{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:20:31Z","timestamp":1761060031124},"reference-count":36,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.3892\/mmr.2015.4529","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T13:08:03Z","timestamp":1446815283000},"page":"9-12","source":"Crossref","is-referenced-by-count":10,"title":["Activating transcription factor 3 - an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review)"],"prefix":"10.3892","volume":"13","author":[{"given":"CHAO-JUN","family":"YANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHI-XING","family":"FAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIAN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"key20180108024610_b1-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.cir.0000442015.53336.12","article-title":"Executive summary: Heart disease and stroke statistics-2014 update: A report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"key20180108024610_b2-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature04768","article-title":"Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4","volume":"441","author":"Gilchrist","year":"2006","journal-title":"Nature"},{"key":"key20180108024610_b3-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1101\/gad.3.12b.2083","article-title":"Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers","volume":"3","author":"Hai","year":"1989","journal-title":"Genes Dev"},{"key":"key20180108024610_b4-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"15819","DOI":"10.1016\/S0021-9258(17)40754-X","article-title":"ATF3 and ATF3 delta Zip: Transcriptional repression versus activation by alternatively spliced isoforms","volume":"269","author":"Chen","year":"1994","journal-title":"J Biol Chem"},{"key":"key20180108024610_b5-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.88.9.3720","article-title":"Cross-family dimerization of transcription factors Fos\/Jun and ATF\/CREB alters DNA binding specificity","volume":"88","author":"Hai","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108024610_b6-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/MCB.24.3.1365-1377.2004","article-title":"Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response","volume":"24","author":"Jiang","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key20180108024610_b7-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3727\/105221610X12819686555015","article-title":"ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: Is modulation of inflammation a unifying component?","volume":"15","author":"Hai","year":"2010","journal-title":"Gene Expr"},{"key":"key20180108024610_b8-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"e108024","DOI":"10.1371\/journal.pone.0108024","article-title":"Etanercept attenuates myocardial ischemia\/reperfusion injury by decreasing inflammation and oxidative stress","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"key":"key20180108024610_b9-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.imlet.2014.09.015","article-title":"The study of the protein complement in myocardial infarction","volume":"162","author":"Ilczuk","year":"2014","journal-title":"Immunol Lett"},{"key":"key20180108024610_b10-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000363001","article-title":"Chronic intermittent hypobaric hypoxia ameliorates ischemia\/reperfusion-induced calcium overload in heart via Na\/Ca2+ exchanger in developing rats","volume":"34","author":"Ma","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"key20180108024610_b11-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bbadis.2014.05.012","article-title":"Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia\/reperfusion","volume":"1852","author":"Xu","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"key20180108024610_b12-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.nutres.2014.08.007","article-title":"Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia\/reperfusion rat model","volume":"34","author":"Kim","year":"2014","journal-title":"Nutr Res"},{"key":"key20180108024610_b13-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1016\/j.transproceed.2011.09.075","article-title":"Activations of mitogen-activated protein kinases and regulation of their downstream molecules after rat lung transplantation from donors after cardiac death","volume":"43","author":"Yamamoto","year":"2011","journal-title":"Transplant Proc"},{"key":"key20180108024610_b14-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuroscience.2012.06.010","article-title":"Increased inflammation and brain injury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice","volume":"220","author":"Wang","year":"2012","journal-title":"Neuroscience"},{"key":"key20180108024610_b15-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neures.2011.05.002","article-title":"Role of activating transcription factor 3 in ischemic penumbra region following transient middle cerebral artery occlusion and reperfusion injury","volume":"70","author":"Song","year":"2011","journal-title":"Neurosci Res"},{"key":"key20180108024610_b16-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.gene.2014.04.002","article-title":"Bioinformatics analysis of time series gene expression in left ventricle (LV) with acute myocardial infarction (AMI)","volume":"543","author":"Zhang","year":"2014","journal-title":"Gene"},{"key":"key20180108024610_b17-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-012-1508-3","article-title":"Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans","volume":"374","author":"Krivoruchko","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"key20180108024610_b18-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2011.38","article-title":"Innate immune signaling in cardiac ischemia","volume":"8","author":"Arslan","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"key20180108024610_b19-mmr-13-01-0009","first-page":"170352","article-title":"Toll-like receptors and myocardial inflammation","volume":"9","author":"Feng","year":"2011","journal-title":"Int J Inflam"},{"key":"key20180108024610_b20-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fimmu.2012.00182","article-title":"Toll-like receptors as modulators of mesenchymal stem cells","volume":"3","author":"Delarosa","year":"2012","journal-title":"Front Immunol"},{"key":"key20180108024610_b21-mmr-13-01-0009","first-page":"865601","article-title":"Modulation of adult mesenchymal stem cells activity by toll-like receptors: Implications on therapeutic potential","volume":"10","author":"DelaRosa","year":"2010","journal-title":"Mediators of Inflamm"},{"key":"key20180108024610_b22-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","article-title":"MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4","volume":"189","author":"Shimazu","year":"1999","journal-title":"J Exp Med"},{"key":"key20180108024610_b23-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.4049\/jimmunol.179.6.3622","article-title":"Negative regulation of TLR-signaling pathways by activating transcription factor-3","volume":"179","author":"Whitmore","year":"2007","journal-title":"J Immunol"},{"key":"key20180108024610_b24-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCRESAHA.109.196261","article-title":"Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid\/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue","volume":"105","author":"Suganami","year":"2009","journal-title":"Circ Res"},{"key":"key20180108024610_b25-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1681\/ASN.2009070690","article-title":"ATF3-mediated epigenetic regulation protects against acute kidney injury","volume":"21","author":"Li","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"key20180108024610_b26-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1681\/ASN.2005111155","article-title":"ATF3 protects against renal ischemia-reperfusion injury","volume":"19","author":"Yoshida","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"key20180108024610_b27-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/jcp.24554","article-title":"Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion","volume":"229","author":"Chen","year":"2014","journal-title":"J Cell Physiol"},{"key":"key20180108024610_b28-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/ajt.12954","article-title":"ATF3-mediated NRF2\/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia\/reperfusion injury","volume":"15","author":"Rao","year":"2014","journal-title":"Am J Transplant"},{"key":"key20180108024610_b29-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physiolgenomics.00166.2004","article-title":"Ischemic but not pharmacological preconditioning elicits a gene expression profile similar to unprotected myocardium","volume":"20","author":"da Silva","year":"2004","journal-title":"Physiol Genomics"},{"key":"key20180108024610_b30-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yjmcc.2014.08.011","article-title":"Endoplasmic reticulum stress-dependent activation of ATF3 mediates the late phase of ischemic preconditioning","volume":"76","author":"Brooks","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"key20180108024610_b31-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2337\/db05-1507","article-title":"NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes","volume":"55","author":"Kim","year":"2006","journal-title":"Diabetes"},{"key":"key20180108024610_b32-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation: A regulatory modification to rival phosphorylation?","volume":"19","author":"Kouzarides","year":"2000","journal-title":"EMBO J"},{"key":"key20180108024610_b33-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(00)00118-5","article-title":"Signaling to chromatin through histone modifications","volume":"103","author":"Cheung","year":"2000","journal-title":"Cell"},{"key":"key20180108024610_b34-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3109\/15376516.2011.557876","article-title":"Acute kidney injury and the potential for ATF3-regulated epigenetic therapy","volume":"21","author":"Cheng","year":"2011","journal-title":"Toxicol Mech Methods"},{"key":"key20180108024610_b35-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cardiores.2007.08.010","article-title":"Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury","volume":"76","author":"Zhao","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20180108024610_b36-mmr-13-01-0009","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.08-108548","article-title":"Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice","volume":"22","author":"Granger","year":"2008","journal-title":"FASEB J"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4529\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T15:11:28Z","timestamp":1653491488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,6]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.3892\/mmr.2015.4529"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4529","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]}}}