{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:46:22Z","timestamp":1790340382565,"version":"4.1.0"},"reference-count":33,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.3892\/mmr.2015.4271","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T12:00:09Z","timestamp":1440763209000},"page":"6679-6687","source":"Crossref","is-referenced-by-count":21,"title":["Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease"],"prefix":"10.3892","volume":"12","author":[{"given":"WANHUA","family":"HU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAODONG","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KELONG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"key20180108021346_b1-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000335568","article-title":"Review of cerebral microangiopathy and Alzheimer's disease: Relation between white matter hyperintensities and microbleeds","volume":"32","author":"Hommet","year":"2011","journal-title":"Dement Geriatr Cogn Disord"},{"key":"key20180108021346_b2-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"key20180108021346_b3-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO;2-3","article-title":"Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment","volume":"49","author":"Kordower","year":"2001","journal-title":"Ann Neurol"},{"key":"key20180108021346_b4-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"key20180108021346_b5-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1212\/WNL.0b013e3181f736a1","article-title":"Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI","volume":"75","author":"Kerchner","year":"2010","journal-title":"Neurology"},{"key":"key20180108021346_b6-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid precursor protein processing and Alzheimer's disease","volume":"34","author":"O'Brien","year":"2011","journal-title":"Annu Rev Neurosci"},{"key":"key20180108021346_b7-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fneur.2013.00083","article-title":"The importance of tau phosphorylation for neurodegenerative diseases","volume":"4","author":"Noble","year":"2013","journal-title":"Front Neurol"},{"key":"key20180108021346_b8-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","article-title":"Tau protein kinases: Involvement in Alzheimer's disease","volume":"12","author":"Martin","year":"2013","journal-title":"Ageing Res Rev"},{"key":"key20180108021346_b9-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"key20180108021346_b10-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0301-0082(02)00079-5","article-title":"Alzheimer's disease and the basal forebrain cholinergic system: Relations to beta-amyloid peptides, cognition and treatment strategies","volume":"68","author":"Auld","year":"2002","journal-title":"Prog Neurobiol"},{"issue":"Suppl 1","key":"key20180108021346_b11-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"S554","DOI":"10.1002\/gepi.2001.21.s1.s554","article-title":"Exploring haplotype sharing methods in general and isolated populations to detect gene(s) of a complex genetic trait","volume":"21","author":"Beckmann","year":"2001","journal-title":"Genet Epidemiol"},{"key":"key20180108021346_b12-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.0308512100","article-title":"Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses","volume":"101","author":"Blalock","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108021346_b13-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/jnr.10351","article-title":"Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling","volume":"70","author":"Colangelo","year":"2002","journal-title":"J Neurosci Res"},{"key":"key20180108021346_b14-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1023\/A:1020952704398","article-title":"Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease","volume":"27","author":"Mufson","year":"2002","journal-title":"Neurochem Res"},{"key":"key20180108021346_b15-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1093\/nar\/gkl404","article-title":"Sequence biases in large scale gene expression profiling data","volume":"34","author":"Siddiqui","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"key20180108021346_b16-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets-update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"key20180108021346_b17-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2164-6-60","article-title":"PathwayVoyager: Pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database","volume":"6","author":"Altermann","year":"2005","journal-title":"BMC Genomics"},{"key":"key20180108021346_b18-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"W478","DOI":"10.1093\/nar\/gks402","article-title":"GeneCodis3: A non-redundant and modular enrichment analysis tool for functional genomics","volume":"40","author":"Tabas-Madrid","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key20180108021346_b19-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1126\/science.1090289","article-title":"A protein interaction map of Drosophila melanogaster","volume":"302","author":"Giot","year":"2003","journal-title":"Science"},{"key":"key20180108021346_b20-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"e1002860","DOI":"10.1371\/journal.pcbi.1002860","article-title":"Adding protein context to the human protein-protein interaction network to reveal meaningful interactions","volume":"9","author":"Schaefer","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"key20180108021346_b21-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"key20180108021346_b22-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/gm452","article-title":"Genes and pathways underlying regional and cell type changes in Alzheimer's disease","volume":"5","author":"Miller","year":"2013","journal-title":"Genome Med"},{"key":"key20180108021346_b23-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/cercor\/bht101","article-title":"Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study","volume":"24","author":"Hokama","year":"2014","journal-title":"Cereb Cortex"},{"key":"key20180108021346_b24-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physiolgenomics.00208.2006","article-title":"Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain","volume":"28","author":"Liang","year":"2007","journal-title":"Physiol Genomics"},{"key":"key20180108021346_b25-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-1119(98)00615-5","article-title":"Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein","volume":"228","author":"Meagher","year":"1999","journal-title":"Gene"},{"key":"key20180108021346_b26-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-1119(01)00620-5","article-title":"Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr","volume":"275","author":"Kleines","year":"2001","journal-title":"Gene"},{"key":"key20180108021346_b27-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1126\/science.1247363","article-title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders","volume":"343","author":"Novarino","year":"2014","journal-title":"Science"},{"key":"key20180108021346_b28-mmr-12-05-6679","first-page":"201","article-title":"S100-mediated signal transduction in the nervous system and neurological diseases","volume":"51","author":"Zimmer","year":"2005","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"key20180108021346_b29-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbamcr.2004.09.011","article-title":"Astrocytic calcium\/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1\/APP transgenic mice models","volume":"1742","author":"Boom","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"key20180108021346_b30-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2119\/2007-00034.Bellucci","article-title":"Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease","volume":"13","author":"Bellucci","year":"2007","journal-title":"Mol Med"},{"key":"key20180108021346_b31-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jneumeth.2011.05.026","article-title":"Normalization of gene expression using SYBR green qPCR: A case for paraoxonase 1 and 2 in Alzheimer's disease brains","volume":"200","author":"Leduc","year":"2011","journal-title":"J Neurosci Methods"},{"key":"key20180108021346_b32-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/cm.20388","article-title":"Cytoskeletal pathologies of Alzheimer disease","volume":"66","author":"Bamburg","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"key":"key20180108021346_b33-mmr-12-05-6679","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1073\/pnas.0709259105","article-title":"Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons","volume":"105","author":"Liang","year":"2008","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4271\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T04:13:54Z","timestamp":1515384834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,28]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,8,28]]},"published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.3892\/mmr.2015.4271"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4271","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,28]]}}}