{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:59:31Z","timestamp":1788587971965,"version":"build-2803163510"},"reference-count":43,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Int"],"DOI":"10.3892\/mi.2025.245","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:33:19Z","timestamp":1748421199000},"page":"1-16","source":"Crossref","is-referenced-by-count":2,"title":["Palliative care in patients with glioblastoma: A systematic review"],"prefix":"10.3892","volume":"5","author":[{"given":"Ahmed","family":"Al\u2011Ghaithi","sequence":"first","affiliation":[{"name":"Department Neurosurgery, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 132, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Al\u2011Barkhati","sequence":"additional","affiliation":[{"name":"Department Neurosurgery, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 132, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al Munqith","family":"Al Abri","sequence":"additional","affiliation":[{"name":"Department Neurosurgery, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 132, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Al Husaini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat 132, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Al\u2011Hajri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Khoula Hospital, Muscat 113, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Al\u2011Saadi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Khoula Hospital, Muscat 113, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"key20250623113457_b1-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.6004\/jnccn.2020.0052","article-title":"Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Nabors","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"issue":"293","key":"key20250623113457_b2-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0536-8","article-title":"Advances in the treatment of newly diagnosed glioblastoma","volume":"13","author":"Theeler","year":"2015","journal-title":"BMC Med"},{"key":"key20250623113457_b3-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jocn.2018.05.002","article-title":"Ten-year survival in glioblastoma. A systematic review","volume":"54","author":"Tykocki","year":"2018","journal-title":"J Clin Neurosci"},{"key":"key20250623113457_b4-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: A randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"key20250623113457_b5-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1001\/jama.2015.16669","article-title":"Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: A randomized clinical trial","volume":"314","author":"Stupp","year":"2015","journal-title":"JAMA"},{"key":"key20250623113457_b6-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","article-title":"CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2014-2018","volume":"23 (12 Suppl 2)","author":"Ostrom","year":"2021","journal-title":"Neuro Oncol"},{"key":"key20250623113457_b7-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3171\/jns.2001.95.2.0190","article-title":"A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival","volume":"95","author":"Lacroix","year":"2001","journal-title":"J Neurosurg"},{"key":"key20250623113457_b8-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1093\/jnci\/85.9.704","article-title":"Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials","volume":"85","author":"Curran","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"key20250623113457_b9-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1056\/NEJM198012043032303","article-title":"Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery","volume":"303","author":"Walker","year":"1980","journal-title":"N Engl J Med"},{"key":"key20250623113457_b10-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med"},{"key":"key20250623113457_b11-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol"},{"issue":"170","key":"key20250623113457_b12-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00170","article-title":"Advances in glioblastoma multiforme treatment: New models for nanoparticle therapy","volume":"9","author":"Ozdemir-Kaynak","year":"2018","journal-title":"Front Physiol"},{"key":"key20250623113457_b13-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4103\/2278-330X.175953","article-title":"Recurrent glioblastoma: Where we stand","volume":"4","author":"Roy","year":"2015","journal-title":"South Asian J Cancer"},{"key":"key20250623113457_b14-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.3171\/2018.7.JNS18228","article-title":"Survival effects of a strategy favoring second-line multimodal treatment compared to supportive care in glioblastoma patients at first progression","volume":"131","author":"Stavrinou","year":"2018","journal-title":"J Neurosurg"},{"key":"key20250623113457_b15-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1001\/jama.2016.16840","article-title":"Association between palliative care and patient and caregiver outcomes: A systematic review and meta-analysis","volume":"316","author":"Kavalieratos","year":"2016","journal-title":"JAMA"},{"key":"key20250623113457_b16-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1177\/1049909115609295","article-title":"The last 10 days of patients with glioblastoma: Assessment of clinical signs and symptoms as well as treatment","volume":"33","author":"Thier","year":"2016","journal-title":"Am J Hosp Palliat Care"},{"key":"key20250623113457_b17-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11060-014-1393-6","article-title":"End-of-life symptoms and care in patients with primary malignant brain tumors: A systematic literature review","volume":"117","author":"Walbert","year":"2014","journal-title":"J Neurooncol"},{"key":"key20250623113457_b18-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"483","DOI":"10.21873\/invivo.12282","article-title":"Palliative radiotherapy of primary glioblastoma","volume":"35","author":"Witteler","year":"2021","journal-title":"In Vivo"},{"key":"key20250623113457_b19-MI-5-4-00245","first-page":"2385","article-title":"Evidence that Mifepristone, a progesterone receptor antagonist, can cross the blood brain barrier and provide palliative benefits for glioblastoma multiforme grade IV","volume":"34","author":"Check","year":"2014","journal-title":"Anticancer Res"},{"key":"key20250623113457_b20-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1200\/JCO.2016.70.1474","article-title":"Integration of palliative care into standard oncology care: American society of clinical oncology clinical practice guideline update","volume":"35","author":"Ferrell","year":"2017","journal-title":"J Clin Oncol"},{"key":"key20250623113457_b21-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1212\/WNL.0b013e3181c67bce","article-title":"Medical decision-making capacity in patients with malignant