{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:16:08Z","timestamp":1761394568680},"reference-count":50,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.3892\/mmr.2014.3046","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T03:11:04Z","timestamp":1417662664000},"page":"2896-2902","source":"Crossref","is-referenced-by-count":4,"title":["Effect of charred Radix et Rhizoma Rhei in a laser-induced choroidal neovascularization murine model"],"prefix":"10.3892","volume":"11","author":[{"given":"DONGMEI","family":"HAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUAN","family":"YAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONG","family":"SUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUANYUAN","family":"GONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XINGWEI","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"key20180108000954_b1-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ajo.2003.11.069","article-title":"The epidemiology of age-related macular degeneration","volume":"137","author":"Klein","year":"2004","journal-title":"Am J Opthalmol"},{"key":"key20180108000954_b2-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000351660","article-title":"Current choroidal neovascularization treatment","volume":"230","author":"Jian","year":"2013","journal-title":"Ophthalmologica"},{"key":"key20180108000954_b3-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/path.4266","article-title":"Mechanisms of age-related macular degeneration and therapeutic opportunities","volume":"232","author":"Campagne","year":"2014","journal-title":"J Pathol"},{"key":"key20180108000954_b4-mmr-11-04-2896","unstructured":"JinMPharmaceutical composition for treating macular degenerationInternational patentWO\/2012\/079419Filed October 13, 2011; issued June 21, 2012"},{"key":"key20180108000954_b5-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1517\/13543776.2013.751972","article-title":"Pharmaceutical composition for treating macular degeneration (W02012079419)","volume":"23","author":"Wang","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"key20180108000954_b6-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1096\/fj.07-8422com","article-title":"Endogenous endostatin inhibits choroidal neovascularization","volume":"21","author":"Marneros","year":"2007","journal-title":"FASEB J"},{"key":"key20180108000954_b7-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"e39890","DOI":"10.1371\/journal.pone.0039890","article-title":"Low-dose lipopolysaccharide pretreatment suppresses choroidal neovascularization via IL-10 induction","volume":"7","author":"Matsumara","year":"2012","journal-title":"PLoS One"},{"key":"key20180108000954_b8-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/nar\/19.9.2499","article-title":"A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells","volume":"19","author":"Andrews","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"key20180108000954_b9-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.1984.01040031330019","article-title":"Age-related macular degeneration and blindness due to neovascular maculopathy","volume":"102","author":"Ferris","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"key20180108000954_b10-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000337154","article-title":"Neovascular age-related macular degeneration","volume":"227","author":"Veritti","year":"2012","journal-title":"Ophthalmologica"},{"key":"key20180108000954_b11-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"e17106","DOI":"10.1371\/journal.pone.0017106","article-title":"CCR3 and choroidal neovascularization","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"key20180108000954_b12-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.ophtha.2006.04.039","article-title":"Photodynamic therapy with intravitreal triamcinolone in predominantly classic choroidal neovascularization: one-year results of a randomized study","volume":"113","author":"Arias","year":"2006","journal-title":"Opthalmology"},{"key":"key20180108000954_b13-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1442-9071.1998.tb01330.x","article-title":"Exudative macular degeneration and intravitreal tramcinolone: 18 month follow up","volume":"26","author":"Challa","year":"1998","journal-title":"Aust N Z J Opthalmol"},{"key":"key20180108000954_b14-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ajo.2007.10.004","article-title":"Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1","volume":"145","author":"Regillo","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"key20180108000954_b15-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2353\/ajpath.2007.061237","article-title":"Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury","volume":"171","author":"Nishijima","year":"2007","journal-title":"Am J Pathol"},{"key":"key20180108000954_b16-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1096\/fj.00-0598fje","article-title":"Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development","volume":"15","author":"Robinson","year":"2001","journal-title":"FASEB J"},{"key":"key20180108000954_b17-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ophtha.2008.09.046","article-title":"Cerebrovascular accidents in ranibizumab","volume":"116","author":"Ueta","year":"2009","journal-title":"Ophthalmology"},{"key":"key20180108000954_b18-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ophtha.2012.05.028","article-title":"Stroke rates after introduction of vascular endothelial growth factor inhibitors for macular degeneration: a time series analysis","volume":"119","author":"Campbell","year":"2012","journal-title":"Ophthalmology"},{"key":"key20180108000954_b19-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ajo.2010.04.029","article-title":"Retinal nerve fiber layer thickness in patients receiving chronic anti-vascular endothelial growth factor therapy","volume":"150","author":"Horsley","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"key20180108000954_b20-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/mt.2013.243","article-title":"Repression of choroidal neovascularization through actin cytoskeleton pathways by mircoRNA-24","volume":"22","author":"Zhou","year":"2014","journal-title":"Mol Ther"},{"key":"key20180108000954_b21-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.ophtha.2008.07.007","article-title":"Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age related macular degeneration?","volume":"115","author":"Schaal","year":"2008","journal-title":"Ophthalmology"},{"key":"key20180108000954_b22-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/01.iae.0000247164.70376.91","article-title":"Combined photodynamic therapy with verteporfin and intravitreal bevacizumab for choroidal neovascularization in age-related macular degeneration","volume":"26","author":"Dhalla","year":"2006","journal-title":"Retina"},{"key":"key20180108000954_b23-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.survophthal.2004.12.006","article-title":"Applications of liposomes in ophthalmology","volume":"50","author":"Ebrahim","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"key20180108000954_b24-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cyto.2009.05.014","article-title":"The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines","volume":"47","author":"Ko","year":"2009","journal-title":"Cytokine"},{"key":"key20180108000954_b25-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10753-011-9393-6","article-title":"Antibacterial