{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:33:52Z","timestamp":1768977232864,"version":"3.49.0"},"reference-count":40,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.3892\/mmr.2016.4824","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T13:38:41Z","timestamp":1453988321000},"page":"2423-2430","source":"Crossref","is-referenced-by-count":33,"title":["Expression of programmed death 1 ligand 1 on periodontal tissue cells as a possible protective feedback mechanism against periodontal tissue destruction"],"prefix":"10.3892","volume":"13","author":[{"given":"JIEHUA","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIEH-MEI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PING","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOQIAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIAO","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WANLU","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENJIE","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENWEN","family":"YUAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUN","family":"FENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"key20180108023512_b1-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/annals.1999.4.1.38","article-title":"Consensus report: Chronic periodontitis","volume":"4","author":"Lindhe","year":"1999","journal-title":"Annals of Periodontology"},{"key":"key20180108023512_b2-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"James Beck(University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washin): Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke","year":"2012","journal-title":"J Dent Res"},{"key":"key20180108023512_b3-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/978-1-4614-5441-0_9","article-title":"Periodontal disease and diabetes","volume":"771","author":"Bascones-Mart\u00ednez","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"key20180108023512_b4-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.4317\/medoral.14.e680","article-title":"Host defence mechanisms against bacterial aggression in periodontal disease: Basic mechanisms","volume":"14","author":"Bascones-Mart\u00ednez","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key20180108023512_b5-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/00220345840630031601","article-title":"Host responses in periodontal diseases","volume":"63","author":"Genco","year":"1984","journal-title":"J Dent Res"},{"key":"key20180108023512_b6-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.joen.2011.12.010","article-title":"T-lymphocyte and cytokine expression in human inflammatory periapical lesions","volume":"38","author":"de Brito","year":"2012","journal-title":"J Endod"},{"key":"key20180108023512_b7-mmr-13-03-2423","first-page":"573","article-title":"Periodontitis and the immune system","volume":"33","author":"Hitzig","year":"1979","journal-title":"Actual Odontostomatol (Paris)"},{"key":"key20180108023512_b8-mmr-13-03-2423","first-page":"123","article-title":"Role of the immune system in chronic periodontitis","volume":"83","author":"Kilian","year":"1979","journal-title":"Tandlaegebladet"},{"key":"key20180108023512_b9-mmr-13-03-2423","first-page":"115","article-title":"The role of adaptive immune response in periodontitis","volume":"48","author":"Wang","year":"2013","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"key20180108023512_b10-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000329670","article-title":"Innate cellular responses to the periodontal biofilm","volume":"15","author":"Benakanakere","year":"2012","journal-title":"Front Oral Biol"},{"key":"key20180108023512_b11-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.0906-6713.2004.003556.x","article-title":"Modulation of the innate immune response within the periodontium","volume":"35","author":"Dixon","year":"2004","journal-title":"Periodontol 2000"},{"key":"key20180108023512_b12-mmr-13-03-2423","first-page":"28","article-title":"Modulation of immune responses to periodontal bacteria","author":"Gemmell","year":"1994","journal-title":"Curr Opin Periodontol"},{"key":"key20180108023512_b13-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1902\/jop.2010.100054","article-title":"Periodontal ligament fibroblasts sustain destructive immune modulators of chronic periodontitis","volume":"81","author":"El-Awady","year":"2010","journal-title":"J Periodontol"},{"key":"key20180108023512_b14-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1034\/j.1600-0722.2003.00051.x","article-title":"Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth","volume":"111","author":"Fukushima","year":"2003","journal-title":"Eur J Oral Sci"},{"key":"key20180108023512_b15-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ijos.2013.19","article-title":"Chondrogenesis of periodontal ligament stem cells by transforming growth factor-\u03b23 and bone morphogenetic protein-6 in a normal healthy impacted third molar","volume":"5","author":"Choi","year":"2013","journal-title":"Int J Oral Sci"},{"key":"key20180108023512_b16-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1034\/j.1600-0714.2002.00188.x","article-title":"SPARC stimulates the synthesis of OPG\/OCIF, MMP-2 and DNA in human periodontal ligament cells","volume":"31","author":"Fujita","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"key20180108023512_b17-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"key20180108023512_b18-mmr-13-03-2423","first-page":"179","article-title":"Immunoregulatory role of B7-H1 in chronicity of inflammatory responses","volume":"3","author":"Dong","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"key20180108023512_b19-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.imbio.2011.05.005","article-title":"B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis","volume":"216","author":"Groeger","year":"2011","journal-title":"Immunobiology"},{"key":"key20180108023512_b20-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.4161\/onci.21335","article-title":"Targeting