{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:57:20Z","timestamp":1694948240959},"reference-count":64,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.3892\/mmr.2015.4019","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T09:03:17Z","timestamp":1435827797000},"page":"5508-5516","source":"Crossref","is-referenced-by-count":4,"title":["Molecular cloning and characterization of presenilin gene in Bombyx mori"],"prefix":"10.3892","volume":"12","author":[{"given":"ZENG-ZHANG","family":"ZHENG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MENG-LING","family":"CHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZONG-BIAO","family":"FAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI-JIAO","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONG-SHENG","family":"SONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"issue":"Suppl 1","key":"key20180108021050_b1-mmr-12-04-5508","first-page":"S5","article-title":"A brief history of Alzheimer's disease gene discovery","volume":"33","author":"Tanzi","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key20180108021050_b2-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2047-9158-2-15","article-title":"Biological function of Presenilin and its role in AD pathogenesis","volume":"2","author":"Zhang","year":"2013","journal-title":"Transl Neurodegener"},{"key":"key20180108021050_b3-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neurobiolaging.2008.06.012","article-title":"Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP","volume":"31","author":"Guerreiro","year":"2010","journal-title":"Neurobiol Aging"},{"key":"key20180108021050_b4-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/hmg\/9.3.325","article-title":"Genetic variability in the regulatory region of presenilin1 associated with risk for Alzheimer's disease and variable expression","volume":"9","author":"Theuns","year":"2000","journal-title":"Hum Mol Genet"},{"key":"key20180108021050_b5-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"Suppl 2","key":"key20180108021050_b6-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"S281","DOI":"10.3233\/JAD-2010-100495","article-title":"Is Alzheimer's disease a disorder of mitochondria-associated membranes?","volume":"20","author":"Schon","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"key20180108021050_b7-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"key20180108021050_b8-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a novel gene on chromosome 1 related to the Alzheimer's Disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"key20180108021050_b9-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/156720508783954695","article-title":"Assembly, maturation and trafficking of the gamma-secretase complex in Alzheimer's disease","volume":"5","author":"Dries","year":"2008","journal-title":"Curr Alzheimer Res"},{"key":"key20180108021050_b10-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(03)00205-8","article-title":"Aph-1, pen-2 and nicastrin with presenilin generate an active gamma-secretase complex","volume":"38","author":"De Strooper","year":"2003","journal-title":"Neuron"},{"key":"key20180108021050_b11-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1474-4422(09)70332-1","article-title":"Gamma-secretases: From cell biology to therapeutic strategies","volume":"9","author":"Bergmans","year":"2010","journal-title":"Lancet Neurol"},{"key":"key20180108021050_b12-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's Disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N Engl J Med"},{"key":"key20180108021050_b13-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/sj.emboj.7600251","article-title":"PS1 activates PI3K thus inhibiting GSK-3 activity and tau over phosphorylation: effects of FAD mutations","volume":"23","author":"Baki","year":"2004","journal-title":"EMBO J"},{"key":"key20180108021050_b14-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/JAD-2012-121204","article-title":"Invertebrate models of Alzheimer's disease","volume":"33","author":"Mhatre","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key20180108021050_b15-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.exger.2010.08.004","article-title":"Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease","volume":"46","author":"Bonner","year":"2011","journal-title":"Exp Gerontol"},{"key":"key20180108021050_b16-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tibs.2009.11.004","article-title":"Alzheimer's disease: Insights from Drosophila melanogaster models","volume":"35","author":"Moloney","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"key20180108021050_b17-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1601-183X.2004.00105.x","article-title":"Invertebrate models of Alzheimer's disease","volume":"4","author":"Link","year":"2005","journal-title":"Genes Brain Behav"},{"key":"key20180108021050_b18-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/377351a0","article-title":"Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene","volume":"377","author":"Levitan","year":"1995","journal-title":"Nature"},{"key":"key20180108021050_b19-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/19091","article-title":"Presenilin is required for activity and nuclear access of notch in Drosophila","volume":"398","author":"Struhl","year":"1999","journal-title":"Nature"},{"key":"key20180108021050_b20-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/19096","article-title":"Neurogenic phenotypes and altered notch processing in Drosophila Presenilin mutants","volume":"398","author":"Ye","year":"1999","journal-title":"Nature"},{"key":"key20180108021050_b21-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1523\/JNEUROSCI.19-19-08435.1999","article-title":"Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling","volume":"19","author":"Guo","year":"1999","journal-title":"J