{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:14:29Z","timestamp":1771956869229,"version":"3.50.1"},"reference-count":32,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.3892\/mmr.2015.4000","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T12:56:05Z","timestamp":1435236965000},"page":"4434-4440","source":"Crossref","is-referenced-by-count":17,"title":["Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis"],"prefix":"10.3892","volume":"12","author":[{"given":"TAE-HO","family":"KIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEUNG-HOON","family":"BAEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEONG OK","family":"LIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANG-HAN","family":"LEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIN-YOON","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"key20180108020256_b1-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin Arthritis Rheum"},{"key":"key20180108020256_b2-mmr-12-03-4434","first-page":"68","article-title":"The role of fat embolism in the etiology of corticosteroid-induced avascular necrosis: clinical and experimental results","volume":"130","author":"Fisher","year":"1978","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b3-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.blo.0000063602.67412.83","article-title":"Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis","volume":"410","author":"Wang","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b4-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/CRIAI:25:1:13","article-title":"Osteonecrosis in patients with SLE","volume":"25","author":"Abu-Shakra","year":"2003","journal-title":"Clin Rev Allergy Immunol"},{"key":"key20180108020256_b5-mmr-12-03-4434","first-page":"783","article-title":"Procoagulants and osteonecrosis","volume":"30","author":"Jones","year":"2003","journal-title":"J Rheumatol"},{"key":"key20180108020256_b6-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00402-004-0760-8","article-title":"Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee","volume":"125","author":"Bjorkman","year":"2005","journal-title":"Arch Orthop Trauma Surg"},{"key":"key20180108020256_b7-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1055\/s-0037-1613138","article-title":"Factor V Leiden and prothrombin gene mutations in femoral head osteonecrosis","volume":"87","author":"Zalavras","year":"2002","journal-title":"Thromb Haemost"},{"key":"key20180108020256_b8-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1210\/endo.140.11.7135","article-title":"Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro","volume":"140","author":"Gohel","year":"1999","journal-title":"Endocrinology"},{"key":"key20180108020256_b9-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2106\/00004623-198567050-00010","article-title":"Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head. A histochemical and electron microscopic study","volume":"67","author":"Kawai","year":"1985","journal-title":"J Bone Joint Surg Am"},{"key":"key20180108020256_b10-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10623320600904211","article-title":"Avascular necrosis of the femoral head: vascular hypotheses","volume":"13","author":"Kerachian","year":"2006","journal-title":"Endothelium"},{"key":"key20180108020256_b11-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.blo.0000127921.13253.e3","article-title":"Genetic background of osteonecrosis: associated with thrombophilic mutations?","volume":"422","author":"Zalavras","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b12-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00003086-200408000-00023","article-title":"Factor V leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults","volume":"425","author":"Bjorkman","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b13-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/01.blo.0000092972.12414.a5","article-title":"Role of thrombotic and fibrinolytic disorders in osteonecrosis of the femoral head","volume":"417","author":"Lee","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b14-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s11999-008-0147-1","article-title":"Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population","volume":"466","author":"Chang","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b15-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1055\/s-0037-1614563","article-title":"Prevalence of prothrombin G20210A, F5 G1691A (Leiden) and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR","volume":"81","author":"Hessner","year":"1999","journal-title":"Thromb Haemost"},{"key":"key20180108020256_b16-mmr-12-03-4434","first-page":"259","article-title":"Factor V Leiden gene mutation in femoral head osteonecrosis","volume":"6","author":"Kim","year":"2003","journal-title":"J Korean Ortho Res Soc"},{"key":"key20180108020256_b17-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.joca.2006.12.007","article-title":"Association study of hypoxia inducible factor 1\u03b1 (HIF1\u03b1) with osteonecrosis of femoral head in a Korean population","volume":"15","author":"Hong","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"key20180108020256_b18-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1469-1809.2008.00490.x","article-title":"Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans","volume":"73","author":"Lee","year":"2009","journal-title":"Ann Hum Genet"},{"key":"key20180108020256_b19-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/genetics\/117.2.331","article-title":"Gametic disequilibrium measures: proceed with caution","volume":"117","author":"Hedrick","year":"1987","journal-title":"Genetics"},{"key":"key20180108020256_b20-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"key20180108020256_b21-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-199701000-00007","article-title":"Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis","volume":"334","author":"Glueck","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b22-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003086-199705000-00021","article-title":"Resistance to activated protein C and Legg-Perthes disease","volume":"338","author":"Glueck","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b23-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0022-3476(98)70326-9","article-title":"Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the F5 Leiden mutation","volume":"132","author":"Gruppo","year":"1998","journal-title":"J Pediatr"},{"key":"key20180108020256_b24-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00003086-199909000-00017","article-title":"The plasminogen activator inhibitor-1 gene, hypofibrinolysis and osteonecrosis","volume":"366","author":"Glueck","year":"1999","journal-title":"Clin Orthop Relat Res"},{"key":"key20180108020256_b25-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.transproceed.2005.12.062","article-title":"Association of corticosteroids and F5, prothrombin and MTHFR gene mutations with avascular osteonecrosis in renal allograft recipients","volume":"38","author":"Celik","year":"2006","journal-title":"Transplant Proc"},{"issue":"Suppl 1","key":"key20180108020256_b26-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/1098-2272(2000)19:1+<::AID-GEPI5>3.0.CO;2-P","article-title":"An analysis of strategies for discovery of single-nucleotide polymorphisms","volume":"19","author":"Eberle","year":"2000","journal-title":"Genet Epidemiol"},{"key":"key20180108020256_b27-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ajpa.20923","article-title":"Mitochondrial DNA analysis of Jomon skeletons from the Funadomari site, Hokkaido and its implication for the origins of Native American","volume":"138","author":"Adachi","year":"2009","journal-title":"Am J Phys Anthropol"},{"key":"key20180108020256_b28-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"e11855","DOI":"10.1371\/journal.pone.0011855","article-title":"Gene flow between the Korean peninsula and its neighboring countries","volume":"5","author":"Jung","year":"2010","journal-title":"PloS one"},{"key":"key20180108020256_b29-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1055\/s-0037-1615100","article-title":"Factor V Leiden (G1691A), the prothrombin 3\u2032-untranslated region variant (G20210A) and thermolabile methylenetetrahydrofolate reductase (C677T): a single genetic test genotypes all three loci-determination of frequencies in the S. Wales population of the UK","volume":"79","author":"Bowen","year":"1998","journal-title":"Thromb Haemost"},{"key":"key20180108020256_b30-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of F5 Leiden","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"key20180108020256_b31-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0038-1655963","article-title":"Prevalence of F5 Leiden mutation in non-European populations","volume":"77","author":"Pepe","year":"1997","journal-title":"Thromb Haemost"},{"key":"key20180108020256_b32-mmr-12-03-4434","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s11999-008-0148-0","article-title":"Heritable thrombo-philia-hypofibrinolysis and osteonecrosis of the femoral head","volume":"466","author":"Glueck","year":"2008","journal-title":"Clin Orthop Relat Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4000\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T19:53:21Z","timestamp":1691783601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,6,25]]},"published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.3892\/mmr.2015.4000"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4000","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}