{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:09:23Z","timestamp":1789416563167,"version":"build-2803163510"},"reference-count":55,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.3892\/mmr.2016.4937","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T13:07:44Z","timestamp":1456232864000},"page":"3319-3325","source":"Crossref","is-referenced-by-count":6,"title":["Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF"],"prefix":"10.3892","volume":"13","author":[{"given":"LIN","family":"QUAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HUA","family":"HE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"key20180108023703_b1-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.anai.2014.07.007","article-title":"Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge","volume":"113","author":"Fujishima","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key20180108023703_b2-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/ACI.0b013e328357a21b","article-title":"Molecular immunology of allergic conjunctivitis","volume":"12","author":"Irkec","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"key20180108023703_b3-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/jop.2011.0005","article-title":"Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allergic conjunctivitis","volume":"27","author":"Williams","year":"2011","journal-title":"J Ocul Pharmacol Ther"},{"key":"key20180108023703_b4-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/112067210601600319","article-title":"Allergy and infections: Long-term improvement of vernal keratoconjunctivitis following viral conjunctivitis","volume":"16","author":"Sgrulletta","year":"2006","journal-title":"Eur J Ophthalmol"},{"key":"key20180108023703_b5-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.3892\/mmr.2014.2399","article-title":"In silico prediction of the T-cell and IgE-binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches","volume":"10","author":"Chen","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20180108023703_b6-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.toxicon.2014.08.007","article-title":"First report of interruption of mast cell degranulation and endothelial cells activation by anti-inflammatory drugs controlling the acute response provoked by Pseudoplatystoma fasciatum fish venom","volume":"90","author":"Lopes-Ferreira","year":"2014","journal-title":"Toxicon"},{"key":"key20180108023703_b7-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1442-9071.2005.01022.x","article-title":"Ocular hypertensive and anti-inflammatory responses to different dosages of topical dexamethasone in children: A randomized trial","volume":"33","author":"Lam","year":"2005","journal-title":"Clin Experiment Ophthalmol"},{"key":"key20180108023703_b8-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3892\/br.2015.509","article-title":"Measurement of interleukins in vitreous infusion fluid","volume":"3","author":"Kase","year":"2015","journal-title":"Biomed Rep"},{"key":"key20180108023703_b9-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000356407","article-title":"High-dose topical bevacizumab for corneal neovascularization","volume":"92","author":"Waisbourd","year":"2013","journal-title":"Pharmacology"},{"key":"key20180108023703_b10-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/IOP.0000000000000059","article-title":"Naphazoline as a confounder in the diagnosis of carotid artery dissection","volume":"31","author":"Pemberton","year":"2015","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"key20180108023703_b11-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.clinthera.2005.04.011","article-title":"A comparison of the clinical efficacy of pheniramine maleate\/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model","volume":"27","author":"Greiner","year":"2005","journal-title":"Clin Ther"},{"key":"key20180108023703_b12-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s12325-014-0155-3","article-title":"Ocular itch relief with alcaftadine 0.25% versus olopatadine 0.2% in allergic conjunctivitis: Pooled analysis of two multicenter randomized clinical trials","volume":"31","author":"McLaurin","year":"2014","journal-title":"Adv Ther"},{"key":"key20180108023703_b13-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5415\/apallergy.2012.2.2.115","article-title":"Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models","volume":"2","author":"Tamura","year":"2012","journal-title":"Asia Pac Allergy"},{"key":"key20180108023703_b14-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1248\/cpb.54.119","article-title":"A rapid derivative spectrophotometric method for simultaneous determination of naphazoline and antazoline in eye drops","volume":"54","author":"Souri","year":"2006","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"key20180108023703_b15-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2500\/aap.2009.30.3298","article-title":"Safety and efficacy of olopatadine hydrochloride nasal spray 0.6% in pediatric subjects with allergic rhinitis","volume":"30","author":"Berger","year":"2009","journal-title":"Allergy Asthma Proc"},{"key":"key20180108023703_b16-mmr-13-04-3319","first-page":"634","article-title":"Primary meningococcal conjunctivitis","volume":"89","author":"Curran","year":"1989","journal-title":"N Y State J Med"},{"key":"key20180108023703_b17-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/0974-8520.100333","article-title":"Rasanjana Madhu Ashchyotana for a mucopurulent