{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:35:03Z","timestamp":1791315303766,"version":"4.3.1"},"reference-count":47,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.3892\/mmr.2015.3381","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T07:35:54Z","timestamp":1424763354000},"page":"303-308","source":"Crossref","is-referenced-by-count":39,"title":["Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis"],"prefix":"10.3892","volume":"12","author":[{"given":"WEI","family":"HE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WENLI","family":"GUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI","family":"QIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHUPING","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIFENG","family":"REN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIJIN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"key20180108022643_b1-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1016\/j.chroma.2010.05.043","article-title":"Validation and use of a fast sample preparation method and liquid chromatography-tandem mass spectrometry in analysis of ultra-trace levels of 98 organophosphorus pesticide and carbamate residues in a total diet study involving diversified food types","volume":"1217","author":"Chung","year":"2010","journal-title":"J Chromatogr A"},{"key":"key20180108022643_b2-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/02652030500239623","article-title":"Baby food production chain: pesticide residues in fresh apples and products","volume":"22","author":"Step\u00e1n","year":"2005","journal-title":"Food Addit Contam"},{"key":"key20180108022643_b3-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1007\/s10661-013-3219-y","article-title":"Consumer exposure to pesticide residues in apples from the region of south-eastern Poland","volume":"185","author":"Szpyrka","year":"2013","journal-title":"Environ Monit Assess"},{"key":"key20180108022643_b4-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1016\/j.fct.2012.08.055","article-title":"Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables","volume":"50","author":"Reiss","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"key20180108022643_b5-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jee\/72.6.837","article-title":"Chlorpyrifos and 3,5,6-trichloro-2-pyridinol: residues in body tissues of swine treated with chlorpyrifos for hog louse and itch mite control","volume":"72","author":"Ivey","year":"1979","journal-title":"J Econ Entomol"},{"key":"key20180108022643_b6-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1289\/ehp.02110549","article-title":"Children\u2019s exposure to chlorpyrifos and parathion in an agricultural community in central Washington State","volume":"110","author":"Fenske","year":"2002","journal-title":"Environ Health Perspect"},{"key":"key20180108022643_b7-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1289\/ehp.6641","article-title":"Prenatal insecticide exposures and birth weight and length among an urban minority cohort","volume":"112","author":"Whyatt","year":"2004","journal-title":"Environ Health Perspect"},{"key":"key20180108022643_b8-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/toxsci\/kfh038","article-title":"Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK\/JNK MAP kinases","volume":"78","author":"Caughlan","year":"2004","journal-title":"Toxicol Sci"},{"key":"key20180108022643_b9-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0890-6238(02)00121-1","article-title":"Developmental toxicity study of chlorpyrifos in rats","volume":"17","author":"Farag","year":"2003","journal-title":"Reprod Toxicol"},{"key":"key20180108022643_b10-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0300-483X(95)03156-A","article-title":"In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides","volume":"104","author":"Bagchi","year":"1995","journal-title":"Toxicology"},{"key":"key20180108022643_b11-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/DMDI.2008.23.3-4.237","article-title":"Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET)","volume":"23","author":"Das","year":"2008","journal-title":"Drug Metabol Drug Interact"},{"key":"key20180108022643_b12-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.toxlet.2013.02.003","article-title":"JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis","volume":"218","author":"Ki","year":"2013","journal-title":"Toxicol Lett"},{"key":"key20180108022643_b13-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/toxsci\/kfp259","article-title":"Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line","volume":"113","author":"Son","year":"2010","journal-title":"Toxicol Sci"},{"key":"key20180108022643_b14-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tox.2007.10.005","article-title":"Oxidative stress and DNA damage induced by cadmium in the human keratinocyte HaCaT cell line: role of glutathione in the resistance to cadmium","volume":"243","author":"Nzengue","year":"2008","journal-title":"Toxicology"},{"key":"key20180108022643_b15-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(99)00115-8","article-title":"Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats","volume":"142","author":"Zhou","year":"1999","journal-title":"Toxicology"},{"key":"key20180108022643_b16-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.chemosphere.2009.01.058","article-title":"Monitoring of pesticides and heavy metals in cucumber fruits produced from different farming systems","volume":"75","author":"Mansour","year":"2009","journal-title":"Chemosphere"},{"key":"key20180108022643_b17-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jhazmat.2006.11.009","article-title":"Organochlorine and organophosphoric insecticides, herbicides and heavy metals residue in industrial wastewaters in Cyprus","volume":"145","author":"Fatta","year":"2007","journal-title":"J Hazard Mater"},{"key":"key20180108022643_b18-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cbf.1411","article-title":"Biochemical effects of chlorpyrifos and deltamethrin on altered antioxidative defense mechanisms and lipid peroxidation in rat liver","volume":"26","author":"Tuzmen","year":"2008","journal-title":"Cell Biochem Funct"},{"key":"key20180108022643_b19-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/toxsci\/kfq266","article-title":"Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions","volume":"118","author":"Rai","year":"2010","journal-title":"Toxicol Sci"},{"key":"key20180108022643_b20-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/toxsci\/kfi274","article-title":"Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats","volume":"88","author":"Padilla","year":"2005","journal-title":"Toxicol Sci"},{"key":"key20180108022643_b21-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"e59553","DOI":"10.1371\/journal.pone.0059553","article-title":"Characterization of the interaction between cadmium and chlorpyrifos with integrative techniques in incurring synergistic hepatoxicity","volume":"8","author":"Chen","year":"2013","journal-title":"PloS