{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:36:10Z","timestamp":1790411770462,"version":"4.1.0"},"reference-count":28,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/mmr.2015.4723","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T03:55:30Z","timestamp":1451274930000},"page":"1881-1887","source":"Crossref","is-referenced-by-count":8,"title":["Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis"],"prefix":"10.3892","volume":"13","author":[{"given":"SHUANG","family":"ZHAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUE-FENG","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEN-FENG","family":"GOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANG","family":"LU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HUA","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHI-TU","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HONG-ZHI","family":"SUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HUA-CHUAN","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"key20180108024337_b1-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1007\/s00018-013-1270-z","article-title":"ING1 and ING2: Multifaceted tumor suppressor genes","volume":"70","author":"Gu\u00e9rillon","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"key20180108024337_b2-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1128\/MCB.25.15.6639-6648.2005","article-title":"ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation","volume":"25","author":"Pedeux","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180108024337_b3-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/srep02137","article-title":"Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage","volume":"3","author":"Bua","year":"2013","journal-title":"Sci Rep"},{"key":"key20180108024337_b4-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.9.19.13208","article-title":"ING2 controls the G1 to S-phase transition by regulating p21 expression","volume":"9","author":"Larrieu","year":"2010","journal-title":"Cell Cycle"},{"key":"key20180108024337_b5-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0092-8674(03)00480-X","article-title":"The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor","volume":"114","author":"Gozani","year":"2003","journal-title":"Cell"},{"key":"key20180108024337_b6-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1021\/ja070195b","article-title":"Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: Chemistry, biology and molecular modeling","volume":"129","author":"Huang","year":"2007","journal-title":"J Am Chem Soc"},{"key":"key20180108024337_b7-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.molcel.2006.07.014","article-title":"Nuclear PtdIns5P as a transducer of stress signaling: An in vivo role for PIP4Kbeta","volume":"23","author":"Jones","year":"2006","journal-title":"Mol Cell"},{"key":"key20180108024337_b8-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.1038\/onc.2010.325","article-title":"Sumoylation of ING2 regulates the transcription mediated by Sin3A","volume":"29","author":"Ythier","year":"2010","journal-title":"Oncogene"},{"key":"key20180108024337_b9-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.febslet.2010.05.033","article-title":"HECT ubiquitin ligase smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation","volume":"584","author":"Nie","year":"2010","journal-title":"FEBS Lett"},{"key":"key20180108024337_b10-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"13269","DOI":"10.1074\/jbc.M708834200","article-title":"ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells","volume":"283","author":"Sarker","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180108024337_b11-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.yexcr.2007.07.029","article-title":"Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues","volume":"314","author":"Walzak","year":"2008","journal-title":"Exp Cell Res"},{"key":"key20180108024337_b12-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"e15541","DOI":"10.1371\/journal.pone.0015541","article-title":"Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas","volume":"5","author":"Saito","year":"2010","journal-title":"PLoS One"},{"key":"key20180108024337_b13-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1073\/pnas.161151798","article-title":"DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53","volume":"98","author":"Nagashima","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108024337_b14-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.0303-6987.2004.0187.x","article-title":"Loss of heterozygosity on chromosome 4q32\u201335 in sporadic basal cell carcinomas: Evidence for the involvement of p33ING2\/ING1L and SAP30 genes","volume":"31","author":"Sironi","year":"2004","journal-title":"J Cutan Pathol"},{"key":"key20180108024337_b15-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00432-008-0507-y","article-title":"Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma","volume":"135","author":"Borkosky","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180108024337_b16-mmr-13-02-1881","first-page":"299","article-title":"Deletion mapping of chromosome 4q22\u201335 and identification of four frequently deleted regions in head and neck cancers","volume":"55","author":"Cetin","year":"2008","journal-title":"Neoplasma"},{"key":"key20180108024337_b17-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.canlet.2007.11.019","article-title":"Decreased expression of ING2 gene and its clinicopathological significance in hepato-cellular carcinoma","volume":"261","author":"Zhang","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180108024337_b18-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.lungcan.2009.11.006","article-title":"Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma","volume":"69","author":"Ythier","year":"2010","journal-title":"Lung Cancer"},{"key":"key20180108024337_b19-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.bjc.6603205","article-title":"Nuclear ING2 expression is reduced in human cutaneous melanomas","volume":"95","author":"Lu","year":"2006","journal-title":"Br J Cancer"},{"key":"key20180108024337_b20-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ijc.24437","article-title":"ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression","volume":"125","author":"Kumamoto","year":"2009","journal-title":"Int J Cancer"},{"key":"key20180108024337_b21-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/modpathol.3800165","article-title":"Improved 1-h rapid immunostaining method using intermittent microwave irradiation: Practicability based on 5 years application in Toyama medical and pharmaceutical university hospital","volume":"17","author":"Kumada","year":"2004","journal-title":"Mod Pathol"},{"key":"key20180108024337_b22-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1002\/ijc.25224","article-title":"Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma","volume":"127","author":"Cengiz","year":"2010","journal-title":"Int J Cancer"},{"key":"key20180108024337_b23-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1128\/MCB.26.8.2947-2954.2006","article-title":"Subcellular targeting of p33ING1b by phosphorylation-dependent 14\u20133\u20133 binding regulates p21WAF1 expression","volume":"26","author":"Gong","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key20180108024337_b24-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"e60943","DOI":"10.1371\/journal.pone.0060943","article-title":"Src regulates the activity of the ING1 tumor suppressor","volume":"8","author":"Yu","year":"2013","journal-title":"PLoS One"},{"key":"key20180108024337_b25-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"e40684","DOI":"10.1371\/journal.pone.0040684","article-title":"Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation","volume":"7","author":"Eapen","year":"2012","journal-title":"PLoS One"},{"key":"key20180108024337_b26-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/embor.2009.180","article-title":"ING2 controls the progression of DNA replication forks to maintain genome stability","volume":"10","author":"Larrieu","year":"2009","journal-title":"EMBO Rep"},{"key":"key20180108024337_b27-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.bbamcr.2008.04.019","article-title":"ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9","volume":"1783","author":"Goeman","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key20180108024337_b28-mmr-13-02-1881","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1016\/j.febslet.2006.05.065","article-title":"Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis","volume":"580","author":"Wang","year":"2006","journal-title":"FEBS Lett"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2015.4723\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:52:51Z","timestamp":1515369171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2015.4723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,28]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/mmr.2015.4723"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2015.4723","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}