{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:11:00Z","timestamp":1771956660529,"version":"3.50.1"},"reference-count":25,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.3892\/mmr.2015.3523","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T13:36:54Z","timestamp":1426858614000},"page":"1247-1252","source":"Crossref","is-referenced-by-count":15,"title":["3,3\u2032-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5\u2032-adenosine monophosphate-activated protein kinase-\u03b1"],"prefix":"10.3892","volume":"12","author":[{"given":"JING","family":"ZONG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QING-QING","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HENG","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIE-YU","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUAN","family":"YUAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHOU-YAN","family":"BIAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WEI","family":"DENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIA","family":"DAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FANG-FANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAN","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI","family":"FANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QI-ZHU","family":"TANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2012,3,20]]},"reference":[{"key":"key20180108022537_b1-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0735-1097(03)00043-3","article-title":"Differential gene expression and genomic patient stratification following left ventricular assist device support","volume":"41","author":"Blaxall","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key20180108022537_b2-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1254\/jphs.10R28FM","article-title":"New molecular mechanisms for cardiovascular disease: transcriptional pathways and novel therapeutic targets in heart failure","volume":"116","author":"Kuwahara","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"key20180108022537_b3-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cardiores.2004.02.003","article-title":"Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy","volume":"63","author":"Proud","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key20180108022537_b4-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pbiomolbio.2013.07.004","article-title":"RASSF1A: A potential novel therapeutic target against cardiac hypertrophy","volume":"113","author":"Duan","year":"2013","journal-title":"Prog Biophys Mol Biol"},{"key":"key20180108022537_b5-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s13105-014-0332-5","article-title":"Attenuation of hyperglycemiamediated oxidative stress by indole-3-carbinol and its metabolite 3,3\u2032-diindolylmethane in C57BL\/6J mice","volume":"70","author":"Jayakumar","year":"2014","journal-title":"J Physiol Biochem"},{"key":"key20180108022537_b6-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/jn.109.112359","article-title":"Antiangiogenic effects of indole-3-carbinol and 3,3\u2032-diindolylmethane are associated with their differential regulation of ERK1\/2 and Akt in tube-forming HUVEC","volume":"140","author":"Kunimasa","year":"2010","journal-title":"J Nutr"},{"key":"key20180108022537_b7-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s11095-008-9581-8","article-title":"Chemoprevention of pancreatic cancer: Characterization of Par-4 and its modulation by 3,3\u2032 diindolylmethane (DIM)","volume":"25","author":"Azmi","year":"2008","journal-title":"Pahrm Res"},{"key":"key20180108022537_b8-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1038\/sj.onc.1208434","article-title":"DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways","volume":"24","author":"Xue","year":"2005","journal-title":"Oncogene"},{"key":"key20180108022537_b9-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jn\/138.1.17","article-title":"3,3\u2032-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages","volume":"138","author":"Cho","year":"2008","journal-title":"J Nutr"},{"key":"key20180108022537_b10-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"e53427","DOI":"10.1371\/journal.pone.0053427","article-title":"3,3\u2032-Diindolylmethane protects against cardiac hypertrophy via 5\u2032-adenosine monophosphate-activated protein kinase-\u03b12","volume":"8","author":"Zong","year":"2013","journal-title":"PLoS One"},{"key":"key20180108022537_b11-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/hh0901.091204","article-title":"Renin-angiotensin system in human failing hearts: message from nonmyocyte cells to myocytes","volume":"88","author":"Matsubara","year":"2001","journal-title":"Circ Res"},{"key":"key20180108022537_b12-mmr-12-01-1247","first-page":"1849","article-title":"Pathological hypertrophy and cardiac interstitium","volume":"83","author":"Weber","year":"1991","journal-title":"Fibrosis and renin-angiotensin-aldosterone system Circulation"},{"key":"key20180108022537_b13-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20180108022537_b14-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"e26744","DOI":"10.1371\/journal.pone.0026744","article-title":"Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fbrosis induced by pressure overload","volume":"6","author":"Zhou","year":"2011","journal-title":"PLoS One"},{"key":"key20180108022537_b15-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro","volume":"47","author":"Watkins","year":"2011","journal-title":"In vitro Cell Dev Biol Anim"},{"key":"key20180108022537_b16-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1042\/BST0381037","article-title":"Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening","volume":"38","author":"Dick","year":"2010","journal-title":"Biochem Soc Trans"},{"key":"key20180108022537_b17-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-4827(76)90447-X","article-title":"Properties of a clonal muscle cell line from rat heart","volume":"98","author":"Kimes","year":"1976","journal-title":"Exp Cell Res"},{"key":"key20180108022537_b18-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","article-title":"AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"52","author":"Zhang","year":"2008","journal-title":"Hyper tension"},{"key":"key20180108022537_b19-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/HYPERTENSIONAHA.112.198895","article-title":"Stem cell antigen 1 protects against cardiac hypertrophy and fibrosis after pressure overload","volume":"60","author":"Zhou","year":"2012","journal-title":"Hypertension"},{"key":"key20180108022537_b20-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180108022537_b21-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jcb.22495","article-title":"Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling","volume":"109","author":"Yan","year":"2010","journal-title":"J Cell Biochem"},{"key":"key20180108022537_b22-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.RES.0000258446.23525.37","article-title":"AMP-activated protein kinase in the heart: role during health and disease","volume":"100","author":"Arad","year":"2007","journal-title":"Circ Res"},{"key":"key20180108022537_b23-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jcb.21197","article-title":"Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy","volume":"100","author":"Li","year":"2007","journal-title":"J Cell Biochem"},{"key":"key20180108022537_b24-mmr-12-01-1247","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(99)80028-3","article-title":"Organization and regulation of mitogen-activated protein kinase signaling pathways","volume":"11","author":"Garrington","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"key20180108022537_b25-mmr-12-01-1247","article-title":"Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1\/2 signaling","author":"Zong","year":"2013","journal-title":"J Cell Biochem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3523\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T23:11:22Z","timestamp":1717801882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,20]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,3,20]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.3892\/mmr.2015.3523"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3523","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,20]]}}}