{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:08:01Z","timestamp":1770340081063,"version":"3.49.0"},"reference-count":48,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.3892\/mmr.2015.3896","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T09:25:06Z","timestamp":1433755506000},"page":"4560-4565","source":"Crossref","is-referenced-by-count":5,"title":["Study of the association of the T869C polymorphism of the transforming growth factor-\u03b21 gene with polycystic ovary syndrome"],"prefix":"10.3892","volume":"12","author":[{"given":"JUNG-HYUN","family":"PARK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAN","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KWANG-HYUN","family":"BAEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"key20180108020707_b1-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.gene.2012.11.049","article-title":"Genetic polymorphism of vitamin D receptor gene affects the phenotype of PCOS","volume":"515","author":"Zadeh-Vakili","year":"2013","journal-title":"Gene"},{"key":"key20180108020707_b2-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/jcem.84.6.5803","article-title":"Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women","volume":"84","author":"Carmina","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108020707_b3-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00006254-199906000-00024","article-title":"Polycystic ovary syndrome: Clinical perspectives and management","volume":"54","author":"Futterweit","year":"1999","journal-title":"Obstet Gynecol Surv"},{"key":"key20180108020707_b4-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"key20180108020707_b5-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"key":"key20180108020707_b6-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/humupd\/dmq032","article-title":"Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence","volume":"17","author":"Qiao","year":"2011","journal-title":"Hum Reprod Update"},{"key":"key20180108020707_b7-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.fertnstert.2013.04.022","article-title":"Transforming growth factor-beta1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation","volume":"100","author":"Tal","year":"2013","journal-title":"Fertil Steril"},{"key":"key20180108020707_b8-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1385\/ENDO:30:1:19","article-title":"The role of genes and environment in the etiology of PCOS","volume":"30","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Endocrine"},{"key":"key20180108020707_b9-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"178364","DOI":"10.1155\/2013\/178364","article-title":"Metabolic disturbance in PCOS: clinical and molecular effects on skeletal muscle tissue","volume":"2013","author":"Dantas","year":"2013","journal-title":"Scientific World J"},{"key":"key20180108020707_b10-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejogrb.2004.06.024","article-title":"PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis?","volume":"118","author":"Doi","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key20180108020707_b11-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.steroids.2011.12.001","article-title":"Metabolic dysfunction in pcos: Relationship to obstructive sleep apnea","volume":"77","author":"Ehrmann","year":"2012","journal-title":"Steroids"},{"key":"key20180108020707_b12-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2005.10.017","article-title":"Genomic variants in polycystic ovary syndrome","volume":"366","author":"Luque-Ram\u00edrez","year":"2006","journal-title":"Clin Chim Acta"},{"key":"key20180108020707_b13-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1210\/jc.2005-0622","article-title":"Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2","volume":"90","author":"Urbanek","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108020707_b14-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1210\/jc.2006-0951","article-title":"Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity","volume":"91","author":"Stewart","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108020707_b15-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1369\/jhc.2010.956615","article-title":"Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS?","volume":"58","author":"Jordan","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"key20180108020707_b16-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","article-title":"Regulation of immune responses by TGF-beta","volume":"16","author":"Letterio","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"key20180108020707_b17-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7258(03)00035-4","article-title":"Genealogy, expression and cellular function of transforming growth factor-beta","volume":"98","author":"Govinden","year":"2003","journal-title":"Pharmacol Ther"},{"key":"key20180108020707_b18-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0065-230X(08)60740-X","article-title":"Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion","volume":"75","author":"Taipale","year":"1998","journal-title":"Adv Cancer Res"},{"key":"key20180108020707_b19-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","article-title":"New insights into TGF-beta-Smad signalling","volume":"29","author":"Ten Dijke","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"key20180108020707_b20-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.cco.0000143682.45316.ae","article-title":"Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter","volume":"17","author":"Bachman","year":"2005","journal-title":"Curr Opin Oncol"},{"key":"key20180108020707_b21-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1242\/jcs.114.24.4359","article-title":"Smad regulation in TGF-beta signal transduction","volume":"114","author":"Moustakas","year":"2001","journal-title":"J Cell Sci"},{"key":"key20180108020707_b22-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/35043051","article-title":"How cells read TGF-beta signals","volume":"1","author":"Massagu\u00e9","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180108020707_b23-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"key20180108020707_b24-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1083\/jcb.200407027","article-title":"TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling","volume":"168","author":"K\u00f6nig","year":"2005","journal-title":"J Cell