{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:15:59Z","timestamp":1789953359316,"version":"4.0.1"},"reference-count":38,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.3892\/mmr.2016.5088","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T06:32:00Z","timestamp":1459837920000},"page":"4414-4420","source":"Crossref","is-referenced-by-count":33,"title":["Inhibition of the Rac1-WAVE2-Arp2\/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells"],"prefix":"10.3892","volume":"13","author":[{"given":"TAO","family":"ZHOU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHEN-HAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HUA","family":"YAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RUI","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIN-BING","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHUN-FA","family":"QIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HONG","family":"XIAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HONG-YI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"key20180108023905_b1-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/neuonc\/nor229","article-title":"Systematic review of supportive care needs in patients with primary malignant brain tumors","volume":"14","author":"Ford","year":"2012","journal-title":"Neuro Oncol"},{"key":"key20180108023905_b2-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/CCO.0b013e32833e078c","article-title":"Supportive care in neurooncology","volume":"22","author":"Pace","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"key20180108023905_b3-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S1470-2045(08)70230-4","article-title":"Psychosocial and supportive-care needs in high-grade glioma","volume":"9","author":"Catt","year":"2008","journal-title":"Lancet Oncol"},{"key":"key20180108023905_b4-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med"},{"key":"key20180108023905_b5-mmr-13-05-4414","first-page":"2349","article-title":"Isolation, karyotype and clonal growth of heterogeneous subpopulations of human malignant gliomas","volume":"41","author":"Shapiro","year":"1981","journal-title":"Cancer Res"},{"key":"key20180108023905_b6-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1158\/0008-5472.CAN-11-0153","article-title":"Heterogeneity maintenance in glioblastoma: A social network","volume":"71","author":"Bonavia","year":"2011","journal-title":"Cancer Res"},{"key":"key20180108023905_b7-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1073\/pnas.1219747110","article-title":"Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics","volume":"110","author":"Sottoriva","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108023905_b8-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/0360-3016(79)90553-4","article-title":"An analysis of dose-effect relationship in the radiotherapy of malignant gliomas","volume":"5","author":"Walker","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108023905_b9-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12035-014-8888-1","article-title":"Mitochondrial KATP channels control glioma radioresistance by regulating ROS-Induced ERK activation","volume":"52","author":"Huang","year":"2015","journal-title":"Mol Neurobiol"},{"key":"key20180108023905_b10-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.200801047","article-title":"Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division","volume":"181","author":"Michaelson","year":"2008","journal-title":"J Cell Biol"},{"key":"key20180108023905_b11-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1158\/1078-0432.CCR-14-0827","article-title":"Molecular pathways: Targeting the kinase effectors of RHO-family GTPases","volume":"21","author":"Prudnikova","year":"2015","journal-title":"Clin Cancer Res"},{"key":"key20180108023905_b12-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1038\/bjc.2014.221","article-title":"Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)","volume":"110","author":"Skvortsov","year":"2014","journal-title":"Br J Cancer"},{"key":"key20180108023905_b13-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.146.2.267","article-title":"Signaling to actin dynamics","volume":"146","author":"Machesky","year":"1999","journal-title":"J Cell Biol"},{"key":"key20180108023905_b14-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments","volume":"112","author":"Pollard","year":"2003","journal-title":"Cell"},{"key":"key20180108023905_b15-mmr-13-05-4414","first-page":"155","article-title":"Structure and role of WASP and WAVE in Rho GTPase signalling in cancer","volume":"11","author":"Lane","year":"2014","journal-title":"Cancer Genomics Proteomics"},{"key":"key20180108023905_b16-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"13638","DOI":"10.1074\/jbc.M113.511360","article-title":"\u03b2Arrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility","volume":"289","author":"Ma","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180108023905_b17-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1091\/mbc.E12-12-0857","article-title":"Arp2\/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin","volume":"24","author":"Koestler","year":"2013","journal-title":"Mol Biol Cell"},{"key":"key20180108023905_b18-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.bmcl.2013.12.115","article-title":"Urokinase-type plasminogen activator expression and Rac1\/WAVE-2\/Arp2\/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells","volume":"24","author":"Ko","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"key20180108023905_b19-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.cellbio.15.1.185","article-title":"Proteins of the ADF\/cofilin