{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:22:14Z","timestamp":1761740534797},"reference-count":38,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.3892\/mmr.2015.4428","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:25:32Z","timestamp":1444692332000},"page":"8101-8106","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of pro-collagen I expression by oxymatrine in hepatic stellate cells is mediated via nuclear translocation of Y-box binding protein 1"],"prefix":"10.3892","volume":"12","author":[{"given":"MEILING","family":"DU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNAN","family":"XU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENSHUAI","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIE","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FEI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"key20180108023059_b1-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCULATIONAHA.107.708016","article-title":"Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice","volume":"116","author":"Krohn","year":"2007","journal-title":"Circulation"},{"key":"key20180108023059_b2-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/bcr1767","article-title":"Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy","volume":"9","author":"Stratford","year":"2007","journal-title":"Breast Cancer Res"},{"key":"key20180108023059_b3-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/gtc.12150","article-title":"YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers","volume":"19","author":"Harada","year":"2014","journal-title":"Genes Cells"},{"key":"key20180108023059_b4-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/nar\/gkh170","article-title":"YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins","volume":"32","author":"Gaudreault","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"key20180108023059_b5-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1074\/jbc.M413353200","article-title":"Transcription factor YB-1 mediates DNA polymerase alpha gene expression","volume":"280","author":"En-Nia","year":"2005","journal-title":"J Biol Chem"},{"key":"key20180108023059_b6-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"28562","DOI":"10.1074\/jbc.M100311200","article-title":"Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters","volume":"276","author":"Stein","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108023059_b7-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/onc.2010.435","article-title":"Human AP endonuclease (APE1\/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1","volume":"30","author":"Sengupta","year":"2011","journal-title":"Oncogene"},{"key":"key20180108023059_b8-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1073\/pnas.85.19.7322","article-title":"Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box","volume":"85","author":"Didier","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108023059_b9-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1158\/1535-7163.1485.3.11","article-title":"The role of nuclear Y-box binding protein 1 as a global marker in drug resistance","volume":"3","author":"Kuwano","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"key20180108023059_b10-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"27988","DOI":"10.1074\/jbc.M212966200","article-title":"YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression","volume":"278","author":"Jurchott","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180108023059_b11-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1134\/S0006297911130049","article-title":"Y-box-binding protein 1 (YB-1) and its functions","volume":"76","author":"Eliseeva","year":"2011","journal-title":"Biochemistry (Mosc)"},{"key":"key20180108023059_b12-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hep.26056","article-title":"Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury","volume":"57","author":"Ghiassi-Nejad","year":"2013","journal-title":"Hepatology"},{"key":"key20180108023059_b13-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0945-053X(01)00163-9","article-title":"A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene","volume":"20","author":"Sun","year":"2001","journal-title":"Matrix Biol"},{"key":"key20180108023059_b14-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"29880","DOI":"10.1074\/jbc.M103145200","article-title":"The Y-box binding protein YB-1 suppresses collagen alpha 1(I) gene transcription via an evolutionarily conserved regulatory element in the proximal promoter","volume":"276","author":"Norman","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108023059_b15-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1074\/jbc.M208724200","article-title":"Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma","volume":"278","author":"Higashi","year":"2003","journal-title":"J Biol Chem"},{"issue":"Suppl 2","key":"key20180108023059_b16-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1111\/j.1440-1746.2011.07006.x","article-title":"Novel anti-fibrotic modalities for liver fibrosis: Molecular targeting and regenerative medicine in fibrosis therapy","volume":"27","author":"Inagaki","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"key20180108023059_b17-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1038\/sj.onc.1208998","article-title":"Y-box factor YB1 controls p53 apoptotic function","volume":"24","author":"Homer","year":"2005","journal-title":"Oncogene"},{"key":"key20180108023059_b18-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0014-5793(97)01296-9","article-title":"Nuclear translocation of the Y-box binding protein by ultraviolet irradiation","volume":"417","author":"Koike","year":"1997","journal-title":"FEBS