{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:56:35Z","timestamp":1791176195851,"version":"4.1.0"},"reference-count":40,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.3892\/mmr.2013.1816","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T13:22:55Z","timestamp":1384953775000},"page":"730-736","source":"Crossref","is-referenced-by-count":9,"title":["Hepatitis C virus alternate reading frame protein decreases interferon-\u03b1 secretion in peripheral blood mononuclear cells"],"prefix":"10.3892","volume":"9","author":[{"given":"XIAODONG","family":"XU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAOJIE","family":"YU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAOZHAO","family":"DENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MING","family":"YUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINHAI","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANYAN","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHENXIAN","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIANGJUN","family":"ZHAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KE","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"key20180108012822_b1-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.2523562","article-title":"Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome","volume":"244","author":"Choo","year":"1989","journal-title":"Science"},{"issue":"Suppl 1","key":"key20180108012822_b2-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1038\/sj.cdd.4401121","article-title":"Hepatitis C virus biology","volume":"10","author":"Giannini","year":"2003","journal-title":"Cell Death Differ"},{"key":"key20180108012822_b3-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1099\/0022-1317-74-11-2391","article-title":"Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of NS-5 region","volume":"74","author":"Simmonds","year":"1993","journal-title":"J Gen Virol"},{"key":"key20180108012822_b4-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.20819","article-title":"Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes","volume":"42","author":"Simmonds","year":"2005","journal-title":"Hepatology"},{"key":"key20180108012822_b5-mmr-09-02-0730","volume-title":"ICTVdB - The Universal Virus Database Version 4","author":"B\u00fcchen-Osmond","year":"2004"},{"key":"key20180108012822_b6-mmr-09-02-0730","first-page":"55","article-title":"Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties","volume-title":"Current Topics in Microbiology and Immunology: The Hepatitis C Viruses","author":"Reed","year":"2000"},{"key":"key20180108012822_b7-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1017\/S1355838201010111","article-title":"Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame","volume":"7","author":"Walewski","year":"2001","journal-title":"RNA"},{"key":"key20180108012822_b8-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1093\/emboj\/20.14.3840","article-title":"Synthesis of a novel hepatitis C virus protein by ribosomal frameshift","volume":"20","author":"Xu","year":"2001","journal-title":"EMBO J"},{"key":"key20180108012822_b9-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"45785","DOI":"10.1074\/jbc.M307174200","article-title":"Unusual multiple recoding events leading to alternative forms of hepatitis C virus core protein from genotype 1b","volume":"278","author":"Boulant","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180108012822_b10-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2005-864786","article-title":"The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein\/F-protein, the double-frameshift protein, and others","volume":"25","author":"Branch","year":"2005","journal-title":"Semin Liver Dis"},{"key":"key20180108012822_b11-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/iub.201","article-title":"The HCV ARFP\/F\/core+1 protein: production and functional analysis of an unconventional viral product","volume":"61","author":"Vassilaki","year":"2009","journal-title":"IUBMB Life"},{"key":"key20180108012822_b12-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/JVI.73.6.4713-4720.1999","article-title":"Hepatitis C virus core protein inhibits Fas-and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation","volume":"73","author":"Marusawa","year":"1999","journal-title":"J Virol"},{"key":"key20180108012822_b13-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/viro.1996.0644","article-title":"Suppression of apoptotic cell death by hepatitis C virus core protein","volume":"226","author":"Ray","year":"1996","journal-title":"Virology"},{"key":"key20180108012822_b14-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1128\/JVI.01640-08","article-title":"Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication","volume":"82","author":"Vassilaki","year":"2008","journal-title":"J Virol"},{"key":"key20180108012822_b15-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1099\/vir.0.80028-0","article-title":"Functional properties of a 16 kDa protein translated from an alternative open reading frame of the core-encoding genomic region of hepatitis C virus","volume":"85","author":"Basu","year":"2004","journal-title":"J Gen Virol"},{"key":"key20180108012822_b16-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0378-1119(98)00030-4","article-title":"Hepatitis C virus core protein represses p21WAF1\/Cip1\/Sid1 promoter activity","volume":"208","author":"Ray","year":"1998","journal-title":"Gene"},{"key":"key20180108012822_b17-mmr-09-02-0730","first-page":"461","article-title":"Hepatitis C virus F protein: A double-edged sword in the potential contribution of chronic inflammation to carcinogenesis","volume":"2","author":"Kong","year":"2009","journal-title":"Mol Med Rep"},{"key":"key20180108012822_b18-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/nm1492","article-title":"Interleukin-10 determines viral clearance or persistence in vivo","volume":"12","author":"Brooks","year":"2006","journal-title":"Nat Med"},{"issue":"5 Suppl 1","key":"key20180108012822_b19-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1002\/hep.1840360716","article-title":"Optimal therapy of hepatitis C","volume":"36","author":"Di