{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:49:25Z","timestamp":1760215765643},"reference-count":19,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.3892\/mmr.2012.1031","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T11:08:54Z","timestamp":1344596934000},"page":"1150-1154","source":"Crossref","is-referenced-by-count":18,"title":["Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells"],"prefix":"10.3892","volume":"6","author":[{"given":"SHUTAI","family":"LIU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUAIZHOU","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAIQING","family":"QIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JING","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAOWEN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENJUAN","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHISHAN","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOHUI","family":"RAUSCH-FAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHONGHAO","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2012,8,10]]},"reference":[{"key":"key20180108014252_b1-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4317\/medoral.17032","article-title":"Periodontal disease and diabetes - Review of the Literature","volume":"16","author":"Bascones-Martinez","year":"2011","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key20180108014252_b2-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.2007.00335.x","article-title":"Activation of Toll-like receptors 2 and 4 by Gram-negative periodontal bacteria","volume":"22","author":"Kikkert","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"key20180108014252_b3-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"37692","DOI":"10.1074\/jbc.M105927200","article-title":"Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritric cells","volume":"276","author":"Re","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108014252_b4-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0765.2011.01405.x","article-title":"Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis","volume":"47","author":"Rojo-Botello","year":"2012","journal-title":"J Periodontal Res"},{"key":"key20180108014252_b5-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1177\/00220345950740111401","article-title":"LPS responsiveness in periodontal ligament cells is regulated by tumor necrosis factor-a","volume":"74","author":"Quintero","year":"1995","journal-title":"J Dent Res"},{"key":"key20180108014252_b6-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1734-1140(09)70122-7","article-title":"Effect of of escin on acute inflammation and the immune system in mice","volume":"61","author":"Wang","year":"2009","journal-title":"Pharmacol Rep"},{"key":"key20180108014252_b7-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/00220345880670011301","article-title":"A comparative study of human periodontal ligament cells and gingival fibroblasts in vitro","volume":"67","author":"Somerman","year":"1988","journal-title":"J Dent Res"},{"key":"key20180108014252_b8-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-0765.2009.01215.x","article-title":"Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells","volume":"45","author":"Pi","year":"2010","journal-title":"J Periodont Res"},{"key":"key20180108014252_b9-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuint.2010.05.001","article-title":"Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes","volume":"57","author":"Zhang","year":"2010","journal-title":"Neurochem Int"},{"key":"key20180108014252_b10-mmr-06-05-1150","first-page":"31","article-title":"Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylla I","volume":"36","author":"Yang","year":"2004","journal-title":"Beijing Da Xue Xue Bao"},{"key":"key20180108014252_b11-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","article-title":"The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction","volume":"74","author":"Graves","year":"2003","journal-title":"J Periodontol"},{"key":"key20180108014252_b12-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1128\/IAI.01241-07","article-title":"Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-\u03b1 production","volume":"76","author":"Ukai","year":"2008","journal-title":"Infect Immun"},{"key":"key20180108014252_b13-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s11095-008-9734-9","article-title":"Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation","volume":"26","author":"Cheung","year":"2009","journal-title":"Pharm Res"},{"key":"key20180108014252_b14-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.intimp.2010.04.004","article-title":"Effect of metronidazole and modulation of cytokine production on human periodontal ligament cells","volume":"10","author":"Antonietta","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"key20180108014252_b15-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1128\/IAI.67.8.4231-4236.1999","article-title":"Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide","volume":"67","author":"Chiang","year":"1999","journal-title":"Infect Immun"},{"key":"key20180108014252_b16-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0757.1997.tb00194.x","article-title":"Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease","volume":"14","author":"Gemmell","year":"1997","journal-title":"Periodontol 2000"},{"key":"key20180108014252_b17-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","article-title":"IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis","volume":"160","author":"Assuma","year":"1998","journal-title":"J Immunol"},{"key":"key20180108014252_b18-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1084\/jem.167.2.332","article-title":"Essential role of B-cell stimulatory factor 2 (BSF-2\/IL-6) for the terminal differentiation of B-cells","volume":"167","author":"Muraguchi","year":"1988","journal-title":"J Exp Med"},{"key":"key20180108014252_b19-mmr-06-05-1150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1902\/jop.1994.65.2.147","article-title":"Assessment of interleukin-6 in the pathogenesis of periodontal disease","volume":"65","author":"Takahashi","year":"1994","journal-title":"J Periodontol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2012.1031\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T07:40:35Z","timestamp":1687678835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2012.1031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,10]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,8,10]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.3892\/mmr.2012.1031"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2012.1031","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,10]]}}}