{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:15:35Z","timestamp":1791918935772,"version":"4.3.4"},"reference-count":38,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3892\/mmr.2012.935","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T12:42:15Z","timestamp":1338986535000},"page":"379-384","source":"Crossref","is-referenced-by-count":17,"title":["Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease"],"prefix":"10.3892","volume":"6","author":[{"given":"RITSU","family":"ITO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOTOKO","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDEYUKI","family":"IHARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROKI","family":"TSUKAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNICHI","family":"FUJII","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHITAKA","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"key20180108014446_b1-mmr-06-02-0379","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell","year":"2007","edition":"4th edition"},{"key":"key20180108014446_b2-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/jeb.201.8.1203","article-title":"Oxygen toxicity: a radical explanation","volume":"201","author":"Fridovich","year":"1998","journal-title":"J Exp Biol"},{"key":"key20180108014446_b3-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1006873518427","article-title":"Reactive oxygen species, mitochondria, apoptosis and aging","volume":"174","author":"Papa","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"key20180108014446_b4-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/15216540252774748","article-title":"Peroxiredoxin, a novel family of peroxidases","volume":"52","author":"Rhee","year":"2001","journal-title":"IUBMB Life"},{"key":"key20180108014446_b5-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1089\/ars.2005.7.619","article-title":"Controlled elimination of intracellular H2O2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification","volume":"7","author":"Rhee","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"key20180108014446_b6-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.freeradbiomed.2005.02.026","article-title":"Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling","volume":"38","author":"Rhee","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20180108014446_b7-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1179\/135100002125000352","article-title":"Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein","volume":"7","author":"Fujii","year":"2002","journal-title":"Redox Rep"},{"key":"key20180108014446_b8-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/bcr1789","article-title":"Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer","volume":"9","author":"Chang","year":"2007","journal-title":"Breast Cancer Res"},{"key":"key20180108014446_b9-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1158\/0008-5472.CAN-07-2683","article-title":"Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae","volume":"68","author":"Iraqui","year":"2008","journal-title":"Cancer Res"},{"key":"key20180108014446_b10-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/carcin\/bgp104","article-title":"Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells","volume":"30","author":"Song","year":"2009","journal-title":"Carcinogenesis"},{"key":"key20180108014446_b11-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature01819","article-title":"Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression","volume":"424","author":"Neumann","year":"2003","journal-title":"Nature"},{"key":"key20180108014446_b12-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"18742","DOI":"10.1073\/pnas.0705904104","article-title":"S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson\u2019s disease","volume":"104","author":"Fang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108014446_b13-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1756-9966-28-93","article-title":"Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma","volume":"28","author":"Cha","year":"2009","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180108014446_b14-mmr-06-02-0379","first-page":"3418","article-title":"Peroxiredoxins in breast carcinoma","volume":"9","author":"Karihtala","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20180108014446_b15-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0022-5347(05)00659-2","article-title":"Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer","volume":"175","author":"Quan","year":"2006","journal-title":"J Urol"},{"key":"key20180108014446_b16-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ijc.20294","article-title":"Peroxiredoxins, a novel protein family in lung cancer","volume":"111","author":"Lehtonen","year":"2004","journal-title":"Int J Cancer"},{"key":"key20180108014446_b17-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-3835(00)00434-1","article-title":"Peroxiredoxin I expression in oral cancer: a potential new tumor marker","volume":"156","author":"Yanagawa","year":"2000","journal-title":"Cancer Lett"},{"key":"key20180108014446_b18-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/bbrc.2001.5989","article-title":"Augmented expression of peroxiredoxin I in lung cancer","volume":"289","author":"Chang","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108014446_b19-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceb.2005.02.004","article-title":"Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins","volume":"17","author":"Rhee","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"key20180108014446_b20-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1126\/science.1130481","article-title":"Cell signaling. H2O2, a necessary evil for cell signaling","volume":"312","author":"Rhee","year":"2006","journal-title":"Science"},{"key":"key20180108014446_b21-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.jbchem.a022632","article-title":"Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions","volume":"127","author":"Okado-Matsumoto","year":"2000","journal-title":"J Biochem"},{"key":"key20180108014446_b22-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071428","article-title":"Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells","volume":"411","author":"Tavender","year":"2008","journal-title":"Biochem J"},{"key":"key20180108014446_b23-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cca.2010.05.016","article-title":"Immunoluminometric assay for quantification of peroxiredoxin 4 in human serum","volume":"411","author":"Schulte","year":"2010","journal-title":"Clin Chim Acta"},{"key":"key20180108014446_b24-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1242\/jcs.067843","article-title":"Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation","volume":"123","author":"Tavender","year":"2010","journal-title":"J Cell Sci"},{"key":"key20180108014446_b25-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1089\/ars.2009.3079","article-title":"B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses","volume":"13","author":"Bertolotti","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key20180108014446_b26-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pep.2010.02.001","article-title":"Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells","volume":"72","author":"Ikeda","year":"2010","journal-title":"Protein Expr Purif"},{"key":"key20180108014446_b27-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0014-5793(98)01736-0","article-title":"Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member","volume":"443","author":"Matsumoto","year":"1999","journal-title":"FEBS Lett"},{"key":"key20180108014446_b28-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/oxfordjournals.jhered.a110416","article-title":"New mutation causing hereditary hepatitis in the laboratory rat","volume":"78","author":"Yoshida","year":"1987","journal-title":"J Hered"},{"key":"key20180108014446_b29-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI115208","article-title":"Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson\u2019s disease","volume":"87","author":"Li","year":"1991","journal-title":"J Clin Invest"},{"key":"key20180108014446_b30-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ng0894-541","article-title":"The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene","volume":"7","author":"Wu","year":"1994","journal-title":"Nat Genet"},{"key":"key20180108014446_b31-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1349-7006.1988.tb00044.x","article-title":"High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis","volume":"79","author":"Masuda","year":"1988","journal-title":"Jpn J Cancer Res"},{"key":"key20180108014446_b32-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/10715760903338071","article-title":"HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats","volume":"44","author":"Marquez-Quinones","year":"2010","journal-title":"Free Radic Res"},{"key":"key20180108014446_b33-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbadis.2005.06.004","article-title":"Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson\u2019s disease","volume":"1741","author":"Samuele","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"key20180108014446_b34-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0925-4439(02)00170-9","article-title":"Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock","volume":"1588","author":"Madhani","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"key20180108014446_b35-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"37423","DOI":"10.1074\/jbc.M506439200","article-title":"Redox imbalance in cystine\/glutamate transporter-deficient mice","volume":"280","author":"Sato","year":"2005","journal-title":"J Biol Chem"},{"key":"key20180108014446_b36-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1089\/ars.2007.1635","article-title":"Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies","volume":"9","author":"Khan","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"key20180108014446_b37-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1179\/135100004225006812","article-title":"Glutathione reductase is expressed at high levels in pancreatic islet cells","volume":"9","author":"Nagaoka","year":"2004","journal-title":"Redox Rep"},{"key":"key20180108014446_b38-mmr-06-02-0379","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1432-1033.2001.01843.x","article-title":"Augmented expression of peroxiredoxin VI in rat lung and kidney after birth implies an antioxidative role","volume":"268","author":"Fujii","year":"2001","journal-title":"Eur J Biochem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2012.935\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:54:59Z","timestamp":1642366499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2012.935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,6,6]]},"published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.3892\/mmr.2012.935"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2012.935","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}