Lett"},{"key":"key20180108023059_b19-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1074\/jbc.M110.151936","article-title":"A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice","volume":"286","author":"Higashi","year":"2011","journal-title":"J Biol Chem"},{"key":"key20180108023059_b20-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3748\/wjg.v7.i1.49","article-title":"Inhibition of hepatitis B virus by oxymatrine in vivo","volume":"7","author":"Chen","year":"2001","journal-title":"World J Gastroenterol"},{"key":"key20180108023059_b21-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.etap.2013.12.005","article-title":"The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice","volume":"37","author":"Pei","year":"2014","journal-title":"Environ Toxicol Pharmacol"},{"key":"key20180108023059_b22-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.freeradbiomed.2014.01.013","article-title":"Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats","volume":"69","author":"Zhang","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"key20180108023059_b23-mmr-12-06-8101","first-page":"193","article-title":"Prophylactic and therapeutic effect of oxymatrine on D-galactosamine-induced rat liver fibrosis","volume":"10","author":"Yang","year":"2002","journal-title":"Chinese Journal of Hepatology"},{"key":"key20180108023059_b24-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.3748\/wjg.v11.i31.4912","article-title":"Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats","volume":"11","author":"Zheng","year":"2005","journal-title":"World J Gastroenterol"},{"key":"key20180108023059_b25-mmr-12-06-8101","first-page":"165","article-title":"Anti-inflammatory effects of oxymatrine through inhibition of nuclear factor-kappa B and mitogen-activated protein kinase activation in lipopolysac-charide-induced BV2 microglia cells","volume":"12","author":"Dong","year":"2013","journal-title":"Iran J Pharm Res"},{"key":"key20180108023059_b26-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.3892\/mmr.2014.3048","article-title":"Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108023059_b27-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.canlet.2008.12.003","article-title":"Hepatitis B virus induced hepatocellular carcinoma","volume":"286","author":"Chemin","year":"2009","journal-title":"Cancer Lett"},{"key":"key20180108023059_b28-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1471-2407-11-185","article-title":"Y-box protein-1\/p18 fragment identifies malignancies in patients with chronic liver disease","volume":"11","author":"Tacke","year":"2011","journal-title":"BMC Cancer"},{"key":"key20180108023059_b29-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"7354","DOI":"10.1158\/1078-0432.CCR-05-1027","article-title":"The up-regulation of Y-box binding proteins (DNA binding protein A and Y-box binding protein-1) as prognostic markers of hepatocellular carcinoma","volume":"11","author":"Yasen","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180108023059_b30-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.3748\/wjg.v18.i31.4199","article-title":"Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells","volume":"18","author":"Chai","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key20180108023059_b31-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1742-7843.2008.00287.x","article-title":"Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture","volume":"103","author":"Chen","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key20180108023059_b32-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.phymed.2012.10.012","article-title":"Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats","volume":"20","author":"Huang","year":"2013","journal-title":"Phytomedicine"},{"key":"key20180108023059_b33-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1210392","article-title":"Differential regulation and properties of MAPKs","volume":"26","author":"Raman","year":"2007","journal-title":"Oncogene"},{"key":"key20180108023059_b34-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/02699050500284218","article-title":"The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions","volume":"24","author":"Yoon","year":"2006","journal-title":"Growth Factors"},{"key":"key20180108023059_b35-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1158\/1078-0432.CCR-12-3705","article-title":"Mutual regulation between Raf\/MEK\/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression","volume":"19","author":"Imada","year":"2013","journal-title":"Clin Cancer Res"},{"key":"key20180108023059_b36-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1158\/0008-5472.CAN-08-1082","article-title":"Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR\/STAT3 pathway and suppresses tumor growth in mice","volume":"68","author":"Lee","year":"2008","journal-title":"Cancer Res"},{"key":"key20180108023059_b37-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"e71071","DOI":"10.1371\/journal.pone.0071071","article-title":"Grape seed procyanidin reversal of p-glycoprotein associated multi-drug resistance via down-regulation of nf-\u03bab and MAPK\/ERK mediated YB-1 activity in A2780\/T cells","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"key20180108023059_b38-mmr-12-06-8101","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1096\/fj.03-0037fje","article-title":"Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells","volume":"17","author":"Hayashida","year":"2003","journal-title":"FASEB J"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4428\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T05:35:01Z","timestamp":1692077701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,12]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,10,12]]},"published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.3892\/mmr.2015.4428"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4428","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,12]]}}}