{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:58:33Z","timestamp":1790402313685,"version":"4.1.0"},"reference-count":52,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/mmr.2016.5870","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T10:21:39Z","timestamp":1476958899000},"page":"5245-5252","source":"Crossref","is-referenced-by-count":24,"title":["Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy"],"prefix":"10.3892","volume":"14","author":[{"given":"Xiuli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"key20180108030939_b1-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2011.183","article-title":"The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives","volume":"8","author":"Chen","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"key20180108030939_b2-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1681\/ASN.V12102098","article-title":"Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy","volume":"12","author":"Kelly","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b3-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.2337\/db06-0477","article-title":"Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy","volume":"55","author":"Schmid","year":"2006","journal-title":"Diabetes"},{"key":"key20180108030939_b4-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/CLEP.S12977","article-title":"The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease","volume":"3","author":"Seckeler","year":"2011","journal-title":"Clin Epidemiol"},{"key":"key20180108030939_b5-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1093\/ndt\/gfl469","article-title":"Urinary tumour necrosis factor-alpha excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients","volume":"21","author":"Navarro","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108030939_b6-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI11951","article-title":"Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)","volume":"108","author":"Oldfield","year":"2001","journal-title":"J Clin Invest"},{"key":"key20180108030939_b7-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1046\/j.1523-1755.1999.00721.x","article-title":"The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?","volume":"56","author":"Gilbert","year":"1999","journal-title":"Kidney Int"},{"key":"key20180108030939_b8-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.semnephrol.2007.01.012","article-title":"Histopathology of diabetic nephropathy","volume":"27","author":"Fioretto","year":"2007","journal-title":"Semin Nephrol"},{"key":"key20180108030939_b9-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.2337\/diabetes.52.12.2975","article-title":"Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose","volume":"52","author":"Lam","year":"2003","journal-title":"Diabetes"},{"key":"key20180108030939_b10-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1046\/j.1523-1755.2000.00311.x","article-title":"Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy","volume":"58","author":"Wada","year":"2000","journal-title":"Kidney Int"},{"key":"key20180108030939_b11-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/ndt\/gft431","article-title":"KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis","volume":"29","author":"Huang","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108030939_b12-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.ki.5002180","article-title":"Phenotypic transitions and fibrosis in diabetic nephropathy","volume":"71","author":"Simonson","year":"2007","journal-title":"Kidney Int"},{"key":"key20180108030939_b13-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J Clin Invest"},{"key":"key20180108030939_b14-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2337\/diab.44.10.1139","article-title":"Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator","volume":"44","author":"Sharma","year":"1995","journal-title":"Diabetes"},{"key":"key20180108030939_b15-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/ki.1994.330","article-title":"Renal TGF-beta regulation in spontaneously diabetic NOD mice with correlations in mesangial cells","volume":"46","author":"Pankewycz","year":"1994","journal-title":"Kidney Int"},{"key":"key20180108030939_b16-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1681\/ASN.V1091891","article-title":"High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: Mediation by autocrine activation of TGF-beta","volume":"10","author":"Han","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b17-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0002-9440(10)64121-1","article-title":"Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor and activation of the Smad signaling pathway in the db\/db mouse","volume":"158","author":"Hong","year":"2001","journal-title":"Am J Pathol"},{"key":"key20180108030939_b18-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2337\/diab.45.4.522","article-title":"Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice","volume":"45","author":"Sharma","year":"1996","journal-title":"Diabetes"},{"key":"key20180108030939_b19-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1681\/ASN.2006070754","article-title":"Role of the Akt\/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: A novel mechanism related to diabetic kidney disease","volume":"17","author":"Kato","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b20-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2353\/ajpath.2006.050921","article-title":"ERK, p38 and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells","volume":"169","author":"Zhang","year":"2006","journal-title":"Am J Pathol"},{"key":"key20180108030939_b21-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.lfs.2006.12.035","article-title":"Zinc deficiency during growth: Influence on renal function and morphology","volume":"80","author":"Tomat","year":"2007","journal-title":"Life Sci"},{"key":"key20180108030939_b22-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fnbeh.2014.00443","article-title":"Behavioral impairments in animal models for zinc deficiency","volume":"8","author":"Hagmeyer","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"key20180108030939_b23-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1385\/BTER:81:3:215","article-title":"Zinc and diabetes mellitus: Is there a need of zinc supplementation in diabetes mellitus patients?","volume":"81","author":"Salgueiro","year":"2001","journal-title":"Biol Trace Elem Res"},{"key":"key20180108030939_b24-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:112:1:1","article-title":"Effect of end-stage renal disease and diabetes on zinc and copper status","volume":"112","author":"Batista","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"key20180108030939_b25-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4149\/gpb_2011_04_356","article-title":"Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model","volume":"30","author":"Ozcelik","journal-title":"Gen Physiol Biophys"},{"key":"key20180108030939_b26-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1900\/RDS.2008.5.102","article-title":"Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: A double blind, randomized, placebo-controlled, cross-over trial","volume":"5","author":"Parham","year":"2008","journal-title":"Rev Diabet Stud"},{"key":"key20180108030939_b27-mmr-14-06-5245","first-page":"CC04","article-title":"Zinc status in type 2 diabetic patients: Relation to the progression of diabetic