{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:47:21Z","timestamp":1778266041820,"version":"3.51.4"},"reference-count":34,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.3892\/mmr.2016.5844","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T08:14:13Z","timestamp":1476346453000},"page":"4837-4843","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin-33-induced immune tolerance is associated with the imbalance of memory and na\u00efve T-lymphocyte subsets"],"prefix":"10.3892","volume":"14","author":[{"given":"Xu","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"key20180108030120_b1-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180108030120_b2-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jhep.2009.12.034","article-title":"Cancer gene discovery in hepatocellular carcinoma","volume":"52","author":"Zender","year":"2010","journal-title":"J Hepatol"},{"key":"key20180108030120_b3-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0140-6736(00)02654-4","article-title":"Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: A randomised trial","volume":"356","author":"Takayama","year":"2000","journal-title":"Lancet"},{"key":"key20180108030120_b4-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/ajg.2012.449","article-title":"Detection of hepatocellular carcinoma at advanced stages among patients in the HALT-C trial: Where did surveillance fail?","volume":"108","author":"Singal","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"key20180108030120_b5-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1053\/j.gastro.2004.09.016","article-title":"Pathogenesis of hepatitis B virus related hepatocellular carcinoma: Old and new paradigms","volume":"127","author":"Br\u00e9chot","year":"2004","journal-title":"Gastroenterology"},{"key":"key20180108030120_b6-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1349-7006.2005.00059.x","article-title":"Chemokines in tumor progression and metastasis","volume":"96","author":"Tanaka","year":"2005","journal-title":"Cancer Sci"},{"key":"key20180108030120_b7-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1200\/JCO.2012.46.3653","article-title":"Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers","volume":"31","author":"Jain","year":"2013","journal-title":"J Clin Oncol"},{"key":"key20180108030120_b8-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000342405","article-title":"Emerging signaling pathways in hepatocellular carcinoma","volume":"1","author":"Moeini","year":"2012","journal-title":"Liver Cancer"},{"key":"key20180108030120_b9-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1755-8794-4-62","article-title":"Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma","volume":"4","author":"Zheng","year":"2011","journal-title":"BMC Med Genomics"},{"key":"key20180108030120_b10-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"e22524","DOI":"10.1371\/journal.pone.0022524","article-title":"DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic","volume":"6","author":"Yin","year":"2011","journal-title":"PLoS One"},{"key":"key20180108030120_b11-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.4049\/jimmunol.152.6.3074","article-title":"Selective expansion of cytotoxic T lymphocytes with a CD4+ CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with hepatitis B virus","volume":"152","author":"Barnaba","year":"1994","journal-title":"J Immunol"},{"key":"key20180108030120_b12-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.antiviral.2006.04.006","article-title":"The flavonoid ellagic acid from a medicinal herb inhibits host immune tolerance induced by the hepatitis B virus-e antigen","volume":"72","author":"Kang","year":"2006","journal-title":"Antiviral Res"},{"key":"key20180108030120_b13-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2011.04.006","article-title":"Breaking B and T cell tolerance using cationic lipid-DNA complexes (CLDC) as a vaccine adjuvant with hepatitis B virus (HBV) surface antigen in transgenic mice expressing HBV","volume":"90","author":"Morrey","year":"2011","journal-title":"Antiviral Res"},{"key":"key20180108030120_b14-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"e1694","DOI":"10.1038\/cddis.2015.42","article-title":"T-cell exhaustion in chronic hepatitis B infection: Current knowledge and clinical significance","volume":"6","author":"Ye","year":"2015","journal-title":"Cell Death Dis"},{"key":"key20180108030120_b15-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1743-422X-11-22","article-title":"Innate immune responses in hepatitis B virus (HBV) infection","volume":"11","author":"Busca","year":"2014","journal-title":"Virol J"},{"key":"key20180108030120_b16-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.1101649","article-title":"Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction","volume":"187","author":"Kastenmuller","year":"2011","journal-title":"J Immunol"},{"key":"key20180108030120_b17-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"key20180108030120_b18-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.0606854104","article-title":"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo","volume":"104","author":"Carriere","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108030120_b19-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/embor.2008.145","article-title":"Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket","volume":"9","author":"Roussel","year":"2008","journal-title":"EMBO Rep"},{"key":"key20180108030120_b20-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.imbio.2015.02.005","article-title":"IL-33\/ST2 axis controls Th2\/IL-31 and Th17 immune response in allergic airway diseases","volume":"220","author":"Vocca","year":"2015","journal-title":"Immunobiology"},{"key":"key20180108030120_b21-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.4049\/jimmunol.1103685","article-title":"IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures","volume":"189","author":"Blom","year":"2012","journal-title":"J Immunol"},{"key":"key20180108030120_b22-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCHEARTFAILURE.109.873240","article-title":"Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling","volume":"2","author":"Seki","year":"2009","journal-title":"Circ Heart Fail"},{"key":"key20180108030120_b23-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.4049\/jimmunol.1000520","article-title":"IL-33 reduces macrophage foam cell formation","volume":"185","author":"McLaren","year":"2010","journal-title":"J Immunol"},{"key":"key20180108030120_b24-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2009.04.081","article-title":"IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes","volume":"384","author":"Wood","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108030120_b25-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/CIRCRESAHA.110.218867","article-title":"Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice","volume":"107","author":"Miller","year":"2010","journal-title":"Circ Res"},{"key":"key20180108030120_b26-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/hep.25893","article-title":"TRAIL but not FasL and TNF\u03b1, regulates IL-33 expression in murine hepatocytes during acute hepatitis","volume":"56","author":"Arshad","year":"2012","journal-title":"Hepatology"},{"key":"key20180108030120_b27-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108030120_b28-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/cmi.2015.25","article-title":"Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients","volume":"12","author":"Xu","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"key20180108030120_b29-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12879-015-0762-x","article-title":"Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection","volume":"15","author":"Hojo-Souza","year":"2015","journal-title":"BMC Infect Dis"},{"key":"key20180108030120_b30-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: Implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key20180108030120_b31-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/jir.2011.0109","article-title":"Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B","volume":"32","author":"Wang","year":"2012","journal-title":"J Interferon Cytokine Res"},{"key":"key20180108030120_b32-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/jir.2013.0122","article-title":"IL-33 enhances humoral immunity against chronic HBV infection through activating CD4(+)CXCR5(+) TFH cells","volume":"35","author":"Zhao","year":"2015","journal-title":"J Interferon Cytokine Res"},{"key":"key20180108030120_b33-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jhep.2009.10.033","article-title":"Mechanisms of HBV-related hepatocarcinogenesis","volume":"52","author":"Neuveut","year":"2010","journal-title":"J Hepatol"},{"key":"key20180108030120_b34-mmr-14-05-4837","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s00535-011-0415-9","article-title":"Hepatitis B virus X gene and hepatocarcinogenesis","volume":"46","author":"Ng","year":"2011","journal-title":"J Gastroenterol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5844\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:28:02Z","timestamp":1692534482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,13]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,10,13]]},"published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.3892\/mmr.2016.5844"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5844","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,13]]}}}