{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:42:08Z","timestamp":1776505328957,"version":"3.51.2"},"reference-count":20,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.3892\/mmr.2013.1683","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T12:47:26Z","timestamp":1379076446000},"page":"1365-1372","source":"Crossref","is-referenced-by-count":18,"title":["In vitro cytotoxicity of silver nanoparticles in primary rat hepatic stellate cells"],"prefix":"10.3892","volume":"8","author":[{"given":"XIAOJING","family":"SUN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHIMING","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHENGYONG","family":"ZHAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YINGWEN","family":"CHENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIE","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BINBIN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2013,9,13]]},"reference":[{"key":"key20180108013528_b1-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/nn800596w","article-title":"Cytotoxicity and genotoxicity of silver nanoparticles in human cells","volume":"3","author":"AshaRani","year":"2009","journal-title":"ACS Nano"},{"key":"key20180108013528_b2-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1166\/jnn.2008.1193","article-title":"Fabrication of biodegradable electrospun poly(L-lactide-co-glycolide) fibers with antimicrobial nanosilver particles","volume":"8","author":"Xu","year":"2008","journal-title":"J Nanosci Nanotechno"},{"key":"key20180108013528_b3-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/135965350801300210","article-title":"Silver nanoparticles inhibit hepatitis B virus replication","volume":"13","author":"Lu","year":"2008","journal-title":"Antivir Ther"},{"key":"key20180108013528_b4-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3180","article-title":"Treating metastatic cancer with nanotechnology","volume":"12","author":"Schroeder","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"key20180108013528_b5-mmr-08-05-1365","first-page":"99","article-title":"Isolation and culture of hepatic stellate cells","volume":"117","author":"Weiskirchen","year":"2005","journal-title":"Methods Mol Med"},{"key":"key20180108013528_b6-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-3155-8-1","article-title":"Mode of antiviral action of silver nanoparticles against HIV-1","volume":"8","author":"Lara","year":"2010","journal-title":"J Nanobiotechnology"},{"key":"key20180108013528_b7-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1088\/0957-4484\/19\/7\/075104","article-title":"Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy","volume":"19","author":"Gopinath","year":"2008","journal-title":"Nanotechnology"},{"key":"key20180108013528_b8-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.biomaterials.2009.09.088","article-title":"Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells","volume":"31","author":"Yuan","year":"2010","journal-title":"Biomaterials"},{"key":"key20180108013528_b9-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1476-511X-10-166","article-title":"Gold nanoparticles induced cloudy swelling to hydropic degeneration, cytoplasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis in the liver","volume":"10","author":"Abdelhalim","year":"2011","journal-title":"Lipids Health Dis"},{"key":"key20180108013528_b10-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1166\/jnn.2010.1719","article-title":"Mechanism for alpha-MnO2 nanowire-induced cytotoxicity in Hela cells","volume":"10","author":"Li","year":"2010","journal-title":"J Nanosci Nanotechnol"},{"key":"key20180108013528_b11-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/43591","article-title":"Condensed matter in cell death","volume":"401","author":"Zamzami","year":"1999","journal-title":"Nature"},{"key":"key20180108013528_b12-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0163-7258(96)00098-8","article-title":"Molecular and clinical aspects of apoptosis","volume":"72","author":"Urne","year":"1996","journal-title":"Pharmacol Ther"},{"key":"key20180108013528_b13-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/wnan.103","article-title":"Metal-based nanoparticles and their toxicity assessment","volume":"2","author":"Schrand","year":"2010","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"key20180108013528_b14-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"key20180108013528_b15-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.181.5.1661","article-title":"Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo","volume":"181","author":"Zamzami","year":"1995","journal-title":"J Exp Med"},{"key":"key20180108013528_b16-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.toxlet.2010.12.010","article-title":"Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis","volume":"201","author":"Piao","year":"2011","journal-title":"Toxicol Lett"},{"key":"key20180108013528_b17-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0167-5699(97)80014-X","article-title":"Mitochondrial control of apoptosis","volume":"18","author":"Kroemer","year":"1997","journal-title":"Immunol Today"},{"key":"key20180108013528_b18-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1440-1746.2004.03344.x","article-title":"Correlation between plasma levels of matrix metalloproteinase (MMP)-9\/MMP-2 ratio and alpha-fetoproteins in chronic hepatitis carrying hepatitis B virus","volume":"19","author":"Chung","year":"2004","journal-title":"J Gastroen Hepatol"},{"key":"key20180108013528_b19-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/clinchem\/46.2.183","article-title":"Expression of matrix metalloproteinase-2 and \u22129 and their inhibitors in peripheral blood cells of patients with chronic hepatitis C","volume":"46","author":"Lichtinghagen","year":"2000","journal-title":"Clin Chem"},{"key":"key20180108013528_b20-mmr-08-05-1365","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1872-034X.2008.00449.x","article-title":"Involvement of PI3K\/PTEN\/AKT\/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9","volume":"39","author":"Chen","year":"2009","journal-title":"Hepatol Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2013.1683\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T15:18:56Z","timestamp":1688483936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2013.1683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,13]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,9,13]]},"published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.3892\/mmr.2013.1683"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2013.1683","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,13]]}}}