{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:58:12Z","timestamp":1782514692443,"version":"3.54.5"},"reference-count":28,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.3892\/mmr.2012.1044","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T12:05:30Z","timestamp":1345550730000},"page":"1018-1022","source":"Crossref","is-referenced-by-count":43,"title":["Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro"],"prefix":"10.3892","volume":"6","author":[{"given":"XIAO-MAN","family":"XU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAN","family":"QU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUE-WEI","family":"FENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LI","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"key20180108014251_b1-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20180108014251_b2-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics, 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"key20180108014251_b3-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","article-title":"Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship","volume":"83","author":"Molina","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"key20180108014251_b4-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/ncponc0932","article-title":"International comparisons of survival from lung cancer: pitfalls and warnings","volume":"4","author":"Erridge","year":"2007","journal-title":"Nat Clin Pract Oncol"},{"key":"key20180108014251_b5-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/cncr.24871","article-title":"Five-year lung cancer survival: which advanced stage nonsmall cell lung cancer patients attain long-term survival?","volume":"116","author":"Wang","year":"2010","journal-title":"Cancer"},{"key":"key20180108014251_b6-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"key20180108014251_b7-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molmed.2007.10.004","article-title":"Distinct mechanisms of tumor invasion and metastasis","volume":"13","author":"Yilmaz","year":"2007","journal-title":"Trends Mol Med"},{"key":"key20180108014251_b8-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-2999(95)00812-8","article-title":"Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens","volume":"298","author":"Guh","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"key20180108014251_b9-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(92)90576-P","article-title":"Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens","volume":"219","author":"Ko","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"key20180108014251_b10-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1515\/znc-2009-5-610","article-title":"Immunomodulatory and anti-inflammatory activity of selected osthole derivatives","volume":"64","author":"Zimecki","year":"2009","journal-title":"Z Naturforsch C"},{"key":"key20180108014251_b11-mmr-06-05-1018","first-page":"451510","article-title":"Studies on the quality of fructus Cnidii-comparison of antibacterial action","volume":"16","author":"Cai","year":"1991","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"key20180108014251_b12-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1248\/bpb.25.809","article-title":"Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol","volume":"25","author":"Matsuda","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"key20180108014251_b13-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1021\/jf2021489","article-title":"Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met\/Akt\/mTOR pathway in human breast cancer cells","volume":"59","author":"Hung","year":"2011","journal-title":"J Agric Food Chem"},{"key":"key20180108014251_b14-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ptr.2044","article-title":"Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study","volume":"21","author":"Chou","year":"2007","journal-title":"Phytother Res"},{"key":"key20180108014251_b15-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1055\/s-2003-45188","article-title":"Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines","volume":"69","author":"Yang","year":"2003","journal-title":"Planta Med"},{"key":"key20180108014251_b16-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-9966-30-33","article-title":"Osthole induces G2\/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K\/Akt pathway","volume":"30","author":"Xu","year":"2011","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180108014251_b17-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","article-title":"Metastasis: from dissemination to organ-specific colonization","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20180108014251_b18-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molmed.2010.01.003","article-title":"Chemokines and chemokine receptors: new insights into cancer-related inflammation","volume":"16","author":"Lazennec","year":"2010","journal-title":"Trends Mol Med"},{"key":"key20180108014251_b19-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/ijc.22024","article-title":"Chemokines and cancer","volume":"119","author":"Zlotnik","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180108014251_b20-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2101","article-title":"Genetic determinants of cancer metastasis","volume":"8","author":"Nguyen","year":"2007","journal-title":"Nat Rev Genet"},{"key":"key20180108014251_b21-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2009.01.033","article-title":"Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9","volume":"279","author":"Ho","year":"2009","journal-title":"Cancer Lett"},{"key":"key20180108014251_b22-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.canlet.2010.04.022","article-title":"Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells","volume":"297","author":"Wang","year":"2010","journal-title":"Cancer Lett"},{"key":"key20180108014251_b23-mmr-06-05-1018","first-page":"783","article-title":"Angiotensin-(1\u20137) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K\/Akt and MAPK signaling pathways","volume":"27","author":"Ni","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180108014251_b24-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1007\/s00018-011-0763-x","article-title":"Matrix metalloproteinases in tumorigenesis: an evolving paradigm","volume":"68","author":"Hua","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"key20180108014251_b25-mmr-06-05-1018","first-page":"1283","article-title":"Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines","volume":"22","author":"Roomi","year":"2009","journal-title":"Oncol Rep"},{"key":"key20180108014251_b26-mmr-06-05-1018","first-page":"181","article-title":"ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB","volume":"36","author":"Park","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180108014251_b27-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2009.06.032","article-title":"Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells","volume":"288","author":"Hung","year":"2010","journal-title":"Cancer Lett"},{"key":"key20180108014251_b28-mmr-06-05-1018","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1271\/bbb.100110","article-title":"Effects of osthole on migration and invasion in breast cancer cells","volume":"74","author":"Yang","year":"2010","journal-title":"Biosci Biotechnol Biochem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2012.1044\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T03:32:38Z","timestamp":1515382358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2012.1044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,21]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,8,21]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.3892\/mmr.2012.1044"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2012.1044","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,21]]}}}