{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:14:14Z","timestamp":1788480854978,"version":"build-2803163510"},"reference-count":44,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.3892\/mmr.2015.3691","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T07:21:35Z","timestamp":1430205695000},"page":"2727-2734","source":"Crossref","is-referenced-by-count":11,"title":["Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin"],"prefix":"10.3892","volume":"12","author":[{"given":"HONG","family":"NI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QI","family":"SUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TIAN","family":"TIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XING","family":"FENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BAO-LIANG","family":"SUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"key20180108021911_b1-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cppeds.2014.12.002","article-title":"Diagnosis and management of childhood epilepsy","volume":"45","author":"Tolaymat","year":"2015","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"key20180108021911_b2-mmr-12-02-2727","first-page":"112","article-title":"Epilepsy: Novel therapeutic targets","volume":"3","author":"Anovadiya","year":"2012","journal-title":"J Pharmacol Pharmacother"},{"key":"key20180108021911_b3-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(11)70393-0","article-title":"Melatonin in experimental seizures and epilepsy","volume":"63","author":"Banach","year":"2011","journal-title":"Pharmacol Rep"},{"key":"key20180108021911_b4-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-079X.2010.00828.x","article-title":"Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy","volume":"50","author":"Uberos","year":"2011","journal-title":"J Pineal Res"},{"key":"key20180108021911_b5-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(11)70393-0","article-title":"Melatonin in experimental seizures and epilepsy","volume":"63","author":"Banach","year":"2011","journal-title":"Pharmacol Rep"},{"key":"key20180108021911_b6-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40264-013-0033-y","article-title":"Does melatonin affect epileptic seizures?","volume":"36","author":"Jain","year":"2013","journal-title":"Drug Saf"},{"key":"key20180108021911_b7-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/0883073809351315","article-title":"Melatonin in epilepsy and febrile seizures","volume":"25","author":"Ardura","year":"2010","journal-title":"J Child Neurol"},{"key":"key20180108021911_b8-mmr-12-02-2727","first-page":"CR389","article-title":"Melatonin and childhood refractory epilepsy-a pilot study","volume":"16","author":"Paprocka","year":"2010","journal-title":"Med Sci Monit"},{"key":"key20180108021911_b9-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/0883073811435916","article-title":"Effect of melatonin on seizure frequency in intractable epilepsy: A pilot study","volume":"27","author":"Goldberg-Stern","year":"2012","journal-title":"J Child Neurol"},{"key":"key20180108021911_b10-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0140-6736(05)79321-1","article-title":"Pro-convulsant effects of oral melatonin in neurologically disabled children","volume":"351","author":"Sheldon","year":"1998","journal-title":"Lancet"},{"key":"key20180108021911_b11-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(11)70393-0","article-title":"Melatonin in experimental seizures and epilepsy","volume":"63","author":"Banach","year":"2011","journal-title":"Pharmacol Rep"},{"key":"key20180108021911_b12-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/S0024-3205(03)00614-3","article-title":"Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats","volume":"73","author":"Musshoff","year":"2003","journal-title":"Life Sci"},{"key":"key20180108021911_b13-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.eplepsyres.2013.09.013","article-title":"Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats","volume":"107","author":"Forcelli","year":"2013","journal-title":"Epilepsy Res"},{"key":"key20180108021911_b14-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.toxlet.2010.02.008","article-title":"Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures","volume":"194","author":"Ni","year":"2010","journal-title":"Toxico Lett"},{"key":"key20180108021911_b15-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2012.12.010","article-title":"Expression profiles of hippocampal regenerative sprouting-related genes and their regulation byE-64 d in a developmental rat model of penicillin-induced recurrent epilepticus","volume":"217","author":"Ni","year":"2013","journal-title":"Toxico Lett"},{"key":"key20180108021911_b16-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11064-011-0578-z","article-title":"Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B","volume":"37","author":"Ni","year":"2012","journal-title":"Neurochem Res"},{"key":"key20180108021911_b17-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.yebeh.2011.07.002","article-title":"The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice","volume":"22","author":"Moezi","year":"2011","journal-title":"Epilepsy Behav"},{"key":"key20180108021911_b18-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yebeh.2011.11.018","article-title":"An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin","volume":"23","author":"Mare\u0161","year":"2012","journal-title":"Epilepsy Behav"},{"key":"key20180108021911_b19-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.toxlet.2009.04.002","article-title":"Effects of penicillin-induced developmental epilepticus on hippocampal regenerative sprouting, related gene expression and cognitive deficits in rats","volume":"188","author":"Ni","year":"2009","journal-title":"Toxico Lett"},{"key":"key20180108021911_b20-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/abio.1999.4461","article-title":"Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction","volume":"278","author":"Johnson","year":"2000","journal-title":"Anal Biochem"},{"key":"key20180108021911_b21-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jpi.12081","article-title":"Melatonin reverses the decreases in hippocampal protein serine\/threonine kinases observed in an animal model of autism","volume":"56","author":"Tian","year":"2014","journal-title":"J Pineal Res"},{"key":"key20180108021911_b22-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1600-079X.2012.01005.x","article-title":"Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury","volume":"53","author":"Koh","year":"2012","journal-title":"J