{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:39:05Z","timestamp":1778503145853,"version":"3.51.4"},"reference-count":33,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.3892\/mmr.2013.1548","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T07:54:23Z","timestamp":1372146863000},"page":"385-392","source":"Crossref","is-referenced-by-count":16,"title":["Rosuvastatin prevents pressure overload-induced myocardial hypertrophy via inactivation of the Akt, ERK1\/2 and GATA4 signaling pathways in rats"],"prefix":"10.3892","volume":"8","author":[{"given":"XUE","family":"XU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEI","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIANGJIU","family":"LIANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"key20180108013642_b1-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"key20180108013642_b2-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1001\/jama.292.19.2343","article-title":"Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events","volume":"292","author":"Okin","year":"2004","journal-title":"JAMA"},{"key":"key20180108013642_b3-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2174\/0929867023369024","article-title":"Clinical significance of pleiotropic effects of statins: lipid reduction and beyond","volume":"9","author":"Auer","year":"2002","journal-title":"Curr Med Chem"},{"key":"key20180108013642_b4-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"31725","DOI":"10.1074\/jbc.272.50.31725","article-title":"Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase","volume":"272","author":"Laufs","year":"1997","journal-title":"J Biol Chem"},{"key":"key20180108013642_b5-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.CIR.103.7.993","article-title":"Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits","volume":"103","author":"Fukumoto","year":"2001","journal-title":"Circulation"},{"key":"key20180108013642_b6-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJM200106283442601","article-title":"Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events","volume":"344","author":"Ridker","year":"2001","journal-title":"N Engl J Med"},{"key":"key20180108013642_b7-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbalip.2004.11.004","article-title":"Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation","volume":"1687","author":"Planavila","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"key20180108013642_b8-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"44390","DOI":"10.1074\/jbc.M103826200","article-title":"Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart","volume":"276","author":"Young","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108013642_b9-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI13350","article-title":"Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy","volume":"108","author":"Takemoto","year":"2001","journal-title":"J Clin Invest"},{"key":"key20180108013642_b10-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1253\/circj.CJ-11-1114","article-title":"Effects of pitavastatin on pressure overload-induced heart failure in mice","volume":"76","author":"Kameda","year":"2012","journal-title":"Circ J"},{"key":"key20180108013642_b11-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijcard.2009.03.111","article-title":"Signal pathways involved in reverse remodeling of the hypertrophic rat heart after pressure unloading","volume":"143","author":"Xu","year":"2010","journal-title":"Int J Cardiol"},{"key":"key20180108013642_b12-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/01.CIR.103.10.1453","article-title":"Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase kinase activity in in vivo pressure overload","volume":"103","author":"Esposito","year":"2001","journal-title":"Circulation"},{"key":"key20180108013642_b13-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"12331","DOI":"10.1073\/pnas.1104499108","article-title":"Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo","volume":"108","author":"van Berlo","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4 Pt 2","key":"key20180108013642_b14-mmr-08-02-0385","first-page":"H485","article-title":"Chronic norepinephrine infusion and adrenergic function of hypertrophied hearts","volume":"248","author":"Siri","year":"1985","journal-title":"Am J Physiol"},{"key":"key20180108013642_b15-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9149(76)90491-4","article-title":"Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy","volume":"37","author":"Teichholz","year":"1976","journal-title":"Am J Cardiol"},{"key":"key20180108013642_b16-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/jgm.1219","article-title":"Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context-dependent in the heart","volume":"10","author":"Leskinen","year":"2008","journal-title":"J Gene Med"},{"key":"key20180108013642_b17-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.CIR.103.1.155","article-title":"Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction","volume":"103","author":"Woodiwiss","year":"2001","journal-title":"Circulation"},{"key":"key20180108013642_b18-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1142\/S0192415X02000612","article-title":"Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats","volume":"30","author":"Hong","year":"2002","journal-title":"Am J Chin Med"},{"key":"key20180108013642_b19-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"e27294","DOI":"10.1371\/journal.pone.0027294","article-title":"\u03b2-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure","volume":"6","author":"Ni","year":"2011","journal-title":"PLoS One"},{"key":"key20180108013642_b20-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1440-1681.2003.03917.x","article-title":"Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats","volume":"30","author":"Li","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20180108013642_b21-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.HYP.0000136395.06810.cf","article-title":"Atorvastatin prevents end-organ injury in salt-sensitive hypertension: role of eNOS and oxidant stress","volume":"44","author":"Zhou","year":"2004","journal-title":"Hypertension"},{"key":"key20180108013642_b22-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/hr.2010.229","article-title":"Simvastatin prevents large blood pressure variability induced aggravation of cardiac hypertrophy in hypertensive rats by inhibiting RhoA\/Ras-ERK pathways","volume":"34","author":"Takayama","year":"2011","journal-title":"Hypertens Res"},{"key":"key20180108013642_b23-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/en.2006-1355","article-title":"Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats","volume":"148","author":"Habibi","year":"2007","journal-title":"Endocrinology"},{"key":"key20180108013642_b24-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2009.10.050","article-title":"Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh","volume":"627","author":"Choi","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"key20180108013642_b25-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/HYPERTENSIONAHA.109.131243","article-title":"Effect of rosuvastatin on cardiac remodeling, function, and progression to heart failure in hypertensive heart with established left ventricular hypertrophy","volume":"54","author":"Chang","year":"2009","journal-title":"Hypertension"},{"key":"key20180108013642_b26-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/eurjhf\/hfr080","article-title":"AKT signalling in the failing heart","volume":"13","author":"Chaanine","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"key20180108013642_b27-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1128\/MCB.21.21.7460-7469.2001","article-title":"The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes","volume":"21","author":"Liang","year":"2001","journal-title":"Mol Cell Biol"},{"key":"key20180108013642_b28-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"24852","DOI":"10.1074\/jbc.M314317200","article-title":"Mitogen-activated protein kinases p38 and ERK 1\/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart","volume":"279","author":"Tenhunen","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180108013642_b29-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108013642_b30-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"28586","DOI":"10.1074\/jbc.M103166200","article-title":"Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes","volume":"276","author":"Morisco","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108013642_b31-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvn001","article-title":"Cardiac hypertrophy is enhanced in PPAR alpha\u2212\/\u2212 mice in response to chronic pressure overload","volume":"78","author":"Smeets","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key20180108013642_b32-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00395-004-0482-7","article-title":"Activation of distinct signal transduction pathways in hypertrophied hearts by pressure and volume overload","volume":"99","author":"Miyamoto","year":"2004","journal-title":"Basic Res Cardiol"},{"key":"key20180108013642_b33-mmr-08-02-0385","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3892\/mmr_00000287","article-title":"Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin\/NFAT3\/GATA4 pathway","volume":"3","author":"Yang","year":"2010","journal-title":"Mol Med Rep"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2013.1548\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:23:41Z","timestamp":1515363821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2013.1548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,6,25]]},"published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.3892\/mmr.2013.1548"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2013.1548","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}