{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:57:00Z","timestamp":1769122620779,"version":"3.49.0"},"reference-count":28,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.3892\/mmr.2016.5980","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T04:10:40Z","timestamp":1480911040000},"page":"97-102","source":"Crossref","is-referenced-by-count":22,"title":["Berberine exerts an anti-inflammatory role in ocular Behcet's disease"],"prefix":"10.3892","volume":"15","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manyun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"key20180108015722_b1-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1211\/jpp.61.07.0001","article-title":"Neuropharmacological and pharmacokinetic properties of berberine: A review of recent research","volume":"61","author":"Ye","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"key20180108015722_b2-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3892\/ijmm.2015.2113","article-title":"Berberine regulates melanin synthesis by activating PI3K\/AKT, ERK and GSK3\u03b2 in B16F10 melanoma cells","volume":"35","author":"Song","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20180108015722_b3-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"e18467","DOI":"10.1371\/journal.pone.0018467","article-title":"Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages","volume":"6","author":"Saha","year":"2011","journal-title":"PLoS One"},{"key":"key20180108015722_b4-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/ijmm.2014.1868","article-title":"The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1","volume":"34","author":"Chi","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20180108015722_b5-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/art.30202","article-title":"Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis","volume":"63","author":"Hu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"key20180108015722_b6-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"28420","DOI":"10.1074\/jbc.M109.012674","article-title":"Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice","volume":"284","author":"Cui","year":"2009","journal-title":"J Biol Chem"},{"key":"key20180108015722_b7-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.0903853","article-title":"Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine","volume":"185","author":"Qin","year":"2010","journal-title":"J Immunol"},{"key":"key20180108015722_b8-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1167\/iovs.12-11217","article-title":"Berberine suppresses Th17 and dendritic cell responses","volume":"54","author":"Yang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180108015722_b9-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical features of chinese patients with Beh\u00e7et's disease","volume":"115","author":"Yang","year":"2008","journal-title":"Ophthalmology"},{"key":"key20180108015722_b10-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat Med"},{"key":"key20180108015722_b11-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2007.01.010","article-title":"IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease","volume":"119","author":"Chi","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"key20180108015722_b12-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1167\/iovs.07-0251","article-title":"Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis","volume":"48","author":"Peng","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180108015722_b13-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.20071258","article-title":"Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category","volume":"205","author":"Luger","year":"2008","journal-title":"J Exp Med"},{"key":"key20180108015722_b14-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.clim.2008.12.007","article-title":"Inhibitory effect of Cyclosporin A and corticosteroids on the production of IFN-gamma and IL-17 by T cells in Vogt-Koyanagi-Harada syndrome","volume":"131","author":"Liu","year":"2009","journal-title":"Clin Immunol"},{"key":"key20180108015722_b15-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.4049\/jimmunol.178.8.4901","article-title":"Stat3 and Stat4 direct development of IL-17-secreting Th cells","volume":"178","author":"Mathur","year":"2007","journal-title":"J Immunol"},{"key":"key20180108015722_b16-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/gene.2014.64","article-title":"Activation of the JAK\/STAT pathway in Behcet's disease","volume":"16","author":"Tulunay","year":"2014","journal-title":"Genes Immun"},{"key":"key20180108015722_b17-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/rheumatology\/ket438","article-title":"Increased Notch pathway activation in Beh\u00e7et's disease","volume":"53","author":"Qi","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"key20180108015722_b18-mmr-15-01-0097","first-page":"1078","article-title":"International Study Group for Beh\u00e7et's Disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"key20180108015722_b19-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/bmj.2.5402.177","article-title":"Human experimentation. Code of ethics of the world medical association. Declaration of Helsinki","volume":"2","author":"Rickham","year":"1964","journal-title":"Br Med J"},{"key":"key20180108015722_b20-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"e13489","DOI":"10.1371\/journal.pone.0013489","article-title":"Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL\/6 mice","volume":"5","author":"Ma","year":"2010","journal-title":"PLoS One"},{"key":"key20180108015722_b21-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0162-3109(99)00189-7","article-title":"Suppression of experimental autoimmune tubulointerstitial nephritis in BALB\/c mice by berberine","volume":"48","author":"Marinova","year":"2000","journal-title":"Immunopharmacology"},{"key":"key20180108015722_b22-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1167\/iovs.07-1186","article-title":"The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits","volume":"49","author":"Gupta","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"key20180108015722_b23-mmr-15-01-0097","first-page":"32","article-title":"Up-regulation of Th17 and related cytokines in Beh\u00e7et's disease corresponding to disease activity","volume":"31","author":"Na","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"key20180108015722_b24-mmr-15-01-0097","first-page":"880","article-title":"Production of interleukin-17 in Behcet's disease is inhibited by cyclosporin A","volume":"16","author":"Chi","year":"2010","journal-title":"Mol Vis"},{"key":"key20180108015722_b25-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clim.2008.06.007","article-title":"The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis","volume":"129","author":"Hedegaard","year":"2008","journal-title":"Clin Immunol"},{"key":"key20180108015722_b26-mmr-15-01-0097","first-page":"295","article-title":"Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes","volume":"2","author":"Xu","year":"2005","journal-title":"Cell Mol Immunol"},{"key":"key20180108015722_b27-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.oooo.2012.09.009","article-title":"Effects of berberine gelatin on recurrent aphthous stomatitis: A randomized, placebo-controlled, double-blind trial in a Chinese cohort","volume":"115","author":"Jiang","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"key20180108015722_b28-mmr-15-01-0097","doi-asserted-by":"crossref","first-page":"905749","DOI":"10.1155\/2015\/905749","article-title":"Application of berberine on treating type 2 diabetes mellitus","volume":"2015","author":"Pang","year":"2015","journal-title":"Int J Endocrinol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.5980\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:55:36Z","timestamp":1515365736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.5980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,5]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,5]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.3892\/mmr.2016.5980"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.5980","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,5]]}}}