conjunctivitis","volume":"33","author":"Joob","year":"2012","journal-title":"Ayu"},{"key":"key20180108023703_b18-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/eye.2009.8","article-title":"Molecular and immunocytochemical identification of coxsackievirus A-24 variant from the acute haemorrhagic conjunctivitis outbreak in Taiwan in 2007","volume":"24","author":"Kuo","year":"2010","journal-title":"Eye (Lond)"},{"key":"key20180108023703_b19-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1128\/IAI.06054-11","article-title":"Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis","volume":"80","author":"Rank","year":"2012","journal-title":"Infect Immun"},{"key":"key20180108023703_b20-mmr-13-04-3319","first-page":"153","article-title":"Azithromycin reduces inflammation in a rat model of acute conjunctivitis","volume":"19","author":"Fernandez-Robredo","year":"2013","journal-title":"Mol Vis"},{"key":"key20180108023703_b21-mmr-13-04-3319","first-page":"2317","article-title":"Influences of Bushen Xingnao Decoction on expression of vascular endothelial growth factor, IL-1\u03b2 and tumor necrosis factor-\u03b1 in vascular dementia rats","volume":"28","author":"Li","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"key20180108023703_b22-mmr-13-04-3319","first-page":"2306","article-title":"Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1\u03b1, and interleukin-1\u03b2 in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis","volume":"19","author":"Borkenstein","year":"2013","journal-title":"Mol Vis"},{"key":"key20180108023703_b23-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3109\/09273948.2010.538121","article-title":"18\u03b2-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis","volume":"19","author":"Cavone","year":"2011","journal-title":"Ocul Immunol Inflamm"},{"key":"key20180108023703_b24-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000312629","article-title":"Olopatadine hydrochloride improves dermatitis score and inhibits scratch behavior in NC\/Nga mice","volume":"153","author":"Murota","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"key20180108023703_b25-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000110112","article-title":"Olopatadine ameliorates rat experimental cutaneous inflammation by improving skin barrier function","volume":"81","author":"Tamura","year":"2008","journal-title":"Pharmacology"},{"key":"key20180108023703_b26-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/intimm\/10.8.1017","article-title":"Induction of Th2 cell differentiation in the primary immune response: Dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4","volume":"10","author":"Liu","year":"1998","journal-title":"Int Immunol"},{"key":"key20180108023703_b27-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"291","DOI":"10.7754\/Clin.Lab.2013.121004","article-title":"Research on the roles of transcription factors T-bet and GATA-3 in aplastic anemia","volume":"60","author":"Chen","year":"2014","journal-title":"Clin Lab"},{"key":"key20180108023703_b28-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1099\/vir.0.80709-0","article-title":"Mousepox conjunctivitis: The role of Fas\/FasL-mediated apoptosis of epithelial cells in virus dissemination","volume":"86","author":"Krzyzowska","year":"2005","journal-title":"J Gen Virol"},{"key":"key20180108023703_b29-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1167\/iovs.14-15100","article-title":"Immunomodulatory effects of galectin-1 on an IgE-mediated allergic conjunctivitis model","volume":"56","author":"Mello","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180108023703_b30-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.intimp.2006.10.012","article-title":"CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo","volume":"7","author":"Wang","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"key20180108023703_b31-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00417-014-2683-6","article-title":"Total IgE and eotaxin (CCL11) contents in tears of patients suffering from seasonal allergic conjunctivitis","volume":"252","author":"Eperon","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"key20180108023703_b32-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/112067210301300801","article-title":"Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis","volume":"13","author":"Acar","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"key20180108023703_b33-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1076\/ocii.12.1.45.28067","article-title":"Correlations between allergen-specific IgE serum levels in patients with allergic conjunctivitis in spring","volume":"12","author":"Mimura","year":"2004","journal-title":"Ocul Immunol Inflamm"},{"key":"key20180108023703_b34-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S1081-1206(10)62513-6","article-title":"Olopatadine inhibits TNFalpha release from human conjunctival mast cells","volume":"84","author":"Cook","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key20180108023703_b35-mmr-13-04-3319","article-title":"Effects of granulocyte-macrophage colony-stimulating factor supplementation in culture medium on embryo quality and pregnancy outcome of women aged over 35 years","author":"Zhou","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"key20180108023703_b36-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1038\/ncomms7994","article-title":"Granulocyte macrophage colony-stimulating factor is required for aortic dissection\/intramural haematoma","volume":"6","author":"Son","year":"2015","journal-title":"Nat