glioma","volume":"73","author":"Triebel","year":"2009","journal-title":"Neurology"},{"key":"key20250623113457_b22-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1177\/0269216314526272","article-title":"The effects of advance care planning on end-of-life care: A systematic review","volume":"28","author":"Brinkman-Stoppelenburg","year":"2014","journal-title":"Palliat Med"},{"key":"key20250623113457_b23-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.jamda.2014.01.008","article-title":"Efficacy of advance care planning: A systematic review and meta-analysis","volume":"15","author":"Houben","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"key20250623113457_b24-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000522558","article-title":"Evading seizures: Phenobarbital reintroduced as a multifunctional approach to end-of-life care","volume":"15","author":"Senderovich","year":"2022","journal-title":"Case Rep Oncol"},{"issue":"8387","key":"key20250623113457_b25-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4344","article-title":"Aggressiveness of care at end of life in patients with high-grade glioma","volume":"10","author":"Harrison","year":"2021","journal-title":"Cancer Med"},{"key":"key20250623113457_b26-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/imj.12211","article-title":"Inpatient palliative care consultation for patients with glioblastoma in a tertiary hospital","volume":"43","author":"Lin","year":"2013","journal-title":"Intern Med J"},{"key":"key20250623113457_b27-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1002\/cam4.2398","article-title":"Glioblastoma Multiforme in the over 70's: \u2018To treat or not to treat with radiotherapy?\u2019","volume":"8","author":"Glynn","year":"2019","journal-title":"Cancer Med"},{"key":"key20250623113457_b28-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/nop\/npw022","article-title":"Palliative and end-of-life care in glioblastoma: Defining and measuring opportunities to improve care","volume":"4","author":"Hemminger","year":"2017","journal-title":"Neurooncol Pract"},{"key":"key20250623113457_b29-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11060-017-2487-8","article-title":"End of life care for glioblastoma patients at a large academic cancer center","volume":"134","author":"Kuchinad","year":"2017","journal-title":"J Neurooncol"},{"key":"key20250623113457_b30-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11060-013-1263-7","article-title":"Mapping the patterns of care, the receipt of palliative care and the site of death for patients with malignant glioma","volume":"116","author":"Sundararajan","year":"2014","journal-title":"J Neurooncol"},{"key":"key20250623113457_b31-MI-5-4-00245","first-page":"210","article-title":"Effects of palliative treatment with temozolomide in patients with high-grade gliomas","volume":"42","author":"Ziobro","year":"2008","journal-title":"Neurol Neurochir Pol"},{"key":"key20250623113457_b32-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1089\/jpm.2007.0137","article-title":"The end-of-life hospital setting in patients with glioblastoma","volume":"11","author":"Oberndorfer","year":"2008","journal-title":"J Palliat Med"},{"key":"key20250623113457_b33-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/jmri.1880080140","article-title":"MR-monitored LITT as a palliative concept in patients with high grade gliomas: Preliminary clinical experience","volume":"8","author":"Reimer","year":"1998","journal-title":"J Magn Reson Imaging"},{"issue":"E5","key":"key20250623113457_b34-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.FOCUS14493","article-title":"Home palliative care and end of life issues in glioblastoma multiforme: Results and comments from a homogeneous cohort of patients","volume":"37","author":"Pompili","year":"2014","journal-title":"Neurosurg Focus"},{"key":"key20250623113457_b35-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"684","DOI":"10.6004\/jadpro.2020.11.7.3","article-title":"Utilizing a palliative care screening tool in patients with glioblastoma","volume":"11","author":"Kim","year":"2020","journal-title":"J Adv Pract Oncol"},{"issue":"2867","key":"key20250623113457_b36-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122867","article-title":"Palliative care service utilization and advance care planning for adult glioblastoma patients: A systematic review","volume":"13","author":"Wu","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"e034378","key":"key20250623113457_b37-MI-5-4-00245","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034378","article-title":"Effect of early palliative care for patients with glioblastoma (EPCOG): A randomised phase III clinical trial protocol","volume":"10","author":"Golla","year":"2020","journal-title":"BMJ Open"},{"key":"key20250623113457_b38-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"899","DOI":"10.21037\/apm-20-1206","article-title":"Update on the management of elderly patients with glioblastoma: A narrative review","volume":"10","author":"Ironside","year":"2021","journal-title":"Ann Palliat Med"},{"key":"key20250623113457_b39-MI-5-4-00245","author":"Teoli"},{"key":"key20250623113457_b40-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"e847","DOI":"10.1016\/j.wneu.2022.11.143","article-title":"Palliative care effects on survival in glioblastoma: Who receives palliative care?","volume":"170","author":"Pando","year":"2023","journal-title":"World Neurosurg"},{"key":"key20250623113457_b41-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.5603\/RPOR.a2022.0113","article-title":"Survival and quality of life analysis in glioblastoma multiforme with adjuvant chemoradiotherapy: A retrospective study","volume":"27","author":"Mohammed","year":"2022","journal-title":"Rep Pract Oncol Radiother"},{"key":"key20250623113457_b42-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1007\/s00520-017-3687-7","article-title":"Screening for symptom burden and supportive needs of patients with glioblastoma and brain metastases and their caregivers in relation to their use of specialized palliative care","volume":"25","author":"Seekatz","year":"2017","journal-title":"Support Care Cancer"},{"key":"key20250623113457_b43-MI-5-4-00245","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1212\/WNL.0000000000013057","article-title":"Causes of death and end-of-life care in patients with intracranial high-grade gliomas: A retrospective observational study","volume":"98","author":"Barbaro","year":"2022","journal-title":"Neurology"}],"container-title":["Medicine International"],"original-title":[],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:35:05Z","timestamp":1750667705000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mi.2025.245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,5,28]]}},"URL":"https:\/\/doi.org\/10.3892\/mi.2025.245","relation":{},"ISSN":["2754-3242","2754-1304"],"issn-type":[{"value":"2754-3242","type":"print"},{"value":"2754-1304","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}