Pineal Res"},{"key":"key20180108021911_b23-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000320643","article-title":"Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model","volume":"99","author":"Cetinkaya","year":"2011","journal-title":"Neonatology"},{"key":"key20180108021911_b24-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"892624","DOI":"10.1155\/2011\/892624","article-title":"Clinical uses of melatonin in pediatrics","volume":"2011","author":"S\u00e1nchez-Barcel\u00f3","year":"2011","journal-title":"Int J Pediatr"},{"key":"key20180108021911_b25-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10517-012-1873-7","article-title":"Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia","volume":"154","author":"Zamorskii","year":"2012","journal-title":"Bull Exp Biol Med"},{"key":"key20180108021911_b26-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yebeh.2013.01.009","article-title":"Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage and behavioral changes in a kainate model of temporal lobe epilepsy","volume":"27","author":"Tchekalarova","year":"2013","journal-title":"Epilepsy Behav"},{"key":"key20180108021911_b27-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"197","DOI":"10.33549\/physiolres.932295","article-title":"Changes in the density of nitrergic neurons in the hippocampus of rats following kainic acid and melatonin administration","volume":"62","author":"Jain","year":"2013","journal-title":"Physiol Res"},{"issue":"Suppl 1","key":"key20180108021911_b28-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"67","DOI":"10.33549\/physiolres.932576","article-title":"Oxidative stress induced by epileptic seizure and its attenuation by melatonin","volume":"62","author":"Mare\u0161","year":"2013","journal-title":"Physiol Res"},{"key":"key20180108021911_b29-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pbb.2013.08.006","article-title":"Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins","volume":"111","author":"Atanasova","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"key20180108021911_b30-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.toxlet.2008.11.003","article-title":"ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats","volume":"184","author":"Ni","year":"2009","journal-title":"Toxicol Lett"},{"key":"key20180108021911_b31-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-4020-8831-5_9","article-title":"Altered lipid metabolism in brain injury and disorders","volume":"49","author":"Adibhatla","year":"2008","journal-title":"Subcell Biochem"},{"key":"key20180108021911_b32-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1471-4159.2012.07670.x","article-title":"Ketone bodies in epilepsy","volume":"121","author":"McNally","year":"2012","journal-title":"J Neurochem"},{"key":"key20180108021911_b33-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbrc.2008.10.034","article-title":"Emerging functional roles of cathepsin E","volume":"377","author":"Zaidi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108021911_b34-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(94)91509-1","article-title":"An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains","volume":"667","author":"Bernstein","year":"1994","journal-title":"Brain Res"},{"key":"key20180108021911_b35-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1046\/j.1471-4159.1998.71062574.x","article-title":"Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E","volume":"71","author":"Tominaga","year":"1998","journal-title":"J Neurochem"},{"key":"key20180108021911_b36-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0167-4889(89)90003-7","article-title":"Effects of exogenous phospholipase enzymes, arachidonic acid and 1-oleoyl-2-acetyl-sn-glycerol on ketogenesis in isolated rat hepatocytes","volume":"1012","author":"Chihara","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"key20180108021911_b37-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1002\/jnr.21268","article-title":"Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide","volume":"85","author":"Farooqui","year":"2007","journal-title":"J Neurosci Res"},{"key":"key20180108021911_b38-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.brainres.2011.10.006","article-title":"Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy","volume":"1426","author":"Ruiz","year":"2011","journal-title":"Brain Res"},{"key":"key20180108021911_b39-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1210\/jc.2007-1826","article-title":"The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy","volume":"93","author":"Koster","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108021911_b40-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1126\/science.1059829","article-title":"Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure","volume":"292","author":"Yamada","year":"2001","journal-title":"Science"},{"key":"key20180108021911_b41-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-2008-1065358","article-title":"Analysis of single nucleotide polymorphisms in the melanocortin-4 receptor promoter in infantile spasms","volume":"38","author":"Liu","year":"2007","journal-title":"Neuropediatrics"},{"key":"key20180108021911_b42-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12031-012-9927-x","article-title":"Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice","volume":"49","author":"Dunleavy","year":"2013","journal-title":"J Mol Neurosci"},{"key":"key20180108021911_b43-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12031-012-9924-0","article-title":"Role of astrocytic leptin signaling against excitotoxicity","volume":"49","author":"Jayaram","year":"2013","journal-title":"J Mol Neurosci"},{"key":"key20180108021911_b44-mmr-12-02-2727","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s11064-013-1037-9","article-title":"Hippocampal gene expression profiling in a rat model of posttraumatic epilepsy reveals temporal upregulation of lipid metabolism-related genes","volume":"38","author":"Ueda","year":"2013","journal-title":"Neurochem Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3691\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T16:59:23Z","timestamp":1717865963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,4,28]]},"published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.3892\/mmr.2015.3691"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3691","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,28]]}}}