{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:03:26Z","timestamp":1789873406835,"version":"4.0.1"},"reference-count":45,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.3892\/mmr.2014.3003","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T04:33:39Z","timestamp":1416976419000},"page":"2999-3008","source":"Crossref","is-referenced-by-count":26,"title":["Multi-dose parecoxib provides an immunoprotective effect by balancing T helper 1 (Th1), Th2, Th17 and regulatory T cytokines following laparoscopy in patients with cervical cancer"],"prefix":"10.3892","volume":"11","author":[{"given":"WENGUANG","family":"MA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KUN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONGQIANG","family":"DU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNQI","family":"LUAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GE","family":"LOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"key20180108000840_b1-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4137\/CMO.S9518","article-title":"Circulating cytokines and nitric oxide are involved in the inhibition of neutrophil migration in patients with uterine cervical neoplasia","volume":"6","author":"Micheli","year":"2012","journal-title":"Clin Med Insights Oncol"},{"key":"key20180108000840_b2-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s12253-011-9471-y","article-title":"Dysregulated expression of both the costimulatory CD28 and inhibitory CTLA-4 molecules in PB T cells of advanced cervical cancer patients suggests systemic immunosuppression related to disease progression","volume":"18","author":"Kosmaczewska","year":"2012","journal-title":"Pathol Oncol Res"},{"key":"key20180108000840_b3-mmr-11-04-2999","first-page":"77","article-title":"Impact of laparoscopic surgery on immune function","volume":"29","author":"Holub","year":"2002","journal-title":"Clin Exp Obstret Gynecol"},{"key":"key20180108000840_b4-mmr-11-04-2999","first-page":"58","article-title":"A pilot study of nimotuzumab combined with cisplatin and 5-FU in patients with advanced esophageal squamous cell carcinoma","volume":"4","author":"Ling","year":"2012","journal-title":"J Thorac Dis"},{"key":"key20180108000840_b5-mmr-11-04-2999","first-page":"98","article-title":"Reoperation for early postoperative complications after gastric cancer surgery in a Chinese hospital","volume":"16","author":"Sah","year":"2010","journal-title":"World J Gastroenterol"},{"key":"key20180108000840_b6-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1399-6576.1992.tb03452.x","article-title":"Effects of anaesthesia and surgery on the immune response","volume":"36","author":"Salo","year":"1992","journal-title":"Acta Anaesthesiol Scand"},{"key":"key20180108000840_b7-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4933-4-4","article-title":"Pathophysiology of ageing, longevity and age related diseases","volume":"4","author":"B\u00fcrkle","year":"2007","journal-title":"Immun Ageing"},{"key":"key20180108000840_b8-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/ol.2011.311","article-title":"Comparative evaluation of surgical stress of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy and laparotomy for early-stage cervical cancer","volume":"2","author":"Hou","year":"2011","journal-title":"Oncol Lett"},{"key":"key20180108000840_b9-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S0100-879X2011007500159","article-title":"Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro","volume":"45","author":"Yang","year":"2012","journal-title":"Braz J Med Biol Res"},{"key":"key20180108000840_b10-mmr-11-04-2999","first-page":"807","article-title":"Immune activation in cervical neoplasia: cross-sectional association between plasma soluble interleukin 2 receptor levels and disease","volume":"6","author":"Hildesheim","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20180108000840_b11-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"key20180108000840_b12-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.coi.2007.04.005","article-title":"Differentiation and function of Th17 T cells","volume":"19","author":"Stockinger","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"key20180108000840_b13-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1746-1596-8-61","article-title":"The Th17\/Treg balance and the expression of related cytokines in Uygur cervical cancer patients","volume":"8","author":"Chen","year":"2013","journal-title":"Diagn Pathol"},{"key":"key20180108000840_b14-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"302416","DOI":"10.1097\/00044067-200507000-00004","article-title":"Surgery-induced immunosuppression and postoperative pain management","volume":"16","author":"Page","year":"2005","journal-title":"AACN Clin Issues"},{"key":"key20180108000840_b15-mmr-11-04-2999","first-page":"58","article-title":"A pilot study of nimotuzumab combined with cisplatin and 5-FU in patients with advanced esophageal squamous cell carcinoma","volume":"4","author":"Ling","year":"2012","journal-title":"J Thorac Dis"},{"key":"key20180108000840_b16-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000542-200502000-00026","article-title":"Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans","volume":"102","author":"Dembo","year":"2005","journal-title":"Anesthesiology"},{"key":"key20180108000840_b17-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/sj.clpt.6100304","article-title":"Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system","volume":"83","author":"Mehta","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"key20180108000840_b18-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pain.2003.12.017","article-title":"The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans","volume":"108","author":"Koppert","year":"2004","journal-title":"Pain"},{"key":"key20180108000840_b19-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2165\/00003495-200161080-00010","article-title":"Parecoxib (parecoxib sodium)","volume":"61","author":"Cheer","year":"2011","journal-title":"Drugs"},{"key":"key20180108000840_b20-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00262-011-1196-y","article-title":"Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors","volume":"61","author":"Eberst\u00e5l","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"key20180108000840_b21-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1007\/s00268-010-0696-9","article-title":"Preincisional versus postincisional administration of parecoxib in colorectal surgery: effect on postoperative pain control and cytokine response. A randomized clinical trial","volume":"34","author":"Pandazi","year":"2010","journal-title":"World J Surg"},{"key":"key20180108000840_b22-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jss.2012.08.030","article-title":"The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats","volume":"178","author":"Peng","year":"2012","journal-title":"J Surg