{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:34:23Z","timestamp":1778582063339,"version":"3.51.4"},"reference-count":31,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/mmr.2015.4692","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T13:13:05Z","timestamp":1450357985000},"page":"1895-1901","source":"Crossref","is-referenced-by-count":26,"title":["MicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis"],"prefix":"10.3892","volume":"13","author":[{"given":"YIFAN","family":"LI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DUQUN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LU","family":"JIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIAJU","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHENGMING","family":"SU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUCHI","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YAOTING","family":"GUI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YONGQING","family":"LAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"key20180108024336_b1-mmr-13-02-1895","first-page":"93","article-title":"Epidemiology of renal-cell carcinoma","volume":"10","author":"Tavani","year":"1997","journal-title":"J Nephrol"},{"key":"key20180108024336_b2-mmr-13-02-1895","unstructured":"National Cancer InstituteSurveillance, epidemiology and end results program. SEER stat fact sheets: Kidney and renal pelvis cancerhttp:\/\/seer.cancer.gov\/statfacts\/html\/kidrp.html. Accessed March 30, 2014"},{"key":"key20180108024336_b3-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"92014","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"key20180108024336_b4-mmr-13-02-1895","unstructured":"Zhejiang ChannelXNAWorld Kidney Day: Kidney Cancer incidence increased year by year become 'invisible killer'Available at: http:\/\/www.zj.xinhuanet.com\/news-center\/science\/2014-03\/13\/c_119759340.htm. Accessed 13 March 2014"},{"key":"key20180108024336_b5-mmr-13-02-1895","first-page":"48","article-title":"Annual report on status of cancer in China, 2010","volume":"26","author":"Chen","year":"2014","journal-title":"Chin J Cancer Res"},{"key":"key20180108024336_b6-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJM199609193351207","article-title":"Renal-cell carcinoma","volume":"335","author":"Motzer","year":"1996","journal-title":"N Engl J Med"},{"key":"key20180108024336_b7-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMra043172","article-title":"Renal-cell carcinoma","volume":"353","author":"Cohen","year":"2005","journal-title":"N Engl J Med"},{"key":"key20180108024336_b8-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-0033-1363837","article-title":"Epidemiology and staging of renal cell carcinoma","volume":"31","author":"Ridge","year":"2014","journal-title":"Semin Intervent Radiol"},{"key":"key20180108024336_b9-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: Contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat Rev Genet"},{"key":"key20180108024336_b10-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"key20180108024336_b11-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"e91884","DOI":"10.1371\/journal.pone.0091884","article-title":"A microRNA signature associated with early recurrence in breast cancer","volume":"9","author":"Perez-Rivas","year":"2014","journal-title":"PLoS One"},{"key":"key20180108024336_b12-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.7314\/APJCP.2012.13.5.1901","article-title":"Differential distribution of miR-20a and miR-20b may underly metastatic heterogeneity of breast cancers","volume":"13","author":"Li","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180108024336_b13-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.18632\/oncotarget.1165","article-title":"Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer","volume":"4","author":"Li","year":"2013","journal-title":"Oncotarget"},{"key":"key20180108024336_b14-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1440-1746.2008.05666.x","article-title":"Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues","volume":"24","author":"Guo","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"key20180108024336_b15-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.4161\/cc.21278","article-title":"Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm","volume":"11","author":"Cheung","year":"2012","journal-title":"Cell Cycle"},{"key":"key20180108024336_b16-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.leukres.2013.02.019","article-title":"MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia","volume":"37","author":"Coskun","year":"2013","journal-title":"Leuk Res"},{"key":"key20180108024336_b17-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1158\/1078-0432.CCR-12-3572","article-title":"Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma","volume":"19","author":"Hui","year":"2013","journal-title":"Clin Cancer Res"},{"key":"key20180108024336_b18-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000363303","article-title":"Underexpression of miR-126 and miR-20b in hereditary and nonhereditary colorectal tumors","volume":"87","author":"Yamaguchi","year":"2014","journal-title":"Oncology"},{"key":"key20180108024336_b19-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"948408","DOI":"10.1155\/2014\/948408","article-title":"Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles","volume":"2014","author":"M\u00fcller","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20180108024336_b20-mmr-13-02-1895","first-page":"479","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010","edition":"7th edition"},{"key":"key20180108024336_b21-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcp.22126","article-title":"miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells","volume":"224","author":"Cascio","year":"2010","journal-title":"J Cell Physiol"},{"key":"key20180108024336_b22-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/pcmr.12217","article-title":"miR-20b regulates expression of proteinase-activated receptor-1 (PAR-1) thrombin receptor in melanoma cells","volume":"27","author":"Saleiban","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"key20180108024336_b23-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2353\/ajpath.2009.080794","article-title":"MiRNAs and cancer","volume":"174","author":"Visone","year":"2009","journal-title":"Am J Pathol"},{"key":"key20180108024336_b24-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2009.01.046","article-title":"Origin, biogenesis and activity of plant microRNAs","volume":"136","author":"Voinnet","year":"2009","journal-title":"Cell"},{"key":"key20180108024336_b25-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.eururo.2012.09.040","article-title":"Potential role of genetic markers in the management of kidney cancer","volume":"63","author":"Junker","year":"2013","journal-title":"Eur Urol"},{"key":"key20180108024336_b26-mmr-13-02-1895","first-page":"537","article-title":"microRNA expression profile in undifferentiated gastric cancer","volume":"34","author":"Katada","year":"2009","journal-title":"Int J Oncol"},{"key":"key20180108024336_b27-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1038\/onc.2010.34","article-title":"Multiple microRNAs modulate p21Cip1\/Waf1 expression by directly targeting its 3\u2032 untranslated region","volume":"29","author":"Wu","year":"2010","journal-title":"Oncogene"},{"key":"key20180108024336_b28-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"e2557","DOI":"10.1371\/journal.pone.0002557","article-title":"Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS One"},{"key":"key20180108024336_b29-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMp030061","article-title":"The von Hippel-Lindau protein, vascular endothelial growth factor and kidney cancer","volume":"349","author":"George","year":"2003","journal-title":"N Engl J Med"},{"key":"key20180108024336_b30-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0140-6736(07)61874-1","article-title":"Targeted drugs for metastatic renal cell carcinoma","volume":"370","author":"Motzer","year":"2007","journal-title":"Lancet"},{"key":"key20180108024336_b31-mmr-13-02-1895","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.juro.2013.03.041","article-title":"The protease activated receptor 1 gene variation IVSn-14 A>T is associated with distant metastasis and cancer specific survival in renal cell carcinoma","volume":"190","author":"de Martino","year":"2013","journal-title":"J Urol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4692\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:37:12Z","timestamp":1718253432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,17]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/mmr.2015.4692"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4692","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}