and anti-inflammatory activity of traditional Chinese herb pairs, Angelica sinensis and Sophora flavescens","volume":"35","author":"Han","year":"2012","journal-title":"Inflammation"},{"key":"key20180108000954_b26-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.clnu.2007.07.008","article-title":"Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model","volume":"26","author":"Chang","year":"2007","journal-title":"Clin Nutr"},{"key":"key20180108000954_b27-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.0909-752X.2006.00168.x","article-title":"Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis","volume":"12","author":"Fuchs","year":"2006","journal-title":"Skin Res Technol"},{"key":"key20180108000954_b28-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1271\/bbb.110076","article-title":"Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells","volume":"75","author":"Cho","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108000954_b29-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.freeradbiomed.2008.12.006","article-title":"Curcumin protects retinal cells from light-and oxidant stress-induced cell death","volume":"46","author":"Mandal","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"key20180108000954_b30-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3109\/14756360903555274","article-title":"Curcumin inhibits TNFalpha-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanism","volume":"25","author":"Lee","year":"2010","journal-title":"J Enzyme Inhib Med Chem"},{"key":"key20180108000954_b31-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1248\/bpb.32.1021","article-title":"Synergistic antioxidant activities of eight traditional Chinese herb pairs","volume":"32","author":"Yang","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"key20180108000954_b32-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1248\/bpb.30.1884","article-title":"Component and antioxidant properties of polysaccharide fractions isolated from Angelica sinensis (OLIV.) DIELS","volume":"30","author":"Yang","year":"2007","journal-title":"Biological Pharmaceutical Bulletin"},{"key":"key20180108000954_b33-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.archoralbio.2011.05.010","article-title":"n-Butanol extracts of Panax notoginseng suppress LPS-induced MMP-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing MAPK in LPS-activated RAW264.7 cells","volume":"56","author":"Jang","year":"2011","journal-title":"Arch Oral Biol"},{"key":"key20180108000954_b34-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1749-8546-5-38","article-title":"Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells","volume":"5","author":"Choi","year":"2010","journal-title":"Chin Med"},{"key":"key20180108000954_b35-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1248\/cpb.31.1115","article-title":"A new antitumor polysaccharide from the mycelia of Poria cocos Wolf","volume":"31","author":"Kanayama","year":"1983","journal-title":"Chem Pharm Bull"},{"key":"key20180108000954_b36-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jep.2010.05.055","article-title":"A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta (1\u201342) level in the brain of Tg-APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"130","author":"Seo","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"key20180108000954_b37-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biopha.2008.01.003","article-title":"Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis","volume":"63","author":"Li","year":"2009","journal-title":"Biomed Pharmacother"},{"key":"key20180108000954_b38-mmr-11-04-2896","first-page":"144","article-title":"Astragalus membranaceus extract promotes neovascularisation by VEGF pathway in rat model of ischemic injury","volume":"66","author":"Zhang","year":"2011","journal-title":"Pharmazie"},{"key":"key20180108000954_b39-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jcb.21403","article-title":"The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo","volume":"103","author":"Lam","year":"2008","journal-title":"J Cell Biochem"},{"key":"key20180108000954_b40-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10456-011-9202-8","article-title":"The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo","volume":"14","author":"Yeh","year":"2011","journal-title":"Angiogenesis"},{"key":"key20180108000954_b41-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/MBC.0b013e3283504148","article-title":"Pollen Typhae is a rapid hemostyptic","volume":"23","author":"Ohkura","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"key20180108000954_b42-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"E279","DOI":"10.1073\/pnas.1100901108","article-title":"Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration","volume":"108","author":"Ding","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108000954_b43-mmr-11-04-2896","first-page":"176","article-title":"Chinese herbs\/Da Huang","volume-title":"Chinese Medicine","author":"Lei","year":"1998","edition":"1st edition"},{"key":"key20180108000954_b44-mmr-11-04-2896","first-page":"CD006791","article-title":"Traditional Chinese Medicine herbs for stopping bleeding from haemorrhoids","volume":"10","author":"Gan","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"key20180108000954_b45-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/sj.onc.1201998","article-title":"Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-\u03baB activation, I\u03baB degradation and expression of cell surface adhesion proteins in human vascular endothelial cells","volume":"17","author":"Kumar","year":"1998","journal-title":"Oncogene"},{"key":"key20180108000954_b46-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180108000954_b47-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1371\/journal.pmed.0030310","article-title":"Macrophages inhibit neovascularization in a murine model of age-related macular degeneration","volume":"3","author":"Apte","year":"2006","journal-title":"PLoS Med"},{"key":"key20180108000954_b48-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1189\/jlb.1110603","article-title":"IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn","volume":"91","author":"Hasegawa","year":"2012","journal-title":"J Leukoc Biol"},{"key":"key20180108000954_b49-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/rmed.2003.1490","article-title":"Coriolus Versicolor Polysaccharide Peptide slows progression of advanced non-small cell lung cancer","volume":"97","author":"Tsang","year":"1997","journal-title":"Respir Med"},{"key":"key20180108000954_b50-mmr-11-04-2896","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S1368980000000604","article-title":"Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine","volume":"3","author":"Lee","year":"2000","journal-title":"Public Health Nutr"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2014.3046\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:10:20Z","timestamp":1566087020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2014.3046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,4]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.3892\/mmr.2014.3046"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2014.3046","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}