{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:11:49Z","timestamp":1768565509127,"version":"3.49.0"},"reference-count":24,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/mmr.2016.5669","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T08:30:51Z","timestamp":1472027451000},"page":"3535-3542","source":"Crossref","is-referenced-by-count":10,"title":["Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment"],"prefix":"10.3892","volume":"14","author":[{"given":"Longwei","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongya","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"key20180108025646_b1-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2165\/11585470-000000000-00000","article-title":"Safety of long-term bisphosphonate therapy for the management of osteoporosis","volume":"71","author":"Lewiecki","year":"2011","journal-title":"Drugs"},{"key":"key20180108025646_b2-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","article-title":"Denosumab and bisphosphonates: Different mechanisms of action and effects","volume":"48","author":"Baron","year":"2011","journal-title":"Bone"},{"key":"key20180108025646_b3-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/sj.bjc.6600297","article-title":"The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells","volume":"86","author":"Senaratne","year":"2002","journal-title":"Br J Cancer"},{"key":"key20180108025646_b4-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10549-013-2613-z","article-title":"Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells","volume":"140","author":"Kaiser","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"key20180108025646_b5-mmr-14-04-3535","first-page":"283","article-title":"Bone-related growth factors and zoledronic acid regulate the PTHrP\/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells","volume":"26","author":"Tenta","year":"2006","journal-title":"Anticancer Res"},{"key":"key20180108025646_b6-mmr-14-04-3535","first-page":"389","article-title":"High concentration of zoledronate inhibits osteogenesis differentiation and promotes apoptosis of human osteoblasts","volume":"24","author":"Hu","year":"2015","journal-title":"China Journal of Stomatology"},{"key":"key20180108025646_b7-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s10495-008-0296-4","article-title":"The cardioprotective effect of postconditioning is mediated by ARC through inhibiting mitochondrial apoptotic pathway","volume":"14","author":"Li","year":"2009","journal-title":"Apoptosis"},{"key":"key20180108025646_b8-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10495-007-0094-4","article-title":"ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis","volume":"12","author":"Li","year":"2007","journal-title":"Apoptosis"},{"key":"key20180108025646_b9-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0014-5793(03)00444-7","article-title":"Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia\/hypoxia","volume":"543","author":"Hong","year":"2003","journal-title":"FEBS Lett"},{"key":"key20180108025646_b10-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1073\/pnas.95.9.5156","article-title":"ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases","volume":"95","author":"Koseki","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108025646_b11-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"9763","DOI":"10.1128\/MCB.24.22.9763-9770.2004","article-title":"Calcium binding of ARC mediates regulation of caspase 8 and cell death","volume":"24","author":"Jo","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key20180108025646_b12-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ceb.2009.09.004","article-title":"Mitochondrial cell death effectors","volume":"21","author":"Brenner","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"key20180108025646_b13-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1517\/14712598.2014.960387","article-title":"Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy","volume":"14","author":"Aino","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"key20180108025646_b14-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108025646_b15-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2184.2011.00750.x","article-title":"Ectopic study of tissue-engineered bone complex with enamel matrix proteins, bone marrow stromal cells in porous calcium phosphate cement scaffolds, in nude mice","volume":"44","author":"Wang","year":"2011","journal-title":"Cell Prolif"},{"key":"key20180108025646_b16-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bbrc.2006.12.094","article-title":"Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase","volume":"353","author":"Wiemer","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108025646_b17-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbrc.2004.11.072","article-title":"Regulation of apoptosis in osteoclasts and osteoblastic cells","volume":"328","author":"Xing","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108025646_b18-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bone.2009.01.009","article-title":"Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation","volume":"44","author":"Ebert","year":"2009","journal-title":"Bone"},{"key":"key20180108025646_b19-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/jnci\/djk054","article-title":"Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis","volume":"99","author":"Daubin\u00e9","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"key20180108025646_b20-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jcms.2014.12.008","article-title":"High doses of bisphosphonates reduce osteoblast-like cell proliferation by arresting the cell cycle and inducing apoptosis","volume":"43","author":"Manzano-Moreno","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"key20180108025646_b21-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.joms.2014.07.004","article-title":"Bisphosphonate uptake in areas of tooth extraction or periapical disease","volume":"72","author":"Cheong","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"key20180108025646_b22-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1158\/0008-5472.CAN-07-5056","article-title":"Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein","volume":"68","author":"Chen","year":"2008","journal-title":"Cancer Res"},{"key":"key20180108025646_b23-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.4161\/cc.7.11.5979","article-title":"ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer","volume":"7","author":"Mercier","year":"2008","journal-title":"Cell Cycle"},{"key":"key20180108025646_b24-mmr-14-04-3535","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.febslet.2005.03.040","article-title":"Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei","volume":"579","author":"Wang","year":"2005","journal-title":"FEBS Lett"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5669\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:11:56Z","timestamp":1515370316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,24]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/mmr.2016.5669"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5669","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}