{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:17:37Z","timestamp":1773109057718,"version":"3.50.1"},"reference-count":37,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/mmr.2016.5954","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T12:48:50Z","timestamp":1479473330000},"page":"5556-5566","source":"Crossref","is-referenced-by-count":9,"title":["Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury"],"prefix":"10.3892","volume":"14","author":[{"given":"Yunhu","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qishan","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"key20180108030901_b1-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.apmr.2012.12.019","article-title":"Participation after multidisciplinary rehabilitation for moderate to severe traumatic brain injury in adults: a systematic review","volume":"94","author":"Brasure","year":"2013","journal-title":"Arch Phys Med Rehabil"},{"key":"key20180108030901_b2-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ana.22555","article-title":"Microglial activation and traumatic brain injury","volume":"70","author":"Faden","year":"2011","journal-title":"Ann Neurol"},{"key":"key20180108030901_b3-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1097\/00003246-200011000-00029","article-title":"Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats","volume":"28","author":"Whalen","year":"2000","journal-title":"Crit Care Med"},{"key":"key20180108030901_b4-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1089\/neu.2004.21.1431","article-title":"The effects of traumatic brain injury on cerebral blood flow and brain tissue nitric oxide levels and cytokine expression","volume":"21","author":"Ahn","year":"2004","journal-title":"J Neurotrauma"},{"key":"key20180108030901_b5-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1002\/jnr.22510","article-title":"Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury","volume":"88","author":"Readnower","year":"2010","journal-title":"J Neurosci Res"},{"key":"key20180108030901_b6-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.1927","article-title":"Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke","volume":"15","author":"Liesz","year":"2009","journal-title":"Nat Med"},{"key":"key20180108030901_b7-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/jcbfm.2008.153","article-title":"Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats","volume":"29","author":"Ishibashi","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20180108030901_b8-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1161\/CIRCULATIONAHA.109.893248","article-title":"Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor \u03b2-coxsackie-adenovirus receptor pathway","volume":"121","author":"Shi","year":"2010","journal-title":"Circulation"},{"key":"key20180108030901_b9-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2217\/imt.10.63","article-title":"Regulatory T cells as potential targets for immunotherapy in inflammatory bowel disease","volume":"2","author":"Strisciuglio","year":"2010","journal-title":"Immunotherapy"},{"key":"key20180108030901_b10-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/eji.200939792","article-title":"Expansion of regulatory T cells via IL-2\/anti-IL-2 mAb complexes suppresses experimental myasthenia","volume":"40","author":"Liu","year":"2010","journal-title":"Eur J Immunol"},{"key":"key20180108030901_b11-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2119\/molmed.2011.00471","article-title":"Statins induce the accumulation of regulatory T cells in atherosclerotic plaque","volume":"18","author":"Meng","year":"2012","journal-title":"Mol Med"},{"key":"key20180108030901_b12-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4103\/0366-6999.155094","article-title":"Role of regulatory T cell in clinical outcome of traumatic brain injury","volume":"128","author":"Li","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"key20180108030901_b13-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"key20180108030901_b14-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180108030901_b15-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key20180108030901_b16-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"e1924","DOI":"10.1371\/journal.pone.0001924","article-title":"Erythropoietin: A potent inducer of peripheral immuno\/inflammatory modulation in autoimmune EAE","volume":"3","author":"Yuan","year":"2008","journal-title":"PLoS One"},{"key":"key20180108030901_b17-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1523\/JNEUROSCI.1227-10.2010","article-title":"Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice","volume":"30","author":"D\u00e9nes","year":"2010","journal-title":"J Neurosci"},{"key":"key20180108030901_b18-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.4049\/jimmunol.1100725","article-title":"Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development","volume":"187","author":"Bassil","year":"2011","journal-title":"J Immunol"},{"key":"key20180108030901_b19-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"key20180108030901_b20-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","article-title":"Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease","volume":"212","author":"Sakaguchi","year":"2006","journal-title":"Immunol Rev"},{"key":"key20180108030901_b21-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0140-6736(00)02689-1","article-title":"Traumatic brain injury","volume":"356","author":"Ghajar","year":"2000","journal-title":"Lancet"},{"key":"key20180108030901_b22-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nurt.2009.10.016","article-title":"Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury","volume":"7","author":"Ziebell","year":"2010","journal-title":"Neurotherapeutics"},{"key":"key20180108030901_b23-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ni1207-1285","article-title":"Competition for cytokines: T(reg) cells take all","volume":"8","author":"Scheffold","year":"2007","journal-title":"Nat Immunol"},{"key":"key20180108030901_b24-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/jmcb\/mjs063","article-title":"TNF-alpha impairs differentiation and function of TGF-beta-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway","volume":"5","author":"Zhang","year":"2013","journal-title":"J Mol Cell Biol"},{"key":"key20180108030901_b25-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1089\/neu.2007.0377","article-title":"Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury","volume":"24","author":"Nagamoto-Combs","year":"2007","journal-title":"J Neurotrauma"},{"key":"key20180108030901_b26-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1007074420772","article-title":"Inflammatory mediators and modulation of blood-brain barrier permeability","volume":"20","author":"Abbott","year":"2000","journal-title":"Cell Mol Neurobiol"},{"key":"key20180108030901_b27-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nrn1252","article-title":"The molecular basis of water transport in the brain","volume":"4","author":"Amiry-Moghaddam","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"key20180108030901_b28-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.134.4.1031","article-title":"Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein","volume":"134","author":"Balda","year":"1996","journal-title":"J Cell Biol"},{"key":"key20180108030901_b29-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.0500989102","article-title":"Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury","volume":"102","author":"Di Giovanni","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108030901_b30-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: Microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann Neurol"},{"key":"key20180108030901_b31-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat Immunol"},{"key":"key20180108030901_b32-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ni1184","article-title":"Natural regulatory T cells and self-tolerance","volume":"6","author":"Schwartz","year":"2005","journal-title":"Nat Immunol"},{"key":"key20180108030901_b33-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.it.2006.05.003","article-title":"CD4+CD25+ Tregs and NKT cells: Regulators regulating regulators","volume":"27","author":"La Cava","year":"2006","journal-title":"Trends Immunol"},{"key":"key20180108030901_b34-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-11-3900","article-title":"Functional defect of regulatory CD4(+)CD25(+) T cells in the thymus of patients with autoimmune myasthenia gravis","volume":"105","author":"Balandina","year":"2005","journal-title":"Blood"},{"key":"key20180108030901_b35-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2567.2005.02220.x","article-title":"Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: Effect of immunosuppressive treatment","volume":"116","author":"Fattorossi","year":"2005","journal-title":"Immunology"},{"key":"key20180108030901_b36-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.4049\/jimmunol.175.12.7898","article-title":"Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia","volume":"175","author":"Liu","year":"2005","journal-title":"J Immunol"},{"key":"key20180108030901_b37-mmr-14-06-5556","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/intimm\/dxn146","article-title":"HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: An additional mechanism of immunosuppression","volume":"21","author":"Ji","year":"2009","journal-title":"Int Immunol"}],"updated-by":[{"DOI":"10.3892\/mmr.2017.6299","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"record-id":"8377"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5954\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T23:54:34Z","timestamp":1692575674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,18]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/mmr.2016.5954"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5954","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]}}}