{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:17:23Z","timestamp":1791951443908,"version":"4.3.4"},"reference-count":49,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/mmr.2015.4689","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T09:49:22Z","timestamp":1450345762000},"page":"1765-1773","source":"Crossref","is-referenced-by-count":48,"title":["Effects of hydrogen sulfide on myocardial fibrosis and PI3K\/AKT1-regulated autophagy in diabetic rats"],"prefix":"10.3892","volume":"13","author":[{"given":"TING","family":"XIAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIAN","family":"LUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHIXIONG","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OU","family":"ZENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"key20180108024257_b1-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4239\/wjd.v4.i5.177","article-title":"Diabetic cardiomyopathy: Pathophysiology, diagnostic evaluation and management","volume":"4","author":"Pappachan","year":"2013","journal-title":"World J Diabetes"},{"key":"key20180108024257_b2-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jacc.2005.09.050","article-title":"The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy","volume":"474","author":"Asbun","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"key20180108024257_b3-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10741-011-9257-z","article-title":"Diabetic cardiomyopathy: Understanding the molecular and cellular basis to progress in diagnosis and treatment","volume":"17","author":"Falc\u00e3o-Pires","year":"2012","journal-title":"Heart Fail Rev"},{"key":"key20180108024257_b4-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/ars.2009.2882","article-title":"Novel insights into hydrogen sulfide-mediated cytoprotection","volume":"12","author":"Calvent","year":"2010","journal-title":"Antioxid Redox Sign"},{"key":"key20180108024257_b5-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/ndt\/gfq749","article-title":"Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide","volume":"26","author":"Yuan","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108024257_b6-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"key20180108024257_b7-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1113\/expphysiol.2011.059725","article-title":"Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury","volume":"96","author":"King","year":"2011","journal-title":"Exp Physiol"},{"key":"key20180108024257_b8-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/BSR20100003","article-title":"Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: A mechanism through cardiac mitochondrial protection","volume":"31","author":"Wang","year":"2011","journal-title":"Biosci Rep"},{"key":"key20180108024257_b9-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J"},{"key":"key20180108024257_b10-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1139\/y03-077","article-title":"Modulation of endogenous production of H2S in rat tissues","volume":"81","author":"Zhao","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"key20180108024257_b11-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1007\/s11033-014-3570-2","article-title":"Involvement of miR-1 in the protective effect of hydrogen sulfide against cardiomyocyte apoptosis induced by ischemia\/reperfusion","volume":"41","author":"Kang","year":"2014","journal-title":"Mol Biol Rep"},{"key":"key20180108024257_b12-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108024257_b13-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"key20180108024257_b14-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1074\/jbc.M114.596593","article-title":"Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model","volume":"289","author":"Zhou","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180108024257_b15-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s10495-014-0978-z","article-title":"Hydrogen sulfide improves left ventricular function in smoking rats via regulation of apoptosis and autophagy","volume":"19","author":"Zhou","year":"2014","journal-title":"Apoptosis"},{"key":"key20180108024257_b16-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy in cell death: An innocent convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J Clin Invest"},{"key":"key20180108024257_b17-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"key20180108024257_b18-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrclinonc.2011.71","article-title":"Autophagy as a target for anticancer therapy","volume":"8","author":"Janku","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"key20180108024257_b19-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/cvr\/cvq102","article-title":"Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP","volume":"87","author":"Younce","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key20180108024257_b20-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0076-6879(08)04017-2","article-title":"Autophagy in load-induced heart disease","volume":"453","author":"Zhu","year":"2009","journal-title":"Methods Enzymol"},{"key":"key20180108024257_b21-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.diabres.2014.01.031","article-title":"The impact of 1,25-dihydroxyvitamin D3 on the expression of connective tissue growth factor and transforming growth factor-\u03b21 in the myocardium of rats with diabetes","volume":"104","author":"Wang","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"key20180108024257_b22-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10735-013-9535-2","article-title":"Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9","volume":"45","author":"Wang","year":"2014","journal-title":"J Mol Histol"},{"key":"key20180108024257_b23-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2014","journal-title":"Br J Pharmacol"},{"key":"key20180108024257_b24-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ars.2012.4888","article-title":"Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats","volume":"20","author":"Liu","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"key20180108024257_b25-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10557-013-6441-5","article-title":"Protective effects of hydrogen sulfide against chronic alcohol intake-induced left ventricular remodeling in rats","volume":"27","author":"Zhou","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"key":"key20180108024257_b26-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/1535370213477989","article-title":"Hydrogen sulfide inhibits high-glucose-induced apoptosis in neonatal rat