Neurosci"},{"key":"key20180108021050_b22-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1534\/genetics.104.035170","article-title":"Presenilin-based genetic screens in Drosophila melano- gaster identify novel notch pathway modifiers","volume":"172","author":"Mahoney","year":"2006","journal-title":"Genetics"},{"key":"key20180108021050_b23-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dvg.20485","article-title":"Identifying genes that interact with Drosophila presenilin and amyloid precursor protein","volume":"47","author":"van de Hoef","year":"2009","journal-title":"Genesis"},{"key":"key20180108021050_b24-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1083\/jcb.146.6.1351","article-title":"Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster","volume":"146","author":"Ye","year":"1999","journal-title":"J Cell Biol"},{"key":"key20180108021050_b25-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1073\/pnas.0308259100","article-title":"Notch is required for long-term memory in Drosophila","volume":"101","author":"Presente","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b26-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/dneu.20532","article-title":"Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant","volume":"67","author":"Knight","year":"2007","journal-title":"Dev Neurobiol"},{"key":"key20180108021050_b27-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1096\/fj.06-6380com","article-title":"A role for presenilin in post-stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila","volume":"21","author":"Lu","year":"2007","journal-title":"FASEB J"},{"key":"key20180108021050_b28-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"e6904","DOI":"10.1371\/journal.pone.0006904","article-title":"Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin","volume":"4","author":"Michno","year":"2009","journal-title":"PLoS One"},{"key":"key20180108021050_b29-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"9510","DOI":"10.1523\/JNEUROSCI.1017-10.2010","article-title":"Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function","volume":"30","author":"McBride","year":"2010","journal-title":"J Neurosci"},{"key":"key20180108021050_b30-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1073\/pnas.96.6.3263","article-title":"Evidence for a physical interaction between presenilin and Notch","volume":"96","author":"Ray","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b31-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"7102","DOI":"10.1073\/pnas.102192599","article-title":"The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling","volume":"99","author":"Roncarati","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b32-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bbrc.2009.10.093","article-title":"Alzheimer's disease and notch signaling","volume":"390","author":"Woo","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108021050_b33-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"e18292","DOI":"10.1371\/journal.pone.0018292","article-title":"An invertebrate hyperglycemic model for the identification of anti-diabetic drugs","volume":"6","author":"Matsumoto","year":"2011","journal-title":"PLoS One"},{"key":"key20180108021050_b34-mmr-12-04-5508","first-page":"226","article-title":"Animal welfare and use of silkworm as a model animal","volume":"6","author":"Sekimizu","year":"2012","journal-title":"Drug Discov Ther"},{"key":"key20180108021050_b35-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1038\/sj.emboj.7600478","article-title":"The presenilin C-terminus is required for ER- retention, nicastrin-binding and gamma-secretase activity","volume":"23","author":"Kaether","year":"2004","journal-title":"EMBO J"},{"key":"key20180108021050_b36-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.semcdb.2008.12.011","article-title":"Gamma-secretase in biology and medicine","volume":"20","author":"Wolfe","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"key20180108021050_b37-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"38390","DOI":"10.1074\/jbc.M111.252429","article-title":"Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding and \u03b3-secretase complex stabilization","volume":"286","author":"Fassler","year":"2011","journal-title":"J Biol Chem"},{"key":"key20180108021050_b38-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1523\/JNEUROSCI.1163-08.2008","article-title":"The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase","volume":"28","author":"Sato","year":"2008","journal-title":"J Neurosci"},{"key":"key20180108021050_b39-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"19793","DOI":"10.1074\/jbc.M802461200","article-title":"Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase","volume":"283","author":"Tolia","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180108021050_b40-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.1073\/pnas.1000778107","article-title":"Structural investigation of the C-terminal catalytic fragment of presenilin 1","volume":"107","author":"Sobhanifar","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b41-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"16474","DOI":"10.1074\/jbc.C300095200","article-title":"Gamma-secretase activity is associated with a conformational change of nicastrin","volume":"278","author":"Shirotani","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180108021050_b42-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1523\/JNEUROSCI.5384-05.2006","article-title":"Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology","volume":"26","author":"Deng","year":"2006","journal-title":"J Neurosci"},{"key":"key20180108021050_b43-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s00018-009-8435-9","article-title":"Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity","volume":"66","author":"McCarthy","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"key20180108021050_b44-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0140-6736(96)90261-5","article-title":"Mutation