Biol"},{"key":"key20180108020707_b25-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"key20180108020707_b26-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.nbd.2008.01.007","article-title":"TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway","volume":"30","author":"Caraci","year":"2008","journal-title":"Neurobiol Dis"},{"key":"key20180108020707_b27-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.neuroscience.2003.10.037","article-title":"Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase\/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1, 2 signaling pathways","volume":"123","author":"Zhu","year":"2004","journal-title":"Neuroscience"},{"key":"key20180108020707_b28-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1389202911314020007","article-title":"Role of the transformin g-growth-factor-beta1 gene in late-onset Alzheimer's disease: implications for the treatment","volume":"14","author":"Bosco","year":"2013","journal-title":"Curr Genomics"},{"key":"key20180108020707_b29-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1471-0528.2010.02527.x","article-title":"Association study of four key folliculogenesis genes in polycystic ovary syndrome","volume":"117","author":"Sproul","year":"2010","journal-title":"BJOG"},{"key":"key20180108020707_b30-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1210\/jc.2005-0695","article-title":"Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis","volume":"90","author":"Welt","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108020707_b31-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/humrep\/16.12.2552","article-title":"Follistatin and activin A serum concentrations in obese and non-obese patients with polycystic ovary syndrome","volume":"16","author":"Eldar-Geva","year":"2001","journal-title":"Hum Reprod"},{"key":"key20180108020707_b32-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1096\/fj.11-181099","article-title":"Linkage of regulators of TGF-beta activity in the fetal ovary to polycystic ovary syndrome","volume":"25","author":"Hatzirodos","year":"2011","journal-title":"FASEB J"},{"issue":"4 Suppl 1","key":"key20180108020707_b33-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/ajkd.2001.27439","article-title":"Association of transforming growth factor-beta1 T29C polymorphism with the progression of diabetic nephropathy","volume":"38","author":"Akai","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"key20180108020707_b34-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1476-511X-10-100","article-title":"Association of transforming growth factor-beta1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study","volume":"10","author":"Peng","year":"2011","journal-title":"Lipids Health Dis"},{"key":"key20180108020707_b35-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12020-011-9503-0","article-title":"Association between the T869C polymorphism of transforming growth factor-beta 1 and diabetic nephropathy: a meta-analysis","volume":"40","author":"Jia","year":"2011","journal-title":"Endocrine"},{"key":"key20180108020707_b36-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/abbs\/gmt003","article-title":"Gene polymorphism of transforming growth factor-beta1 in Egyptian patients with type 2 diabetes and diabetic nephropathy","volume":"45","author":"El-Sherbini","year":"2013","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180108020707_b37-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.canep.2013.04.013","article-title":"Clinical significance of serum transforming growth factor-beta1 in lung cancer","volume":"37","author":"Hou","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"key20180108020707_b38-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00439-005-0112-y","article-title":"Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms","volume":"119","author":"Shah","year":"2006","journal-title":"Hum Genet"},{"key":"key20180108020707_b39-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"key":"key20180108020707_b40-mmr-12-03-4560","first-page":"F829","article-title":"The emerging role of transforming growth factor-beta in kidney diseases","volume":"266","author":"Sharma","year":"1994","journal-title":"Am J Physiol"},{"key":"key20180108020707_b41-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM199411103311907","article-title":"Transforming growth factor beta in tissue fibrosis","volume":"331","author":"Border","year":"1994","journal-title":"N Engl J Med"},{"key":"key20180108020707_b42-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-0028-1108006","article-title":"Roles for transforming growth factor beta superfamily proteins in early folliculogenesis","volume":"27","author":"Trombly","year":"2009","journal-title":"Semin Reprod Med"},{"key":"key20180108020707_b43-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.fertnstert.2010.05.047","article-title":"A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome","volume":"94","author":"Raja-Khan","year":"2010","journal-title":"Fertil Steril"},{"key":"key20180108020707_b44-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1933719113485294","article-title":"The role of TGF-beta in polycystic ovary syndrome","volume":"21","author":"Raja-Khan","year":"2014","journal-title":"Reprod Sci"},{"key":"key20180108020707_b45-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2007-992925","article-title":"Implications of polycystic ovary syndrome on oocyte development","volume":"26","author":"Dumesic","year":"2008","journal-title":"Semin Reprod Med"},{"key":"key20180108020707_b46-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"p69","DOI":"10.1159\/000104874","article-title":"TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes","volume":"106","author":"Buraczynska","year":"2007","journal-title":"Nephron Physiol"},{"key":"key20180108020707_b47-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1046\/j.1523-1755.2003.00919.x","article-title":"Association of transforming growth factor-beta (TGF-beta) T869C (Leu 10Pro) gene polymorphisms with type 2 diabetic nephropathy in Chinese","volume":"63","author":"Wong","year":"2003","journal-title":"Kidney Int"},{"key":"key20180108020707_b48-mmr-12-03-4560","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.3896\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:13:30Z","timestamp":1748434410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.3896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,6,8]]},"published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.3892\/mmr.2015.3896"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.3896","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}