family: Essential regulators of actin dynamics","volume":"15","author":"Bamburg","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"key20180108023905_b20-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"33827","DOI":"10.1074\/jbc.274.48.33827","article-title":"Control of actin dynamics in cell motility. Role of ADF\/cofilin","volume":"274","author":"Carlier","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180108023905_b21-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"reviews3007","DOI":"10.1186\/gb-2002-3-5-reviews3007","article-title":"The ADF\/cofilin family: Actin-remodeling proteins","volume":"3","author":"Maciver","year":"2002","journal-title":"Genome Biol"},{"key":"key20180108023905_b22-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/bj20020231","article-title":"The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability","volume":"365","author":"Moriyama","year":"2002","journal-title":"Biochem J"},{"key":"key20180108023905_b23-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ydbio.2004.11.010","article-title":"The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration","volume":"278","author":"Gurniak","year":"2005","journal-title":"Dev Biol"},{"key":"key20180108023905_b24-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1755-5949.2012.00353.x","article-title":"Over-expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance","volume":"18","author":"Yan","year":"2012","journal-title":"Cns Neurosci Ther"},{"key":"key20180108023905_b25-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.3892\/mmr.2014.3125","article-title":"Increasing radiosensitivity with the downregulation of cofilin-1 in U251 human glioma cells","volume":"11","author":"Du","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108023905_b26-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nature12611","article-title":"Inhibitory signalling to the Arp2\/3 complex steers cell migration","volume":"503","author":"Dang","year":"2013","journal-title":"Nature"},{"key":"key20180108023905_b27-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1349-7006.2010.01552.x","article-title":"Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells","volume":"101","author":"Ho","year":"2010","journal-title":"Cancer Sci"},{"key":"key20180108023905_b28-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1038\/sj.onc.1209706","article-title":"Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K\/Akt\/NF-kappaB signal transduction pathway","volume":"25","author":"Cheng","year":"2006","journal-title":"Oncogene"},{"key":"key20180108023905_b29-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1158\/0008-5472.CAN-05-4340","article-title":"Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src\/epidermal growth factor receptor-mediated p38\/Akt and phosphatidylinositol 3-kinase\/Akt signaling pathways","volume":"66","author":"Park","year":"2006","journal-title":"Cancer Res"},{"key":"key20180108023905_b30-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrc2148","article-title":"The cofilin pathway in breast cancer invasion and metastasis","volume":"7","author":"Wang","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"key20180108023905_b31-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1074\/jbc.M607711200","article-title":"IQGAP1 stimulates actin assembly through the N-WASP-Arp2\/3 pathway","volume":"282","author":"Le Clainche","year":"2007","journal-title":"J Biol Chem"},{"key":"key20180108023905_b32-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1242\/jcs.01211","article-title":"Synergistic interaction between the Arp2\/3 complex and cofilin drives stimulated lamellipod extension","volume":"117","author":"DesMarais","year":"2004","journal-title":"J Cell Sci"},{"key":"key20180108023905_b33-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"513","DOI":"10.18632\/oncoscience.74","article-title":"Rac1 as a multifunctional therapeutic target to prevent and combat cancer metastasis","volume":"1","author":"Arnold","year":"2014","journal-title":"Oncoscience"},{"key":"key20180108023905_b34-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: Building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"key20180108023905_b35-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3892\/ol.2014.2361","article-title":"Hsa-microRNA-101 suppresses migration and invasion by targeting Rac1 in thyroid cancer cells","volume":"8","author":"Wang","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180108023905_b36-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cub.2004.04.008","article-title":"Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells","volume":"14","author":"Lorenz","year":"2004","journal-title":"Curr Biol"},{"key":"key20180108023905_b37-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tcb.2010.01.001","article-title":"ADF\/cofilin: A functional node in cell biology","volume":"20","author":"Bernstein","year":"2010","journal-title":"Trends Cell Biol"},{"key":"key20180108023905_b38-mmr-13-05-4414","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fgene.2011.00058","article-title":"MicroRNA control of invasion and metastasis pathways","volume":"2","author":"Sreekumar","year":"2011","journal-title":"Front Genet"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5088\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T04:23:41Z","timestamp":1567743821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,5]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,4,5]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.3892\/mmr.2016.5088"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5088","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,5]]}}}