One"},{"key":"key20180108022643_b22-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0021-9150(03)00254-5","article-title":"Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity","volume":"170","author":"Mingrone","year":"2003","journal-title":"Atherosclerosis"},{"key":"key20180108022643_b23-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ejcn.2012.83","article-title":"Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals","volume":"66","author":"Xia","year":"2012","journal-title":"Eur J Clin Nutr"},{"key":"key20180108022643_b24-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/B:REMD.0000021434.98627.dc","article-title":"The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans","volume":"5","author":"Krssak","year":"2004","journal-title":"Rev Endocr Metab Disord"},{"key":"key20180108022643_b25-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/hep.22907","article-title":"A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte","volume":"49","author":"Moreau","year":"2009","journal-title":"Hepatology"},{"key":"key20180108022643_b26-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.yexcr.2011.02.003","article-title":"PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1\/FASN\/ACC pathway in renal proximal tubular cells","volume":"317","author":"Hao","year":"2011","journal-title":"Exp Cell Res"},{"key":"key20180108022643_b27-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2184.2007.00498.x","article-title":"Overexpression of fatty acid synthase gene activates HER1\/HER2 tyrosine kinase receptors in human breast epithelial cells","volume":"41","author":"Vazquez-Martin","year":"2008","journal-title":"Cell Prolif"},{"key":"key20180108022643_b28-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jbior.2013.09.004","article-title":"Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments","volume":"54","author":"Wu","year":"2014","journal-title":"Adv Biol Regul"},{"key":"key20180108022643_b29-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1194\/jlr.M022178","article-title":"Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter","volume":"53","author":"Jeon","year":"2012","journal-title":"J Lipid Res"},{"key":"key20180108022643_b30-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"29341","DOI":"10.1074\/jbc.M802477200","article-title":"Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)","volume":"283","author":"Choi","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180108022643_b31-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J Clin Invest"},{"key":"key20180108022643_b32-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"19353","DOI":"10.1074\/jbc.M201584200","article-title":"Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)\/Lep(ob) mice","volume":"277","author":"Yahagi","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180108022643_b33-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0031-9422(96)00533-X","article-title":"Two acylated anthocyanins from purple sweet potato","volume":"44","author":"Goda","year":"1997","journal-title":"Phytochemistry"},{"key":"key20180108022643_b34-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1021\/nn402330b","article-title":"Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosis in macrophages","volume":"7","author":"Qu","year":"2013","journal-title":"ACS Nano"},{"key":"key20180108022643_b35-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.nutres.2011.09.026","article-title":"Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese mice","volume":"31","author":"Hwang","year":"2011","journal-title":"Nutr Res"},{"key":"key20180108022643_b36-mmr-12-01-0303","first-page":"1047","article-title":"Assessment of chlorpyrifos toxicity on certain organs in rat, Rattus norvegicus","volume":"30","author":"Akhtar","year":"2009","journal-title":"J Environ Biol"},{"key":"key20180108022643_b37-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10534-006-9015-1","article-title":"Characterization and in vitro cytotoxicity testing of ethanolamine-derived cadmium chelating agents","volume":"20","author":"Zhukalin","year":"2007","journal-title":"Biometals"},{"key":"key20180108022643_b38-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cbi.2006.04.003","article-title":"Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity","volume":"161","author":"Gottschalg","year":"2006","journal-title":"Chem Biol Interact"},{"key":"key20180108022643_b39-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cbi.2005.08.004","article-title":"Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity","volume":"156","author":"Goel","year":"2005","journal-title":"Chem Biol Interact"},{"key":"key20180108022643_b40-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.gene.2004.11.031","article-title":"Quantitative PCR analysis of two molluscan metallothionein genes unveils differential expression and regulation","volume":"345","author":"Dondero","year":"2005","journal-title":"Gene"},{"key":"key20180108022643_b41-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"139","DOI":"10.7150\/ijms.8.139","article-title":"Relationship between anti-CCP antibodies and oxidant and anti-oxidant activity in patients with rheumatoid arthritis","volume":"8","author":"Ediz","year":"2011","journal-title":"Int J Med Sci"},{"key":"key20180108022643_b42-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0141-1136(00)00051-9","article-title":"Interactions of chlorpyrifos and methyl mercury: a mechanistic approach to assess chemical mixtures","volume":"50","author":"Steevens","year":"2000","journal-title":"Mar Environ Res"},{"key":"key20180108022643_b43-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1113\/jphysiol.2006.108506","article-title":"Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders","volume":"574","author":"Viollet","year":"2006","journal-title":"J Physiol"},{"key":"key20180108022643_b44-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhep.2009.03.026","article-title":"Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1","volume":"51","author":"Yuan","year":"2009","journal-title":"J Hepatol"},{"key":"key20180108022643_b45-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbrc.2010.09.016","article-title":"Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice","volume":"401","author":"Lee","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108022643_b46-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/bss0700221","article-title":"Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs)","author":"Rawson","year":"2003","journal-title":"Biochem Soc Symp"},{"key":"key20180108022643_b47-mmr-12-01-0303","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/jn\/109.3.437","article-title":"Cadmium and the food chain: the effect of dietary cadmium on tissue composition in chicks and laying hens","volume":"109","author":"Leach","year":"1979","journal-title":"J Nutr"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3381\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T01:48:11Z","timestamp":1566352091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,2,24]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.3892\/mmr.2015.3381"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3381","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}