinari","year":"2012","journal-title":"Clin Cancer Res"},{"key":"key20251014162131_b20-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1039\/c4np00006d","article-title":"Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species","volume":"31","author":"Pan","year":"2014","journal-title":"Nat Prod Rep"},{"key":"key20251014162131_b21-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1021\/ml300110s","article-title":"Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeutics","volume":"3","author":"Haddach","year":"2012","journal-title":"ACS Med Chem Lett"},{"key":"key20251014162131_b22-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ccr.2012.05.019","article-title":"Inhibition of RNA polymerase i as a therapeutic strategy to promote cancer-specific activation of p53","volume":"22","author":"Bywater","year":"2012","journal-title":"Cancer Cell"},{"key":"key20251014162131_b23-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1158\/0008-5472.CAN-10-1728","article-title":"Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth","volume":"71","author":"Drygin","year":"2011","journal-title":"Cancer Res"},{"key":"key20251014162131_b24-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1158\/2159-8290.CD-18-1455","article-title":"First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: Results of a phase I dose-escalation study","volume":"9","author":"Khot","year":"2019","journal-title":"Cancer Discov"},{"key":"key20251014162131_b25-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.3892\/etm.2016.3201","article-title":"Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa","volume":"11","author":"Daker","year":"2016","journal-title":"Exp Ther Med"},{"key":"key20251014162131_b26-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/(sici)1097-0215(19990924)83:1<121::aid-ijc21>3.0.co;2-f","article-title":"Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus","volume":"83","author":"Cheung","year":"1999","journal-title":"Int J Cancer"},{"key":"key20251014162131_b27-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/ijc.2910260202","article-title":"Establishment of a cell line (NPC\/HK1) from a differentiated squamous carcinoma of the nasopharynx","volume":"26","author":"Huang","year":"1980","journal-title":"Int J Cancer"},{"key":"key20251014162131_b28-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/s0167-4889(02)00208-2","article-title":"Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6\/E7 viral oncogenes","volume":"1590","author":"Tsao","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"key20251014162131_b29-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/ijc.22032","article-title":"Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase","volume":"119","author":"Li","year":"2006","journal-title":"Int J Cancer"},{"key":"key20251014162131_b30-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1002\/ijc.23374","article-title":"Authentication of nasopharyngeal carcinoma tumor lines","volume":"122","author":"Chan","year":"2008","journal-title":"Int J Cancer"},{"issue":"101039","key":"key20251014162131_b31-MCO-23-5-02890","article-title":"Content of luteolin and luteolin-7-\u041e-glucoside from the leaves of Vernonia amygdalina Del., and synergistic inhibitory effect with cisplatin on nasopharyngeal carcinoma cells","volume":"45","author":"Daker","year":"2023","journal-title":"Chem Data Collect"},{"key":"key20251014162131_b32-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"34","key":"key20251014162131_b33-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1186\/s12896-019-0528-4","article-title":"Development of a luciferase\/luciferin cell proliferation (XenoLuc) assay for real-time measurements of Gfp-Luc2-modified cells in a co-culture system","volume":"19","author":"Teow","year":"2019","journal-title":"BMC Biotechnol"},{"key":"key20251014162131_b34-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"key20251014162131_b35-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50 (W1)","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"key20251014162131_b36-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"420","DOI":"10.6026\/97320630001420","article-title":"GeneVenn-A web application for comparing gene lists using Venn diagrams","volume":"1","author":"Pirooznia","year":"2007","journal-title":"Bioinformation"},{"key":"key20251014162131_b37-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"key20251014162131_b38-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nature23095","article-title":"Cancer: Keeping it real to kill glioblastoma","volume":"547","author":"Northcott","year":"2017","journal-title":"Nature"},{"key":"key20251014162131_b39-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/d41586-018-05890-8","article-title":"The mice with human tumours: Growing pains for a popular cancer model","volume":"560","author":"Willyard","year":"2018","journal-title":"Nature"},{"issue":"189","key":"key20251014162131_b40-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0462-4","article-title":"Patient-derived xenografts: A relevant preclinical model for drug development","volume":"35","author":"Pompili","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"key20251014162131_b41-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.neo.7900101","article-title":"Cell cycle and apoptosis","volume":"2","author":"Pucci","year":"2000","journal-title":"Neoplasia"},{"key":"key20251014162131_b42-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"key":"key20251014162131_b43-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1158\/0008-5472.CAN-05-0648","article-title":"Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma","volume":"65","author":"Hui","year":"2005","journal-title":"Cancer Res"},{"key":"key20251014162131_b44-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/14728222.2020.1751820","article-title":"Emerging therapeutic targets for nasopharyngeal carcinoma: Opportunities and challenges","volume":"24","author":"Baloche","year":"2020","journal-title":"Expert Opin Ther Targets"},{"key":"key20251014162131_b45-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"E3473","DOI":"10.1073\/pnas.1202637109","article-title":"Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells","volume":"109","author":"Tsang","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20251014162131_b46-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1038\/sj.onc.1202749","article-title":"Mysterious liaisons: The relationship between c-Myc and the cell cycle","volume":"18","author":"Obaya","year":"1999","journal-title":"Oncogene"},{"issue":"10","key":"key20251014162131_b47-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00010","article-title":"Strategies to inhibit Myc and their clinical applicability","volume":"5","author":"Whitfield","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"key20251014162131_b48-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1158\/2159-8290.CD-14-1040","article-title":"Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer","volume":"5","author":"Wiegering","year":"2015","journal-title":"Cancer Discov"},{"key":"key20251014162131_b49-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1073\/pnas.97.7.3260","article-title":"Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion","volume":"97","author":"Coller","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20251014162131_b50-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/s0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"key20251014162131_b51-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"D1056","DOI":"10.1093\/nar\/gky1133","article-title":"Open targets platform: New developments and updates two years on","volume":"47 (D1)","author":"Carvalho-Silva","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"key20251014162131_b52-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.bbagrm.2015.05.002","article-title":"The translation factor eIF5A and human cancer","volume":"1849","author":"Mathews","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"key20251014162131_b53-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"49251","DOI":"10.1074\/jbc.M407165200","article-title":"A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis","volume":"279","author":"Li","year":"2004","journal-title":"J Biol Chem"},{"issue":"25795","key":"key20251014162131_b54-MCO-23-5-02890","doi-asserted-by":"publisher","DOI":"10.1038\/srep25795","article-title":"Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells","volume":"6","author":"Mandal","year":"2016","journal-title":"Sci Rep"},{"key":"key20251014162131_b55-MCO-23-5-02890","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0167-4889(94)90003-5","article-title":"Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation","volume":"1221","author":"Hanauske-Abel","year":"1994","journal-title":"Biochim Biophys Acta"}],"container-title":["Molecular and Clinical Oncology"],"original-title":[],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:21:42Z","timestamp":1760448102000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mco.2025.2890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,8,19]]}},"URL":"https:\/\/doi.org\/10.3892\/mco.2025.2890","relation":{},"ISSN":["2049-9450","2049-9469"],"issn-type":[{"type":"print","value":"2049-9450"},{"type":"electronic","value":"2049-9469"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}