cardiomyocytes","volume":"238","author":"Zhou","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20180108024257_b27-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"H703","DOI":"10.1152\/ajpheart.00257.2011","article-title":"Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat","volume":"303","author":"Xu","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20180108024257_b28-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"e20856","DOI":"10.1371\/journal.pone.0020856","article-title":"Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice","volume":"6","author":"Bish","year":"2011","journal-title":"PLoS One"},{"key":"key20180108024257_b29-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0008-6363(00)00003-1","article-title":"Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling","volume":"46","author":"Li","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key20180108024257_b30-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1073\/pnas.97.23.12746","article-title":"Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy","volume":"97","author":"Li","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108024257_b31-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1172\/JCI116842","article-title":"In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds","volume":"92","author":"Maquart","year":"1993","journal-title":"J Clin Invest"},{"key":"key20180108024257_b32-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1006\/jmcc.1997.0420","article-title":"Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan","volume":"29","author":"Dixon","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"key20180108024257_b33-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.RES.84.10.1223","article-title":"Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis","volume":"84","author":"Cowan","year":"1999","journal-title":"Circ Res"},{"key":"key20180108024257_b34-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/PRS.0000000000000504","article-title":"Adipose tissue-derived stromal cells inhibit TGF-\u03b21-induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion","volume":"134","author":"Spiekman","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"key20180108024257_b35-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbrc.2014.05.089","article-title":"Apamin inhibits hepatic fibrosis through suppression of transforming growth factor \u03b21-induced hepatocyte epithelial-mesenchymal transition","volume":"450","author":"Lee","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108024257_b36-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"e70196","DOI":"10.1371\/journal.pone.0070196","article-title":"Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease","volume":"8","author":"Harris","year":"2013","journal-title":"PLoS One"},{"key":"key20180108024257_b37-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.bbamcr.2014.06.005","article-title":"Heparanase is a key player in renal fibrosis by regulating TGF-\u03b2 expression and activity","volume":"1843","author":"Masola","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key20180108024257_b38-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"728741","DOI":"10.1155\/2015\/728741","article-title":"An altered pattern of myocardial histopathological and molecular changes underlies the different characteristics of type-1 and type-2 diabetic cardiac dysfunction","volume":"2015","author":"Radovits","year":"2015","journal-title":"J Diabetes Res"},{"key":"key20180108024257_b39-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"420929","DOI":"10.1155\/2014\/420929","article-title":"Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis","volume":"2014","author":"Yu","year":"2014","journal-title":"J Diabetes Res"},{"key":"key20180108024257_b40-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"A17","DOI":"10.1253\/circj.CJ-08-0669","article-title":"Cell death in heart failure","volume":"72","author":"Nishida","year":"2008","journal-title":"Circ J"},{"key":"key20180108024257_b41-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/1074248410370327","article-title":"Autophagy: Definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury","volume":"15","author":"Dong","year":"2010","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key20180108024257_b42-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4161\/auto.19314","article-title":"Autophagy proteins play cyto-protective and cytocidal roles in leucine starvation-induced cell death in Saccharomyces cerevisiae","volume":"8","author":"Dziedzic","year":"2012","journal-title":"Autophagy"},{"key":"key20180108024257_b43-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2008.163","article-title":"The role of autophagy in the heart","volume":"16","author":"Nishida","year":"2009","journal-title":"Cell Death Differ"},{"key":"key20180108024257_b44-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1172\/JCI26185","article-title":"Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4","volume":"116","author":"Espert","year":"2006","journal-title":"J Clin Invest"},{"key":"key20180108024257_b45-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.cdd.4400759","article-title":"Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells","volume":"7","author":"Saeki","year":"2000","journal-title":"Cell Death Differ"},{"key":"key20180108024257_b46-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2353\/ajpath.2006.050137","article-title":"Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor","volume":"168","author":"Miyata","year":"2006","journal-title":"Am J Pathol"},{"key":"key20180108024257_b47-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1172\/JCI27523","article-title":"Cardiac autophagy is a maladaptive response to hemodynamic stress","volume":"117","author":"Zhu","year":"2007","journal-title":"J Clin Invest"},{"key":"key20180108024257_b48-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4161\/auto.5638","article-title":"Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion","volume":"4","author":"Matsui","year":"2008","journal-title":"Autophagy"},{"key":"key20180108024257_b49-mmr-13-02-1765","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","article-title":"Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: Role of autophagy paradox and toxic aldehyde","volume":"32","author":"Ma","year":"2011","journal-title":"Eur Heart J"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4689\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T04:52:16Z","timestamp":1515387136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,17]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/mmr.2015.4689"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4689","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}