{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:07:00Z","timestamp":1753438020309},"reference-count":33,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.3892\/mmr.2014.3056","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T13:36:15Z","timestamp":1417786575000},"page":"2981-2990","source":"Crossref","is-referenced-by-count":11,"title":["Overexpression of astrocyte-elevated gene-1 is associated with ovarian cancer development and progression"],"prefix":"10.3892","volume":"11","author":[{"given":"BO","family":"ZHOU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUE","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BIN","family":"SHU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KUNMEI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEZHEN","family":"XUE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NING","family":"SU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JING","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAO","family":"XI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"key20180108000856_b1-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180108000856_b2-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1525-1438.2005.00445.x","article-title":"Ovarian cancer: is the news good enough?","volume":"15","author":"Poveda","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"key20180108000856_b3-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.pgp.0000101080.35393.16","article-title":"The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin","volume":"23","author":"Seidman","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"key20180108000856_b4-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm1230","article-title":"Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract","volume":"11","author":"Cheng","year":"2005","journal-title":"Nat Med"},{"key":"key20180108000856_b5-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"594. e1","DOI":"10.1016\/j.ajog.2007.05.027","article-title":"The association of tea consumption with ovarian cancer risk: A meta-analysis","volume":"197","author":"Zhou","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"key20180108000856_b6-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"key20180108000856_b7-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12672-010-0054-2","article-title":"Microenvironment and pathogenesis of epithelial ovarian cancer","volume":"1","author":"Saad","year":"2010","journal-title":"Horm Cancer"},{"key":"key20180108000856_b8-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1038\/sj.onc.1205445","article-title":"Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH","volume":"21","author":"Su","year":"2002","journal-title":"Oncogene"},{"key":"key20180108000856_b9-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2005.04.006","article-title":"Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1","volume":"353","author":"Kang","year":"2005","journal-title":"Gene"},{"key":"key20180108000856_b10-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1158\/1078-0432.CCR-07-4054","article-title":"Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival","volume":"14","author":"Li","year":"2008","journal-title":"Clin Cancer Res"},{"key":"key20180108000856_b11-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/carcin\/bgp064","article-title":"Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis","volume":"30","author":"Yu","year":"2009","journal-title":"Carcinogenesis"},{"key":"key20180108000856_b12-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI36460","article-title":"Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression","volume":"119","author":"Yoo","year":"2009","journal-title":"J Clin Invest"},{"key":"key20180108000856_b13-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00384-010-1009-3","article-title":"Prognostic significance of AEG-1 expression in colorectal carcinoma","volume":"25","author":"Song","year":"2010","journal-title":"Int J Colorectal Dis"},{"key":"key20180108000856_b14-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1038\/sj.onc.1210572","article-title":"Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity","volume":"26","author":"Kikuno","year":"2007","journal-title":"Oncogene"},{"key":"key20180108000856_b15-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/IGC.0b013e3182145561","article-title":"AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers","volume":"21","author":"Li","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"key20180108000856_b16-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2008.11.013","article-title":"MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer","volume":"15","author":"Hu","year":"2009","journal-title":"Cancer Cell"},{"key":"key20180108000856_b17-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1158\/0008-5472.CAN-09-4009","article-title":"Molecular mechanism of chemoresistance by astrocyte elevated gene-1","volume":"70","author":"Yoo","year":"2010","journal-title":"Cancer Res"},{"key":"key20180108000856_b18-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"21300","DOI":"10.1073\/pnas.0910936106","article-title":"Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis","volume":"106","author":"Emdad","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108000856_b19-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1158\/0008-5472.CAN-05-3029","article-title":"Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis","volume":"66","author":"Emdad","year":"2006","journal-title":"Cancer Res"},{"key":"key20180108000856_b20-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"17390","DOI":"10.1073\/pnas.0608386103","article-title":"Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc","volume":"103","author":"Lee","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108000856_b21-mmr-11-04-2981","article-title":"Histological Typing of Ovarian Tumors","volume-title":"World Health Organization International Histological Classification of Tumours","author":"Scully","year":"1999"},{"key":"key20180108000856_b22-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-61779-286-1_8","article-title":"Use of formalin-fixed and paraffin-embedded tissues for diagnosis and therapy in routine clinical settings","volume":"785","author":"Berg","year":"2011","journal-title":"Methods Mol Biol"},{"key":"key20180108000856_b23-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00109-006-0097-6","article-title":"Quantitative real-time RT-PCR data analysis: current concepts and the novel \u2018gene expression\u2019s CT difference\u2019 formula","volume":"84","author":"Schefe","year":"2006","journal-title":"J Mol Med (Berl)"},{"key":"key20180108000856_b24-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/PGP.0b013e3181ffd2f7","article-title":"Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma","volume":"30","author":"Meng","year":"2011","journal-title":"Int J Gynecol Pathol"},{"key":"key20180108000856_b25-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12032-010-9475-6","article-title":"Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer","volume":"28","author":"Jian-bo","year":"2011","journal-title":"Med Oncol"},{"key":"key20180108000856_b26-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12032-012-0383-9","article-title":"AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis","volume":"30","author":"Ke","year":"2013","journal-title":"Med Oncol"},{"key":"key20180108000856_b27-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1746-1596-5-38","article-title":"Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue","volume":"5","author":"Su","year":"2010","journal-title":"Diagn Pathol"},{"key":"key20180108000856_b28-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/onc.2009.93","article-title":"Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma","volume":"28","author":"Lee","year":"2009","journal-title":"Oncogene"},{"key":"key20180108000856_b29-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1158\/1535-7163.MCT-09-0752","article-title":"Astrocyte elevated gene-1: A novel target for human glioma therapy","volume":"9","author":"Emdad","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"key20180108000856_b30-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1158\/0008-5472.CAN-09-3838","article-title":"Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion","volume":"70","author":"Liu","year":"2010","journal-title":"Cancer Res"},{"key":"key20180108000856_b31-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/mc.21894","article-title":"Astrocyte elevated gene-1 interacts with \u03b2-catenin and increases migration and invasion of colorectal carcinoma","volume":"52","author":"Zhang","year":"2013","journal-title":"Mol Carcinog"},{"key":"key20180108000856_b32-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.onc.1210713","article-title":"Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling","volume":"27","author":"Lee","year":"2008","journal-title":"Oncogene"},{"key":"key20180108000856_b33-mmr-11-04-2981","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1038\/onc.2009.171","article-title":"Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1","volume":"28","author":"Li","year":"2009","journal-title":"Oncogene"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2014.3056\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:45:06Z","timestamp":1515372306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2014.3056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12,5]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.3892\/mmr.2014.3056"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2014.3056","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}