{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:56:42Z","timestamp":1778648202112,"version":"3.51.4"},"reference-count":22,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.3892\/mmr.2013.1467","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T05:47:32Z","timestamp":1368078452000},"page":"211-216","source":"Crossref","is-referenced-by-count":9,"title":["Association of NAT1 and NAT2 genes with nonsyndromic cleft lip and palate"],"prefix":"10.3892","volume":"8","author":[{"given":"TAO","family":"SONG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DI","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONGQIAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAIDONG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NINGBEI","family":"YIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHENMIN","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"key20180108013857_b1-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1097\/SCS.0b013e31822e5e4d","article-title":"Genetics of syndromic and nonsyndromic cleft lip and palate","volume":"22","author":"Stuppia","year":"2011","journal-title":"J Craniofac Surg"},{"key":"key20180108013857_b2-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1096-9926(199607)54:1<27::AID-TERA4>3.0.CO;2-0","article-title":"Maternal alcohol use and risk of orofacial cleft birth defects","volume":"54","author":"Munger","year":"1996","journal-title":"Teratology"},{"key":"key20180108013857_b3-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1597\/02-142.1","article-title":"Smoking and orofacial clefts: a United Kingdom-based case-control study","volume":"41","author":"Little","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"key20180108013857_b4-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1601-0825.2011.01810.x","article-title":"Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts","volume":"17","author":"Jia","year":"2011","journal-title":"Oral Dis"},{"key":"key20180108013857_b5-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1212\/WNL.0b013e3182574f39","article-title":"Comparative safety of antiepileptic drugs during pregnancy","volume":"78","author":"Hern\u00e1ndez-Diaz","year":"2012","journal-title":"Neurology"},{"key":"key20180108013857_b6-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/SMJ.0b013e31802f7d38","article-title":"Spatial distribution of orofacial cleft defect births in Harris County, Texas, 1990 to 1994, and historical evidence for the presence of low-level radioactivity in tap water","volume":"100","author":"Cech","year":"2007","journal-title":"South Med J"},{"key":"key20180108013857_b7-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1597\/06-011.1","article-title":"Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts","volume":"44","author":"Ramirez","year":"2007","journal-title":"Cleft Palate Craniofac J"},{"key":"key20180108013857_b8-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-12-398339-8.00005-7","article-title":"Arylamine N-acetyltransferases - from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention","volume":"63","author":"Sim","year":"2012","journal-title":"Adv Pharmacol"},{"key":"key20180108013857_b9-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2217\/pgs.11.88","article-title":"Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations","volume":"12","author":"Mortensen","year":"2011","journal-title":"Pharmacogenomics"},{"key":"key20180108013857_b10-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/03602530500251204","article-title":"Arylamine N-acetyltransferases: what we learn from genes and genomes","volume":"37","author":"Boukouvala","year":"2005","journal-title":"Drug Metab Rev"},{"key":"key20180108013857_b11-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0773.1998.tb01461.x","article-title":"Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2","volume":"83","author":"Smelt","year":"1998","journal-title":"Pharmacol Toxicol"},{"key":"key20180108013857_b12-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0006-2952(92)90373-Q","article-title":"Arylamine N-acetyltransferase in human red blood cells","volume":"44","author":"Ward","year":"1992","journal-title":"Biochem Pharmacol"},{"issue":"Pt 1","key":"key20180108013857_b13-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3070001","article-title":"Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells","volume":"307","author":"Minchin","year":"1995","journal-title":"Biochem J"},{"key":"key20180108013857_b14-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/mrd.20852","article-title":"Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts","volume":"75","author":"Erickson","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"key20180108013857_b15-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/01.ede.0000112214.33432.cc","article-title":"Maternal smoking and the risk of orofacial clefts: susceptibility with NAT1 and NAT2 polymorphisms","volume":"15","author":"Lammer","year":"2004","journal-title":"Epidemiology"},{"key":"key20180108013857_b16-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/bdra.20081","article-title":"Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts","volume":"70","author":"Lammer","year":"2004","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key20180108013857_b17-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/EDE.0b013e3181690731","article-title":"Maternal smoking and oral clefts: the role of detoxification pathway genes","volume":"19","author":"Lie","year":"2008","journal-title":"Epidemiology"},{"key":"key20180108013857_b18-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/510518","article-title":"Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants","volume":"80","author":"Shi","year":"2007","journal-title":"Am J Hum Genet"},{"key":"key20180108013857_b19-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/tera.10096","article-title":"Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use","volume":"66","author":"van Rooij","year":"2002","journal-title":"Teratology"},{"key":"key20180108013857_b20-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2217\/14622416.8.8.1075","article-title":"Silent SNPs: impact on gene function and phenotype","volume":"8","author":"Komar","year":"2007","journal-title":"Pharmacogenomics"},{"key":"key20180108013857_b21-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/sj.tpj.6500170","article-title":"Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene","volume":"3","author":"Cornish","year":"2003","journal-title":"Pharmacogenomics J"},{"key":"key20180108013857_b22-mmr-08-01-0211","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/mol.64.1.170","article-title":"Generation and functional characterization of arylamine N-acetyltransferase Nat1\/Nat2 double-knockout mice","volume":"64","author":"Sugamori","year":"2003","journal-title":"Mol Pharmacol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2013.1467\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:26:18Z","timestamp":1515363978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2013.1467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,9]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,5,9]]},"published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.3892\/mmr.2013.1467"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2013.1467","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,9]]}}}