Bisceglie","year":"2002","journal-title":"Hepatology"},{"key":"key20180108012822_b20-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.4049\/jimmunol.172.8.4907","article-title":"Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection","volume":"172","author":"Anthony","year":"2004","journal-title":"J Immunol"},{"key":"key20180108012822_b21-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1086\/383248","article-title":"Quantification and functional analysis of plasmacytoid dendritic cells in patients with chronic hepatitis C virus infection","volume":"189","author":"Goutagny","year":"2004","journal-title":"J Infect Dis"},{"key":"key20180108012822_b22-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.4049\/jimmunol.177.10.6758","article-title":"Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection","volume":"177","author":"Dolganiuc","year":"2006","journal-title":"J Immunol"},{"key":"key20180108012822_b23-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.imlet.2013.05.002","article-title":"Th1 and Th2 cytokine profiles induced by hepatitis C virus F protein in peripheral blood mononuclear cells from chronic hepatitis C patients","volume":"152","author":"Yue","year":"2013","journal-title":"Immunol Lett"},{"key":"key20180108012822_b24-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"13449","DOI":"10.1074\/jbc.M601124200","article-title":"The NS5A protein of the hepatitis C virus genotype 1a is cleaved by caspases to produce C-terminal-truncated forms of the protein that reside mainly in the cytosol","volume":"281","author":"Kalamvoki","year":"2006","journal-title":"J Biol Chem"},{"key":"key20180108012822_b25-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1348-0421.2008.00067.x","article-title":"Decreased interferon-alpha production and impaired regulatory function of plasmacytoid dendritic cells induced by the hepatitis C virus NS 5 protein","volume":"52","author":"Amjad","year":"2008","journal-title":"Microbiol Immunol"},{"key":"key20180108012822_b26-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U","article-title":"Identification of CpG oligonucleotide sequences with high induction of IFN-alpha\/beta in plasmacytoid dendritic cells","volume":"31","author":"Krug","year":"2001","journal-title":"Eur J Immunol"},{"key":"key20180108012822_b27-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1128\/IAI.64.5.1762-1769.1996","article-title":"Human monocyte CD14 is upregulated by lipopolysaccharide","volume":"64","author":"Landmann","year":"1996","journal-title":"Infect Immun"},{"key":"key20180108012822_b28-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1872-034X.2008.00452.x","article-title":"Hepatitis C virus F protein inhibits cell apoptosis by activation of intracellular NF-kappa-B pathway","volume":"39","author":"Shao","year":"2009","journal-title":"Hepatol Res"},{"key":"key20180108012822_b29-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/hep.20406","article-title":"Antigenic relevance of F protein in chronic hepatitis C virus infection","volume":"40","author":"Komurian-Pradel","year":"2004","journal-title":"Hepatology"},{"key":"key20180108012822_b30-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1141","article-title":"Plasmacytoid dendritic cells in immunity","volume":"5","author":"Colonna","year":"2004","journal-title":"Nat Immunol"},{"key":"key20180108012822_b31-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.micro.58.030603.123836","article-title":"Cell-mediated immunity and the outcome of hepatitis C virus infection","volume":"58","author":"Shoukry","year":"2004","journal-title":"Annu Rev Microbiol"},{"key":"key20180108012822_b32-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2172-9-28","article-title":"Enhanced IL-10 production in response to hepatitis C virus proteins by peripheral blood mononuclear cells from human immunodeficiency virus-monoinfected individuals","volume":"9","author":"Barrett","year":"2008","journal-title":"BMC Immunol"},{"key":"key20180108012822_b33-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/jmv.20283","article-title":"Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells","volume":"75","author":"Siavoshian","year":"2005","journal-title":"J Med Virol"},{"key":"key20180108012822_b34-mmr-09-02-0730","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-22038-2","volume-title":"Interleukin-10","author":"De Vries","year":"1995"},{"key":"key20180108012822_b35-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2893.2009.01094.x","article-title":"Low interleukin-10 production by monocytes of patients with a self-limiting hepatitis C virus infection","volume":"16","author":"Martin-Blondel","year":"2009","journal-title":"J Viral Hepat"},{"key":"key20180108012822_b36-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1023\/A:1020558317162","article-title":"Dendritic cells: a link between innate and adaptive immunity","volume":"19","author":"Palucka","year":"1999","journal-title":"J Clin Immunol"},{"key":"key20180108012822_b37-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"key20180108012822_b38-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1471-4906(00)01794-4","article-title":"Modulating the immune response with dendritic cells and their growth factors","volume":"22","author":"Pulendran","year":"2001","journal-title":"Trends Immunol"},{"key":"key20180108012822_b39-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"20358","DOI":"10.1074\/jbc.M301284200","article-title":"DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2","volume":"278","author":"Lozach","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180108012822_b40-mmr-09-02-0730","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)80693-5","article-title":"Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2013.1816\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:19:01Z","timestamp":1746051541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2013.1816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,11,20]]},"published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.3892\/mmr.2013.1816"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2013.1816","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}