PD-1\/PD-L1 interactions for cancer immunotherapy","volume":"1","author":"Zitvogel","year":"2012","journal-title":"Oncoimmunology"},{"key":"key20180108023512_b21-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.imbio.2011.10.016","article-title":"Interferon-\u03b3-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway","volume":"217","author":"Chen","year":"2012","journal-title":"Immunobiology"},{"key":"key20180108023512_b22-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1084\/jem.20090847","article-title":"PD-L1 regulates the development, maintenance, and function of induced regulatory T cells","volume":"206","author":"Francisco","year":"2009","journal-title":"J Exp Med"},{"key":"key20180108023512_b23-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3892\/ol.2013.1238","article-title":"Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand-1 surface expression","volume":"5","author":"Lu","year":"2013","journal-title":"Oncol Lett"},{"key":"key20180108023512_b24-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cellimm.2011.10.020","article-title":"Human periodontal ligament cells facilitate leukocyte recruitment and are influenced in their immunomodulatory function by Th17 cytokine release","volume":"272","author":"Konermann","year":"2012","journal-title":"Cell Immunol"},{"key":"key20180108023512_b25-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/00220345720510043801","article-title":"In vitro culture of periodontal ligament cells","volume":"51","author":"Arnold","year":"1972","journal-title":"J Dent Res"},{"key":"key20180108023512_b26-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1002\/eji.1830220903","article-title":"Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutinin: Three different mechanisms?","volume":"22","author":"Binns","year":"1992","journal-title":"Eur J Immunol"},{"key":"key20180108023512_b27-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1600-051X.2009.01393.x","article-title":"Mouse model of experimental periodontitis induced by Porphyromonas gingivalis\/Fusobacterium nucleatum infection: Bone loss and host response","volume":"36","author":"Polak","year":"2009","journal-title":"J Clin Periodontol"},{"key":"key20180108023512_b28-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.126.12.2611","article-title":"Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle","volume":"126","author":"Karlsson","year":"1999","journal-title":"Development"},{"key":"key20180108023512_b29-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1086\/515178","article-title":"The potential role of chemokines and inflammatory cytokines in periodontal disease progression","volume":"28","author":"Graves","year":"1999","journal-title":"Clin Infect Dis"},{"key":"key20180108023512_b30-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9","article-title":"PD-1: PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2","volume":"32","author":"Carter","year":"2002","journal-title":"Eur J Immunol"},{"key":"key20180108023512_b31-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1902\/annals.2002.7.1.62","article-title":"Immune processes in periodontal disease: A review","volume":"7","author":"Kinane","year":"2002","journal-title":"Ann Periodontol"},{"key":"key20180108023512_b32-mmr-13-03-2423","first-page":"39","article-title":"The role of cytokines in the pathogenesis of periodontal disease","author":"Alexander","year":"1994","journal-title":"Curr Opin Periodontol"},{"key":"key20180108023512_b33-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-0765.1993.tb02113.x","article-title":"Role of cytokines and inflammatory mediators in tissue destruction","volume":"28","author":"Birkedal-Hansen","year":"1993","journal-title":"J Periodontal Res"},{"issue":"Suppl 8","key":"key20180108023512_b34-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"S1569","DOI":"10.1902\/jop.2008.080233","article-title":"Inflammation and bone loss in periodontal disease","volume":"79","author":"Cochran","year":"2008","journal-title":"J Periodontol"},{"key":"key20180108023512_b35-mmr-13-03-2423","first-page":"40","article-title":"Cellular and immune mechanisms in juvenile periodontitis","volume":"27","author":"Hashim","year":"1979","journal-title":"J West Soc Periodontol Periodontal Abstr"},{"key":"key20180108023512_b36-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"key20180108023512_b37-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1172\/JCI19210","article-title":"Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection","volume":"113","author":"Subudhi","year":"2004","journal-title":"J Clin Invest"},{"key":"key20180108023512_b38-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ijc.21775","article-title":"Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro","volume":"119","author":"Blank","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180108023512_b39-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1365-2591.2003.00627.x","article-title":"Inflammatory infiltrate of chronic periradicular lesions: An immunohistochemical study","volume":"36","author":"Liapatas","year":"2003","journal-title":"Int Endod J"},{"key":"key20180108023512_b40-mmr-13-03-2423","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.celrep.2014.01.020","article-title":"Tissue-expressed B7-H1 critically controls intestinal inflammation","volume":"6","author":"Scandiuzzi","year":"2014","journal-title":"Cell Rep"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.4824\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T17:01:17Z","timestamp":1654189277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.4824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,1,28]]},"published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.3892\/mmr.2016.4824"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.4824","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}