{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:45Z","timestamp":1790816205252,"version":"4.1.0"},"reference-count":34,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.3892\/mmr.2016.5034","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T13:23:02Z","timestamp":1458566582000},"page":"4058-4064","source":"Crossref","is-referenced-by-count":38,"title":["NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity"],"prefix":"10.3892","volume":"13","author":[{"given":"XIAO-DONG","family":"ZOU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHAO-QING","family":"GUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHI-WEI","family":"HU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEI-LANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"key20180108023938_b1-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35072550","article-title":"Experimental models of Parkinson's disease","volume":"2","author":"Beal","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"key20180108023938_b2-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1074\/jbc.M511560200","article-title":"6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta","volume":"281","author":"Hanrott","year":"2006","journal-title":"J Biol Chem"},{"issue":"Suppl 2","key":"key20180108023938_b3-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1016\/j.parkreldis.2008.04.015","article-title":"The 6-hydroxy-dopamine model: News from the past","volume":"14","author":"Blandini","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"key20180108023938_b4-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10072-010-0245-1","article-title":"Parkinson's disease: Oxidative stress and therapeutic approaches","volume":"31","author":"Surendran","year":"2010","journal-title":"Neurol Sci"},{"key":"key20180108023938_b5-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1046\/j.1471-4159.2000.0741605.x","article-title":"Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants","volume":"74","author":"Soto-Otero","year":"2000","journal-title":"J Neurochem"},{"key":"key20180108023938_b6-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neulet.2014.08.016","article-title":"7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K\/Akt and JNK pathways","volume":"581","author":"Han","year":"2014","journal-title":"Neurosci Lett"},{"key":"key20180108023938_b7-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuint.2014.09.001","article-title":"A novel tetramethylpyrazine bisnitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-\u03baB and the PKC\u03b1\/PI3-K\/Akt pathways","volume":"78","author":"Xu","year":"2014","journal-title":"Neurochem Int"},{"key":"key20180108023938_b8-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s11064-014-1367-2","article-title":"Carvedilol attenuates 6-hydroxydo-pamine-induced cell death in PC12 Cells: Involvement of Akt and Nrf2\/ARE pathways","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem Res"},{"key":"key20180108023938_b9-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"key20180108023938_b10-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L","article-title":"Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis","volume":"32","author":"Rongvaux","year":"2002","journal-title":"Eur J Immunol"},{"key":"key20180108023938_b11-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MOG.0b013e32801b3c8f","article-title":"The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt\/PBEF\/visfatin in mammals","volume":"23","author":"Revollo","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"key20180108023938_b12-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells","volume":"279","author":"Revollo","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180108023938_b13-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/ars.2007.1672","article-title":"NAD+\/NADH and NADP+\/NADPH in cellular functions and cell death: Regulation and biological consequences","volume":"10","author":"Ying","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"key20180108023938_b14-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000104152","article-title":"H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion","volume":"20","author":"Furukawa","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"key20180108023938_b15-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3892\/etm.2014.1842","article-title":"Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease","volume":"8","author":"Lu","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180108023938_b16-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"key20180108023938_b17-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1098014","article-title":"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration","volume":"305","author":"Araki","year":"2004","journal-title":"Science"},{"key":"key20180108023938_b18-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1074\/jbc.M109.090266","article-title":"Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure","volume":"285","author":"Tanno","year":"2010","journal-title":"J Biol Chem"},{"key":"key20180108023938_b19-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1158\/0008-5472.CAN-08-3365","article-title":"The critical role of the class III histone deacetylase SIRT1 in cancer","volume":"69","author":"Liu","year":"2009","journal-title":"Cancer Res"},{"key":"key20180108023938_b20-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"key20180108023938_b21-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.arr.2007.09.002","article-title":"Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging","volume":"7","author":"Salminen","year":"2008","journal-title":"Ageing Res Rev"},{"key":"key20180108023938_b22-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.08.011","article-title":"Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses","volume":"123","author":"Chen","year":"2005","journal-title":"Cell"},{"key":"key20180108023938_b23-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2008.04.176","article-title":"Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression","volume":"372","author":"Hasegawa","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108023938_b24-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/emm.2007.2","article-title":"SIRT1 promotes DNA repair activity and deacetylation of Ku70","volume":"39","author":"Jeong","year":"2007","journal-title":"Exp Mol Med"},{"key":"key20180108023938_b25-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.jprot.2011.11.008","article-title":"Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention","volume":"75","author":"Bu","year":"2012","journal-title":"J Proteomics"},{"key":"key20180108023938_b26-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"e78220","DOI":"10.1371\/journal.pone.0078220","article-title":"Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS One"},{"key":"key20180108023938_b27-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog Neurobiol"},{"key":"key20180108023938_b28-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","article-title":"Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP","volume":"318","author":"Schober","year":"2004","journal-title":"Cell Tissue Res"},{"key":"key20180108023938_b29-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.freeradbiomed.2006.12.004","article-title":"Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxide-dependent and-independent action","volume":"42","author":"Saito","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"key20180108023938_b30-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2006.06.079","article-title":"Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway","volume":"1113","author":"Fujita","year":"2006","journal-title":"Brain Res"},{"key":"key20180108023938_b31-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"E632","DOI":"10.1208\/aapsj080472","article-title":"NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity","volume":"8","author":"Yang","year":"2006","journal-title":"AAPS J"},{"key":"key20180108023938_b32-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1111\/j.1742-4658.2005.04864.x","article-title":"Poly (ADP-ribose). The most elaborate metabolite of NAD+","volume":"272","author":"B\u00fcrkle","year":"2005","journal-title":"FEBS J"},{"key":"key20180108023938_b33-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: Where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J Neurochem"},{"key":"key20180108023938_b34-mmr-13-05-4058","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.bbapap.2009.10.022","article-title":"SIRT1-dependent regulation of chromatin and transcription: Linking NAD metabolism and signaling to the control of cellular functions","volume":"1804","author":"Zhang","year":"2010","journal-title":"Biochim Biophys Acta"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5034\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T04:49:05Z","timestamp":1515386945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,21]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.3892\/mmr.2016.5034"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5034","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}