{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:08:19Z","timestamp":1768730899531,"version":"3.49.0"},"reference-count":25,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.3892\/mmr.2014.2712","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T06:51:59Z","timestamp":1413874319000},"page":"242-248","source":"Crossref","is-referenced-by-count":17,"title":["Effect of vitamin C administration on hydrogen peroxide-induced cytotoxicity in periodontal ligament cells"],"prefix":"10.3892","volume":"11","author":[{"given":"WENLEI","family":"WU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NANFEI","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIUJING","family":"FENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TINGZHE","family":"SUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PINGPING","family":"SHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WEIBIN","family":"SUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"key20180108001941_b1-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2006.09.030","article-title":"Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function","volume":"42","author":"Fialkow","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"key20180108001941_b2-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0757.2006.00178.x","article-title":"The role of reactive oxygen and antioxidant species in periodontal tissue destruction","volume":"43","author":"Chapple","year":"2007","journal-title":"Periodontol 2000"},{"key":"key20180108001941_b3-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/JOE-12-0072","article-title":"Reactive oxygen and nitrogen species generation, antioxidant defenses, and beta-cell function: a critical role for amino acids","volume":"214","author":"Newsholme","year":"2012","journal-title":"J Endocrinol"},{"key":"key20180108001941_b4-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"key20180108001941_b5-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.2174\/1381612811319150003","article-title":"Periodontitis and redox status: a review","volume":"19","author":"Nibali","year":"2013","journal-title":"Curr Pharm Des"},{"key":"key20180108001941_b6-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.pbi.2013.07.002","article-title":"ROS signaling loops - production, perception, regulation","volume":"16","author":"Wrzaczek","year":"2013","journal-title":"Curr Opin Plant Biol"},{"key":"key20180108001941_b7-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1902\/jop.2012.120252","article-title":"Therapeutic effects of alpha lipoic acid and vitamin C on alveolar bone resorption after experimental periodontitis in rats: a biochemical, histochemical, and stereologic study","volume":"84","author":"Akman","year":"2013","journal-title":"J Periodontol"},{"key":"key20180108001941_b8-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif"},{"key":"key20180108001941_b9-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0765.2010.01331.x","article-title":"The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell","volume":"46","author":"J\u00f6nsson","year":"2011","journal-title":"J Periodontal Res"},{"key":"key20180108001941_b10-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0003-9969(90)90062-F","article-title":"Characteristics of human periodontal ligament cells in vitro","volume":"35","author":"Somerman","year":"1990","journal-title":"Arch Oral Biol"},{"key":"key20180108001941_b11-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1089\/ars.2012.4817","article-title":"Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system","volume":"18","author":"Burgoyne","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"key20180108001941_b12-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.abb.2012.09.014","article-title":"Transcriptional and translational regulation of cytokine signaling in inflammatory beta-cell dysfunction and apoptosis","volume":"528","author":"Novotny","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"key20180108001941_b13-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/0022034510375830","article-title":"Oxidative stress, systemic inflammation, and severe periodontitis","volume":"89","author":"D\u2019Aiuto","year":"2010","journal-title":"J Dent Res"},{"key":"key20180108001941_b14-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1007\/s11427-010-4075-4","article-title":"Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages","volume":"53","author":"Lin","year":"2010","journal-title":"Sci China Life Sci"},{"key":"key20180108001941_b15-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-0765.2005.00818.x","article-title":"Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis","volume":"40","author":"Tsai","year":"2005","journal-title":"J Periodontal Res"},{"key":"key20180108001941_b16-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/jn\/137.3.657","article-title":"The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations","volume":"137","author":"Chapple","year":"2007","journal-title":"J Nutr"},{"key":"key20180108001941_b17-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00005-007-0047-1","article-title":"Total antioxidant status and 8-hydroxy-2\u2032-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients","volume":"55","author":"Konopka","year":"2007","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"key20180108001941_b18-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"key20180108001941_b19-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.placenta.2003.12.005","article-title":"Vitamin C exacerbates hydrogen peroxide induced apoptosis and concomitant PGE2 release in amnion epithelial and mesenchymal cells, and in intact amnion","volume":"25","author":"Kumar","year":"2004","journal-title":"Placenta"},{"key":"key20180108001941_b20-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.foodchem.2012.06.050","article-title":"Vitamin C induces apoptosis in AGS cells by down-regulation of 14-3-3sigma via a mitochondrial dependent pathway","volume":"135","author":"Nagappan","year":"2012","journal-title":"Food Chem"},{"key":"key20180108001941_b21-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.freeradbiomed.2005.01.017","article-title":"Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C","volume":"38","author":"Dhar-Mascare\u00f1o","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20180108001941_b22-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/jcb.24092","article-title":"Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment","volume":"113","author":"Gobbo","year":"2012","journal-title":"J Cell Biochem"},{"key":"key20180108001941_b23-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/carcin\/20.6.1035","article-title":"Effect of vitamin C supplementation on chromosome damage, apoptosis and necrosis ex vivo","volume":"20","author":"Crott","year":"1999","journal-title":"Carcinogenesis"},{"key":"key20180108001941_b24-mmr-11-01-0242","first-page":"811","article-title":"Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells","volume":"18","author":"Hong","year":"2007","journal-title":"Oncol Rep"},{"key":"key20180108001941_b25-mmr-11-01-0242","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/S0024-3205(02)01942-2","article-title":"Preconditioning with millimolar concentrations of vitamin C or N-acetylcysteine protects L6 muscle cells insulin-stimulated viability and DNA synthesis under oxidative stress","volume":"71","author":"Orzechowski","year":"2002","journal-title":"Life Sci"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2014.2712\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:28:51Z","timestamp":1565954931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2014.2712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,21]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,10,21]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.3892\/mmr.2014.2712"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2014.2712","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,21]]}}}