{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T16:06:09Z","timestamp":1781971569343,"version":"3.54.5"},"reference-count":38,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/mmr.2016.5166","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T09:21:53Z","timestamp":1461316913000},"page":"5077-5083","source":"Crossref","is-referenced-by-count":16,"title":["Post-translational modifications of \u03b1-synuclein contribute to neurodegeneration in the colon of elderly individuals"],"prefix":"10.3892","volume":"13","author":[{"given":"QI","family":"XUAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU-XIAN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIAN-GANG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PIU","family":"CHAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHENG-LI","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YE-QING","family":"CUI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"key20180108024856_b1-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"188","DOI":"10.12968\/bjon.2006.15.4.20542","article-title":"Constipation in older patients: Effects on quality of life","volume":"15","author":"Norton","year":"2006","journal-title":"Br J Nurs"},{"key":"key20180108024856_b2-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1365-2982.2008.01165.x","article-title":"Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation","volume":"20","author":"Wattchow","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"key20180108024856_b3-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.neurobiolaging.2006.05.019","article-title":"Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats","volume":"28","author":"Phillips","year":"2007","journal-title":"Neurobiol Aging"},{"key":"key20180108024856_b4-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2007.04.005","article-title":"Innervation of the gastrointestinal tract: Patterns of aging","volume":"136","author":"Phillips","year":"2007","journal-title":"Auton Neurosci"},{"key":"key20180108024856_b5-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4161\/cib.3.2.10964","article-title":"The regulation of synaptic function by alpha-synuclein","volume":"3","author":"Bellani","year":"2010","journal-title":"Commun Integr Biol"},{"key":"key20180108024856_b6-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1091\/mbc.E08-03-0302","article-title":"{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics","volume":"20","author":"Sousa","year":"2009","journal-title":"Mol Biol Cell"},{"key":"key20180108024856_b7-mmr-13-06-5077","first-page":"29","article-title":"Expression of alpha-synuclein in different brain parts of adult and aged rats","volume":"56","author":"Adamczyk","year":"2005","journal-title":"J Physiol Pharmacol"},{"key":"key20180108024856_b8-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Arizona Parkinson's Disease Consortium: Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol"},{"key":"key20180108024856_b9-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.wco.0000168241.53853.32","article-title":"The role of alpha-synuclein and tau in neurodegenerative movement disorders","volume":"18","author":"Wenning","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"key20180108024856_b10-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuroscience.2008.02.074","article-title":"Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?","volume":"153","author":"Phillips","year":"2008","journal-title":"Neuroscience"},{"key":"key20180108024856_b11-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"Alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat Cell Biol"},{"key":"key20180108024856_b12-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","article-title":"Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"key":"key20180108024856_b13-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nn1443","article-title":"Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a drosophila model of parkinson disease","volume":"8","author":"Chen","year":"2005","journal-title":"Nat Neurosci"},{"key":"key20180108024856_b14-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(03)00367-3","article-title":"Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers","volume":"542","author":"Yamin","year":"2003","journal-title":"FEBS Lett"},{"key":"key20180108024856_b15-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"e9956","DOI":"10.1371\/journal.pone.0009956","article-title":"Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats","volume":"5","author":"Yu","year":"2010","journal-title":"PLoS One"},{"key":"key20180108024856_b16-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s00702-011-0636-3","article-title":"Increased expression of \u03b1-synuclein in aged human brain associated with neuromelanin accumulation","volume":"118","author":"Xuan","year":"2011","journal-title":"J Neural Transm (Vienna)"},{"key":"key20180108024856_b17-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuroscience.2006.12.028","article-title":"Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody","volume":"145","author":"Yu","year":"2007","journal-title":"Neuroscience"},{"key":"key20180108024856_b18-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/ageing\/afh040","article-title":"Effects of ageing on gastrointestinal motor function","volume":"33","author":"Madsen","year":"2004","journal-title":"Age Ageing"},{"key":"key20180108024856_b19-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/BF01296139","article-title":"Effect of age, gender and parity on anal canal pressures. Contribution of impaired anal sphincter