analysis of presenillin 1 gene in Alzheimer's disease","volume":"347","author":"Boteva","year":"1996","journal-title":"Lancet"},{"key":"key20180108021050_b45-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0140-6736(95)91723-3","article-title":"Familial Alzheimer's disease associated with S182 codon 286 mutation","volume":"346","author":"Chapman","year":"1995","journal-title":"Lancet"},{"key":"key20180108021050_b46-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00001756-199703030-00041","article-title":"Cloning and characterization of the Drosophila presenilin homologue","volume":"8","author":"Boulianne","year":"1997","journal-title":"Neuroreport"},{"key":"key20180108021050_b47-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00001756-199702100-00017","article-title":"Isolation and characterization of Drosophila presenilin homolog","volume":"8","author":"Hong","year":"1997","journal-title":"Neuroreport"},{"key":"key20180108021050_b48-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1073\/pnas.0810916106","article-title":"Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans","volume":"106","author":"Calvo","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b49-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1128\/MCB.20.23.8635-8642.2000","article-title":"Upstream open reading frames as regulators of mRNA translation","volume":"20","author":"Morris","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key20180108021050_b50-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrg2142","article-title":"Translation matters: Protein synthesis defects in inherited disease","volume":"8","author":"Scheper","year":"2007","journal-title":"Nat Rev Genet"},{"key":"key20180108021050_b51-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng.276","article-title":"Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis","volume":"41","author":"Wen","year":"2009","journal-title":"Nat Genet"},{"key":"key20180108021050_b52-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2164-9-61","article-title":"Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species","volume":"9","author":"Hayden","year":"2008","journal-title":"BMC Genomics"},{"key":"key20180108021050_b53-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/gb-2011-12-7-121","article-title":"Sex lethal and upstream ORFs: A bait-and-trap system for ribosomes","volume":"12","author":"Yao","year":"2011","journal-title":"Genome Biol"},{"key":"key20180108021050_b54-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"27633","DOI":"10.1074\/jbc.M604997200","article-title":"Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex","volume":"281","author":"Tolia","year":"2006","journal-title":"J Biol Chem"},{"key":"key20180108021050_b55-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1074\/jbc.M109.055590","article-title":"The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing","volume":"285","author":"Wanngren","year":"2010","journal-title":"J Biol Chem"},{"key":"key20180108021050_b56-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1242\/jcs.113.19.3499","article-title":"Physical and genetic interaction of filamin with presenilin in Drosophila","volume":"113","author":"Guo","year":"2000","journal-title":"J Cell Sci"},{"key":"key20180108021050_b57-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-1119(01)00770-3","article-title":"Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins","volume":"280","author":"Zhang","year":"2001","journal-title":"Gene"},{"key":"key20180108021050_b58-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/mcne.1999.0805","article-title":"Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin","volume":"15","author":"Nowotny","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"key20180108021050_b59-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1073\/pnas.96.12.6959","article-title":"Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations","volume":"96","author":"Song","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021050_b60-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1523\/JNEUROSCI.19-11-04229.1999","article-title":"Presenilin 1 facilitates the constitutive turnover of \u03b2-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in \u03b2-catenin-signaling pathway","volume":"19","author":"Kang","year":"1999","journal-title":"J Neurosci"},{"key":"key20180108021050_b61-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1523\/JNEUROSCI.4386-03.2004","article-title":"Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability","volume":"24","author":"Stutzmann","year":"2004","journal-title":"J Neurosci"},{"key":"key20180108021050_b62-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.152.4.785","article-title":"Presenilin 1 negatively regulates beta-catenin\/T cell factor\/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing","volume":"152","author":"Soriano","year":"2001","journal-title":"J Cell Biol"},{"key":"key20180108021050_b63-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1523\/JNEUROSCI.16-23-07513.1996","article-title":"Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues","volume":"16","author":"Lee","year":"1996","journal-title":"J Neurosci"},{"key":"key20180108021050_b64-mmr-12-04-5508","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1098\/rstb.2010.0271","article-title":"Ageing and protein aggregation-mediated disorders: from invertebrates to mammals","volume":"366","author":"Dillin","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4019\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T18:37:07Z","timestamp":1652726227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,2]]},"references-count":64,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,7,2]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.3892\/mmr.2015.4019"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4019","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,2]]}}}