{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:15:23Z","timestamp":1780773323601,"version":"3.54.1"},"reference-count":56,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/mmr.2016.5866","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T08:06:51Z","timestamp":1476950811000},"page":"5281-5287","source":"Crossref","is-referenced-by-count":8,"title":["Lipopolysaccharide-induced cytokine expression pattern in peripheral blood mononuclear cells in childhood obesity"],"prefix":"10.3892","volume":"14","author":[{"given":"Yu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"key20180108030911_b1-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0022-3476(04)00243-4","article-title":"Severe obesity associated with cardiovascular deconditioning, high prevalence of cardiovascular risk factors, diabetes mellitus\/hyperinsulinemia, and respiratory compromise","volume":"144","author":"Gidding","year":"2004","journal-title":"J Pediatr"},{"key":"key20180108030911_b2-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.pupt.2012.05.002","article-title":"Effects of obesity and weight loss on airway physiology and inflammation in asthma","volume":"26","author":"Sideleva","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"key20180108030911_b3-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jpeds.2007.09.010","article-title":"Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later","volume":"152","author":"Morrison","year":"2008","journal-title":"J Pediatr"},{"key":"key20180108030911_b4-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.2337\/diabetes.51.10.3120","article-title":"Components of the \u2018metabolic syndrome\u2019 and incidence of type 2 diabetes","volume":"51","author":"Hanson","year":"2002","journal-title":"Diabetes"},{"key":"key20180108030911_b5-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1001\/jama.1986.03380200073024","article-title":"Incidence of coronary heart diseases and lipoprotein cholesterol levels: the Framingham study","volume":"256","author":"Castelli","year":"1986","journal-title":"JAMA"},{"key":"key20180108030911_b6-mmr-14-06-5281","first-page":"351","article-title":"Relationship of blood lipids to anthropometric measures and family medical history in an ethnically diverse school aged population","volume":"1","author":"Wong","year":"1991","journal-title":"Ethn Dis"},{"key":"key20180108030911_b7-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2332\/allergolint.10-OA-0252","article-title":"Bimodal effects of obesity ratio on disease duration of respiratory syncytial virus infection in children","volume":"60","author":"Akiyama","year":"2011","journal-title":"Allergol Int"},{"key":"key20180108030911_b8-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/intimm\/dxh317","article-title":"Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob\/ob mice","volume":"17","author":"Wieland","year":"2005","journal-title":"Int Immunol"},{"key":"key20180108030911_b9-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/mi.2010.76","article-title":"Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica","volume":"4","author":"Guo","year":"2011","journal-title":"Mucosal Immunol"},{"key":"key20180108030911_b10-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.prrv.2006.08.002","article-title":"Obesity and inflammation in children","volume":"7","author":"Schwarzenberg","year":"2006","journal-title":"Paediatr Respir Rev"},{"key":"key20180108030911_b11-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrmicro1068","article-title":"LPS, TLR4 and infectious disease diversity","volume":"3","author":"Miller","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"key20180108030911_b12-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.taap.2010.03.006","article-title":"Arsenic alters monocyte superoxide anion and nitric oxide production in environmentally exposed children","volume":"245","author":"Luna","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20180108030911_b13-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2172-9-24","article-title":"Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide","volume":"9","author":"Wong","year":"2008","journal-title":"BMC Immunol"},{"key":"key20180108030911_b14-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2337\/dc09-1799","article-title":"Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects","volume":"33","author":"Dasu","year":"2010","journal-title":"Diabetes Care"},{"key":"key20180108030911_b15-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type III interferon-lambda production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat Med"},{"key":"key20180108030911_b16-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"key20180108030911_b17-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2222.2006.02450.x","article-title":"Impaired virus-induced interferon-alpha2 release in adult asthmatic patients","volume":"36","author":"Gehlhar","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"key20180108030911_b18-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1183\/09031936.00172008","article-title":"Toll-like receptor 7 function is reduced in adolescents with asthma","volume":"35","author":"Roponen","year":"2010","journal-title":"Eur Respir J"},{"key":"key20180108030911_b19-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/jc.2008-0425","article-title":"Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance","volume":"93","author":"Hivert","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108030911_b20-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"key20180108030911_b21-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/j.2047-6310.2012.00098.x","article-title":"Increased toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents","volume":"8","author":"Hardy","year":"2013","journal-title":"Pediatr Obes"},{"key":"key20180108030911_b22-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/clinchem\/36.1.15","article-title":"Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints","volume":"36","author":"Warnick","year":"1990","journal-title":"Clin Chem"},{"key":"key20180108030911_b23-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"key20180108030911_b24-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Ana Biochem"},{"key":"key20180108030911_b25-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108030911_b26-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.bcp.2013.09.004","article-title":"Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells","volume":"86","author":"Hilbert","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"key20180108030911_b27-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/tx9701384","article-title":"Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms","volume":"11","author":"Sakurai","year":"1998","journal-title":"Chem Res Toxicol"},{"key":"key20180108030911_b28-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2008.02.035","article-title":"Reactive species: A cell damaging rout assisting to chemical carcinogens","volume":"266","author":"Goetz","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180108030911_b29-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180108030911_b30-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2527\/1997.7561514x","article-title":"Time course of increased plasma cytokines, cortisol