{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:59:48Z","timestamp":1780473588836,"version":"3.54.1"},"reference-count":29,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/mmr.2016.5947","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T13:34:52Z","timestamp":1479303292000},"page":"5760-5766","source":"Crossref","is-referenced-by-count":7,"title":["Etomidate inhibits nuclear factor-\u03baB through decreased expression of glucocorticoid receptor in septic rats"],"prefix":"10.3892","volume":"14","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"key20180108031109_b1-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit Care Med"},{"key":"key20180108031109_b2-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/ALN.0b013e3181ff72b5","article-title":"Clinical and molecular pharmacology of etomidate","volume":"114","author":"Forman","year":"2011","journal-title":"Anesthesiology"},{"key":"key20180108031109_b3-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"R150","DOI":"10.1186\/cc13988","article-title":"Comparison of clinical outcome variables in patients with and without etomidate-facilitated anesthesia induction ahead of major cardiac surgery: A retrospective analysis","volume":"18","author":"Heinrich","year":"2014","journal-title":"Crit Care"},{"key":"key20180108031109_b4-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"639","DOI":"10.4187\/respcare.01956","article-title":"Etomidate, adrenal function, and mortality in critically ill patients","volume":"58","author":"Sunshine","year":"2013","journal-title":"Respir Care"},{"key":"key20180108031109_b5-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1097\/CCM.0b013e31825fec26","article-title":"Etomidate is associated with mortality and adrenal insufficiency in sepsis: A meta-analysis*","volume":"40","author":"Chan","year":"2012","journal-title":"Crit Care Med"},{"key":"key20180108031109_b6-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jss.2014.07.001","article-title":"Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency","volume":"193","author":"Zhang","year":"2015","journal-title":"J Surg Res"},{"key":"key20180108031109_b7-mmr-14-06-5760","first-page":"2432","article-title":"Hyperinsulinemic-euglycemic clamp in the conscious rat","author":"Hughey","year":"2011","journal-title":"J Vis Exp"},{"key":"key20180108031109_b8-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat Protoc"},{"key":"key20180108031109_b9-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01.shk.0000144134.03598.c5","article-title":"Genetic determinants influencing the response to injury, inflammation, and sepsis","volume":"23","author":"De Maio","year":"2005","journal-title":"Shock"},{"key":"key20180108031109_b10-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108031109_b11-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: The gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol"},{"key":"key20180108031109_b12-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00011-014-0713-9","article-title":"Posttreatment with propofol attenuates lipopolysaccharide-induced up-regulation of inflammatory molecules in primary microglia","volume":"63","author":"Peng","year":"2014","journal-title":"Inflamm Res"},{"key":"key20180108031109_b13-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"562154","DOI":"10.1155\/2013\/562154","article-title":"Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4\/NF-\u03baB pathway","volume":"2013","author":"Wu","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20180108031109_b14-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00000542-200607000-00019","article-title":"Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage","volume":"105","author":"Kim","year":"2006","journal-title":"Anesthesiology"},{"key":"key20180108031109_b15-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3390\/toxins2061357","article-title":"The glucocorticoid receptor: A revisited target for toxins","volume":"2","author":"Marketon","year":"2010","journal-title":"Toxins (Basel)"},{"key":"key20180108031109_b16-mmr-14-06-5760","first-page":"161","article-title":"Etomidate as an induction agent in septic patients: red flags or false alarms?","volume":"11","author":"Kulstad","year":"2010","journal-title":"West J Emerg Med"},{"key":"key20180108031109_b17-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00000542-198412000-00004","article-title":"Effects of etomidate on hormonal responses to surgical stress","volume":"61","author":"Fragen","year":"1984","journal-title":"Anesthesiology"},{"key":"key20180108031109_b18-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1399-6576.1985.tb02238.x","article-title":"Etomidate infusion and adrenocortical function. A study in elective surgery","volume":"29","author":"Wanscher","year":"1985","journal-title":"Acta Anaesthesiol Scand"},{"key":"key20180108031109_b19-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1096\/fj.12-216382","article-title":"Mechanisms of the anti-inflammatory effects of glucocorticoids: Genomic and nongenomic interference with MAPK signaling pathways","volume":"26","author":"Ayroldi","year":"2012","journal-title":"FASEB J"},{"key":"key20180108031109_b20-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0854.2011.01288.x","article-title":"On the trail of the glucocorticoid receptor: Into the nucleus and back","volume":"13","author":"Vandevyver","year":"2012","journal-title":"Traffic"},{"key":"key20180108031109_b21-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1096\/fj.14-254755","article-title":"Targeting glucocorticoid side effects: Selective glucocorticoid receptor modulator or glucocorticoid-induced leucine zipper? A perspective","volume":"28","author":"Ayroldi","year":"2014","journal-title":"FASEB J"},{"key":"key20180108031109_b22-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2012.02.033","article-title":"Crosstalk between NFkB and glucocorticoid signaling: A potential target of breast cancer therapy","volume":"322","author":"Ling","year":"2012","journal-title":"Cancer Lett"},{"key":"key20180108031109_b23-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.270.5234.286","article-title":"Immunosuppression by glucocorticoids: Inhibition of NF-kappaB activity through induction of I kappa B synthesis","volume":"270","author":"Auphan","year":"1995","journal-title":"Science"},{"key":"key20180108031109_b24-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00003246-200103000-00006","article-title":"Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients","volume":"29","author":"Abraham","year":"2001","journal-title":"Crit Care Med"},{"key":"key20180108031109_b25-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/cc7088","article-title":"Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis","volume":"12","author":"Weber","year":"2008","journal-title":"Crit Care"},{"key":"key20180108031109_b26-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1128\/IAI.01213-09","article-title":"Characterization and modulation of the immunosuppressive phase of sepsis","volume":"78","author":"Muenzer","year":"2010","journal-title":"Infect Immun"},{"key":"key20180108031109_b27-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/CCM.0b013e31822d7938","article-title":"Corticosteroid after etomidate in critically ill patients: A randomized controlled trial","volume":"40","author":"Payen","year":"2012","journal-title":"Crit Care Med"},{"key":"key20180108031109_b28-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"14801","DOI":"10.1073\/pnas.1313945110","article-title":"Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation","volume":"110","author":"Kanczkowski","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108031109_b29-mmr-14-06-5760","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1097\/CCM.0b013e31827c0c8d","article-title":"Benzodiazepine augmented \u03b3-amino-butyric acid signaling increases mortality from pneumonia in mice","volume":"41","author":"Sanders","year":"2013","journal-title":"Crit Care Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5947\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:56:08Z","timestamp":1692572168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,16]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/mmr.2016.5947"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5947","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}