Res"},{"key":"key20180108000840_b23-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ygyno.2006.11.011","article-title":"A comparison of laparoscopic radical hysterectomy and pelvic lymphadenectomy and laparotomy in the treatment of Ib-IIa cervical cancer","volume":"105","author":"Li","year":"2007","journal-title":"Gynecol Oncol"},{"key":"key20180108000840_b24-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1213\/01.ANE.0000134807.73615.5C","article-title":"The effects of propofol, small-dose isoflurane, and nitrous oxide on cortical somatosensory evoked potential and bispectral index monitoring in adolescents undergoing spinal fusion","volume":"99","author":"Clapcich","year":"2004","journal-title":"Anesth Analg"},{"key":"key20180108000840_b25-mmr-11-04-2999","first-page":"316","article-title":"Intraperitoneal and intravenous routes for pain relief in laparoscopic cholecystectomy","volume":"9","author":"Jabbour-Khoury","year":"2005","journal-title":"JSLS"},{"key":"key20180108000840_b26-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2710.2004.00558.x","article-title":"Systematic review of the analgesic efficacy and tolerability of COX-2 inhibitors in post-operative pain control","volume":"29","author":"Chen","year":"2004","journal-title":"J Clin Pharm Ther"},{"key":"key20180108000840_b27-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1399-6576.2005.00666.x","article-title":"Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies","volume":"49","author":"Straube","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"key20180108000840_b28-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00000539-200109000-00036","article-title":"The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively","volume":"93","author":"Desjardins","year":"2001","journal-title":"Anesth Analg"},{"key":"key20180108000840_b29-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"757","DOI":"10.7150\/ijms.4916","article-title":"Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy","volume":"9","author":"Zhang","year":"2012","journal-title":"Int J Med Sci"},{"key":"key20180108000840_b30-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00000542-200208000-00004","article-title":"Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery","volume":"97","author":"Barton","year":"2002","journal-title":"Anesthesiology"},{"key":"key20180108000840_b31-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1158\/1078-0432.CCR-03-0498","article-title":"Disease-stage variance in functional CD4(+) T-cell responses against novel pan-human leukocyte antigen-D region presented human papillomavirus-16 E7 epitopes","volume":"10","author":"Warrino","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180108000840_b32-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.4049\/jimmunol.167.5.2972","article-title":"Predominant Th2\/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer","volume":"167","author":"Sheu","year":"2001","journal-title":"J Immunol"},{"key":"key20180108000840_b33-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.4049\/jimmunol.174.3.1446","article-title":"Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-beta","volume":"174","author":"Rao","year":"2005","journal-title":"J Immunol"},{"key":"key20180108000840_b34-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/08941930701598792","article-title":"Pharmacological immunomodulation of surgical trauma","volume":"20","author":"Navarro-Zorraquino","year":"2007","journal-title":"J Invest Surg"},{"key":"key20180108000840_b35-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2249.2007.03468.x","article-title":"Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia","volume":"150","author":"Visser","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"key20180108000840_b36-mmr-11-04-2999","first-page":"716","article-title":"Combined general and regional anesthesia and effects on immune function in patients with benign ovarian tumors treated by laparoscopic therapy","volume":"6","author":"Cheng","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"key20180108000840_b37-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"658","DOI":"10.12968\/hosp.1999.60.9.1198","article-title":"Effects of anaesthesia on the human immune system","volume":"60","author":"Hunter","year":"1999","journal-title":"Hosp Med"},{"key":"key20180108000840_b38-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.bjc.6603385","article-title":"Prognostic relevance of Tiam1 protein expression in prostate carcinomas","volume":"95","author":"Engers","year":"2006","journal-title":"Br J Cancer"},{"key":"key20180108000840_b39-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/bja\/aeq096","article-title":"Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery","volume":"104","author":"Gehling","year":"2010","journal-title":"Br J Anaesth"},{"key":"key20180108000840_b40-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.4049\/jimmunol.1101559","article-title":"Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation","volume":"187","author":"Ang","year":"2011","journal-title":"J Immunol"},{"key":"key20180108000840_b41-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1177\/030006051204000518","article-title":"Comparison of preincisional and postincisional parecoxib administration on postoperative pain control and cytokine response after total hip replacement","volume":"40","author":"Bao","year":"2012","journal-title":"J Int Med Res"},{"key":"key20180108000840_b42-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4049\/jimmunol.175.2.813","article-title":"Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses","volume":"175","author":"Sharma","year":"2005","journal-title":"J Immunol"},{"key":"key20180108000840_b43-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00262-005-0669-2","article-title":"Cyclooxygenase inhibitors modulate NK activities that control metastatic disease","volume":"54","author":"Kundu","year":"2005","journal-title":"Cancer Immunol Immunother"},{"key":"key20180108000840_b44-mmr-11-04-2999","first-page":"1425","article-title":"Serum levels of Th17-related cytokines in Behcet disease patients after cataract surgery","volume":"17","author":"Jiang","year":"2011","journal-title":"Mol Vis"},{"key":"key20180108000840_b45-mmr-11-04-2999","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00000539-200006000-00028","article-title":"The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients","volume":"90","author":"Sacerdote","year":"2000","journal-title":"Anesth Analg"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2014.3003\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T17:01:36Z","timestamp":1566061296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2014.3003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,26]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,11,26]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.3892\/mmr.2014.3003"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2014.3003","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,26]]}}}