nephropathy","volume":"8","author":"Al-Timimi","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"key20180108030939_b28-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1872-034X.2007.00065.x","article-title":"Possible inhibitory effect of oral zinc supplementation on hepatic fibrosis through downregulation of TIMP-1: A pilot study","volume":"37","author":"Takahashi","year":"2007","journal-title":"Hepatol Res"},{"key":"key20180108030939_b29-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/FJC.0b013e3181833eb8","article-title":"Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism","volume":"52","author":"Gandhi","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20180108030939_b30-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000129650","article-title":"The effect of zinc supplements in cystic fibrosis patients","volume":"52","author":"Van Biervliet","year":"2008","journal-title":"Ann Nutr Metab"},{"key":"key20180108030939_b31-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12011-012-9451-4","article-title":"Zinc supplementation attenuates high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells","volume":"150","author":"Zhang","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"key20180108030939_b32-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1440-1797.2007.00796.x","article-title":"Rodent models of streptozotocin-induced diabetic nephropathy","volume":"12","author":"Tesch","year":"2007","journal-title":"Nephrology (Carlton)"},{"key":"key20180108030939_b33-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3892\/ijmm.2015.2170","article-title":"Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells","volume":"35","author":"Zhang","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20180108030939_b34-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4684-0796-9_17","article-title":"Implications of the inhibition of animal tumors by dietary zinc deficiency","volume":"91","author":"Pories","year":"1977","journal-title":"Adv Exp Med Biol"},{"key":"key20180108030939_b35-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1523-1755.2001.00776.x","article-title":"Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy","volume":"60","author":"Wang","year":"2001","journal-title":"Kidney Int"},{"key":"key20180108030939_b36-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1681\/ASN.2004070578","article-title":"Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment and tubulointerstitial injury in advanced experimental diabetic nephropathy","volume":"16","author":"Kelly","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b37-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2337\/diabetes.47.3.414","article-title":"Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: Effects of ACE inhibition","volume":"47","author":"Gilbert","year":"1998","journal-title":"Diabetes"},{"key":"key20180108030939_b38-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4269\/ajtmh.1992.47.383","article-title":"The effect of zinc deficiency on granuloma formation, liver fibrosis and antibody responses in experimental schistosomiasis","volume":"47","author":"Nawar","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"key20180108030939_b39-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF02784619","article-title":"Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes","volume":"32","author":"Gomot","year":"1992","journal-title":"Biol Trace Elem Res"},{"key":"key20180108030939_b40-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.coph.2006.01.005","article-title":"Zinc metabolism in the airway: Basic mechanisms and drug targets","volume":"6","author":"Zalewski","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"key20180108030939_b41-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bcp.2009.04.009","article-title":"Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling","volume":"78","author":"Szuster-Ciesielska","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"key20180108030939_b42-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1681\/ASN.2006050525","article-title":"Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: Implications for diabetic renal disease","volume":"17","author":"Burns","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b43-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jnutbio.2008.12.010","article-title":"Zinc supplementation partially prevents renal pathological changes in diabetic rats","volume":"21","author":"Tang","year":"2010","journal-title":"J Nutr Biochem"},{"key":"key20180108030939_b44-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12011-012-9508-4","article-title":"Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats","volume":"150","author":"\u00d6zcelik","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"key20180108030939_b45-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"F614","DOI":"10.1152\/ajprenal.90500.2008","article-title":"C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: Implications for treatment of diabetic nephropathy","volume":"296","author":"Hills","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20180108030939_b46-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1681\/ASN.2008121226","article-title":"New insights into epithelial-mesenchymal transition in kidney fibrosis","volume":"21","author":"Liu","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b47-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1523-1755.1999.00590.x","article-title":"Molecular mechanisms of diabetic renal hypertrophy","volume":"56","author":"Wolf","year":"1999","journal-title":"Kidney Int"},{"key":"key20180108030939_b48-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"e22806","DOI":"10.1371\/journal.pone.0022806","article-title":"The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells","volume":"6","author":"Lv","year":"2011","journal-title":"PLoS One"},{"key":"key20180108030939_b49-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/01.ASN.0000065640.77499.D7","article-title":"Extracellular matrix metabolism in diabetic nephropathy","volume":"14","author":"Mason","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"key20180108030939_b50-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2008.08.040","article-title":"Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms","volume":"1237","author":"Corniola","year":"2008","journal-title":"Brain Res"},{"key":"key20180108030939_b51-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/0196-9781(95)02030-6","article-title":"Differential effects of transforming growth factor-beta on osteoclast-like cell formation in mouse marrow culture: Relation to the effect of zinc-chelating dipeptides","volume":"16","author":"Yamaguchi","year":"1995","journal-title":"Peptides"},{"key":"key20180108030939_b52-mmr-14-06-5245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12011-014-9979-6","article-title":"Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-\u03b21 and TNF-\u03b1 signaling pathways in HLE B-3 cells","volume":"159","author":"Du","year":"2014","journal-title":"Biol Trace Elem Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5870\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T20:47:11Z","timestamp":1657486031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,10,20]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/mmr.2016.5870"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5870","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}