{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:54:48Z","timestamp":1773950088615,"version":"3.50.1"},"reference-count":32,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.3892\/mmr.2015.3265","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T09:09:07Z","timestamp":1422436147000},"page":"4087-4092","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin"],"prefix":"10.3892","volume":"11","author":[{"given":"CHENG","family":"LIU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"key20180108002220_b1-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids - a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol Surg"},{"key":"key20180108002220_b2-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1524-475X.2010.00598.x","article-title":"Improvement of hypertrophic scarring by using topical anti-fibrogenic\/anti-inflammatory factors in a rabbit ear model","volume":"18","author":"Rahmani-Neishaboor","year":"2010","journal-title":"Wound Repair Regen"},{"key":"key20180108002220_b3-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1742-481X.2012.01118.x","article-title":"Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings","volume":"11","author":"Huang","year":"2014","journal-title":"Int Wound J"},{"key":"key20180108002220_b4-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.jid.5700701","article-title":"Inflammation in wound repair: molecular and cellular mechanisms","volume":"127","author":"Eming","year":"2007","journal-title":"J Invest Dermatol"},{"key":"key20180108002220_b5-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"key20180108002220_b6-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"key20180108002220_b7-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.burns.2008.06.020","article-title":"Potential cellular and molecular causes of hypertrophic scar formation","volume":"35","author":"van der Veer","year":"2009","journal-title":"Burns"},{"key":"key20180108002220_b8-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1096\/fj.10-178087","article-title":"Mechanical force prolongs acute inflammation via T-cell-dependent pathways during scar formation","volume":"25","author":"Wong","year":"2011","journal-title":"FASEB J"},{"key":"key20180108002220_b9-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2011","journal-title":"Nat Med"},{"key":"key20180108002220_b10-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1046\/j.1523-1747.1998.00329.x","article-title":"Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars","volume":"111","author":"Kr\u00f6tzsch-G\u00f3mez","year":"1998","journal-title":"J Invest Dermatol"},{"key":"key20180108002220_b11-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00004630-199711000-00002","article-title":"The 1997 Moyer Award. Cytokine production in patients with hypertrophic burn scars","volume":"18","author":"Polo","year":"1997","journal-title":"J Burn Care Rehabil"},{"key":"key20180108002220_b12-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3892\/or.2013.2741","article-title":"The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review)","volume":"30","author":"Wei","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180108002220_b13-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2013.08.023","article-title":"Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer","volume":"341","author":"Shrimali","year":"2013","journal-title":"Cancer Lett"},{"key":"key20180108002220_b14-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/ndt\/gfp245","article-title":"In vitro anti-fibrotic activities of herbal compounds and herbs","volume":"24","author":"Hu","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108002220_b15-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1055\/s-2008-1074581","article-title":"Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells","volume":"74","author":"Lin","year":"2008","journal-title":"Planta Med"},{"key":"key20180108002220_b16-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis","volume":"21","author":"Aarabi","year":"2007","journal-title":"FASEB J"},{"key":"key20180108002220_b17-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/jid.2012.486","article-title":"Xiamenmycin attenuates hypertrophic scars by suppressing local inflammation and the effects of mechanical stress","volume":"133","author":"Liu","year":"2013","journal-title":"J Invest Dermatol"},{"key":"key20180108002220_b18-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-3024.2008.01047.x","article-title":"Different effect of Toxoplasma gondii infection on adhesion capacity of fibroblasts and monocytes","volume":"30","author":"Pfaff","year":"2008","journal-title":"Parasite Immunol"},{"key":"key20180108002220_b19-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1248\/bpb.34.1432","article-title":"Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes","volume":"34","author":"Ha","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"key20180108002220_b20-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3892\/ijmm.2013.1565","article-title":"CCN5 overexpression inhibits profibrotic phenotypes via the PI3K\/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis","volume":"33","author":"Zhang","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20180108002220_b21-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/hep.23186","article-title":"Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis","volume":"50","author":"Son","year":"2009","journal-title":"Hepatology"},{"key":"key20180108002220_b22-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2353\/ajpath.2010.090123","article-title":"Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis","volume":"176","author":"Le Cras","year":"2010","journal-title":"Am J Pathol"},{"key":"key20180108002220_b23-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/srep03470","article-title":"HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis","volume":"3","author":"Son","year":"2013","journal-title":"Sci Rep"},{"key":"key20180108002220_b24-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3346\/jkms.2014.29.2.230","article-title":"Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction: the role of PI3K-Akt-FoxO3a signaling","volume":"29","author":"Yoon","year":"2014","journal-title":"J Korean Med Sci"},{"key":"key20180108002220_b25-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/SAP.0b013e3181c60f88","article-title":"Perioperative conditions affect long-term hypertrophic scar formation","volume":"65","author":"van der Veer","year":"2010","journal-title":"Ann Plast Surg"},{"key":"key20180108002220_b26-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1167\/iovs.07-0393","article-title":"Emodin suppression of ocular surface inflammatory reaction","volume":"48","author":"Kitano","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180108002220_b27-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.burns.2011.12.012","article-title":"Post-burn hypertrophic scars are characterized by high levels of IL-1\u03b2 mRNA and protein and TNF-\u03b1 type I receptors","volume":"38","author":"Salgado","year":"2012","journal-title":"Burns"},{"key":"key20180108002220_b28-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1524-475X.2003.11504.x","article-title":"In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars","volume":"11","author":"Reno","year":"2003","journal-title":"Wound Repair Regen"},{"key":"key20180108002220_b29-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/path.1539","article-title":"Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation","volume":"202","author":"Dasu","year":"2004","journal-title":"J Pathol"},{"key":"key20180108002220_b30-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.burns.2011.12.017","article-title":"Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways","volume":"38","author":"Song","year":"2012","journal-title":"Burns"},{"key":"key20180108002220_b31-mmr-11-06-4087","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.intimp.2008.01.027","article-title":"Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression","volume":"8","author":"Lee","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"key20180108002220_b32-mmr-11-06-4087","first-page":"1381","article-title":"Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation","volume":"39","author":"Wei","year":"2011","journal-title":"Int J Oncol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3265\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:01:23Z","timestamp":1515373283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,1,28]]},"published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.3892\/mmr.2015.3265"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3265","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}