and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide","volume":"75","author":"Webel","year":"1997","journal-title":"J Anim Sci"},{"key":"key20180108030911_b31-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1210\/jcem.85.10.6914","article-title":"Insulin resistance and substrate utilization in human endotoxemia","volume":"85","author":"Agwunobi","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180108030911_b32-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"E1133","DOI":"10.1152\/ajpendo.2000.278.6.E1133","article-title":"Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I","volume":"278","author":"Lang","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20180108030911_b33-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"E159","DOI":"10.1152\/ajpendo.00595.2005","article-title":"Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia","volume":"291","author":"Orellana","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20180108030911_b34-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1824-7288-40-20","article-title":"Serum trace elements in obese Egyptian children: A case-control study","volume":"40","author":"Azab","year":"2014","journal-title":"Ital J Pediatr"},{"key":"key20180108030911_b35-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1152\/physiolgenomics.00024.2007","article-title":"Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome","volume":"30","author":"Wong","year":"2007","journal-title":"Physiol Genomics"},{"key":"key20180108030911_b36-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1203\/01.PDR.0000110526.02282.F3","article-title":"Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia","volume":"55","author":"Orellana","year":"2004","journal-title":"Pediatr Res"},{"key":"key20180108030911_b37-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00024382-199412000-00009","article-title":"Glucose, lactate, insulin, and somatostatin responses to endotoxin in developing rats","volume":"2","author":"Yelich","year":"1994","journal-title":"Shock"},{"key":"key20180108030911_b38-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0091-6749(96)80146-1","article-title":"Update on cytokines","volume":"97","author":"Borish","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"key20180108030911_b39-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1128\/JVI.02347-08","article-title":"Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection","volume":"83","author":"Okeoma","year":"2009","journal-title":"J Virol"},{"key":"key20180108030911_b40-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0167-5699(97)01197-3","article-title":"Signal transduction through NF-kappa B","volume":"19","author":"May","year":"1998","journal-title":"Immunol Today"},{"key":"key20180108030911_b41-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.intimp.2013.09.011","article-title":"Maturation inside and outside bone marrow dendritic cells (BMDCs) modulated by interferon-\u03b1 (IFN-\u03b1)","volume":"17","author":"Song","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"key20180108030911_b42-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1128\/JVI.02824-12","article-title":"Response of hepatitis C virus to long-term passage in the presence of alpha interferon: Multiple mutations and a common phenotype","volume":"87","author":"Perales","year":"2013","journal-title":"J Virol"},{"key":"key20180108030911_b43-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"35.e21","DOI":"10.1016\/j.urolonc.2013.02.010","article-title":"Interferon-alpha in the treatment paradigm for non-muscle-invasive bladder cancer","volume":"32","author":"Lamm","year":"2014","journal-title":"Urol Oncol"},{"key":"key20180108030911_b44-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.cr.7290309","article-title":"The host type I interferon response to viral and bacterial infections","volume":"15","author":"Perry","year":"2005","journal-title":"Cell Res"},{"key":"key20180108030911_b45-mmr-14-06-5281","first-page":"112","article-title":"Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression","volume":"10","author":"Zhang","year":"2008","journal-title":"Cell Microbiol"},{"key":"key20180108030911_b46-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon-gamma during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2007","journal-title":"Adv Immunol"},{"key":"key20180108030911_b47-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by gamma (c) family cytokines","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key20180108030911_b48-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(86)90625-2","article-title":"A model system for peptide hormone action in differentiation: Interleukin 2 induces a B lymphoma to transcribe the J chain gene","volume":"47","author":"Blackman","year":"1986","journal-title":"Cell"},{"key":"key20180108030911_b49-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/291335a0","article-title":"Interleukin-2 augments natural killer cell activity","volume":"291","author":"Henney","year":"1981","journal-title":"Nature"},{"key":"key20180108030911_b50-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.6429853","article-title":"Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes","volume":"225","author":"Reem","year":"1984","journal-title":"Science"},{"key":"key20180108030911_b51-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.coi.2011.08.003","article-title":"IL-2 family cytokines: New insights into the complex roles of IL-2 as a broad regulator of t helper cell differentiation","volume":"23","author":"Liao","year":"2011","journal-title":"Current Opinion Immunology"},{"key":"key20180108030911_b52-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.bi.63.070194.001135","article-title":"Nitric oxide: A physiologic messenger molecule","volume":"63","author":"Bredt","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"key20180108030911_b53-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1084\/jem.184.2.557","article-title":"Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production\/nitric oxide synthase type 2 expression","volume":"184","author":"Anstey","year":"1996","journal-title":"J Exp Med"},{"key":"key20180108030911_b54-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"531026","DOI":"10.1155\/2013\/531026","article-title":"Nitric oxide-dependent regulation of cytokines release in type-II diabetes mellitus","volume":"2013","author":"Elahi","year":"2013","journal-title":"ISRN Inflamm"},{"key":"key20180108030911_b55-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10719-006-9007-y","article-title":"O-acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL)","volume":"24","author":"Ghosh","year":"2007","journal-title":"Glycoconj J"},{"key":"key20180108030911_b56-mmr-14-06-5281","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/339005","article-title":"Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: The importance of IgE","volume":"185","author":"Faulkner","year":"2002","journal-title":"J Infect Dis"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5866\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T20:18:34Z","timestamp":1601151514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,10,20]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/mmr.2016.5866"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5866","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}