{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:38:55Z","timestamp":1780090735589,"version":"3.54.0"},"reference-count":21,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.3892\/mmr.2016.4916","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T05:10:44Z","timestamp":1455858644000},"page":"3169-3172","source":"Crossref","is-referenced-by-count":37,"title":["Point mutation in mitochondrial tRNA gene is associated with polycystic ovary syndrome and insulin resistance"],"prefix":"10.3892","volume":"13","author":[{"given":"YU","family":"DING","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUANGCHAO","family":"ZHUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAIJUAN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIANHANG","family":"LENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"key20180108023551_b1-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"key20180108023551_b2-mmr-13-04-3169","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"key20180108023551_b3-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2007.08.001","article-title":"The management of insulin resistance in polycystic ovary syndrome","volume":"18","author":"Teede","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"key20180108023551_b4-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"5 Suppl 1","key":"key20180108023551_b5-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.amjmed.2006.01.009","article-title":"Etiology of insulin resistance","volume":"119","author":"Petersen","year":"2006","journal-title":"Am J Med"},{"key":"key20180108023551_b6-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.2337\/db07-0275","article-title":"Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome","volume":"56","author":"Skov","year":"2007","journal-title":"Diabetes"},{"key":"key20180108023551_b7-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1210\/jc.2009-0466","article-title":"Mitochondrial complex I impairment in leukocytes from polycystic ovary syndrome patients with insulin resistance","volume":"94","author":"Victor","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108023551_b8-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00404-012-2358-7","article-title":"Analysis of mitochondrial DNA sequence variants in patients with polycystic ovary syndrome","volume":"286","author":"Zhuo","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"key20180108023551_b9-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10528-009-9308-5","article-title":"A 9-bp deletion homoplasmy in women with polycystic ovary syndrome revealed by mitochondrial genome-mutation screen","volume":"48","author":"Zhuo","year":"2010","journal-title":"Biochem Genet"},{"key":"key20180108023551_b10-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Work-shop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"key20180108023551_b11-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/nar\/26.4.967","article-title":"Automating the identification of DNA variations using quality-based fluorescence re-sequencing: Analysis of the human mitochondrial genome","volume":"26","author":"Rieder","year":"1998","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"key20180108023551_b12-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"D611","DOI":"10.1093\/nar\/gki079","article-title":"MITOMAP: A human mitochondrial genome database-2004 update","volume":"33","author":"Brandon","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"key20180108023551_b13-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/hmg\/ddl130","article-title":"Updating the East Asian mtDNA phylogeny: A prerequisite for the identification of pathogenic mutations","volume":"15","author":"Kong","year":"2006","journal-title":"Hum Mol Genet"},{"key":"key20180108023551_b14-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/ajmg.a.32285","article-title":"Mitochondrial ND5 T12338C, tRNA(Cys) T5802C and tRNA(Thr) G15927A variants may have a modifying role in the phenotypic manifestation of deafness-associated 12S rRNA A1555 G mutation in three Han Chinese pedigrees","volume":"146A","author":"Chen","year":"2008","journal-title":"Am J Med Genet A"},{"key":"key20180108023551_b15-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/13779","article-title":"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA","volume":"23","author":"Andrews","year":"1999","journal-title":"Nat Genet"},{"key":"key20180108023551_b16-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3109\/19401736.2012.710205","article-title":"Clinical and molecular characterization of a Han Chinese family with high penetrance of essential hypertension","volume":"23","author":"Teng","year":"2012","journal-title":"Mitochondrial DNA"},{"key":"key20180108023551_b17-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.ophtha.2010.09.003","article-title":"Leber's hereditary optic neuropathy is associated with the T12338C mutation in mitochondrial ND5 gene in six Han Chinese families","volume":"118","author":"Liu","year":"2011","journal-title":"Ophthalmology"},{"key":"key20180108023551_b18-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbrc.2004.12.140","article-title":"Maternally inherited nonsyndromic hearing loss is associated with the T7511C mutation in the mitochondrial tRNASerUCN gene in a Japanese family","volume":"328","author":"Li","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108023551_b19-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/nar\/gkh226","article-title":"Biochemical characterization of the mitochondrial tRNASer (UCN) T7511C mutation associated with nonsyndromic deafness","volume":"32","author":"Li","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"key20180108023551_b20-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1074\/jbc.270.21.12885","article-title":"Human mitochondrial tRNA processing","volume":"270","author":"Rossmanith","year":"1995","journal-title":"J Biol Chem"},{"key":"key20180108023551_b21-mmr-13-04-3169","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/bbrc.1996.0453","article-title":"A novel mitochondrial DNA point mutation in the tRNA (Ile) gene is associated with progressive external ophtalmoplegia","volume":"220","author":"Silvestri","year":"1996","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.4916\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:45:10Z","timestamp":1515368710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.4916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,2,19]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.3892\/mmr.2016.4916"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.4916","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}