{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:43:29Z","timestamp":1789224209523,"version":"build-2803163510"},"reference-count":21,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.3892\/mmr.2015.3430","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T14:48:11Z","timestamp":1425480491000},"page":"419-425","source":"Crossref","is-referenced-by-count":17,"title":["Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia"],"prefix":"10.3892","volume":"12","author":[{"given":"YAFEN","family":"YU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAN","family":"HU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUESHA","family":"XING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING","family":"SONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANG","family":"LUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HONGWEI","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,3,4]]},"reference":[{"key":"key20180108022858_b1-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1302\/0301-620X.64B4.6807993","article-title":"Spondylo-epiphysial dysplasia tarda with Progressive arthropathy. A \u201cnew\u201d disorder of autosomal recessive inheritance","volume":"64","author":"Wynne-Davies","year":"1982","journal-title":"J Bone Joint Surg Br"},{"key":"key20180108022858_b2-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/12699","article-title":"Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia","volume":"23","author":"Hurvitz","year":"1999","journal-title":"Nat Genet"},{"key":"key20180108022858_b3-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jbspin.2006.11.014","article-title":"Progressive pseudorheumatoid dysplasia: three cases in one family","volume":"74","author":"Bennani","year":"2007","journal-title":"Joint Bone Spine"},{"key":"key20180108022858_b4-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajmg.c.31333","article-title":"The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): a review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals","volume":"160C","author":"Garcia Segarra","year":"2012","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"key20180108022858_b5-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ajmg.a.30906","article-title":"Molecular study of WISP3 in nine families originating from the Middle-East and presenting with progressive pseudorheumatoid dysplasia: identification of two novel mutations and description of a founder effect","volume":"138A","author":"Delague","year":"2005","journal-title":"Am J Med Genet A"},{"key":"key20180108022858_b6-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1002\/ajmg.a.35620","article-title":"Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia","volume":"158A","author":"Dalal","year":"2012","journal-title":"Am J Med Genet A"},{"key":"key20180108022858_b7-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"e38643","DOI":"10.1371\/journal.pone.0038643","article-title":"Novel and recurrent mutations of WISP3 in two Chinese families with progressive pseudorheumatoid dysplasia","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS One"},{"key":"key20180108022858_b8-mmr-12-01-0419","first-page":"194","article-title":"Clinical diagnosis and WISP3 gene mutation analysis for progressive pseudorheumatoid dysplasia","volume":"48","author":"Ye","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"key20180108022858_b9-mmr-12-01-0419","first-page":"e151","article-title":"Progressive pseudorheumatoid chondrodysplasia of childhood","volume":"48","author":"Shivanand","year":"2007","journal-title":"Singapore Med J"},{"key":"key20180108022858_b10-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/(SICI)1096-8628(19981012)79:5<376::AID-AJMG9>3.0.CO;2-H","article-title":"International nomenclature and classification of the osteohondrodysplasias (1997): International Working Group on Constitutional Diseases of Bone","volume":"79","year":"1998","journal-title":"Am J Med Genet"},{"key":"key20180108022858_b11-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1073\/pnas.95.25.14717","article-title":"WISP3 genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors","volume":"95","author":"Pennica","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108022858_b12-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/MCB.25.1.414-421.2005","article-title":"WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice","volume":"25","author":"Kutz","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180108022858_b13-mmr-12-01-0419","first-page":"795","article-title":"The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis","volume":"25","author":"Zuo","year":"2010","journal-title":"Histol Histopathol"},{"key":"key20180108022858_b14-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tibs.2008.07.006","article-title":"The CCN family of proteins: structure-function relationships","volume":"33","author":"Holbourn","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"key20180108022858_b15-mmr-12-01-0419","first-page":"437096","article-title":"The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20180108022858_b16-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1172\/JCI32001","article-title":"The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling","volume":"117","author":"Nakamura","year":"2007","journal-title":"J Clin Invest"},{"key":"key20180108022858_b17-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/art.20005","article-title":"WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes","volume":"50","author":"Sen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"key20180108022858_b18-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"679763","DOI":"10.1155\/2013\/679763","article-title":"Dysfunction of collagen synthesis and secretion in chondrocytes induced by wisp3 mutation","volume":"2013","author":"Wang","year":"2013","journal-title":"Int J Endocrinol"},{"key":"key20180108022858_b19-mmr-12-01-0419","first-page":"8","article-title":"Construction of WISP3 gene\u2019s mutants in SEDT-PA and their expression in COS-7 cells","volume":"33","author":"Wang","year":"2008","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"key20180108022858_b20-mmr-12-01-0419","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bone.2008.11.005","article-title":"Identification of novel mutations in WISP3 gene in two unrelated Chinese families with progressive pseudorheumatoid dysplas","volume":"44","author":"Yue","year":"2009","journal-title":"Bone"},{"key":"key20180108022858_b21-mmr-12-01-0419","first-page":"190","article-title":"Patients with progressive pseudorheumatoid dysplasia: from clinical diagnosis to molecular studies","volume":"5","author":"Ye","year":"2012","journal-title":"Mol Med Rep"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3430\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T16:51:18Z","timestamp":1566406278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,3,4]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.3892\/mmr.2015.3430"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3430","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}