function to fecal incontinence","volume":"32","author":"McHugh","year":"1987","journal-title":"Dig Dis Sci"},{"key":"key20180108024856_b20-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1566-0702(03)00072-9","article-title":"Aging of the myenteric plexus: Neuronal loss is specific to cholinergic neurons","volume":"106","author":"Phillips","year":"2003","journal-title":"Auton Neurosci"},{"key":"key20180108024856_b21-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"G489","DOI":"10.1152\/ajpgi.00091.2002","article-title":"Aging and neural control of the GI tractI. Age-related changes in the enteric nervous system","volume":"283","author":"Wade","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20180108024856_b22-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2982.2008.01245.x","article-title":"Effect of age on the enteric nervous system of the human colon","volume":"21","author":"Bernard","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"key20180108024856_b23-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1136\/gut.2008.162503","article-title":"Pathological lesions in colonic biopsies during Parkinson's disease","volume":"57","author":"Lebouvier","year":"2008","journal-title":"Gut"},{"key":"key20180108024856_b24-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.expneurol.2009.07.025","article-title":"Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat","volume":"220","author":"Phillips","year":"2009","journal-title":"Exp Neurol"},{"key":"key20180108024856_b25-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"e12728","DOI":"10.1371\/journal.pone.0012728","article-title":"Colonic biopsies to assess the neuropathology of parkinson's disease and its relationship with symptoms","volume":"5","author":"Lebouvier","year":"2010","journal-title":"PLoS One"},{"key":"key20180108024856_b26-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.neurobiolaging.2008.09.010","article-title":"Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats","volume":"31","author":"Choi","year":"2010","journal-title":"Neurobiol Aging"},{"key":"key20180108024856_b27-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1471-4159.2010.06832.x","article-title":"Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain","volume":"114","author":"Siebert","year":"2010","journal-title":"J Neurochem"},{"key":"key20180108024856_b28-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/brain\/awm302","article-title":"Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in parkinson's disease","volume":"131","author":"Orimo","year":"2008","journal-title":"Brain"},{"key":"key20180108024856_b29-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1365-2982.2008.01165.x","article-title":"Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation","volume":"20","author":"Wattchow","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"key20180108024856_b30-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mrgentox.2008.09.013","article-title":"Environmental-induced oxidative stress in neurodegenerative disorders and aging","volume":"674","author":"Migliore","year":"2009","journal-title":"Mutat Res"},{"key":"key20180108024856_b31-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2006.03.003","article-title":"Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats","volume":"401","author":"Miwa","year":"2006","journal-title":"Neurosci Lett"},{"key":"key20180108024856_b32-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1460-9568.2007.05736.x","article-title":"Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D","volume":"26","author":"Takahashi","year":"2007","journal-title":"Eur J Neurosci"},{"key":"key20180108024856_b33-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/NEN.0b013e318180f0bd","article-title":"Pathological modifications of alpha-synuclein in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated squirrel monkeys","volume":"67","author":"McCormack","year":"2008","journal-title":"J Neuropath Exp Neur"},{"key":"key20180108024856_b34-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1523\/JNEUROSCI.0143-07.2008","article-title":"Neuroinflammation and oxidation\/nitration of alpha-synuclein linked to dopaminergic neurodegeneration","volume":"28","author":"Gao","year":"2008","journal-title":"J Neurosci"},{"key":"key20180108024856_b35-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"47746","DOI":"10.1074\/jbc.M408906200","article-title":"Functional consequences of alpha-synuclein tyrosine nitration: Diminished binding to lipid vesicles and increased fibril formation","volume":"279","author":"Hodara","year":"2004","journal-title":"J Biol Chem"},{"key":"key20180108024856_b36-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180108024856_b37-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0002-9440(10)64553-1","article-title":"Alpha-synuclein promotes mitochondrial deficit and oxidative stress","volume":"157","author":"Hsu","year":"2000","journal-title":"Am J Pathol"},{"key":"key20180108024856_b38-mmr-13-06-5077","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.0903691106","article-title":"Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein","volume":"106","author":"Desplats","year":"2009","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5166\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T22:35:48Z","timestamp":1718490948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,22]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/mmr.2016.5166"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5166","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}