Commun"},{"key":"key20180108023703_b37-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3892\/etm.2014.1652","article-title":"Combined application of alginate dressing and human granulocyte-macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers","volume":"7","author":"Huang","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180108023703_b38-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.4049\/jimmunol.1101755","article-title":"Synergism between curdlan and GM-CSF confers a strong inflammatory signature to dendritic cells","volume":"188","author":"Min","year":"2012","journal-title":"J Immunol"},{"key":"key20180108023703_b39-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2222.2005.02147.x","article-title":"Olopatadine hydrochloride suppresses the rebound phenomenon after discontinuation of treatment with a topical steroid in mice with chronic contact hypersensitivity","volume":"35","author":"Tamura","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"key20180108023703_b40-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2013.03.008","article-title":"Menstrual cycle and reproductive aging alters immune reactivity, NGF expression, antioxidant enzyme activities, and intracellular signaling pathways in the peripheral blood mononuclear cells of healthy women","volume":"32","author":"Priyanka","year":"2013","journal-title":"Brain Behav Immun"},{"key":"key20180108023703_b41-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3892\/ijmm.2013.1387","article-title":"Proteomic analysis of NGF-induced transdifferentiation of adrenal medullary cells","volume":"32","author":"Hu","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20180108023703_b42-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fertnstert.2013.10.038","article-title":"Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-\u03b1 or interleukin-1\u03b2","volume":"101","author":"Mita","year":"2014","journal-title":"Fertil Steril"},{"key":"key20180108023703_b43-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2008.05.067","article-title":"Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo","volume":"1226","author":"Taishi","year":"2008","journal-title":"Brain Res"},{"key":"key20180108023703_b44-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00408-005-2546-3","article-title":"Human lung fibroblast response to NGF, IL-1beta, and dexamethsone","volume":"183","author":"Antonelli","year":"2005","journal-title":"Lung"},{"key":"key20180108023703_b45-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/10520295.2012.703692","article-title":"Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells","volume":"87","author":"Gruber","year":"2012","journal-title":"Biotech Histochem"},{"key":"key20180108023703_b46-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cyto.2008.01.009","article-title":"Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice","volume":"42","author":"Vieira","year":"2008","journal-title":"Cytokine"},{"key":"key20180108023703_b47-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-0028-1083782","article-title":"NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFalpha","volume":"40","author":"Ryan","year":"2008","journal-title":"Horm Metab Res"},{"key":"key20180108023703_b48-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000243718","article-title":"Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats","volume":"84","author":"Tamura","year":"2009","journal-title":"Pharmacology"},{"key":"key20180108023703_b49-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.3892\/mmr.2014.2961","article-title":"Paxillin regulates vascular endothelial growth factor A-induced in vitro angiogenesis of human umbilical vein endothelial cells","volume":"11","author":"Yang","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108023703_b50-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108023703_b51-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3892\/mco.2012.41","article-title":"Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration","volume":"1","author":"Xu","year":"2013","journal-title":"Mol Clin Oncol"},{"key":"key20180108023703_b52-mmr-13-04-3319","article-title":"Resveratrol reduces IL-6 and VEGF secretion from co-cultured A549 lung cancer cells and adipose-derived mesenchymal stem cells","author":"Sahin","year":"2015","journal-title":"Tumour Biol"},{"key":"key20180108023703_b53-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/j.1471-0528.2011.02925.x","article-title":"Impaired vascular permeability regulation caused by the VEGF(1)(6)(5)b splice variant in pre-eclampsia","volume":"118","author":"Bills","year":"2011","journal-title":"BJOG"},{"key":"key20180108023703_b54-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2014.09.025","article-title":"Neurons limit angiogenesis by titrating VEGF in retina","volume":"159","author":"Okabe","year":"2014","journal-title":"Cell"},{"key":"key20180108023703_b55-mmr-13-04-3319","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5415\/apallergy.2011.1.3.138","article-title":"Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography","volume":"1","author":"Tamura","year":"2011","journal-title":"Asia Pac Allergy"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.4937\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T22:22:47Z","timestamp":1567635767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.4937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,2,23]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.3892\/mmr.2016.4937"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.4937","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]}}}